debrisoquin and antipyrine

debrisoquin has been researched along with antipyrine in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (73.91)	18.7374
1990's	5 (21.74)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (4.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Iyun, AO; Lennard, MS; Silas, JH; Smith, AJ; Tucker, GT	1
Pelkonen, O	1
Aitio, ML; Arvela, P; Bartsch, H; Béréziat, JC; Hietanen, E	1
Akita, H; Hamada, K; Iida, S; Kobayashi, S; Sakai, H; Tanaka, E; Uchida, E; Yasuhara, H	1
Law, MR	1
Kobayashi, S; Misawa, S; Tanaka, E; Yasuhara, H	1
Desager, JP; Harvengt, C; Horsmans, Y; Leclercq, V; Van Nieuwenhuyze, Y	1
Agron, L; Bigot, MC; Camsonne, R; Dao, MT; Debruyne, D; Gram, LF; Grollier, G; Lacotte, J; Moulin, M	1
Kobayashi, S; Oguchi, K; Tanaka, E; Uchida, E; Yasuhara, H	1
Crewe, HK; Lennard, MS; Tucker, GT; Woods, HF	1
Breimer, DD; Bruining, GJ; De Jongh, BM; Tenkate-Westerhof, EW; Teunissen, MW	1
Boobis, AR; Davies, DS; Kahn, GC; Murray, S; Robertz, GM	1
Boobis, AR; Davies, DS	1
Bertilsson, L; Birkett, DJ; Dahlqvist, R; Eichelbaum, M; Säwe, J; Sjöqvist, F	1
Bertilsson, L; Eichelbaum, M; Säwe, J	1
Breimer, DD; Buruma, OJ; de Wolff, FA; Ferrari, MD; Vermeij, P	1
Inaba, T; Kalow, W; Mahon, WA; Otton, SV	1
Boobis, AR; Brodie, MJ; Davies, DS; Kahn, GC; Murray, S	1
Breimer, DD; Danhof, M; Idle, JR; Sloan, TP; Smith, RL; Teunissen, MW	1
Inaba, T; Kalow, W; Otton, SV	1
Caraher, MT; Idle, JR; Mucklow, JC; Rawlins, MD; Sloan, T; Smith, RL; Wood, P	1
Bertilsson, L; Eichelbaum, M; Mellström, B; Säwe, J; Schulz, HU; Sjöqvist, F	1

Reviews

2 review(s) available for debrisoquin and antipyrine

Article	Year
Carcinogen metabolism and individual susceptibility. Scandinavian journal of work, environment & health, 1992, Volume: 18 Suppl 1 Topics: Acetylation; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carcinogens; Debrisoquin; Forecasting; Humans; Lung Neoplasms; Metabolism; Polymorphism, Genetic; Sparteine; Urinary Bladder Neoplasms	1992
Genetic predisposition to lung cancer. British journal of cancer, 1990, Volume: 61, Issue:2 Topics: Antigens, Neoplasm; Antipyrine; Aryl Hydrocarbon Hydroxylases; Chromosome Aberrations; Chromosome Disorders; Debrisoquin; Genetic Markers; Humans; Lung Neoplasms	1990

Trials

1 trial(s) available for debrisoquin and antipyrine

Article	Year
The influence of changes in dietary fat on the clearance of antipyrine and 4-hydroxylation of debrisoquine. British journal of clinical pharmacology, 1980, Volume: 9, Issue:3 Topics: Adult; Antipyrine; Debrisoquin; Dietary Fats; Humans; Hydroxylation; Isoquinolines; Male	1980

