deferoxamine and pyridoxal isonicotinoyl hydrazone

deferoxamine has been researched along with pyridoxal isonicotinoyl hydrazone in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's8 (34.78)18.2507
2000's10 (43.48)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Avramovici-Grisaru, S; Hershko, C; Link, G; Sarel, S1
Bernhardt, PV; Islam, M; Kalinowski, DS; Kumar, N; Liao, YT; Lovejoy, DB; Richardson, DR; Sharpe, PC; Yu, Y1
Bernhardt, PV; Kalinowski, DS; Richardson, DR; Sharpe, PC2
Bernhardt, PV; Islam, M; Kalinowski, DS; Lovejoy, DB; Richardson, DR; Richardson, V; Sharpe, PC1
Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Kovacevic, Z; Lovejoy, DB; Richardson, DR; Sharpe, PC; Siafakas, AR; Stefani, C; Yu, Y1
Campbell, RA; Gale, GR; Jones, MM; Litchenberg, WH; Singh, PK; Smith, AB1
Eisenstein, RS; Garcia-Mayol, D; Munro, HN; Pettingell, W1
Baker, E; Richardson, DR1
Finch, CA; Huebers, HA; Kim, BK1
Baker, E; Vitolo, ML; Webb, J1
Finch, CA; Johnson, DK; Pippard, MJ1
Ponka, P; Richardson, DR; Tran, EH1
Ponka, P; Richardson, DR1
Crowe, A; Morgan, EH1
Bhattacharya, M; Chemtob, S; Hanna, N; Hardy, P; Lachapelle, P; Ponka, P; Varma, DR1
Milnes, K; Richardson, DR1
Gao, J; Richardson, DR1
Breuer, W; Cabantchik, ZI; Hershko, C; Konijn, AM; Link, G; Ponka, P1
Richardson, DR1
Cabantchik, ZI; Hershko, CM; Konijn, AM; Link, GM1
Bast, A; den Hartog, GJ; Kaiserová, H; Kvasnicková, E; Schröterová, L; Simůnek, T1
Kovacevic, Z; Richardson, DR; Yu, Y1

Reviews

2 review(s) available for deferoxamine and pyridoxal isonicotinoyl hydrazone

ArticleYear
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Animals; Antineoplastic Agents; Humans; Iron; Iron Chelating Agents; Ribonucleotide Reductases; Thiosemicarbazones

2009
Therapeutic potential of iron chelators in cancer therapy.
    Advances in experimental medicine and biology, 2002, Volume: 509

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Deferoxamine; Humans; Iron; Iron Chelating Agents; Isoniazid; Neoplasms; Pyridoxal; Thiosemicarbazones; Tumor Suppressor Protein p53

2002

Other Studies

21 other study(ies) available for deferoxamine and pyridoxal isonicotinoyl hydrazone

ArticleYear
Syntheses of iron bis(pyridoxal isonicotinoylhydrazone)s and the in vivo iron-removal properties of some pyridoxal derivatives.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:2

    Topics: Animals; Chelating Agents; Hydrogen-Ion Concentration; Iron; Isoniazid; Kinetics; Liver; Magnetic Resonance Spectroscopy; Pyridoxal; Rats; Spectrophotometry, Infrared; Spleen; Structure-Activity Relationship

1983
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Ferric Compounds; Ferrous Compounds; Humans; Iron; Iron Chelating Agents; Ligands; Molecular Structure; Nitrobenzoates; Oxidation-Reduction; Protein Binding; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2007
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
    Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Electrochemistry; Ferrous Compounds; Humans; Hydrazones; Hydroxylation; Iron; Iron Chelating Agents; Ligands; Molecular Structure; Oxidation-Reduction; Structure-Activity Relationship; Thiones; Transferrin

2007
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; Hydrazones; Hydroxylation; Iron; Iron Chelating Agents; Iron Overload; Iron Radioisotopes; Isonicotinic Acids; Ketones; Ligands; Oxidation-Reduction; Pyrazines; Structure-Activity Relationship

2008
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemical Techniques; Humans; Iron; Iron Chelating Agents; Oxidation-Reduction; Pyridines; Stereoisomerism; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2009
Comparative iron mobilizing actions of deferoxamine, 1,2-dimethyl-3-hydroxypyrid-4-one, and pyridoxal isonicotinoyl hydrazone in iron hydroxamate-loaded mice.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 73, Issue:3

    Topics: Animals; Deferiprone; Deferoxamine; Hydroxamic Acids; Iron; Isoniazid; Male; Mice; Mice, Inbred Strains; Pyridones; Pyridoxal; Tissue Distribution

1991
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Feb-01, Volume: 88, Issue:3

    Topics: Animals; Cell Line; Deferoxamine; Enzyme Induction; Ferritins; Fibroblasts; Heme; Heme Oxygenase (Decyclizing); Iron; Isoniazid; Kinetics; Pyridoxal; Rats

1991
The release of iron and transferrin from the human melanoma cell.
    Biochimica et biophysica acta, 1991, Feb-19, Volume: 1091, Issue:3

    Topics: Antigens, Neoplasm; Cell Line; Deferoxamine; Humans; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Pyridoxal; Transferrin

