debrisoquin and dextromethorphan

debrisoquin has been researched along with dextromethorphan in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (26.32)	18.7374
1990's	15 (39.47)	18.2507
2000's	12 (31.58)	29.6817
2010's	1 (2.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Commandeur, JN; Funae, Y; Hiroi, T; ter Laak, AM; Venhorst, J; Vermeulen, NP	1
Gerdin, E; Modiri, AR; Rane, A	1
Cherrie, J; Evans, WE; Meyer, WH; Petros, WP; Relling, MV; Schell, MJ	1
Kronbach, T	1
Bargetzi, MJ; Follath, F; Haefeli, WE; Meyer, UA	1
Canoll, PD; Klein, M; Musacchio, JM	1
Alvarez, F; Gueguen, M; Jacqz-Aigrain, E; Robieux, I; Zanger, UM	1
Bergman, U; Laurell, H; Lindström, B; Mortimer, O; Rane, A	1
Belec, L; De Cremoux, H; Gherardi, R; Larrey, D; Louarn, F; Pessayre, D; Tinel, M	1
Crom, WR; Evans, WE; Meyer, WH; Mirro, J; Petros, WP; Relling, MV	1
Avram, MJ; Henthorn, TK; Krejcie, TC	1
Avram, MJ; Benitez, J; Cobaleda, J; Gibbons, RD; Henthorn, TK; Krejcie, TC; Llerena, A; Martinez, C	1
Küpfer, A; Zeugin, T; Zysset, T	1
Catin, T; Gut, J; Kronbach, T; Mathys, D; Meyer, UA	1
Küpfer, A; Pfaff, G; Schmid, B	1
Küpfer, A; Pfaff, G; Preisig, R; Schmid, B	1
Hawes, EM; Hubbard, JW; McKay, G; Midha, KK; Roy, SD	1
Bechtel, Y; Becker, MC; Bendriss, A; Bendriss, EK; Bresson-Hadni, S; Gillet, M; Joanne, C; Magnette, J; Mantion, G; Paintaud, G	1
Anthony, LB; Boeve, TJ; Hande, KR	1
Galteau, MM; Jacqz-Aigrain, E; Krishnamoorthy, R; Mura, C; Panserat, S; Vincent-Viry, M	1
Atchison, BA; Douglas, AM; Drummer, OH; Somogyi, AA	1
Bertilsson, L; Kiivet, RA; Sjöqvist, F; Svensson, JO	1
Bauer, S; Brockmöller, J; Reum, T; Roots, I; Sachse, C	1
Bauer, S; Brockmöller, J; Roots, I; Sachse, C	1
Bechtel, PR; Bechtel, Y; Mantion, G; Miguet, JP; Monek, O; Paintaud, G	1
Bruce-Mensah, K; Droll, K; Gaedigk, A; Otton, SV; Sellers, EM; Tyndale, RF	1
Bechtel, PR; Bechtel, Y; Berard, M; Haffen, E; Masuyer, C; Paintaud, G	1
Chowdry, J; Ellis, SW; Gross, E; Harlow, J; Hayhurst, GP; Hilton, E; Lennard, MS; Tucker, GT	1
Brockmoller, J; Friedman, D; Lira, M; McElroy, S; Milos, PM; Richmond, J; Roots, I; Sachse, C; Silber, BM	1
Abdi, YA; Bertilsson, L; Dandara, C; Gustafsson, LL; Hasler, J; Ingelman-Sundberg, M; Sayi, J; Svensson, JO; Wennerholm, A	1
Crespi, C; Gaedigk, A; Leeder, JS; Marcucci, KA; Pearce, RE; Steimel, DT	1
Friis, C; Skaanild, MT	1
Crewe, KH; Ozdemir, M; Rostami-Hodjegan, A; Tucker, GT	1
Allorge, D; Blaney, FE; Bréant, D; Broly, F; Cauffiez, C; Chevalier, D; Chowdry, J; Ellis, SW; Harlow, J; Lhermitte, M; Lo-Guidice, JM; Tucker, GT	1
Frank, D; Fuhr, U; Jaehde, U	1
Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA	1
DiMaio Knych, HK; Stanley, SD	1
Corado, CR; Knych, HK; McKemie, DS	1

Reviews

1 review(s) available for debrisoquin and dextromethorphan

Article	Year
Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping. European journal of clinical pharmacology, 2007, Volume: 63, Issue:4 Topics: Area Under Curve; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Evaluation Studies as Topic; Humans; Phenotype; Polymorphism, Genetic	2007

