Compounds > deferoxamine

deferoxamine and di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone

deferoxamine has been researched along with di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (40.00)29.6817
2010's9 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernhardt, PV; Islam, M; Kalinowski, DS; Lovejoy, DB; Richardson, DR; Senaratne, D; Sharpe, PC1
Bernhardt, PV; Islam, M; Kalinowski, DS; Kumar, N; Liao, YT; Lovejoy, DB; Richardson, DR; Sharpe, PC; Yu, Y1
Bernhardt, PV; Kalinowski, DS; Richardson, DR; Sharpe, PC2
Bernhardt, PV; Islam, M; Kalinowski, DS; Lovejoy, DB; Richardson, DR; Richardson, V; Sharpe, PC1
Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Kovacevic, Z; Lovejoy, DB; Richardson, DR; Sharpe, PC; Siafakas, AR; Stefani, C; Yu, Y1
Codd, R; Groebler, LK; Kalinowski, DS; Liu, J; Obando, D; Richardson, DR; Schipanski, LG; Witting, PK1
Brychtova, K; Csollei, J; Dvorakova, L; Jampilek, J; Kalinowski, DS; Opatrilova, R; Placek, L; Raich, I; Richardson, DR1
Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Lovejoy, DB; Punnia-Moorthy, G; Richardson, DR; Sharpe, PC; Stefani, C1
Brychtova, K; Dvorakova, L; Jampilek, J; Kacerova, S; Kalinowski, DS; Opatrilova, R; Placek, L; Raich, I; Richardson, DR1
Kalinowski, DS; Kovacevic, Z; Merlot, AM; Mrozek-Wilczkiewicz, A; Musiol, R; Pantarat, N; Polanski, J; Ratuszna, A; Richardson, DR; Serda, M; Szurko, A1
Basha, MT; Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Lovejoy, DB; Obeidy, P; Prichard, T; Richardson, DR; Seebacher, N; Sharp, DM; Sharpe, PC; Stefani, C1
Bernhardt, PV; Gutierrez, E; Jansson, PJ; Kalinowski, DS; Richardson, DR; Stefani, C1
Kalinowski, DS; Kumar, N; Lukmantara, AY; Richardson, DR1
Anjum, R; Bernhardt, PV; Hibbs, D; Kalinowski, DS; Lin, HY; Palanimuthu, D; Poon, R; Richardson, DR; Sahni, S1

Reviews

1 review(s) available for deferoxamine and di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone

ArticleYear
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Animals; Antineoplastic Agents; Humans; Iron; Iron Chelating Agents; Ribonucleotide Reductases; Thiosemicarbazones

2009

Other Studies

14 other study(ies) available for deferoxamine and di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone

ArticleYear
Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.
    Journal of medicinal chemistry, 2006, Nov-02, Volume: 49, Issue:22

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; DNA; Electrochemistry; Humans; Hydroxylation; Iron; Iron Chelating Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Oxidation-Reduction; Plasmids; Pyridines; Spectrophotometry, Infrared; Structure-Activity Relationship; Thiosemicarbazones

2006
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Ferric Compounds; Ferrous Compounds; Humans; Iron; Iron Chelating Agents; Ligands; Molecular Structure; Nitrobenzoates; Oxidation-Reduction; Protein Binding; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2007
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
    Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Electrochemistry; Ferrous Compounds; Humans; Hydrazones; Hydroxylation; Iron; Iron Chelating Agents; Ligands; Molecular Structure; Oxidation-Reduction; Structure-Activity Relationship; Thiones; Transferrin

2007
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; Hydrazones; Hydroxylation; Iron; Iron Chelating Agents; Iron Overload; Iron Radioisotopes; Isonicotinic Acids; Ketones; Ligands; Oxidation-Reduction; Pyrazines; Structure-Activity Relationship

2008
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemical Techniques; Humans; Iron; Iron Chelating Agents; Oxidation-Reduction; Pyridines; Stereoisomerism; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2009
Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Adamantane; Administration, Oral; Animals; Binding Sites; Carboxylic Acids; Cell Proliferation; Cells, Cultured; Chelating Agents; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Deferoxamine; Dogs; Ferric Compounds; Humans; Inhibitory Concentration 50; Iron; Iron Chelating Agents; Iron Overload; Kidney; Models, Molecular; Molecular Structure; Neuroectodermal Tumors, Primitive, Peripheral; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Transferrin

2010
Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers.
    Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24

    Topics: Administration, Cutaneous; Caproates; Drug Carriers; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Molecular Structure; Skin Absorption; Structure-Activity Relationship

2010
Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
    Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemistry; Fluoresceins; Fluorescent Dyes; Fluorometry; Humans; Hydrophobic and Hydrophilic Interactions; Iron Chelating Agents; Molecular Structure; Oxidation-Reduction; Pyridines; Reactive Oxygen Species; Structure-Activity Relationship; Thiosemicarbazones

2011
Investigation of substituted 6-aminohexanoates as skin penetration enhancers.
    Bioorganic & medicinal chemistry, 2012, Jan-01, Volume: 20, Issue:1

    Topics: Administration, Topical; Aminocaproic Acid; Animals; Antineoplastic Agents; Caproates; Cell Line, Tumor; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Pyrrolidines; Skin; Skin Absorption; Stereoisomerism; Swine

2012
Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Deferoxamine; Humans; Iron; Iron Chelating Agents; Neoplasms; Quinolines; Thiosemicarbazones

2012
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
    Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Copper; Crystallography, X-Ray; Dimerization; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Injections, Intravenous; Ketones; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Oxidation-Reduction; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin; Transplantation, Heterologous

2012
Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
    Journal of medicinal chemistry, 2013, Jan-10, Volume: 56, Issue:1

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Ferric Compounds; Ferrous Compounds; Humans; Iron Chelating Agents; Ligands; Methemoglobin; Molecular Structure; Oxidation-Reduction; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2013
Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy.
    Bioorganic & medicinal chemistry letters, 2013, Feb-15, Volume: 23, Issue:4

    Topics: Animals; Benzoates; Cell Growth Processes; Chelating Agents; Crystallography, X-Ray; Humans; Iron Chelating Agents; Mice; Pyridines; Structure-Activity Relationship; Thiosemicarbazones

2013
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: Alzheimer Disease; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiosemicarbazones; Tumor Cells, Cultured

2017