deferiprone and ascorbic acid

deferiprone has been researched along with ascorbic acid in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (14.29)	18.7374
1990's	4 (28.57)	18.2507
2000's	3 (21.43)	29.6817
2010's	4 (28.57)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Bai, R; Chen, Y; Gu, J; Han, J; Su, J; Xie, Y; Yang, K; Yu, S; Yuan, S; Zhang, C; Zhou, T	1
Aldouri, MA; Barr, J; Hoffbrand, AV; Kontoghiorghes, GJ; Kourouclaris, T; Sheppard, L; Wonke, B	1
Dandona, P; Hoffbrand, AV; Jeremy, JY; Kontoghiorghes, GJ	1
Barr, J; Bartlett, AN; Kontoghiorghes, GJ; Nortey, P; Sheppard, L	1
Dresow, B; Fischer, R; Gabbe, EE; Nielsen, P; Piga, A	1
Hershko, C; Konijn, AM; Link, G	1
Atanackovic, G; Diav-Citrin, O; Koren, G	1
El Kelany, RS; Emara, AM; Moustafa, KA	1
Brunk, UT; Hider, RC; Kissner, R; Koppenol, WH; Merkofer, M	1
Devanur, LD; Hider, RC; Neubert, H	1
Baccan, MM; Chiarelli-Neto, O; Espósito, BP; Pereira, RM	1
Cançado, RD; de Barros, JC; Espósito, BP; Naoum, FA; Ruiz, LP; Ruiz, MA; Sobreira, JT; Tanaka, PY	1
Qiao, C; Wang, L; Xiao, SH; Xue, J	1
Kichigina, LA; Kontoghiorghes, GJ; Polyakov, NE; Selyutina, OY; Timoshnikov, VA	1

Trials

2 trial(s) available for deferiprone and ascorbic acid

Article	Year
Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one. British medical journal (Clinical research ed.), 1987, Dec-12, Volume: 295, Issue:6612 Topics: Administration, Oral; Adolescent; Adult; Aged; Ascorbic Acid; Clinical Trials as Topic; Deferiprone; Deferoxamine; Drug Therapy, Combination; Female; Humans; Iron; Iron Chelating Agents; Male; Middle Aged; Neural Tube Defects; Pyridones; Thalassemia	1987
Oral iron chelation therapy with deferiprone. Monitoring of biochemical, drug and iron excretion changes. Arzneimittel-Forschung, 1995, Volume: 45, Issue:1 Topics: Adult; Aged; Ascorbic Acid; beta-Thalassemia; Deferiprone; Feces; Female; Ferritins; Humans; Iron; Iron Chelating Agents; Male; Middle Aged; Myelodysplastic Syndromes; Pyridones	1995

Article

Year

Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one.

British medical journal (Clinical research ed.), 1987, Dec-12, Volume: 295, Issue:6612

Topics: Administration, Oral; Adolescent; Adult; Aged; Ascorbic Acid; Clinical Trials as Topic; Deferiprone; Deferoxamine; Drug Therapy, Combination; Female; Humans; Iron; Iron Chelating Agents; Male; Middle Aged; Neural Tube Defects; Pyridones; Thalassemia

1987

Oral iron chelation therapy with deferiprone. Monitoring of biochemical, drug and iron excretion changes.

Arzneimittel-Forschung, 1995, Volume: 45, Issue:1

Topics: Adult; Aged; Ascorbic Acid; beta-Thalassemia; Deferiprone; Feces; Female; Ferritins; Humans; Iron; Iron Chelating Agents; Male; Middle Aged; Myelodysplastic Syndromes; Pyridones

