debromoaplysiatoxin has been researched along with mezerein* in 2 studies
2 other study(ies) available for debromoaplysiatoxin and mezerein
| Article | Year |
|---|---|
Induction of nitroblue tetrazolium reduction in mouse peritoneal macrophages by tumour promoters and inhibition of the induced nitroblue tetrazolium reduction by some inhibitors.
Two polyacetates, aplysiatoxin and debromoaplysiatoxin, as well as 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein and teleocidin enhance nitroblue tetrazolium (NBT) reduction in mouse peritoneal macrophages in vitro. The ED50 values for NBT reduction of these 5 TPA-type tumor promoters were 4.2 ng/ml for TPA, 36 ng/ml for mezerein, 0.53 ng/ml for teleocidin, 1.5 ng/ml for aplysiatoxin and 108 ng/ml for debromoaplysiatoxin. The NBT reduction induced by the 5 tumor promoters is inhibited by 2 inhibitors of tumor promotion, retinoic acid and dibromoacetophenone. The possibility that tumor promotion by TPA-type tumor promoters involves similar mechanisms such as superoxide anion radicals release in cell membranes is discussed. Topics: Acetophenones; Animals; Carcinogens; Cells, Cultured; Diterpenes; Female; Free Radicals; Lyngbya Toxins; Macrophages; Mice; Mice, Inbred Strains; Nitroblue Tetrazolium; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Tretinoin | 1985 |
Effects of tumor promoters on the frequency of metallothionein I gene amplification in cells exposed to cadmium.
Three potent tumor promoters of different classes, 12-O-tetradecanoylphorbol-13-acetate, dihydroteleocidin B, and aplysiatoxin, and two moderate tumor promoters, mezerein and debromoaplysiatoxin, enhanced the frequency of appearance of cadmium-resistant Chinese hamster lung cells when the cells were exposed to cytotoxic levels of CdCl2. With these compounds, the activity to induce cadmium-resistant cells correlated well with the potency of tumor-promoting activity. Cadmium resistance, which persisted after removal of the tumor promoters, was associated with the overproduction of metallothionein I messenger RNA. The amplified metallothionein I genes were shown by Southern blotting experiments. The relevance of the gene amplification caused by tumor promoters is discussed in relation to cancer development and progression. Topics: Alkaloids; Animals; Cadmium; Carcinogens; Cell Line; Cricetinae; Cricetulus; Diterpenes; Gene Amplification; Genes; Lactones; Lung; Lyngbya Toxins; Metallothionein; Mollusk Venoms; Phorbol Esters; Terpenes; Tetradecanoylphorbol Acetate | 1983 |