debrisoquin has been researched along with codeine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 10 (62.50) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Commandeur, JN; Funae, Y; Hiroi, T; ter Laak, AM; Venhorst, J; Vermeulen, NP | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Bertilsson, L; Dahl, ML; Heim, M; Ingelman-Sundberg, M; Johansson, I; Meyer, UA; Säwe, J; Sjöqvist, F; Yue, QY | 1 |
| Hasselström, J; Säwe, J; Svensson, JO; Yue, QY | 1 |
| Säwe, J; Sjöqvist, F; Svensson, JO; Yue, QY | 1 |
| Alm, C; Säwe, J; Sjöqvist, F; Svensson, JO; Yue, QY | 1 |
| Arendt-Nielsen, L; Brøsen, K; Gram, LF; Poulsen, L; Sindrup, SH | 1 |
| Caraco, Y; Sheller, J; Wood, AJ | 3 |
| Brøsen, K; Sindrup, SH | 1 |
| Dahl, ML; Dalén, P; Frengell, C; Sjöqvist, F | 1 |
| Hasselström, J; Säwe, J; Yue, QY | 1 |
| Bechtel, PR; Bechtel, Y; Berard, M; Haffen, E; Masuyer, C; Paintaud, G | 1 |
| Guo, B; He, MM; Li, C; Liu, H; Shen, H; Wang, L; Wrighton, SA | 1 |
1 review(s) available for debrisoquin and codeine
| Article | Year |
|---|---|
The pharmacogenetics of codeine hypoalgesia.
Topics: Analgesics, Opioid; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Enzyme Inhibitors; Humans; Mixed Function Oxygenases; Morphine; Oxidation-Reduction; Pain; Pain Threshold; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Sparteine | 1995 |
3 trial(s) available for debrisoquin and codeine
| Article | Year |
|---|---|
Pharmacogenetic determination of the effects of codeine and prediction of drug interactions.
Topics: Adult; Codeine; Cross-Over Studies; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Double-Blind Method; Drug Interactions; Humans; Male; Pupil; Quinidine; Reflex, Pupillary; Respiration | 1996 |
The effect of codeine on gastrointestinal transit in extensive and poor metabolisers of debrisoquine.
Topics: Adult; Breath Tests; Codeine; Debrisoquin; Female; Gastrointestinal Transit; Humans; Hydrogen; Male; Narcotics; Phenotype; Sympatholytics | 1997 |
Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects.
Topics: Adult; Analgesics, Opioid; Asian People; Biotransformation; Codeine; Cross-Over Studies; Dealkylation; Debrisoquin; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Morphine; Psychomotor Performance; Pupil; Quinidine; Respiratory Mechanics; White People | 1999 |
12 other study(ies) available for debrisoquin and codeine
| Article | Year |
|---|---|
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Ligands; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Protein Binding; Quinidine; Quinine; Rabbits; Rats; Sequence Homology, Amino Acid; Sparteine; Species Specificity | 2003 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine.
Topics: Adolescent; Adult; Alleles; Asian People; Blotting, Southern; China; Codeine; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Gene Amplification; Humans; Hydroxylation; Japan; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; White People | 1991 |
Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine.
Topics: Administration, Oral; Adult; Codeine; Debrisoquin; Female; Half-Life; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Reference Values; White People | 1991 |
A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.
Topics: Administration, Oral; Adult; Asian People; Chromatography, High Pressure Liquid; Codeine; Debrisoquin; Female; Humans; Male; Middle Aged; Phenotype; Reference Values; White People | 1991 |
Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation.
Topics: Adolescent; Adult; Aged; Codeine; Dealkylation; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Phenotype | 1989 |
Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?
Topics: Adult; Brain; Codeine; Cold Temperature; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Liver; Male; Middle Aged; Mixed Function Oxygenases; Pain; Pain Measurement; Phenotype; Sparteine | 1993 |
Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects.
Topics: Adult; Codeine; Cytochrome P-450 CYP2D6; Dealkylation; Debrisoquin; Drug Interactions; Humans; Male; Miotics; Narcotics; Pharmacogenetics; Psychomotor Performance; Respiration; Rifampin | 1997 |
Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine.
Topics: Abdominal Pain; Adult; Analgesics, Opioid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Humans | 1997 |
On the assessment of drug metabolism by assays of codeine and its main metabolites.
Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Glucuronides; Humans; Linear Models; Male; Methylation; Middle Aged; Morphine; Phenotype; Polymorphism, Genetic; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.
Topics: Atomoxetine Hydrochloride; Cocaine; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dextromethorphan; Enzyme Inhibitors; Ethanolamines; Fluoxetine; Humans; Hydroxylation; Imipramine; Kinetics; Microsomes; Molecular Structure; Nortriptyline; Polymorphism, Single Nucleotide; Propylamines; Quinidine; Recombinant Proteins; Thioridazine; Tramadol | 2007 |