Trials

4 trial(s) available for debrisoquin and dextromethorphan

Article	Year
Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolites in man. British journal of clinical pharmacology, 1989, Volume: 27, Issue:2 Topics: Adult; Automobile Driving; Debrisoquin; Dextromethorphan; Dextrorphan; Double-Blind Method; Humans; Levorphanol; Noscapine; Phenotype; Random Allocation	1989
CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting. AAPS pharmSci, 2000, Volume: 2, Issue:4 Topics: Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Genotype; Humans; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic	2000
The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:1 Topics: Adrenergic Agents; Adrenergic beta-Antagonists; Adult; Aged; Alleles; Analgesics, Opioid; Antitussive Agents; Black People; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Genotype; Humans; Isoenzymes; Kinetics; Male; Metoprolol; Middle Aged; Phenotype; Substrate Specificity; White People	2002
Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH. Journal of clinical pharmacology, 2004, Volume: 44, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Ammonium Chloride; Cross-Over Studies; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Humans; Hydrogen-Ion Concentration; Male; Methods; Metoprolol; Middle Aged; Molecular Probes; Sodium Bicarbonate; Tablets, Enteric-Coated; Urine	2004

Other Studies

33 other study(ies) available for debrisoquin and dextromethorphan

Article	Year
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1 Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Ligands; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Quinidine; Quinine; Rabbits; Rats; Sequence Homology, Amino Acid; Sparteine; Species Specificity	2003
Ethylmorphine O-deethylation cosegregates with the debrisoquin genetic metabolic polymorphism. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:3 Topics: Adult; Chromatography, High Pressure Liquid; Dealkylation; Debrisoquin; Dextromethorphan; Ethylmorphine; Female; Humans; Male; Metabolic Clearance Rate; Metabolism; Middle Aged; Polymorphism, Genetic; Regression Analysis	1992
Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Black People; Child; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Dextrorphan; DNA; Female; Humans; Phenotype; Polymorphism, Restriction Fragment Length; White People	1991
Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6. Methods in enzymology, 1991, Volume: 206 Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Microsomes, Liver; Mixed Function Oxygenases; Spectrometry, Fluorescence; Substrate Specificity	1991
Potent inhibition of cytochrome P450IID6 (debrisoquin 4-hydroxylase) by flecainide in vitro and in vivo. Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:5 Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Debrisoquin; Dextromethorphan; Ethanolamines; Flecainide; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenotype; Sparteine	1990
SKF 525-A and cytochrome P-450 ligands inhibit with high affinity the binding of [3H]dextromethorphan and sigma ligands to guinea pig brain. Life sciences, 1991, Volume: 48, Issue:6 Topics: Animals; Binding, Competitive; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Guinea Pigs; Kinetics; Ligands; Lobeline; Mixed Function Oxygenases; Neurotransmitter Uptake Inhibitors; Piperazines; Proadifen; Receptors, Opioid; Receptors, sigma; Sparteine	1991
Cytochrome P450IID subfamily in non-human primates. Catalytical and immunological characterization. Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11 Topics: Animals; Autoantibodies; Binding, Competitive; Cross Reactions; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Isoenzymes; Kinetics; Macaca fascicularis; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating	1991
Extensive oxidative metabolism of dextromethorphan in patients with almitrine neuropathy. British journal of clinical pharmacology, 1989, Volume: 27, Issue:3 Topics: Aged; Almitrine; Debrisoquin; Dextromethorphan; Female; Hereditary Sensory and Autonomic Neuropathies; Humans; Levorphanol; Male; Middle Aged; Piperazines	1989
Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:5 Topics: Acetylation; Adolescent; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Debrisoquin; Dextromethorphan; Dextrorphan; Female; Humans; Isoquinolines; Levorphanol; Male; Oxidation-Reduction; Pediatrics; Phenotype	1989
Alfentanil clearance is independent of the polymorphic debrisoquin hydroxylase. Anesthesiology, 1989, Volume: 71, Issue:5 Topics: Alfentanil; Debrisoquin; Dextromethorphan; Female; Humans; Hydroxylation; Indocyanine Green; Kinetics; Male; Phenotype; Polymorphism, Genetic	1989
Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:3 Topics: Debrisoquin; Dextromethorphan; Female; Humans; Isoquinolines; Levorphanol; Male; Oxidation-Reduction; Phenotype; Spain; Statistics as Topic	1989
In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat. An animal model of the debrisoquine-type polymorphic oxidation in man. Biochemical pharmacology, 1988, Aug-15, Volume: 37, Issue:16 Topics: Algorithms; Animals; Debrisoquin; Dextromethorphan; Female; Isoquinolines; Levorphanol; Models, Biological; Muridae; Oxidation-Reduction; Polymorphism, Genetic; Rats; Rats, Inbred Strains; Reference Values	1988
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. Analytical biochemistry, 1987, Volume: 162, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Ethanolamines; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Polymorphism, Genetic	1987
Pharmacogenetics of dextromethorphan O-demethylation in man. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:5 Topics: Adult; Biotransformation; Chromatography, Gas; Debrisoquin; Dextromethorphan; Dextrorphan; Female; Genetic Variation; Humans; Isoquinolines; Kinetics; Levorphanol; Male; Oxidation-Reduction; Phenotype; Polymorphism, Genetic	1986
