deamino-arginine-vasopressin and butaprost

Apical membrane targeting of the collecting duct water channel aquaporin-2 (AQP2) is essential for body water balance. As this event is regulated by Gs coupled 7-transmembrane receptors such as the vasopressin type 2 receptor (V2R) and the prostanoid receptors EP2 and EP4, it is believed to be cAMP dependent. However, on the basis of recent reports, it was hypothesized in the current study that increased cAMP levels are not necessary for AQP2 membrane targeting. The role and dynamics of cAMP signaling in AQP2 membrane targeting in Madin-Darby canine kidney and mouse cortical collecting duct (mpkCCD

Topics: Alprostadil; Animals; Aquaporin 2; Cell Line; Cell Membrane; Cyclic AMP; Deamino Arginine Vasopressin; Dinoprostone; Dogs; Kidney Tubules, Collecting; Mice; Pyrrolidinones; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Receptors, Vasopressin; Signal Transduction