debrisoquin and losartan
debrisoquin has been researched along with losartan in 3 studies
Research
Studies (3)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (33.33) | 18.2507 |
2000's | 1 (33.33) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Alván, G; Dalén, P; Furtek, C; Jonzon, B; Lo, MW; McCrea, J; Ritter, M; Sandwall, P; Sjöqvist, F | 1 |
Bertilsson, L; Gustafsson, LL; Mahindi, M; Nordmark, A; Pihlsgård, M; Wennerholm, A | 1 |
Trials
1 trial(s) available for debrisoquin and losartan
Article | Year |
---|---|
Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.
Topics: Administration, Oral; Adult; Amodiaquine; Antihypertensive Agents; Antimalarials; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Confidence Intervals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Debrisoquin; Drug Interactions; Humans; Losartan; Middle Aged; Phenotype; Time Factors | 2006 |
Other Studies
2 other study(ies) available for debrisoquin and losartan
Article | Year |
---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine (cytochrome P450 2D6) and mephenytoin (cytochrome P450 2C19).
Topics: Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Losartan; Male; Mephenytoin; Mixed Function Oxygenases; Polymorphism, Genetic | 1999 |