Page last updated: 2024-09-05

deflazacort and methotrexate

deflazacort has been researched along with methotrexate in 7 studies

Compound Research Comparison

Studies
(deflazacort)
Trials
(deflazacort)
Recent Studies (post-2010)
(deflazacort)
Studies
(methotrexate)
Trials
(methotrexate)
Recent Studies (post-2010) (methotrexate)
4529911541,5935,66611,969

Protein Interaction Comparison

ProteinTaxonomydeflazacort (IC50)methotrexate (IC50)
Thymidylate synthase Escherichia coli1.8
nuclear receptor coactivator 3 isoform aHomo sapiens (human)0.211
Toll-like receptor 4Homo sapiens (human)1.04
Fatty-acid amide hydrolase 1Mus musculus (house mouse)0.08
Dihydrofolate reductaseHomo sapiens (human)0.0522
Dihydrofolate reductaseMus musculus (house mouse)0.0331
Dihydrofolate reductase Bos taurus (cattle)0.0348
Dihydrofolate reductaseGallus gallus (chicken)0.0545
Dihydrofolate reductaseEnterococcus faecium0.0014
Dihydrofolate reductaseLacticaseibacillus casei0.0138
Thymidylate synthaseHomo sapiens (human)0.343
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0147
Thymidylate synthaseEscherichia coli K-120.0181
Dihydrofolate reductaseEscherichia coli K-120.1529
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K10.084
Folate receptor betaHomo sapiens (human)0.1585
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0011
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)0.0012
Folate receptor alphaHomo sapiens (human)0.2263
Dihydrofolate reductasePneumocystis carinii0.0717
Histidine decarboxylaseRattus norvegicus (Norway rat)0.0014
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)0.01
Bifunctional purine biosynthesis protein ATICHomo sapiens (human)0.01
Delta-type opioid receptorRattus norvegicus (Norway rat)0.003
Mu-type opioid receptorRattus norvegicus (Norway rat)0.003
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.003
Reduced folate transporterHomo sapiens (human)0.012
Dihydrofolate reductaseMycobacterium tuberculosis H37Rv0.0174
Folylpolyglutamate synthase, mitochondrialHomo sapiens (human)3.2
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii0.0547
Bifunctional dihydrofolate reductase-thymidylate synthaseTrypanosoma cruzi0.11
Dihydrofolate reductase Bacillus anthracis0.0136
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.0047
Proton-coupled folate transporterHomo sapiens (human)0.1207

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Emery, HM1
di Girolamo, C; Giuliano, F; Melillo, E; Melillo, G; Pappone, N; Rengo, C1
Gran, JT1
Baixauli Rubio, A; Calvo Catalá, J; Campos Fernández, C; García Vicente, S; Rodríguez Górriz, E1
Altintop, L; Bektas, A; Cakar, B; Hokelek, M; Karaoglanoglu, M; Yildiz, L1
Bajaj, S; Bose, SK; Sardana, K1

Reviews

2 review(s) available for deflazacort and methotrexate

ArticleYear
Treatment of juvenile rheumatoid arthritis.
    Current opinion in rheumatology, 1993, Volume: 5, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Erythropoietin; gamma-Globulins; Glucocorticoids; Humans; Hydroxychloroquine; Methotrexate; Nutritional Physiological Phenomena; Pain Management; Pregnenediones; Sulfasalazine

1993
Current therapy of polymyalgia rheumatica.
    Scandinavian journal of rheumatology, 1999, Volume: 28, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Humans; Immunosuppressive Agents; Methotrexate; Pain; Polymyalgia Rheumatica; Pregnenediones

1999

Other Studies

5 other study(ies) available for deflazacort and methotrexate

ArticleYear
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cavitary lung tuberculosis in a rheumatoid arthritis patient treated with low-dose methotrexate and steroid pulse therapy.
    British journal of rheumatology, 1998, Volume: 37, Issue:10

    Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Methotrexate; Mycobacterium tuberculosis; Pregnenediones; Radiography; Sputum; Tuberculosis, Pulmonary

1998
[Rare opportunistic disease in a patient treated with immunosuppressive therapy for rheumatoid arthritis].
    Anales de medicina interna (Madrid, Spain : 1984), 2003, Volume: 20, Issue:5

    Topics: Arthritis, Rheumatoid; Bone Marrow; Humans; Immunocompromised Host; Immunosuppressive Agents; Leishmaniasis, Visceral; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pregnenediones

2003
Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report.
    Annals of clinical microbiology and antimicrobials, 2010, Sep-20, Volume: 9

    Topics: Aged; Albendazole; Animals; Antinematodal Agents; Arthritis, Rheumatoid; Asthma; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Intestinal Diseases, Parasitic; Ivermectin; Methotrexate; Opportunistic Infections; Pregnenediones; Soil; Strongyloides stercoralis; Strongyloidiasis

2010
Successful treatment of PAPA syndrome with minocycline, dapsone, deflazacort and methotrexate: a cost-effective therapy with a 2-year follow-up.
    Clinical and experimental dermatology, 2019, Volume: 44, Issue:5

    Topics: Acne Vulgaris; Anti-Inflammatory Agents; Arthritis, Infectious; Cost-Benefit Analysis; Dapsone; Dermatologic Agents; Drug Therapy, Combination; Humans; Methotrexate; Minocycline; Pregnenediones; Pyoderma Gangrenosum; Skin

2019