1991
Effectiveness of oral iron chelators assayed in the rat.
    American journal of hematology, 1987, Volume: 24, Issue:3

    Topics: Administration, Oral; Animals; Deferoxamine; Female; Ferritins; Iron Chelating Agents; Isoniazid; Male; Pyridoxal; Rats; Rats, Inbred Strains

1987
Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture.
    Biochemical pharmacology, 1985, Sep-01, Volume: 34, Issue:17

    Topics: Animals; Cells, Cultured; Chelating Agents; Deferoxamine; Iron; Isoniazid; Liver; Male; Pyridoxal; Rats; Rats, Inbred Strains; Transferrin

1985
A rapid assay for evaluation of iron-chelating agents in rats.
    Blood, 1981, Volume: 58, Issue:4

    Topics: Animals; Bile; Deferoxamine; Female; Ferritins; Injections, Intravenous; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Liver; Male; Pyridoxal; Rats; Rats, Inbred Strains; Time Factors

1981
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents.
    Blood, 1995, Dec-01, Volume: 86, Issue:11

    Topics: Antineoplastic Agents; Biological Transport, Active; Cell Division; Deferoxamine; Gallium; Humans; Iron; Iron Chelating Agents; Isoniazid; Pyridoxal; Transferrin; Tumor Cells, Cultured

1995
The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis.
    The Journal of laboratory and clinical medicine, 1994, Volume: 124, Issue:5

    Topics: Deferoxamine; DNA; Humans; Iron; Iron Chelating Agents; Isoniazid; Neuroblastoma; Osmolar Concentration; Pyridoxal; Thymidine; Transferrin; Tumor Cells, Cultured

1994
Effects of chelators on iron uptake and release by the brain in the rat.
    Neurochemical research, 1994, Volume: 19, Issue:1

    Topics: 2,2'-Dipyridyl; Aging; Animals; Biological Transport; Bone and Bones; Brain; Deferiprone; Deferoxamine; Female; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Kidney; Liver; Male; Pentetic Acid; Pyridones; Pyridoxal; Rats; Rats, Wistar

1994
Prevention of postasphyxia electroretinal dysfunction with a pyridoxal hydrazone.
    Free radical biology & medicine, 1997, Volume: 22, Issue:1-2

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Deferoxamine; Disease Models, Animal; Electroretinography; Humans; Hydrogen Peroxide; Infant, Newborn; Iron Chelating Agents; Isoniazid; Malondialdehyde; Oxidative Stress; Peroxides; Pyridoxal; Retina; Swine; Vision Disorders

1997
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone.
    Blood, 1997, Apr-15, Volume: 89, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Benzaldehydes; Cell Cycle; Cell Division; Deferoxamine; DNA Fragmentation; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Ferritins; Growth Inhibitors; HL-60 Cells; Humans; Hydrazones; Iron; Iron Chelating Agents; Isoniazid; Ligands; Molecular Structure; Naphthols; Neoplasm Proteins; Neoplasms; Pyridoxal; Structure-Activity Relationship; Transferrin; Tumor Cells, Cultured

1997
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression.
    Blood, 2001, Aug-01, Volume: 98, Issue:3

    Topics: Antineoplastic Agents; Cell Cycle; Cyclins; Deferoxamine; Female; Genes, Retinoblastoma; Humans; Hydroxyurea; Iron; Iron Chelating Agents; Isoniazid; Pyridoxal; Structure-Activity Relationship; Tumor Cells, Cultured

2001
Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells.
    Blood, 2003, May-15, Volume: 101, Issue:10

    Topics: Animals; Animals, Newborn; Blood Transfusion; Cells, Cultured; Deferoxamine; Female; Ferritins; Heart; Iron; Iron Chelating Agents; Iron Radioisotopes; Isoniazid; Kinetics; Pyridoxal; Rats; Rats, Wistar

2003
Iron chelation therapy.
    Current hematology reports, 2005, Volume: 4, Issue:2

    Topics: Administration, Oral; Benzoates; beta-Thalassemia; Chelation Therapy; Chemical and Drug Induced Liver Injury; Deferasirox; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; Infusions, Intravenous; Iron Chelating Agents; Iron Overload; Isoniazid; Pyridones; Pyridoxal; Survival; Triazoles

2005
Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
    British journal of pharmacology, 2006, Volume: 149, Issue:7

    Topics: Aldehydes; Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deferoxamine; Doxorubicin; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrazones; Hydrogen Peroxide; Iron; Iron Chelating Agents; Iron Compounds; Isoniazid; Lipid Peroxidation; Lung Neoplasms; Oxidative Stress; Pyridoxal; Razoxane; Time Factors

2006
Chelators to the rescue: different horses for different courses!
    Chemical research in toxicology, 2011, Mar-21, Volume: 24, Issue:3

    Topics: Aldehydes; Animals; Deferoxamine; Humans; Hydrazones; Iron Chelating Agents; Iron Overload; Isoniazid; Myocardial Reperfusion Injury; Neoplasms; Pyridines; Pyridoxal; Rats; Reactive Oxygen Species; Thiosemicarbazones

2011