1995

Other Studies

12 other study(ies) available for deferiprone and ascorbic acid

Article	Year
Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Hydrogen Peroxide; Iron Chelating Agents; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyridines; Scopolamine; Structure-Activity Relationship	2019
The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitro. The Biochemical journal, 1988, Aug-15, Volume: 254, Issue:1 Topics: Aluminum; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Calcimycin; Deferiprone; Deferoxamine; Epinephrine; Epoprostenol; Hydrogen Peroxide; Iron; Iron Chelating Agents; Male; Pyridones; Rats; Rats, Inbred Strains	1988
Effect of oral iron chelator L1 on iron absorption in man. Annals of the New York Academy of Sciences, 1998, Jun-30, Volume: 850 Topics: Administration, Oral; Ascorbic Acid; Deferiprone; Delayed-Action Preparations; Ferrous Compounds; Humans; Intestinal Absorption; Iron; Iron Chelating Agents; Liver; Male; Pyridones	1998
Cardioprotective effect of alpha-tocopherol, ascorbate, deferoxamine, and deferiprone: mitochondrial function in cultured, iron-loaded heart cells. The Journal of laboratory and clinical medicine, 1999, Volume: 133, Issue:2 Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Cells, Cultured; Deferiprone; Deferoxamine; Heart; Intracellular Membranes; Iron; Iron Chelating Agents; Mitochondria, Heart; Myocardium; NAD; Pyridones; Rats; Succinate Dehydrogenase; Vitamin E	1999
An investigation into variability in the therapeutic response to deferiprone in patients with thalassemia major. Therapeutic drug monitoring, 1999, Volume: 21, Issue:1 Topics: Adult; Ascorbic Acid; beta-Thalassemia; Deferiprone; Ferritins; Humans; Iron; Iron Chelating Agents; Outcome Assessment, Health Care; Patient Compliance; Pyridones; Treatment Outcome	1999
Comparative study of the protective effect between deferoxamine and deferiprone on chronic iron overload induced cardiotoxicity in rats. Human & experimental toxicology, 2006, Volume: 25, Issue:7 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Ascorbic Acid; Deferiprone; Deferoxamine; Deoxyguanosine; Glutathione; Heart; Heart Diseases; Iron; Iron Chelating Agents; Iron Overload; Male; Myocardium; Pyridones; Rats; Thiobarbituric Acid Reactive Substances	2006
Fenton chemistry and iron chelation under physiologically relevant conditions: Electrochemistry and kinetics. Chemical research in toxicology, 2006, Volume: 19, Issue:10 Topics: Ascorbic Acid; Deferiprone; Electrochemistry; Electrodes; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxylation; Iron; Iron Chelating Agents; Kinetics; Molecular Structure; Pyridones; Water	2006
The fenton activity of iron(III) in the presence of deferiprone. Journal of pharmaceutical sciences, 2008, Volume: 97, Issue:4 Topics: Ascorbic Acid; Deferiprone; Edetic Acid; Hydrogen Peroxide; Hydroxyl Radical; Iron; Iron Chelating Agents; Oxidation-Reduction; Pyridones; Spectrometry, Mass, Electrospray Ionization	2008
Quercetin as a shuttle for labile iron. Journal of inorganic biochemistry, 2012, Volume: 107, Issue:1 Topics: Animals; Antioxidants; Ascorbic Acid; Binding, Competitive; Cattle; Coordination Complexes; Deferiprone; Ferrous Compounds; Fluoresceins; HeLa Cells; Humans; Iron; Iron Chelating Agents; Oxidation-Reduction; Pyridones; Quaternary Ammonium Compounds; Quercetin; Rutin; Transferrin	2012
Assessment of labile plasma iron in patients who undergo hematopoietic stem cell transplantation. Acta haematologica, 2014, Volume: 131, Issue:4 Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cohort Studies; Deferiprone; Female; Fluorescent Dyes; Follow-Up Studies; Graft Survival; Hematopoietic Stem Cell Transplantation; Humans; Iron; Iron Chelating Agents; Iron Overload; Male; Middle Aged; Predictive Value of Tests; Pyridones; Rhodamines; Severity of Illness Index; Transplantation Conditioning; Young Adult	2014
Mefloquine in combination with hemin causes severe damage to adult Schistosoma japonicum in vitro. Acta tropica, 2014, Volume: 131 Topics: 2,2'-Dipyridyl; Animals; Anthelmintics; Ascorbic Acid; Cysteine; Deferiprone; Deferoxamine; Drug Synergism; Drug Therapy, Combination; Ferric Compounds; Ferrous Compounds; Glutathione; Hemin; Inhibitory Concentration 50; Iron Chelating Agents; Mefloquine; Protoporphyrins; Pyridones; Schistosoma japonicum	2014
Antioxidant Activity of Deferasirox and Its Metal Complexes in Model Systems of Oxidative Damage: Comparison with Deferiprone. Molecules (Basel, Switzerland), 2021, Aug-20, Volume: 26, Issue:16 Topics: Antioxidants; Ascorbic Acid; Coordination Complexes; Deferasirox; Deferiprone; Humans; Iron; Iron Chelating Agents; Iron Overload; Linoleic Acid; Metals; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species	2021