debrisoquin has been researched along with nortriptyline in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (53.57) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Commandeur, JN; Funae, Y; Hiroi, T; ter Laak, AM; Venhorst, J; Vermeulen, NP | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Brockmöller, J; Müller, N; Roots, I | 1 |
| Ayesh, R; Cholerton, S; Dawling, S; Hayler, A; Idle, JR; Oates, NS; Smith, RL; Widdop, B | 1 |
| Bertilsson, L; Sjöqvist, F | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D | 1 |
| Baumann, P | 1 |
| Woolhouse, NM | 1 |
| Birgersson, C; Eriksson, O; Göransson, M; Morgan, ET; Spina, E; von Bahr, C; Woodhouse, K | 1 |
| Bertilsson, L; Mellström, B; Säwe, J; Sjöqvist, F | 1 |
| Benitez, J; Bertilsson, L; Nordin, C; Siwers, B | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Schnyder, C; Wertheimer, J | 1 |
| Aberg-Wistedt, A; Bertilsson, L; Gustafsson, LL; Nordin, C | 1 |
| Asberg, M; Bertilsson, L; Mårtenson, B; Mellström, B; Sjökvist, F | 1 |
| Birgersson, C; Blanck, A; Göransson, M; Mellström, B; Nilsell, K; von Bahr, C | 1 |
| Adjepon-Yamoah, KK; Bertilsson, L; Hedman, A; Mellström, B; Sjöqvist, F; Woolhouse, NM | 1 |
| Bertilsson, L; Lou, YC; Mellström, B; Säwe, J; Sjöqvist, F | 1 |
| Bertilsson, L; Mellström, B; Säwe, J; Schulz, HU; Sjöqvist, F | 1 |
| Bertilsson, L; Eichelbaum, M; Mellström, B; Säwe, J; Schulz, HU; Sjöqvist, F | 1 |
| Alván, G; Jerling, M | 1 |
| Gu, NF; Jiang, WD; Yin, JL; Yu, P; Zhang, XH | 1 |
| Bertilsson, L; Dahl, ML; Nordin, C | 1 |
| Andersson, K; Bertilsson, L; Härtter, S; Laine, K; Svensson, JO; Tybring, G; Widén, J | 1 |
| Begley, A; Frye, RF; Kirshner, M; Miller, MD; Mulsant, BH; Pollock, BG; Reynolds, CF; Solai, LK; Sorisio, D; Sweet, RA | 1 |
| Bertilsson, L; Dahl, ML; Dalén, P; Eichelbaum, M; Roh, HK; Tybring, G; Wilkinson, GR | 1 |
| Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
| Bertilsson, L | 1 |
2 review(s) available for debrisoquin and nortriptyline
| Article | Year |
|---|---|
Slow hydroxylation of tricyclic antidepressants--relationship to polymorphic drug oxidation.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Kinetics; Male; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic; Smoking; Twins, Dizygotic; Twins, Monozygotic | 1986 |
Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects.
Topics: Antidepressive Agents; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Asian People; Clomipramine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Ethnicity; Humans; Mediterranean Region; Metabolic Networks and Pathways; Mixed Function Oxygenases; Mutation; Nortriptyline; Polymorphism, Genetic; Sweden; White People | 2007 |
4 trial(s) available for debrisoquin and nortriptyline
| Article | Year |
|---|---|
[The use of low-dose amitriptyline in psychogeriatrics. A clinical, pharmacokinetic and pharmacogenetic study].
Topics: Aged; Amitriptyline; Debrisoquin; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Male; Nortriptyline; Psychological Tests | 1985 |
Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype.
Topics: Adult; Aged; Alleles; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Nortriptyline; Polymerase Chain Reaction; Regression Analysis | 1996 |
Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.
Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Paroxetine; Phenotype; Tremor; Xerostomia | 2001 |
Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.
