debrisoquin and phenformin

debrisoquin has been researched along with phenformin in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199010 (71.43)18.7374
1990's0 (0.00)18.2507
2000's2 (14.29)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Commandeur, JN; Funae, Y; Hiroi, T; ter Laak, AM; Venhorst, J; Vermeulen, NP1
Arastoo, M; Coxon, GD; Furman, BL; Harvey, AL; Kennedy, AR; McTavish, J; Mooney, MH; Tettey, JM; Waigh, RD1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Park, BK1
Evans, DA1
Woolhouse, NM1
Eichelbaum, M; Idle, JR; Oates, NS; Smith, RL; Woolhouse, NM1
Idle, JR; Oates, NS; Shah, RR; Smith, RL1
Alvan, G; Bertilsson, L; Sawe, J; Sjöqvist, F; Wiholm, BE1
Eichelbaum, M2
Boobis, AR; Davies, DS; Kahn, GC; Murray, S; Robertz, GM1
Al-Dabbagh, SG; Idle, JR; Küpfer, A; Ritchie, JC; Smith, RL1

Reviews

2 review(s) available for debrisoquin and phenformin

ArticleYear
Ethnic differences in reactions to drugs and xenobiotics. Therapy.
    Progress in clinical and biological research, 1986, Volume: 214

    Topics: Acetylation; Debrisoquin; Drug Interactions; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Hydroxylation; Mass Screening; Methyltransferases; Pharmaceutical Preparations; Pharmacogenetics; Phenformin; Polymorphism, Genetic; Sparteine

1986
[Genetic polymorphism of oxidative drug metabolism. Therapeutic and toxicologic implications].
    Der Internist, 1983, Volume: 24, Issue:3

    Topics: Adrenergic beta-Antagonists; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Hydroxylation; Mephenytoin; Oxidation-Reduction; Perhexiline; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenotype; Phenytoin; Polymorphism, Genetic; Receptors, Drug; Sparteine

1983

Other Studies

12 other study(ies) available for debrisoquin and phenformin

ArticleYear
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
    Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1

    Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Ligands; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Quinidine; Quinine; Rabbits; Rats; Sequence Homology, Amino Acid; Sparteine; Species Specificity

2003
Benzylguanidines and other galegine analogues inducing weight loss in mice.
    Journal of medicinal chemistry, 2009, Jun-11, Volume: 52, Issue:11

    Topics: Animals; Anti-Obesity Agents; Benzyl Compounds; Dietary Fats; Guanidines; Male; Mice; Mice, Inbred BALB C; Mice, Obese; Microsomes, Liver; Weight Loss

2009
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Metabolic basis of adverse drug reactions.
    Journal of the Royal College of Physicians of London, 1986, Volume: 20, Issue:3

    Topics: Acetaminophen; Acetylation; Adrenergic beta-Antagonists; Adult; Age Factors; Child; Debrisoquin; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Enzyme Inhibitors; Humans; Perhexiline; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenotype; Polymorphism, Genetic; Succinylcholine

1986
The debrisoquine/sparteine oxidation polymorphism: evidence of genetic heterogeneity among Ghanaians.
    Progress in clinical and biological research, 1986, Volume: 214

    Topics: Debrisoquin; Ethnicity; Ghana; Heterozygote; Homozygote; Humans; Isoquinolines; Microsomes, Liver; Nortriptyline; Oxidation-Reduction; Phenformin; Polymorphism, Genetic; Sparteine

1986
Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Female; Ghana; Humans; Isoquinolines; Kinetics; Male; Middle Aged; Phenformin; Phenotype; Sparteine; White People

1985
Phenformin-induced lacticacidosis associated with impaired debrisoquine hydroxylation.
    Lancet (London, England), 1981, Apr-11, Volume: 1, Issue:8224

    Topics: Acidosis; Aged; Debrisoquin; Female; Humans; Isoquinolines; Lactates; Middle Aged; Phenformin; Phenotype

1981
Hydroxylation of debrisoquine in patients with lacticacidosis after phenformin.
    Lancet (London, England), 1981, May-16, Volume: 1, Issue:8229

    Topics: Acidosis; Debrisoquin; Humans; Hydroxylation; Isoquinolines; Phenformin

1981
Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man.
    Molecular pharmacology, 1983, Volume: 23, Issue:2

    Topics: Antipyrine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Guanidines; Humans; Isoquinolines; Microsomes, Liver; Mixed Function Oxygenases; Phenformin; Sparteine; Substrate Specificity

1983
Polymorphic drug oxidation in humans.
    Federation proceedings, 1984, May-15, Volume: 43, Issue:8

    Topics: Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Debrisoquin; Humans; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenytoin; Polymorphism, Genetic; Sparteine; Tolbutamide

1984
Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains.
    Biochemical pharmacology, 1982, Oct-15, Volume: 31, Issue:20

    Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Hydroxylation; In Vitro Techniques; Isoquinolines; Kinetics; Male; Metiamide; Microsomes, Liver; Phenformin; Protein Binding; Rats; Rats, Inbred Strains; Sparteine; Spectrophotometry

1982