deacetyldiltiazem has been researched along with n-monodemethyldiltiazem in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 9 (50.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Finegan, BA; Hussain, MD; Tam, YK | 1 |
| Bai, SA; Lankford, S; Maskasame, C | 1 |
| Derendorf, H; Lefevre, JF; Lopez, LM; Schaefer, HG; Ververs, FF | 1 |
| Ito, K; Kurosawa, N; Kurosawa, S; Owada, E; Soeda, H | 1 |
| Boucher, S; Caillé, G; Du Souich, P; Lery, L; Lery, N; Pilon, D; Spenard, J; Varin, F; Vezina, M | 1 |
| Boyd, RA; Chin, SK; Don-Pedro, O; Giacomini, KM; Sheiner, LB; Verotta, D; Williams, RL | 1 |
| Höglund, P; Nilsson, LG | 4 |
| Abernethy, DR; Mitchell, JR; Montamat, SC | 1 |
| Abernethy, DR; Montamat, SC | 1 |
| Caillé, G; du Souich, P; Homsy, W; Lefebvre, M | 1 |
| Abadi, AH; Lopez, LM; Rutledge, DR | 1 |
| Abadi, AH; Beaudreau, CA; Lopez, LM; Rutledge, DR | 1 |
| Caillé, G; du Souich, P; Homsy, W | 1 |
| Aramayona, JJ; Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C | 1 |
| Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C | 1 |
1 trial(s) available for deacetyldiltiazem and n-monodemethyldiltiazem
| Article | Year |
|---|---|
Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Delayed-Action Preparations; Diltiazem; Drug Administration Schedule; Food; Humans; Male; Middle Aged | 1990 |
17 other study(ies) available for deacetyldiltiazem and n-monodemethyldiltiazem
| Article | Year |
|---|---|
Pharmacokinetics of diltiazem in patients undergoing coronary artery bypass grafting.
Topics: Administration, Oral; Aged; Coronary Artery Bypass; Diltiazem; Female; Humans; Male; Middle Aged; Preoperative Care | 1992 |
The effects of chronic oral diltiazem and cimetidine dosing on the pharmacokinetics and negative dromotropic action of intravenous and oral diltiazem in the dog.
Topics: Administration, Oral; Animals; Blood Proteins; Cimetidine; Depression, Chemical; Diltiazem; Dogs; Drug Administration Schedule; Drug Interactions; Female; Infusions, Intravenous; Neural Conduction; Protein Binding | 1992 |
Simultaneous assay of propranolol, diltiazem and metabolites of diltiazem in human plasma by liquid chromatography.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Male; Propranolol; Spectrophotometry, Ultraviolet | 1990 |
Pharmacokinetics of diltiazem in patients with liver cirrhosis.
Topics: Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Creatinine; Delayed-Action Preparations; Diltiazem; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Regression Analysis | 1990 |
The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Diltiazem; Half-Life; Humans; Male; Protein Binding | 1989 |
Pharmacokinetics of diltiazem and its metabolites after repeated multiple-dose treatments in healthy volunteers.
Topics: Adult; Biotransformation; Blood Chemical Analysis; Diltiazem; Feces; Female; Half-Life; Humans; Middle Aged; Reference Values | 1989 |
Pharmacokinetics of diltiazem and its metabolites after repeated single dosing in healthy volunteers.
Topics: Adult; Chromatography, High Pressure Liquid; Diltiazem; Female; Half-Life; Humans; Male; Middle Aged | 1989 |
Pharmacokinetics of diltiazem and its metabolites after single and multiple dosing in healthy volunteers.
Topics: Administration, Oral; Adult; Biotransformation; Capsules; Diltiazem; Feces; Female; Half-Life; Humans; Male; Middle Aged; Reference Values | 1989 |
Physiological disposition of intravenously administered 14C-labeled diltiazem in healthy volunteers.
Topics: Adult; Blood Pressure; Diltiazem; Electrocardiography; Female; Half-Life; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Scintillation Counting | 1988 |
High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma.
Topics: Aged; Biotransformation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Hypertension; Kinetics; Male; Spectrophotometry, Ultraviolet | 1987 |
N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Diltiazem; Female; Half-Life; Humans; Hypertension; Kinetics; Male | 1987 |
Metabolism of diltiazem in hepatic and extrahepatic tissues of rabbits: in vitro studies.
Topics: Animals; Diltiazem; In Vitro Techniques; Intestinal Mucosa; Kidney; Liver; Male; Rabbits | 1995 |
Liquid chromatographic determination of celiprolol, diltiazem, desmethyldiltiazem and deacetyldiltiazem in plasma using a short alkyl chain silanol deactivated column.
Topics: Celiprolol; Chromatography, High Pressure Liquid; Diltiazem; Humans; Reference Standards; Reproducibility of Results; Silanes | 1994 |
High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column.
Topics: Chromatography, High Pressure Liquid; Diltiazem; Humans; Hypertension; Indicators and Reagents; Male; Silanes; Spectrophotometry, Ultraviolet | 1993 |
The site of absorption in the small intestine determines diltiazem bioavailability in the rabbit.
Topics: Animals; Biological Availability; Biotransformation; Blood Gas Analysis; Calcium Channel Blockers; Diltiazem; Half-Life; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Rabbits | 1995 |
Diltiazem blood pharmacokinetics in the pregnant and non-pregnant rabbit: maternal and foetal tissue levels.
Topics: Animals; Antihypertensive Agents; Brain; Diltiazem; Female; Fetal Blood; Fetus; Injections, Intravenous; Kidney; Kinetics; Maternal-Fetal Exchange; Muscles; Placenta; Pregnancy; Pregnancy, Animal; Regression Analysis; Tissue Distribution; Uterus | 2000 |
Altered diltiazem metabolism in the neonatal rabbit following intra-uterine chronic exposure to diltiazem.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Chromatography, High Pressure Liquid; Diltiazem; Female; Intestinal Mucosa; Liver; Lung; Maternal Exposure; Pregnancy; Rabbits; Time Factors; Tissue Distribution | 2001 |