debrisoquin has been researched along with 2-hydroxydesipramine in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brøsen, K; Gram, LF; Kragh-Sørensen, P | 1 |
| Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV | 1 |
| Birgersson, C; Ericsson, O; Mellström, B; Sjöqvist, F; Spina, E; Steiner, E; von Bahr, C | 1 |
| Alm, C; Dahl, ML; Ingelman-Sundberg, M; Iselius, L; Johansson, I; Lee, D; Sjöqvist, F; Svensson, JO | 1 |
| Avenoso, A; Campo, GM; Caputi, AP; Perucca, E; Spina, E | 1 |
2 trial(s) available for debrisoquin and 2-hydroxydesipramine
| Article | Year |
|---|---|
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism.
Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine | 1986 |
Phenobarbital induces the 2-hydroxylation of desipramine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Desipramine; Enzyme Induction; Epilepsy; Half-Life; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Polymorphism, Genetic | 1996 |
3 other study(ies) available for debrisoquin and 2-hydroxydesipramine
| Article | Year |
|---|---|
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin.
Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine | 1991 |
Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes.
Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Microsomes, Liver; Middle Aged; Phenotype | 1984 |
Polymorphic 2-hydroxylation of desipramine. A population and family study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Child; Debrisoquin; Desipramine; Female; Genetic Linkage; Genotype; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sweden | 1993 |