Other Studies

20 other study(ies) available for debrisoquin and antipyrine

Article	Year
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Polymorphic hydroxylation of debrisoquine. Lancet (London, England), 1977, Oct-01, Volume: 2, Issue:8040 Topics: Antipyrine; Biological Availability; Biotransformation; Debrisoquin; Humans; Hydroxylation; Isoquinolines	1977
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital. Pharmacology & toxicology, 1992, Volume: 70, Issue:6 Pt 1 Topics: Animals; Antipyrine; Debrisoquin; Diethylnitrosamine; Liver; Male; Microsomes, Liver; Neoplasms, Experimental; Organ Size; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism; Warfarin	1992
The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates. British journal of clinical pharmacology, 1991, Volume: 31, Issue:3 Topics: Adult; Antipyrine; Debrisoquin; Diltiazem; Dimethadione; Drug Interactions; Half-Life; Humans; Liver; Male; Mixed Function Oxygenases; Trimethadione	1991
Strain differences of antipyrine, trimethadione, and debrisoquine metabolism in female rats. Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:2 Topics: Analysis of Variance; Animals; Antipyrine; Debrisoquin; Female; Isoquinolines; Oxazoles; Rats; Rats, Inbred Strains; Species Specificity; Trimethadione	1990
Influence of rifampicin, phenobarbital and cimetidine on mixed function monooxygenase in extensive and poor metabolizers of debrisoquine. International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:12 Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Debrisoquin; Half-Life; Humans; Hydroxylation; Isoquinolines; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Rifampin	1989
Quinidine disposition in relation to antipyrine elimination and debrisoquine phenotype in alcoholic patients with and without cirrhosis. International journal of clinical pharmacology research, 1989, Volume: 9, Issue:5 Topics: Adult; Aged; Alcoholism; Antipyrine; Chromatography, Liquid; Debrisoquin; Female; Half-Life; Humans; Isoquinolines; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Quinidine	1989
Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively. Japanese journal of pharmacology, 1989, Volume: 49, Issue:3 Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Isoenzymes; Isoquinolines; Phenotype; Rats; Rats, Inbred Strains; Species Specificity	1989
Metoprolol oxidation by rat liver microsomes. Inhibition by debrisoquine and other drugs. Biochemical pharmacology, 1986, Aug-15, Volume: 35, Issue:16 Topics: Animals; Antipyrine; Cimetidine; Debrisoquin; Guanidines; Isoquinolines; Metoprolol; Microsomes, Liver; Ranitidine; Rats; Rats, Inbred Strains	1986
Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia. British journal of clinical pharmacology, 1985, Volume: 20, Issue:6 Topics: Adolescent; Adrenal Hyperplasia, Congenital; Antipyrine; Biotransformation; Child; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Kinetics; Male; Metabolic Clearance Rate	1985
Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man. Molecular pharmacology, 1983, Volume: 23, Issue:2 Topics: Antipyrine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Guanidines; Humans; Isoquinolines; Microsomes, Liver; Mixed Function Oxygenases; Phenformin; Sparteine; Substrate Specificity	1983
Variants of human microsomal enzymes. Biochemical Society transactions, 1983, Volume: 11, Issue:4 Topics: Antipyrine; Carbon Monoxide; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoquinolines; Microsomes, Liver; Mixed Function Oxygenases; NADP; Polymorphism, Genetic	1983
Theophylline metabolism in relation to antipyrine, debrisoquine, and sparteine metabolism. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:6 Topics: Adult; Antipyrine; Debrisoquin; Female; Humans; Isoquinolines; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Saliva; Smoking; Sparteine; Theophylline	1984
Antipyrine metabolism in relation to polymorphic oxidations of sparteine and debrisoquine. British journal of clinical pharmacology, 1983, Volume: 15, Issue:3 Topics: Adult; Antipyrine; Debrisoquin; Female; Humans; Isoquinolines; Kinetics; Male; Middle Aged; Polymorphism, Genetic; Saliva; Smoking; Sparteine	1983
Impairment of phenytoin parahydroxylation as a cause of severe intoxication. Therapeutic drug monitoring, 1983, Volume: 5, Issue:2 Topics: Aged; Antipyrine; Debrisoquin; Humans; Hydroxylation; Kinetics; Male; Phenytoin	1983
In vitro metabolism of sparteine by human liver: competitive inhibition by debrisoquine. Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:1 Topics: Antipyrine; Debrisoquin; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Isoquinolines; Liver; Sparteine	1982
Evidence for an enzymatic defect in the 4-hydroxylation of debrisoquine by human liver. British journal of clinical pharmacology, 1981, Volume: 11, Issue:1 Topics: Antipyrine; Debrisoquin; Humans; Hydroxylation; In Vitro Techniques; Isoquinolines; Microsomes, Liver; Oxidation-Reduction; Phenotype	1981
Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation. Pharmacology, 1981, Volume: 22, Issue:6 Topics: Aging; Antipyrine; Body Weight; Debrisoquin; Female; Half-Life; Humans; Hydroxylation; Isoquinolines; Male; Metabolism, Inborn Errors; Oxidation-Reduction; Phenotype; Smoking	1981
Deficient metabolism of debrisoquine and sparteine. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:4 Topics: Amobarbital; Antipyrine; Debrisoquin; Half-Life; Humans; Hydroxylation; Isoquinolines; Male; Oxidation-Reduction; Phenotype; Sparteine	1980
Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man. Life sciences, 1980, Nov-03, Volume: 27, Issue:18 Topics: Adult; Antipyrine; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Middle Aged; Nortriptyline; Oxidation-Reduction; Phenotype; Saliva	1980