debrisoquin and losartan

debrisoquin has been researched along with losartan in 3 studies

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Alván, G; Dalén, P; Furtek, C; Jonzon, B; Lo, MW; McCrea, J; Ritter, M; Sandwall, P; Sjöqvist, F1
Bertilsson, L; Gustafsson, LL; Mahindi, M; Nordmark, A; Pihlsgård, M; Wennerholm, A1

Trials

1 trial(s) available for debrisoquin and losartan

ArticleYear
Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:7

    Topics: Administration, Oral; Adult; Amodiaquine; Antihypertensive Agents; Antimalarials; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Confidence Intervals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Debrisoquin; Drug Interactions; Humans; Losartan; Middle Aged; Phenotype; Time Factors

2006

Other Studies

2 other study(ies) available for debrisoquin and losartan

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine (cytochrome P450 2D6) and mephenytoin (cytochrome P450 2C19).
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:4

    Topics: Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Losartan; Male; Mephenytoin; Mixed Function Oxygenases; Polymorphism, Genetic

1999
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