dazoxiben has been researched along with aspirin in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (73.47) | 18.7374 |
| 1990's | 9 (18.37) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lumley, P; Watts, IS; Wharton, KA; White, BP | 1 |
| Asai, F; Ito, T; Matsuda, K; Oshima, T; Ushiyama, S | 1 |
| Dabros, W; Gryglewski, RJ; Korbut, R; Ocetkiewicz, A | 1 |
| Arnout, J; Deckmyn, H; Hoet, B; Vermylen, J | 1 |
| Anderson, HV; Buja, LM; De Clerck, F; Golino, P; NcNatt, JM; Rosolowsky, M; Willerson, JT; Yao, SK | 1 |
| Kienast, J; Verstraete, M | 1 |
| Hornberger, W; Patscheke, H | 1 |
| Hatakeyama, H; Hori, Y; Kurosawa, A; Yamada, K | 1 |
| Ingerman-Wojenski, CM; Silver, MJ | 1 |
| Arnout, J; Deckmyn, H; Gresele, P; Huybrechts, E; Pieters, G; Vermylen, J | 1 |
| Feldhoff, CM; Gresele, P; Pieters, G; Vermylen, J | 1 |
| Carter, AJ; Cowley, AJ; Hanley, SP; Heptinstall, S; Jones, EW | 1 |
| Dorn, GW; Halushka, PV | 1 |
| Cowley, AJ; Heptinstall, S; Sills, T | 1 |
| Ghai, R; Lindsay, LA; Olson, RW; Sakane, Y; Smith, EF | 1 |
| Ambler, J; Butler, KD; Butler, PA; Shand, RA; Wallis, RB | 1 |
| Andries, R; Bourgain, RH; Braquet, P; Decuyper, K | 1 |
| Cassina, G; Livio, M; Macconi, D; Morelli, C; Morzenti, G; Remuzzi, G | 1 |
| Bertelé, V; Castagnoli, MN; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Bjornsson, TD; Hanson, SR; Harker, LA | 1 |
| Bounameaux, H; Collen, D; De Cock, F; Gresele, P; Hanss, M; Vermylen, J | 1 |
| Carter, AJ; Heptinstall, S | 1 |
| Dietrich, M; Nawroth, PP; Stern, DM | 1 |
| Thaulow, E | 1 |
| Cowley, AJ; Hanley, SP; Jones, EW | 1 |
| Claypool, DA; Didisheim, P; Stropp, JQ; Uchiyama, S | 1 |
| Dorsch, W; Hintschich, C; Neuhauser, J; Weber, J | 1 |
| Cockbill, SR; Cowley, AJ; Hanley, SP; Heptinstall, S; Jones, EW | 1 |
| Brash, A; Fitzgerald, G; Oates, JA | 1 |
| Stimler, NP | 1 |
| Butler, RR; Cook, JA; Halushka, PV; Rambo, W; Reines, HD; Wise, WC | 1 |
| Bertelé, V; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Dale, J; Myhre, E; Thaulow, E | 1 |
| Deckmyn, H; Van Houtte, E; Vermylen, J; Verstraete, M | 1 |
| Hanson, SR; Harker, LA | 1 |
| Bertelé, V; Cerletti, C; de Gaetano, G; Dejana, E; Falanga, A; Tomasiak, M | 1 |
| Randall, MJ; Wilding, RI | 2 |
| Dale, J; Myhre, E; Parry, J; Thaulow, E | 1 |
| Bertelé, V; Cerletti, C; de Gaetano, G; Di Minno, G; Silver, MJ | 1 |
| Amore, C; Buczko, W; D'Adamo, MC; De Curtis, A; De Gaetano, G; Donati, MB; Iacoviello, L | 1 |
| Ambrosio, G; Chiariello, M; Golino, P; Gresele, P; Leproux, GB; Pascucci, I; Ragni, M; Russolillo, E | 1 |
| Ambrosio, G; Chiariello, M; Condorelli, M; de Clerk, F; Focaccio, A; Golino, P; Pace, L; Ragni, M; Villari, B | 1 |
| Berens, ME; Djawaheri, J; Giese, A; Hagel, C; Kim, EL; Westphal, M; Zapf, S | 1 |
| Gresele, P; Mezzasoma, AM; Venditti, G; Vezza, R | 1 |
| Arrebola, MM; De La Cruz, JP; Escalante, R; Guerrero, A; Sánchez de La Cuesta, F; Villalobos, MA | 2 |
| Rudzevich, AJ; Shapovalova, EM | 1 |
2 review(s) available for dazoxiben and aspirin
| Article | Year |
|---|---|
Pharmacological manipulation of the thromboxane pathway in blood platelets.
Topics: Animals; Antithrombins; Aspirin; Blood Platelets; Epoprostenol; Humans; Imidazoles; Pentanoic Acids; Platelet Activation; Pyridines; Thromboxane-A Synthase | 1990 |
Pharmacology of the interaction between platelets and vessel wall.
Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Dextrans; Diltiazem; Dipyridamole; Epoprostenol; Humans; Imidazoles; Ketanserin; Piperidines; Pyrazoles; Pyrazolones; Sulfinpyrazone; Sulfonamides; Thiophenes; Ticlopidine | 1986 |
5 trial(s) available for dazoxiben and aspirin
| Article | Year |
|---|---|
Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Cyclooxygenase Inhibitors; Hemostasis; Humans; Imidazoles; Indomethacin; Male; Platelet Aggregation; Prostaglandins; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane-A Synthase | 1987 |
Thromboxane synthetase inhibitors, thromboxane receptor antagonists, and aspirin in cardiovascular disease.
Topics: Animals; Aspirin; Cardiovascular Diseases; Cats; Clinical Trials as Topic; Dogs; Female; Humans; Imidazoles; Male; Rabbits; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase | 1985 |
Aspirin, indomethacin and dazoxiben do not affect the fibrinolytic activation induced by venous occlusion.
Topics: Aspirin; Double-Blind Method; Fibrinolysis; Humans; Imidazoles; Indomethacin; Male; Prostaglandins; Serum Globulins; Tissue Plasminogen Activator; Vascular Diseases; Veins | 1985 |
Different effects of thromboxane synthetase inhibitors on platelets from different individuals.
Topics: Arachidonic Acids; Aspirin; Clinical Trials as Topic; Double-Blind Method; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Thromboxane-A Synthase | 1982 |
The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aspirin; Blood Platelets; Humans; Imidazoles; Male; Middle Aged; Oxidoreductases; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Thromboxane B2; Thromboxane-A Synthase | 1983 |
42 other study(ies) available for dazoxiben and aspirin
| Article | Year |
|---|---|
Thromboxane (Tx) A2 receptor blockade and TxA2 synthase inhibition alone and in combination: comparison of anti-aggregatory efficacy in human platelets.
Topics: Aspirin; Biphenyl Compounds; Drug Interactions; Fatty Acids, Monounsaturated; Heptanoic Acids; Humans; Imidazoles; In Vitro Techniques; Male; Pentanoic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase | 1991 |
In vitro antiplatelet profiles of the new thromboxane synthetase inhibitor sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Aspirin; Dogs; Humans; Imidazoles; In Vitro Techniques; Male; Methacrylates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiophenes; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1991 |
A biological method for studying the interaction between platelets and vascular endothelium.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Aspirin; Blood Platelets; Endothelium, Vascular; Epoprostenol; Imidazoles; Indomethacin; Leukotrienes; Lipid Peroxides; Platelet Adhesiveness; Rabbits; Superoxide Dismutase; Thrombosis; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
Combined thromboxane A2 synthetase inhibition and receptor blockade are effective in preventing spontaneous and epinephrine-induced canine coronary cyclic flow variations.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Epinephrine; Epoprostenol; Ergolines; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Pentanoic Acids; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin Antagonists; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Hydrogen peroxide and methyl mercury are primary stimuli of eicosanoid release in human platelets.
Topics: Arachidonic Acids; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Eicosanoids; Epoprostenol; Humans; Hydrogen Peroxide; Iloprost; Imidazoles; Indomethacin; Methylmercury Compounds; Platelet Aggregation; Serotonin; Thrombin | 1989 |
Effect of a novel thromboxane A2 receptor antagonist, S-145, on collagen-induced ECG changes and thrombocytopenia in rodents.
Topics: Administration, Oral; Animals; Aspirin; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Collagen; Electrocardiography; Fatty Acids, Monounsaturated; Imidazoles; In Vitro Techniques; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Prostaglandins; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombocytopenia; Thromboxane A2 | 1989 |
Model system to study interaction of platelets with damaged arterial wall. II. Inhibition of smooth muscle cell proliferation by dipyridamole and AH-P719.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arteries; Arteriosclerosis; Aspirin; Blood Platelets; Cell Division; Dipyridamole; Endothelium, Vascular; Heparin; Imidazoles; Male; Microscopy, Electron, Scanning; Models, Cardiovascular; Muscle, Smooth, Vascular; Rabbits | 1988 |
Acetylsalicylic acid, BM 13.177 and picotamide improve the survival of endotoxin-infused rabbits.
Topics: Animals; Aspirin; Endotoxins; Female; Imidazoles; Male; Methylprednisolone; Phthalic Acids; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Shock, Septic; Sulfonamides; Thromboxane-A Synthase | 1988 |
The effects of dazoxiben, an inhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and platelet behaviour in different individuals.
Topics: Adult; Aspirin; Blood Platelets; Cold Temperature; Cyclic AMP; Female; Forearm; Humans; Imidazoles; Male; Oxidoreductases; Platelet Aggregation; Thromboxane-A Synthase; Vascular Resistance; Vasoconstriction | 1985 |
Aspirin and dazoxiben as inhibitors of platelet behaviour: modification of their effects by agents that alter cAMP production.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Arachidonic Acids; Aspirin; Blood Platelets; Cyclic AMP; Drug Interactions; Epoprostenol; Humans; Imidazoles; In Vitro Techniques; Platelet Aggregation; Serotonin | 1986 |
Dazoxiben, UK 38,485 and aspirin: duration of effect for preventing thrombotic sudden death in rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Imidazoles; Male; Rabbits; Thrombocytopenia; Thrombosis; Thromboxane B2; Time Factors | 1986 |
Prolongation of platelet survival in hypercholesterolaemic rabbits by CGS 12970 (3-methyl-2-(3-pyridyl)-1 indoleoctanoic acid) and dazoxiben.
Topics: Animals; Aspirin; Blood Platelets; Cell Survival; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Hypercholesterolemia; Imidazoles; Pyridines; Rabbits; Sulfinpyrazone; Thromboxane B2; Thromboxane-A Synthase | 1987 |
Exchange of cyclooxygenase dependent metabolites between vessel wall and platelets in arterial thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Imidazoles; Male; Mesenteric Arteries; Platelet Aggregation; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thrombosis; Thromboxane A2; Tranylcypromine | 1988 |
Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catechols; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Prostanoic Acids; Quinacrine; Radioimmunoassay; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Drug Synergism; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostanoic Acids; Thromboxane B2; Thromboxane-A Synthase | 1985 |
Effects of platelet-modifying drugs on arterial thromboembolism in baboons. Aspirin potentiates the antithrombotic actions of dipyridamole and sulfinpyrazone by mechanism(s) independent of platelet cyclooxygenase inhibition.
Topics: Animals; Aspirin; Blood Platelets; Cell Survival; Cyclooxygenase Inhibitors; Dipyridamole; Drug Synergism; Femoral Artery; Fibrinolytic Agents; Imidazoles; Male; Papio; Sulfinpyrazone; Thromboembolism | 1985 |
Platelet aggregation in whole blood: the role of thromboxane A2 and adenosine diphosphate.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Epinephrine; Flurbiprofen; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Thromboxane production by perturbed bovine aortic endothelial cells in culture.
Topics: Animals; Aorta; Aspirin; Cattle; Cells, Cultured; Clone Cells; Cycloheximide; Dactinomycin; Endothelium; Endotoxins; Imidazoles; Thromboxane B2; Thromboxanes; Time Factors | 1985 |
Platelet function in blood from the coronary sinus in patients with arteriosclerotic heart disease.
Topics: Adenosine Diphosphate; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Coronary Disease; Coronary Vessels; Humans; Imidazoles; In Vitro Techniques; Male; Platelet Aggregation; Platelet Count; Vena Cava, Superior | 1983 |
Effects of dazoxiben, an inhibitor of thromboxane synthetase, on forearm vasoconstriction in response to cold stimulation, and on human blood vessel prostacyclin production.
Topics: Adult; Aspirin; Blood Vessels; Cold Temperature; Epoprostenol; Forearm; Humans; Imidazoles; Male; Oxidoreductases; Prostaglandins; Regional Blood Flow; Thromboxane-A Synthase; Time Factors; Vascular Resistance; Vasoconstriction | 1983 |
Filter bleeding time: a new in vitro test of hemostasis. II. Application to the study of von Willebrand disease and platelet function inhibitors.
Topics: Adult; Animals; Aspirin; Blood Platelets; Epoprostenol; Female; Humans; Imidazoles; Male; Platelet Function Tests; Swine; Swine Diseases; Thromboxane-A Synthase; von Willebrand Diseases | 1983 |
Sequential histamine inhalations cause increased bronchial histamine reactivity in guinea pigs: role of platelets, thromboxanes and prostacyclin.
Topics: Animals; Aspirin; Blood Platelets; Bronchi; Bronchial Provocation Tests; Chemical Phenomena; Chemistry; Cimetidine; Epoprostenol; Guinea Pigs; Histamine; Imidazoles; Male; Platelet Aggregation; Pyridines; Receptors, Histamine H1; Receptors, Histamine H2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Effects of dazoxiben and low-dose aspirin on platelet behaviour in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Female; Humans; Imidazoles; Male; Oxidoreductases; Thromboxane-A Synthase | 1983 |
Comparison of the effects of selective inhibition of thromboxane synthase with those of inhibition of the cyclooxygenase enzyme in man.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imidazoles; Male; Oxidoreductases; Pyridines; Thromboxane-A Synthase; Time Factors | 1984 |
Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Complement C5; Complement C5a, des-Arginine; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Indomethacin; Lung; Muscle Contraction; Piroxicam; Prostaglandins E; Prostaglandins F; SRS-A; Thiazines; Thromboxane B2 | 1984 |
The potential role of thromboxane and prostacyclin in endotoxic and septic shock.
Topics: Animals; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Fatty Acids; Gentamicins; Ibuprofen; Imidazoles; Methacrylates; Peritonitis; Rats; Rats, Inbred Strains; Shock, Septic; Thromboxane-A Synthase; Thromboxanes | 1984 |
Inhibition of arachidonate-induced human platelet aggregation by a single low oral dose of aspirin in combination with a thromboxane synthase inhibitor.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Female; Humans; Imidazoles; Male; Oxidoreductases; Platelet Aggregation; Thromboxane-A Synthase | 1984 |
Effects of a selective thromboxane synthetase inhibitor, dazoxiben, and of acetylsalicylic acid on myocardial ischemia in patients with coronary artery disease.
Topics: Aspirin; Cardiac Pacing, Artificial; Coronary Disease; Humans; Imidazoles; Lactates; Male; Middle Aged; Myocardium; Oxidoreductases; Platelet Aggregation; Thromboxane-A Synthase | 1984 |
Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom.
Topics: Animals; Aspirin; Dinoprost; Drug Interactions; Fibrinolytic Agents; Functional Laterality; Imidazoles; Kinetics; Male; Prostaglandins F; Pyrazoles; Pyrazolones; Rabbits; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1983 |
Ex vivo and in vivo evaluation of drugs that inhibit platelet function.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Dipyridamole; Imidazoles; Male; Papio; Platelet Aggregation; Sulfinpyrazone; Thiazines; Thiophenes; Ticlopidine | 1983 |
Platelet thromboxane synthetase inhibitors with low doses of aspirin: possible resolution of the "aspirin dilemma".
Topics: Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imidazoles; Methacrylates; Oxidoreductases; Platelet Aggregation; Thromboxane-A Synthase | 1983 |
Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01).
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Electric Stimulation; Imidazoles; Indium; Male; Oxidoreductases; Rabbits; Radioisotopes; Thrombosis; Thromboxane B2; Thromboxane-A Synthase | 1983 |
Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Clot Retraction; Epoprostenol; Fatty Acids, Unsaturated; Fibrin; Humans; Imidazoles; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostaglandins E; Prostaglandins H; Prostaglandins, Synthetic; Thromboxane B2 | 1982 |
Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01).
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Aspirin; Carotid Artery Thrombosis; Cells, Cultured; Enzyme Inhibitors; Fibrinolytic Agents; Imidazoles; In Vitro Techniques; Oxidoreductases; Platelet Aggregation; Rabbits; Thromboxane B2; Thromboxane-A Synthase | 1982 |
Prostacyclin is required for t-PA release after venous occlusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Pressure; Dose-Response Relationship, Drug; Fibrinolysis; Iloprost; Imidazoles; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Thromboxane-A Synthase; Tissue Plasminogen Activator; Vena Cava, Inferior | 1994 |
The in vivo antiplatelet effects of thromboxane A2 synthase inhibitors are potentiated by simultaneous thromboxane A2/prostaglandin H2 receptor blockade.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane-A Synthase | 1993 |
Endogenous prostaglandin endoperoxides may alter infarct size in the presence of thromboxane synthase inhibition: studies in a rabbit model of coronary artery occlusion-reperfusion.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Pentanoic Acids; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rabbits; Receptors, Thromboxane; Thromboxane-A Synthase | 1993 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Imidazoles; Indomethacin; Lysine; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Oligodendroglia; Pentanoic Acids; Phenotype; Pyridines; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1999 |
Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Imidazoles; Inositol Phosphates; Kidney; Methacrylates; Phenylacetates; Platelet Activating Factor; Platelet Activation; Prostaglandin H2; Prostaglandins H; Protein Isoforms; Receptors, Thromboxane; Recombinant Fusion Proteins; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2002 |
Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interaction.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Aspirin; Blood Platelets; Chlorobenzenes; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rabbits; Receptors, Thromboxane; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 2002 |
Effects of camonagrel, a selective inhibitor of platelet thromboxane synthase, on the platelet-subendothelium interaction.
Topics: Adolescent; Adult; Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Indans; Male; Middle Aged; Platelet Aggregation; Prostaglandins; Prostaglandins E; Rabbits; Thrombosis; Thromboxane B2; Thromboxane-A Synthase; Tunica Intima | 2003 |
Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Fibrinogen; Imidazoles; Male; Platelet Aggregation; Quinacrine; Rats; Thrombin | 2007 |