Dextromethorphan as a safe probe for debrisoquine hydroxylation polymorphism. Lancet (London, England), 1984, Sep-01, Volume: 2, Issue:8401 Topics: Debrisoquin; Dextromethorphan; Humans; Hydroxylation; Isoquinolines; Levorphanol; Phenotype	1984
Methoxyphenamine and dextromethorphan as safe probes for debrisoquine hydroxylation polymorphism. Lancet (London, England), 1984, Dec-15, Volume: 2, Issue:8416 Topics: Debrisoquin; Dextromethorphan; Humans; Hydroxylation; Isoquinolines; Levorphanol; Methamphetamine; Phenotype; Polymorphism, Genetic	1984
Stability of debrisoquine (CYP2D6) phenotype in liver transplant patients. Therapeutic drug monitoring, 1995, Volume: 17, Issue:2 Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Female; Humans; Kinetics; Liver Transplantation; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Time Factors	1995
Cytochrome P-450IID6 phenotyping in cancer patients: debrisoquin and dextromethorphan as probes. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2 Topics: Aged; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Humans; Male; Middle Aged; Mixed Function Oxygenases; Neoplasm Metastasis; Neoplasms; Phenotype; Regression Analysis; Sensitivity and Specificity	1995
DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers. Human genetics, 1993, Volume: 92, Issue:4 Topics: Adolescent; Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; DNA; DNA Mutational Analysis; Female; Gene Expression Regulation, Enzymologic; Genotype; Haplotypes; Humans; Male; Mixed Function Oxygenases; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Random Allocation	1993
Interpretation of a simple PCR analysis of the CYP2D6(A) and CYP2D6(B) null alleles associated with the debrisoquine/sparteine genetic polymorphism. Pharmacogenetics, 1994, Volume: 4, Issue:3 Topics: Alleles; Base Sequence; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; DNA Primers; Genotype; Heterozygote; Humans; Mixed Function Oxygenases; Molecular Sequence Data; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Sequence Deletion; Sparteine	1994
Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians. Pharmacology & toxicology, 1993, Volume: 72, Issue:2 Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Debrisoquin; Dextromethorphan; Estonia; Female; Humans; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic	1993
A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D615. Pharmacogenetics, 1996, Volume: 6, Issue:3* Topics: Adult; Alleles; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Exons; Frameshift Mutation; Humans; Male; Phenotype; Pseudogenes	1996
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. American journal of human genetics, 1997, Volume: 60, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alleles; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Genetic Heterogeneity; Genetic Linkage; Genetic Variation; Genotype; Humans; Male; Middle Aged; Multigene Family; Mutation; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length	1997
Influence of donor and recipient genotypes on CYP2D6 phenotype after liver transplantation: a study of mutations CYP2D63 and CYP2D64. European journal of clinical pharmacology, 1998, Volume: 54, Issue:1 Topics: Adult; Aged; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Genotype; Humans; Liver Transplantation; Male; Middle Aged; Mutation; Phenotype; Retrospective Studies	1998
Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians. Pharmacogenetics, 1998, Volume: 8, Issue:4 Topics: Adult; Aged; Alleles; Asian People; Black People; Cross-Over Studies; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Phenotype; Sparteine; Substrate Specificity; White People	1998
On the assessment of drug metabolism by assays of codeine and its main metabolites. Therapeutic drug monitoring, 2000, Volume: 22, Issue:3 Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Glucuronides; Humans; Linear Models; Male; Methylation; Middle Aged; Morphine; Phenotype; Polymorphism, Genetic; Reproducibility of Results; Sensitivity and Specificity	2000
Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6. The Biochemical journal, 2001, Apr-15, Volume: 355, Issue:Pt 2 Topics: Alkylation; Catalysis; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Kinetics; Metoprolol; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine; Substrate Specificity	2001
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:5 Topics: Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Ethanolamines; Genetic Variation; Insecta; Kinetics; Phenotype; Substrate Specificity; Transfection	2002
Is cytochrome P450 CYP2D activity present in pig liver? Pharmacology & toxicology, 2002, Volume: 91, Issue:4 Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Ethanolamines; Female; Male; Microsomes, Liver; Substrate Specificity; Swine; Swine, Miniature	2002
Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins, 2005, May-01, Volume: 59, Issue:2 Topics: Amino Acid Substitution; Arginine; Cloning, Molecular; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Gene Frequency; Genetic Variation; Genotype; Histidine; Humans; Kinetics; Microsomes; Oxidation-Reduction; Phenotype; Polymerase Chain Reaction; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity	2005
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8 Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol	2007
Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochemical pharmacology, 2008, Oct-01, Volume: 76, Issue:7 Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; DNA, Complementary; Female; Horses; Humans; Liver; Male; Molecular Sequence Data; Sequence Alignment	2008
Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. American journal of veterinary research, 2016, Volume: 77, Issue:9 Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Female; Horses; Isoenzymes; Male; Polymorphism, Single Nucleotide	2016