debrisoquin has been researched along with quinine in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Commandeur, JN; Funae, Y; Hiroi, T; ter Laak, AM; Venhorst, J; Vermeulen, NP | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chalcroft, S; Wanwimolruk, S | 1 |
| Ayesh, R; Cholerton, S; Dawling, S; Hayler, A; Idle, JR; Oates, NS; Smith, RL; Widdop, B | 1 |
| Dahlqvist, R; Dumont, E; Spina, E; Steiner, E | 1 |
| Boobis, AR; Davies, DS; Kobayashi, S; Murray, S; Sesardic, D; Watson, D | 1 |
| Crewe, HK; Lennard, MS; Otton, SV; Tucker, GT; Woods, HF | 1 |
| Boobis, AR; Davies, DS; Murray, S; Seddon, CE; Speirs, CJ | 1 |
| Huang, Y; Masubuchi, Y; Mizukami, T; Narimatsu, S; Suzuki, T | 2 |
| Fujita, S; Itoh, S; Iwata, H; Kamataki, T; Kazusaka, A; Masuda, M; Nakamura, A; Ohashi, K; Tasaki, T; Yamamoto, Y | 1 |
| Blackburn, MG; Ellis, SW; Harlow, J; Hayhurst, GP; Larsson, C; Lennard, MS; Lightfoot, T; Lim, CK; Mahling, J; Rowland-Yeo, K; Smith, G; Tucker, GT; Wolf, CR | 1 |
| Chiba, M; Lin, JH; Lin, Y; Neway, W; Nishime, JA | 1 |
| Gelboin, HV; Gonzalez, FJ; Granvil, CP; Idle, JR; Krausz, KW | 1 |
1 review(s) available for debrisoquin and quinine
| Article | Year |
|---|---|
Inhibition of desipramine 2-hydroxylation by quinidine and quinine in rapid and slow debrisoquine hydroxylators.
Topics: Debrisoquin; Depression, Chemical; Desipramine; Humans; Hydroxylation; Isoquinolines; Phenotype; Quinidine; Quinine | 1989 |
14 other study(ies) available for debrisoquin and quinine
| Article | Year |
|---|---|
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Ligands; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Quinidine; Quinine; Rabbits; Rats; Sequence Homology, Amino Acid; Sparteine; Species Specificity | 2003 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics of quinine.
Topics: Adult; Debrisoquin; Female; Half-Life; Humans; Male; Oxidation-Reduction; Phenotype; Quinine | 1991 |
Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers.
Topics: Adult; Debrisoquin; Desipramine; Female; Humans; Male; Metabolic Clearance Rate; Molecular Structure; Nortriptyline; Phenotype; Quinidine; Quinine; Reference Values; Stereoisomerism | 1991 |
The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Humans; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; Quinidine; Quinine; Rats; Rats, Inbred Strains; Species Specificity | 1989 |
Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.
Topics: Cytochrome P-450 Enzyme System; Dealkylation; Debrisoquin; Humans; Hydroxylation; In Vitro Techniques; Isoquinolines; Kinetics; Metoprolol; Microsomes, Liver; Quinidine; Quinine; Sparteine | 1988 |
Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; In Vitro Techniques; Isoenzymes; Isoquinolines; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenotype; Quinidine; Quinine | 1986 |
Development of a high-performance liquid chromatographic method for the analysis of enatiomer/enantiomer interaction in oxidative metabolism of bunitrolol in rat liver microsomes.
Topics: Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Debrisoquin; Gas Chromatography-Mass Spectrometry; Male; Microsomes, Liver; Oxidation-Reduction; Propanolamines; Quinidine; Quinine; Rats; Rats, Wistar; Stereoisomerism | 1994 |
In-vitro metabolic interaction of bunitrolol enantiomers in rabbit liver microsomes.
Topics: Adrenergic beta-Antagonists; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Propanolamines; Quinidine; Quinine; Rabbits; Rats; Rats, Wistar; Species Specificity; Stereoisomerism | 1996 |
Expression and characterization of dog CYP2D15 using baculovirus expression system.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Catalysis; Cell Line; Cloning, Molecular; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Dogs; Enzyme Inhibitors; Microsomes, Liver; Molecular Sequence Data; Pharmaceutical Preparations; Quinine; Recombinant Proteins; Substrate Specificity | 1998 |
Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalytic Domain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Enzyme Inhibitors; Kinetics; Ligands; Metoprolol; Mutagenesis, Site-Directed; Oxidation-Reduction; Propranolol; Quinidine; Quinine; Serine; Substrate Specificity; Yeasts | 2000 |
Comparative in vitro metabolism of indinavir in primates--a unique stereoselective hydroxylation in monkey.
Topics: Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; HIV Protease Inhibitors; Humans; Hydroxylation; Indinavir; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Molecular Conformation; Molecular Structure; Primates; Quinidine; Quinine | 2000 |
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
Topics: Adrenergic Agents; Antimalarials; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxylation; Microsomes; Quinidine; Quinine | 2002 |