deferoxamine and 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone

deferoxamine has been researched along with 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's9 (60.00)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernhardt, PV; Islam, M; Kalinowski, DS; Kumar, N; Liao, YT; Lovejoy, DB; Richardson, DR; Sharpe, PC; Yu, Y1
Bernhardt, PV; Kalinowski, DS; Richardson, DR; Sharpe, PC2
Bernhardt, PV; Islam, M; Kalinowski, DS; Lovejoy, DB; Richardson, DR; Richardson, V; Sharpe, PC1
Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Kovacevic, Z; Lovejoy, DB; Richardson, DR; Sharpe, PC; Siafakas, AR; Stefani, C; Yu, Y1
Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Lovejoy, DB; Punnia-Moorthy, G; Richardson, DR; Sharpe, PC; Stefani, C1
Kalinowski, DS; Kovacevic, Z; Merlot, AM; Mrozek-Wilczkiewicz, A; Musiol, R; Pantarat, N; Polanski, J; Ratuszna, A; Richardson, DR; Serda, M; Szurko, A1
Basha, MT; Bernhardt, PV; Jansson, PJ; Kalinowski, DS; Lovejoy, DB; Obeidy, P; Prichard, T; Richardson, DR; Seebacher, N; Sharp, DM; Sharpe, PC; Stefani, C1
Bernhardt, PV; Gutierrez, E; Jansson, PJ; Kalinowski, DS; Richardson, DR; Stefani, C1
Hašková, P; Hergeselová, T; Hrušková, K; Kovaříková, P; Liptáková, L; Mingas, P; Potůčková, E; Šimůnek, T; Vávrová, K1
Darnell, G; Richardson, DR1
Antholine, WE; Chitambar, CR; Green, DA; Richardson, DR; Wong, SJ1
Chaston, TB; Lovejoy, DB; Richardson, DR; Watts, RN1
Le, NT; Richardson, DR1
Fu, D; Nurtjahja-Tjendraputra, E; Phang, JM; Richardson, DR1

Reviews

1 review(s) available for deferoxamine and 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone

ArticleYear
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Animals; Antineoplastic Agents; Humans; Iron; Iron Chelating Agents; Ribonucleotide Reductases; Thiosemicarbazones

2009

Other Studies

14 other study(ies) available for deferoxamine and 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone

ArticleYear
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Ferric Compounds; Ferrous Compounds; Humans; Iron; Iron Chelating Agents; Ligands; Molecular Structure; Nitrobenzoates; Oxidation-Reduction; Protein Binding; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2007
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
    Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Electrochemistry; Ferrous Compounds; Humans; Hydrazones; Hydroxylation; Iron; Iron Chelating Agents; Ligands; Molecular Structure; Oxidation-Reduction; Structure-Activity Relationship; Thiones; Transferrin

2007
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Antineoplastic Agents; Ascorbic Acid; Benzoates; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; Hydrazones; Hydroxylation; Iron; Iron Chelating Agents; Iron Overload; Iron Radioisotopes; Isonicotinic Acids; Ketones; Ligands; Oxidation-Reduction; Pyrazines; Structure-Activity Relationship

2008
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemical Techniques; Humans; Iron; Iron Chelating Agents; Oxidation-Reduction; Pyridines; Stereoisomerism; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2009
Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
    Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Electrochemistry; Fluoresceins; Fluorescent Dyes; Fluorometry; Humans; Hydrophobic and Hydrophilic Interactions; Iron Chelating Agents; Molecular Structure; Oxidation-Reduction; Pyridines; Reactive Oxygen Species; Structure-Activity Relationship; Thiosemicarbazones

2011
Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Deferoxamine; Humans; Iron; Iron Chelating Agents; Neoplasms; Quinolines; Thiosemicarbazones

2012
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
    Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Copper; Crystallography, X-Ray; Dimerization; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Injections, Intravenous; Ketones; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Oxidation-Reduction; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin; Transplantation, Heterologous

2012
Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
    Journal of medicinal chemistry, 2013, Jan-10, Volume: 56, Issue:1

    Topics: Antineoplastic Agents; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Ferric Compounds; Ferrous Compounds; Humans; Iron Chelating Agents; Ligands; Methemoglobin; Molecular Structure; Oxidation-Reduction; Pyridines; Structure-Activity Relationship; Thiosemicarbazones; Transferrin

2013
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
    European journal of medicinal chemistry, 2016, Sep-14, Volume: 120

    Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Drug Stability; Humans; Hydrazines; Hydrazones; Hydrophobic and Hydrophilic Interactions; Iron Chelating Agents; Rats; Structure-Activity Relationship

2016
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation.
    Blood, 1999, Jul-15, Volume: 94, Issue:2

    Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chelation Therapy; Deferoxamine; Growth Inhibitors; Iron; Iron Chelating Agents; Isoniazid; Ligands; RNA, Neoplasm; Tumor Cells, Cultured

1999
Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:11

    Topics: Antineoplastic Agents; Cell Division; Deferoxamine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Hydroxyurea; Iron Chelating Agents; Isoniazid; Mutation; Protein Subunits; Ribonucleotide Reductases; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001
Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:1

    Topics: Animals; Ascorbic Acid; Blotting, Northern; Blotting, Western; Cell Division; Chelating Agents; Deferoxamine; DNA; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Humans; Iron; Iron Chelating Agents; Isoniazid; Models, Chemical; Oxidation-Reduction; Oxygen; Plasmids; Protein Binding; Pyridines; Rats; Thiosemicarbazones; Time Factors; Tumor Cells, Cultured

2003
Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.
    Carcinogenesis, 2003, Volume: 24, Issue:6

    Topics: Cell Cycle; Cells, Cultured; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Dactinomycin; Deferoxamine; DNA Damage; Gene Expression Regulation; Humans; Iron Chelating Agents; Isoniazid; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Receptors, Transferrin; RNA, Messenger; Tumor Suppressor Protein p53

2003
Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.
    Blood, 2007, May-01, Volume: 109, Issue:9

    Topics: Anemia, Iron-Deficiency; Animals; Cell Cycle; Cell Line, Tumor; Deferoxamine; G1 Phase; Half-Life; Humans; Iron; Iron Chelating Agents; Isoniazid; Mice; Proteasome Endopeptidase Complex; S Phase; Siderophores; Ubiquitin

2007