Topics: Adrenergic Agents; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Debrisoquin; Depressive Disorder; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Nortriptyline; Paroxetine; Time Factors | 2002 |
22 other study(ies) available for debrisoquin and nortriptyline
| Article | Year |
|---|---|
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Ligands; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Quinidine; Quinine; Rabbits; Rats; Sequence Homology, Amino Acid; Sparteine; Species Specificity | 2003 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine.
Topics: Alleles; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Debrisoquin; Depression; Drug Interactions; Female; Fluoxetine; Fluvoxamine; Half-Life; Humans; Middle Aged; Nortriptyline; Phenotype; Spectrophotometry, Ultraviolet | 1991 |
Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers.
Topics: Adult; Debrisoquin; Desipramine; Female; Humans; Male; Metabolic Clearance Rate; Molecular Structure; Nortriptyline; Phenotype; Quinidine; Quinine; Reference Values; Stereoisomerism | 1991 |
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic | 1986 |
New aspects in research on blood levels and bioavailability of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Biological Availability; Debrisoquin; Depressive Disorder; Humans; Kinetics; Maprotiline; Mephenytoin; Nortriptyline | 1986 |
The debrisoquine/sparteine oxidation polymorphism: evidence of genetic heterogeneity among Ghanaians.
Topics: Debrisoquin; Ethnicity; Ghana; Heterozygote; Homozygote; Humans; Isoquinolines; Microsomes, Liver; Nortriptyline; Oxidation-Reduction; Phenformin; Polymorphism, Genetic; Sparteine | 1986 |
Oxidation of tricyclic antidepressant drugs, debrisoquine and 7-ethoxyresorufin, by human liver preparations.
Topics: Adult; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Genetic Variation; Humans; Hydroxylation; Isoquinolines; Kinetics; Liver; Male; Microsomes, Liver; Nortriptyline; Oxazines; Oxidation-Reduction; Structure-Activity Relationship | 1986 |
Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers.
Topics: Administration, Oral; Adult; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Phenotype | 1986 |
Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
Topics: Debrisoquin; Depressive Disorder; Humans; Hydroxylation; Isoquinolines; Nortriptyline | 1985 |
Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Hydroxylation; Isoquinolines; Lithium; Nortriptyline | 1985 |
Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implications.
Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Nortriptyline; Phenotype | 1981 |
Correlation between nortriptyline and debrisoquine hydroxylation in the human liver.
Topics: Adult; Aged; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Debrisoquin; Female; Humans; Hydroxylation; Isoenzymes; Isoquinolines; Male; Microsomes, Liver; Middle Aged; NADPH-Ferrihemoprotein Reductase; Nortriptyline; Structure-Activity Relationship | 1983 |
Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects.
Topics: Administration, Oral; Adult; Debrisoquin; Female; Ghana; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Nortriptyline; Phenotype; Sweden | 1984 |
Amitriptyline metabolism: relationship to polymorphic debrisoquine hydroxylation.
Topics: Adult; Amitriptyline; Debrisoquin; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Smoking | 1983 |
E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation.
Topics: Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Nortriptyline; Phenotype; Stereoisomerism | 1981 |
Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man.
Topics: Adult; Antipyrine; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Middle Aged; Nortriptyline; Oxidation-Reduction; Phenotype; Saliva | 1980 |
Nonlinear kinetics of nortriptyline in relation to nortriptyline clearance as observed during therapeutic drug monitoring.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Monitoring; Humans; Mixed Function Oxygenases; Nortriptyline; Phenotype; Regression Analysis | 1994 |
[Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers].
Topics: Adult; Amitriptyline; Asian People; Debrisoquin; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Nortriptyline; Phenotype; Polymorphism, Genetic; Species Specificity | 1993 |
Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians.
Topics: Adult; Antidepressive Agents, Tricyclic; Asian People; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Genotype; Homozygote; Humans; Korea; Male; Middle Aged; Nortriptyline; White People | 2003 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |