debrisoquin and mephenytoin

debrisoquin has been researched along with mephenytoin in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (25.71)	18.7374
1990's	42 (60.00)	18.2507
2000's	8 (11.43)	29.6817
2010's	2 (2.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bertilsson, L; Du, YL; Iselius, L; Kuang, TY; Liao, XM; Liu, Y; Lou, YQ; Reviriego, J; Sjöqvist, F; Wang, KY	1
Black, C; Branch, RA; Csuka, ME; Lupoli, S; May, G; Wilkinson, GR	1
Guttendorf, RJ; Wedlund, PJ	1
Alm, C; Barret, L; Bertling, I; Dahlöf, C	1
Kallio, J	1
Alván, G; Dahl, ML	1
Brøsen, K	1
Lee, EJ	1
Brøsen, K; Gram, LF; Kragh-Sørensen, P	1
Eichelbaum, M; Gross, AS; Kroemer, HK	1
Alm, C; Bertilsson, L; Christenson, I; Dahl-Puustinen, ML; Ostman, J; Thunberg, E; Wikström, I	1
Alván, G; Bechtel, P; Gundert-Remy, U; Iselius, L	1
Blum, M; Grant, D; Meyer, UA; Skoda, RC; Zanger, UM	1
Alván, G; Aquilonius, SM; Gudjonsson, O; Reviriego, J; Sanz, E	1
Gonzalez, FJ	1
Du, YL; Lou, YQ	1
Bertilsson, L; Sanz, EJ	1
Bellino, L; Black, CM; Branch, RA; Csuka, ME; May, DG; Olsen, NJ; Porter, JA; Tanner, SB; Wilkinson, GR	1
Bertilsson, L; Henthorn, TK; Sanz, E; Säwe, J; Tybring, G; Villén, T	1
Bertilsson, L; Buemi, AL; Sanz, E; Spina, E	1
Alm, C; Bertilsson, L; Sanz, EJ; Villén, T	1
Atiba, JO; Blaschke, TF; Wilkinson, GR	1
Küpfer, A; Meyer, JW; Woggon, B	1
Baumann, P; Bosshart, P; Gabris, G; Gastpar, M; Koeb, L; Woggon, B	1
Billante, C; Jacqz, E; Mathieu, H; Moysan, F	1
Kalow, W	1
Inaba, T	1
Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D	1
Baumann, P	1
Branch, RA; Jaczq, E; Kaisary, A; McAllister, CB; Ray, WA; Smith, P; Wilkinson, GR	1
Gurtner, HP; Küpfer, A; Preisig, R; Saner, H	1
Branch, RA; Goto, F; Jacqz, E; McAllister, CB; Nakamura, K; Ray, WA; Wilkinson, GR	1
Eichelbaum, M	2
Küpfer, A; Preisig, R	1
Aslanian, WS; Branch, RA; McAllister, CB; Wedlund, PJ; Wilkinson, GR	1
Flockhart, DA; Hadidi, HF; Idle, JR; Irshaid, YM; Woosley, RL	1
Caraco, Y; Tateishi, T; Wood, AJ	1
Wood, AJ; Zhou, HH	1
Basci, NE; Bozkurt, A; Brosen, K; Isimer, A; Kayaalp, SO; Sayal, A	1
Jayakody, RL; Lennard, MS; Smith, CA; Tucker, GT; Weerasuriya, K; Wolf, CR	1
Cobaleda, J; Dahl, ML; Herraíz, AG; Johansson, I; LLerena, A	1
Clauw, DJ; Flockhart, DA; Hewett, J; Sale, EB; Woosley, RL	1
Alm, C; Andreasson, K; Bertilsson, L; Dahl, ML; Elwin, CE; Gyllenpalm, M; Tybring, G	1
Bertilsson, L; Dahl, ML	1
Bertilsson, L; Bondesson, U; Dahl, ML; Lindström, L; Llerena, A	1
Branch, RA; May, DG; Porter, J; Wilkinson, GR	1
Benítez, J; Bertilsson, L; Llerena, A; Valdivielso, MJ	1
Bertilsson, L; Kiivet, RA; Sjöqvist, F; Svensson, JO	1
Dahl, ML; Kiivet, RA; Marandi, T; Rägo, L; Sjöqvist, F	1
Huang, SL; Luo, X; Xie, HG; Xu, ZH; Zeng, FD; Zhou, HH	1
Caraco, Y; Wilkinson, GR; Wood, AJ	1
Alvan, G; Dalén, P; Olsen, H; Wakelkamp, M	1
Bertilsson, L; Cha, YN; Dahl, ML; Ingelman-Sundberg, M; Johansson, I; Roh, HK	1
Alm, C; Alvan, G; Bani, M; Benedetti, MS; Bertilsson, L; Böttiger, Y; Casati, M; Dostert, P; Fiorentini, F; Poggesti, I	1
Meyer, UA; Zanger, UM	1
Adedoyin, A; Branch, RA; Frye, RF; Matzke, GR; Porter, JA	1
Dahl, ML; Kiivet, R; Marandi, T; Rägo, L; Sjöqvist, F	1
Adedoyin, A; Arns, PA; Branch, RA; Richards, WO; Wilkinson, GR	1
Alván, G; Dalén, P; Furtek, C; Jonzon, B; Lo, MW; McCrea, J; Ritter, M; Sandwall, P; Sjöqvist, F	1
Adedoyin, A; Branch, RA; Frye, RF; Romkes, M; Wilson, JW	1
Alvan, G; Bertilsson, L; Dahl, ML; Ingelman-Sundberg, M; Sjöqvist, F	1
Dickins, M; Gibson, A; Palmer, JL; Pleasance, S; Scott, RJ	1
Branch, RA; Frye, RF	1
Ding, LR; Fischer, NE; Inaba, T; Ishii, M; Xu, BQ	1
Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK	1
Branch, RA; Frye, RF; Romkes, M; Tracy, TS; Zgheib, NK	1

Reviews

15 review(s) available for debrisoquin and mephenytoin

Article	Year
Genetic aspects of drug disposition and therapeutics. Journal of clinical pharmacology, 1992, Volume: 32, Issue:2 Topics: Acetylation; Arylamine N-Acetyltransferase; Debrisoquin; Drug Design; Humans; Mephenytoin; Pharmacokinetics; Phenotype; Polymorphism, Genetic; Therapeutics	1992
[Heritable polymorphisms in oxidative drug metabolism]. Duodecim; laaketieteellinen aikakauskirja, 1990, Volume: 106, Issue:5 Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; In Vitro Techniques; Mephenytoin; Nifedipine; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin; Polymorphism, Genetic; Rats	1990
[Knowledge about metabolic capacity is important in drug therapy]. Lakartidningen, 1992, Feb-05, Volume: 89, Issue:6 Topics: Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Mephenytoin; Pharmaceutical Preparations; Phenotype; Polymorphism, Genetic	1992
[The significance of cytochrome P450 gene superfamily for the clinical pharmacokinetics of drugs]. Ugeskrift for laeger, 1991, Feb-04, Volume: 153, Issue:6 Topics: Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Mephenytoin; Oxidation-Reduction; Pharmacokinetics; Polymorphism, Genetic; Sparteine	1991
Genetic polymorphisms in drug metabolism--its relevance to Asian populations. Annals of the Academy of Medicine, Singapore, 1991, Volume: 20, Issue:1 Topics: Aldehyde Dehydrogenase; Arylamine N-Acetyltransferase; Asian People; Debrisoquin; Ethanol; Humans; Hydroxylation; Mephenytoin; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	1991
Genetic polymorphism of drug metabolism in humans. Advances in experimental medicine and biology, 1991, Volume: 283 Topics: Acetylation; Debrisoquin; Drug-Related Side Effects and Adverse Reactions; Humans; Mephenytoin; Pharmaceutical Preparations; Polymorphism, Genetic; Sparteine	1991
Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. European journal of clinical pharmacology, 1990, Volume: 39, Issue:6 Topics: Debrisoquin; Europe; Genetics, Population; Humans; Hydrolysis; Mephenytoin; Meta-Analysis as Topic; Oxidation-Reduction; Polymorphism, Genetic	1990
Genetic polymorphisms of drug metabolism. Progress in liver diseases, 1990, Volume: 9 Topics: Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Liver; Mephenytoin; Mutation; Pharmaceutical Preparations; Polymorphism, Genetic; Sparteine	1990
Hereditary polymorphisms of human drug metabolizing enzymes and cancer susceptibility. Birth defects original article series, 1990, Volume: 26, Issue:1 Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Debrisoquin; Genetic Predisposition to Disease; Humans; Mephenytoin; Neoplasms; Oxidation-Reduction; Polymorphism, Genetic	1990
[Polymorphism of drug oxidation and its molecular mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica, 1990, Volume: 25, Issue:5 Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Polymorphism, Genetic	1990
Genetics of drug transformation. Clinical biochemistry, 1986, Volume: 19, Issue:2 Topics: Alcoholism; Biotransformation; Cytochromes; Debrisoquin; Ethanol; Genes, Recessive; Genetics; Humans; Mephenytoin; Pharmaceutical Preparations; Phenotype; Sparteine	1986
Genetic polymorphism of mephenytoin metabolism. Progress in clinical and biological research, 1986, Volume: 214 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical Phenomena; Chemistry; China; Cytochrome P-450 CYP2C19; Debrisoquin; Dogs; Ethnicity; Humans; Hydantoins; Hydroxylation; Japan; Kinetics; Liver; Mephenytoin; Mephobarbital; Mice; Mixed Function Oxygenases; Ontario; Phenotype; Polymorphism, Genetic; Sparteine; Tennessee; White People	1986
[Genetic polymorphism of oxidative drug metabolism. Therapeutic and toxicologic implications]. Der Internist, 1983, Volume: 24, Issue:3 Topics: Adrenergic beta-Antagonists; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Hydroxylation; Mephenytoin; Oxidation-Reduction; Perhexiline; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenotype; Phenytoin; Polymorphism, Genetic; Receptors, Drug; Sparteine	1983
Genetically variable metabolism of antidepressants and neuroleptic drugs in man. Pharmacogenetics, 1993, Volume: 3, Issue:2 Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; China; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Liver; Male; Mephenytoin; Polymorphism, Genetic; Sweden	1993
Molecular mechanisms of genetic polymorphisms of drug metabolism. Annual review of pharmacology and toxicology, 1997, Volume: 37 Topics: Acetylation; Alleles; Animals; Arylamine N-Acetyltransferase; Debrisoquin; Ethnicity; Gene Frequency; Humans; Liver; Mephenytoin; Mutation; Pharmaceutical Preparations; Polymorphism, Genetic; Sparteine	1997

Trials

11 trial(s) available for debrisoquin and mephenytoin

Article	Year
Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine. British journal of clinical pharmacology, 1989, Volume: 28, Issue:2 Topics: Adult; Debrisoquin; Humans; Hydantoins; Hydroxylation; Isoquinolines; Ketoconazole; Male; Mephenytoin; Oxidation-Reduction; Phenotype; Stereoisomerism	1989
S-mephenytoin hydroxylation phenotypes in a Jordanian population. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Debrisoquin; Female; Gene Frequency; Humans; Hydroxylation; Jordan; Male; Mephenytoin; Metabolism; Middle Aged; Phenotype; Prevalence; Sympatholytics	1995
Interethnic difference in omeprazole's inhibition of diazepam metabolism. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:1 Topics: Adult; Asian People; China; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Diazepam; Double-Blind Method; Drug Interactions; Ethnicity; Humans; Male; Mephenytoin; Nordazepam; Omeprazole; Tennessee; White People	1995
S-mephenytoin, sparteine and debrisoquine oxidation: genetic polymorphisms in a Turkish population. British journal of clinical pharmacology, 1994, Volume: 38, Issue:5 Topics: Adolescent; Adult; Cohort Studies; Debrisoquin; Female; Health Personnel; Humans; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Polymorphism, Genetic; Sparteine; Stereoisomerism; Turkey; White People	1994
Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole. Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:4 Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; China; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Omeprazole; White People	1996
Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans. British journal of clinical pharmacology, 1996, Volume: 42, Issue:6 Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Pressure; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Half-Life; Heart Rate; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Nicergoline; Phenotype; Vasodilator Agents	1996
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4 Topics: Adult; Analysis of Variance; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Interactions; Humans; Male; Mephenytoin; Phenotype; Reference Values	1997
Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:1 Topics: Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Liver Diseases; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Stereoisomerism; Sympatholytics	1998
An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A). British journal of clinical pharmacology, 2001, Volume: 52, Issue:5 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Diclofenac; Drug Interactions; Female; Humans; Male; Mephenytoin; Midazolam; Muscle Relaxants, Central; Oxidoreductases, N-Demethylating	2001
Liver disease selectively modulates cytochrome P450--mediated metabolism. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3 Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline	2006
Validation of incorporating flurbiprofen into the Pittsburgh cocktail. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Caffeine; Chlorzoxazone; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Therapy, Combination; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Male; Mephenytoin; Middle Aged	2006

Other Studies

44 other study(ies) available for debrisoquin and mephenytoin

Article	Year
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:4 Topics: China; Chromatography, Gas; Debrisoquin; Humans; Hydroxylation; Mephenytoin; Phenotype; Polymorphism, Genetic; Sweden	1992
Activity of oxidative routes of metabolism of debrisoquin, mephenytoin, and dapsone is unrelated to the pathogenesis of vinyl chloride-induced disease. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:6 Topics: Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Humans; Male; Mephenytoin; Middle Aged; Occupational Diseases; Oxidation-Reduction; Phenotype; Regression Analysis; Vinyl Chloride	1992
Cytochrome P-450-dependent hydroxylation in migraine. Cephalalgia : an international journal of headache, 1992, Volume: 12, Issue:3 Topics: Chromatography, Gas; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Migraine Disorders	1992
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin. Therapeutic drug monitoring, 1991, Volume: 13, Issue:2 Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine	1991
Lack of relationship between glibenclamide metabolism and debrisoquine or mephenytoin hydroxylation phenotypes. British journal of clinical pharmacology, 1990, Volume: 30, Issue:3 Topics: Adult; Debrisoquin; Female; Glyburide; Humans; Hydroxylation; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Phenotype; Polymorphism, Genetic	1990
Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease. British journal of clinical pharmacology, 1990, Volume: 30, Issue:2 Topics: Aged; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Parkinson Disease; Phenotype	1990
d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo. Therapeutic drug monitoring, 1990, Volume: 12, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Dextropropoxyphene; Female; Humans; Hydantoins; Hydroxylation; Isomerism; Isoquinolines; Male; Mephenytoin; Polymorphism, Genetic	1990
Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin. Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:3 Topics: Acetylation; Adult; Biotransformation; Dapsone; Debrisoquin; Disease Susceptibility; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Logistic Models; London; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Scleroderma, Systemic; Tennessee	1990
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4 Topics: Adult; Benzodiazepines; Debrisoquin; Diazepam; Female; Humans; Hydantoins; Isoquinolines; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Smoking	1989
Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests. Therapeutic drug monitoring, 1989, Volume: 11, Issue:6 Topics: Adult; Debrisoquin; Diazepam; Drug Interactions; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Phenotype	1989
S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:5 Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Sweden	1989
Importance of oxidative polymorphism on clinical efficacy and side-effects of imipramine--a retrospective study. Pharmacopsychiatry, 1988, Volume: 21, Issue:6 Topics: Debrisoquin; Depressive Disorder; Female; Humans; Imipramine; Male; Mephenytoin; Middle Aged; Oxidation-Reduction	1988
Acetylation of maprotiline and desmethylmaprotiline in depressive patients phenotyped with sulfamidine, debrisoquine, and mephenytoin. Arzneimittel-Forschung, 1988, Volume: 38, Issue:2 Topics: Acetylation; Anthracenes; Debrisoquin; Depressive Disorder; Gas Chromatography-Mass Spectrometry; Humans; Maprotiline; Mephenytoin; Phenotype; Sulfamethazine	1988
The non-human primate: a possible model for human genetically determined polymorphisms in oxidative drug metabolism. Molecular pharmacology, 1988, Volume: 34, Issue:2 Topics: Animals; Biotransformation; Debrisoquin; Female; Hydantoins; Isoquinolines; Macaca; Macaca fascicularis; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic	1988
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. International clinical psychopharmacology, 1986, Volume: 1, Issue:2 Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic	1986
New aspects in research on blood levels and bioavailability of antidepressants. Psychopathology, 1986, Volume: 19 Suppl 2 Topics: Amitriptyline; Antidepressive Agents; Biological Availability; Debrisoquin; Depressive Disorder; Humans; Kinetics; Maprotiline; Mephenytoin; Nortriptyline	1986
Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer research, 1987, Oct-15, Volume: 47, Issue:20 Topics: Acetylation; Aged; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Debrisoquin; Disease Susceptibility; Female; Humans; Male; Mathematics; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Risk Factors; Smoking; Urinary Bladder Neoplasms	1987
Polymorphic debrisoquine and mephenytoin hydroxylation in patients with pulmonary hypertension of vascular origin after aminorex fumarate. European journal of clinical pharmacology, 1986, Volume: 31, Issue:4 Topics: Adult; Aged; Aminorex; Animals; Appetite Depressants; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Hypertension, Pulmonary; In Vitro Techniques; Isoquinolines; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazoles; Phenotype; Polymorphism, Genetic; Rats; Rats, Inbred Strains	1986
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Female; Genotype; Humans; Hydantoins; Hydroxylation; Isoquinolines; Japan; Male; Mephenytoin; Middle Aged; Phenotype; Random Allocation; White People	1985
Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. European journal of clinical pharmacology, 1984, Volume: 26, Issue:6 Topics: Adult; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic	1984
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; Tennessee; White People	1984
Polymorphic drug oxidation in humans. Federation proceedings, 1984, May-15, Volume: 43, Issue:8 Topics: Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Debrisoquin; Humans; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenacetin; Phenformin; Phenytoin; Polymorphism, Genetic; Sparteine; Tolbutamide	1984
Stereoselective disposition of carvedilol is determined by CYP2D6. Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:5 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Carbazoles; Carvedilol; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Half-Life; Humans; Mephenytoin; Metabolic Clearance Rate; Mixed Function Oxygenases; Pharmacogenetics; Phenotype; Propanolamines; Stereoisomerism	1995
Debrisoquine and mephenytoin oxidation in Sinhalese: a population study. British journal of clinical pharmacology, 1994, Volume: 38, Issue:5 Topics: Adult; Asian People; Cohort Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Ethnicity; Female; Gene Expression Regulation, Enzymologic; Genotype; Heterozygote; Homozygote; Humans; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Mutation; Oxidation-Reduction; Sri Lanka; White People	1994
Debrisoquin and mephenytoin hydroxylation phenotypes and CYP2D6 genotype in patients treated with neuroleptic and antidepressant agents. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:6 Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Genotype; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic	1993
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:4 Topics: Alleles; Arylamine N-Acetyltransferase; Case-Control Studies; Dapsone; Debrisoquin; Eosinophilia-Myalgia Syndrome; Female; Genotype; Humans; Mephenytoin; Phenotype; Xenobiotics	1994
Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:2 Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Mianserin; Middle Aged; Mixed Function Oxygenases; Polymorphism, Genetic; Stereoisomerism; Sweden; White People	1994
Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms. British journal of clinical pharmacology, 1994, Volume: 37, Issue:1 Topics: Administration, Oral; Adult; Clozapine; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; Sweden; Tissue Distribution	1994
Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population. Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:5 Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Regression Analysis; White People	1994
Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes. Pharmacology & toxicology, 1993, Volume: 73, Issue:1 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Phenotype; Reproducibility of Results; Stereoisomerism; Time Factors	1993
Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians. Pharmacology & toxicology, 1993, Volume: 72, Issue:2 Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Debrisoquin; Dextromethorphan; Estonia; Female; Humans; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic	1993
Debrisoquin and S-mephenytoin hydroxylation phenotypes and CYP2D6 genotypes in an Estonian population. Pharmacology & toxicology, 1996, Volume: 78, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Estonia; Female; Genotype; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Sympatholytics	1996
Genetic polymorphisms of debrisoquine and S-mephenytoin oxidation metabolism in Chinese populations: a meta-analysis. Pharmacogenetics, 1996, Volume: 6, Issue:3 Topics: China; Debrisoquin; Female; Genetic Heterogeneity; Humans; Male; Mephenytoin; Oxidation-Reduction; Pharmacogenetics; Polymorphism, Genetic	1996
Formation of meprobamate from carisoprodol is catalysed by CYP2C19. Pharmacogenetics, 1996, Volume: 6, Issue:5 Topics: Administration, Oral; Adult; Analgesics; Aryl Hydrocarbon Hydroxylases; Carisoprodol; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Inactivation, Metabolic; Male; Mephenytoin; Meprobamate; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Muscle Relaxants, Central	1996
Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population. Pharmacogenetics, 1996, Volume: 6, Issue:5 Topics: Adult; Asian People; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Gene Frequency; Genotype; Humans; Korea; Male; Mephenytoin; Phenotype; Point Mutation; Polymorphism, Genetic	1996
Debrisoquine and S-mephenytoin hydroxylation polymorphisms in a Russian population living in Estonia. European journal of clinical pharmacology, 1997, Volume: 53, Issue:3-4 Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Genotype; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Polymerase Chain Reaction; Polymorphism, Genetic	1997
Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine (cytochrome P450 2D6) and mephenytoin (cytochrome P450 2C19). European journal of clinical pharmacology, 1999, Volume: 55, Issue:4 Topics: Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Losartan; Male; Mephenytoin; Mixed Function Oxygenases; Polymorphism, Genetic	1999
In vivo modulation of CYP enzymes by quinidine and rifampin. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4 Topics: Acetylation; Administration, Oral; Adrenergic alpha-Antagonists; Adult; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Drug Administration Schedule; Enzyme Inhibitors; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Quinidine; Reference Values; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline	2000
Moving toward genetic profiling in patient care: the scope and rationale of pharmacogenetic/ecogenetic investigation. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:4 Pt 2 Topics: Cytochrome P-450 CYP2D6; Debrisoquin; Ethnicity; Genetic Testing; Humans; Hydroxylation; Mephenytoin; Patient Care; Pharmacogenetics; Polymorphism, Genetic; Sparteine	2001
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects. British journal of clinical pharmacology, 2002, Volume: 53, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dapsone; Debrisoquin; Disulfiram; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mephenytoin; Mixed Function Oxygenases; Time Factors	2002
Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6. Life sciences, 2003, Mar-14, Volume: 72, Issue:17 Topics: Alpha-Globulins; Animals; Aryl Hydrocarbon Hydroxylases; Blood Proteins; Cattle; Chromatography, Thin Layer; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; gamma-Globulins; Humans; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Orosomucoid; Protein Binding; Serum Albumin; Serum Albumin, Bovine	2003