daunorubicin has been researched along with paclitaxel in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.97) | 18.7374 |
| 1990's | 15 (22.39) | 18.2507 |
| 2000's | 27 (40.30) | 29.6817 |
| 2010's | 18 (26.87) | 24.3611 |
| 2020's | 3 (4.48) | 2.80 |
| Authors | Studies |
|---|---|
| Barrows, LR; Ireland, CM; Kokoshka, JM | 1 |
| Heijn, M; Hooijberg, JH; Lankelma, J; Scheffer, GL; Szabó, G; Westerhoff, HV | 1 |
| Hargrove, P; Kim, RB; Lan, LB; Lecureur, V; Schuetz, EG; Schuetz, JD; Sun, D | 1 |
| Braun, PD; Kar, AK; Wandless, TJ | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Gibbons, S; Kaatz, GW; Zloh, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Burkett, BA; Chan, KF; Chan, TH; Chow, LM; Wong, IL; Zhao, Y | 1 |
| Cai, X; Duan, JX; Hart, C; Lan, L; Matteucci, M; Meng, F | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Benfenati, E; Raska, I; Toropov, AA; Toropova, AP | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bao, XZ; Cai, Y; Cui, ZN; Huang, Z; Li, YS; Liu, GJ; Wang, H; Wang, J; Wang, SJ; Wei, B; Wu, R; Yang, X; Ye, XY; Zhao, DS | 1 |
| Gottesman, MM; Mickisch, GH; Pai, LH; Pastan, I | 1 |
| Gottesman, MM; Licht, T; Merlino, GT; Mickisch, GH; Pastan, I | 1 |
| Glover, DJ | 1 |
| Gupta, RS | 1 |
| Racker, E; Westcott, D; Wu, LT | 1 |
| Dalma-Weizhausz, J; Orr, GM; Renardel de Lavalette, VW; Ryan, SJ; Sorgente, N; Verdoorn, C | 1 |
| Cheng, E; Chuang, YJ; Niedzwiecki, D; Sordillo, PP; Sternberg, CN | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Mahoney, ME; Ponnathpur, V; Ray, S; Self, S; Tang, C; Tourkina, E | 1 |
| Decker, D; Kessel, D; Sykes, E; Woodburn, K | 1 |
| Gosland, M; Hoffman, T; Huang, L; Liu, Y; Vore, M | 1 |
| Baguley, BC; Davey, MW; Davey, RA; Hargrave, RM; Harvie, RM; Su, GM | 1 |
| Das, KC; White, CW | 1 |
| Blagosklonny, MV; Fojo, T; Iglesias, A; Zhan, Z | 1 |
| Gehl, J; Mir, LM; Skovsgaard, T | 1 |
| Blaschke, TF; Duran, GE; Man, MC; Sikic, BI; Washington, CB | 1 |
| Aita, P; Bearz, A; Boiocchi, M; Colussi, AM; Corona, G; Crivellari, D; Robieux, I; Sorio, R; Stocco, F; Toffoli, G | 1 |
| Brouwer, E; Nooter, K; Sparreboom, A; Stoter, G; van Zuylen, L; Verweij, J | 1 |
| Borst, P; Sarkadi, B; Smith, AJ; Szabo, K; Szakacs, G; van Helvoort, A; van Meer, G; Varadi, A; Welker, E | 1 |
| Atadja, P; Cohen, D; Roninson, IB; Uchiyama, N; Watanabe, T | 1 |
| Davey, M; Davey, R; Locke, V | 1 |
| Bootle, D; Charlton, P; Dangerfield, W; Liddle, C; Mistry, P; Okiji, S; Plumb, JA; Stewart, AJ; Templeton, D | 1 |
| Chen, Z; Fu, J; Wang, W | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, E | 1 |
| Leslie, KK | 1 |
| An, S; Jin, X; Kang, Q; Li, Y; Wang, S; Xu, J | 1 |
| Bengala, C; Biadi, O; Conte, PF; Danesi, R; Del Tacca, M; Donati, S; Favre, C; Fogli, S; Guarneri, V; Innocenti, F; Mariani, M; Pazzagli, I | 1 |
| Kakumoto, M; Kita, T; Kobayashi, H; Nakamura, T; Okamura, N; Okumura, K; Sakaeda, T; Takara, K; Yagami, T | 1 |
| O'Shaughnessy, J | 1 |
| Rivera, E | 1 |
| Baggett, B; Gillies, RJ; Mahoney, BP; Raghunand, N | 1 |
| Damon, L; Demirer, T; Derigs, G; Ferrante, P; Kröger, N; Rosti, G; Wandt, H; Zander, AR | 1 |
| Hu, X; Lu, Q; Pan, Q; Zhang, K | 1 |
| Emel'yanov, MO; Korystov, YN; Korystova, AF; Kublik, LN; Shaposhnikova, VV | 1 |
| Fu, J; He, S; Pan, Y; Sun, C | 1 |
| Bermingham, S; McMahon, GP; O'Connor, R; Regan, F | 1 |
| Deguchi, T; Fujita, Y; Ito, M; Kojima, K; Nozawa, Y | 1 |
| Fodor, Z; Galuska, L; Goda, K; Hernádi, Z; Krasznai, ZT; Mikecz, P; Szabó, G; Tóth, A | 1 |
| Chalfant, CE; Goehe, RW; Hawkins, AJ; Massiello, A; Mayton, EK; Mukerjee, P; Murudkar, CS; Park, MA; Pinkerman, RL; Shultz, JC; Wijesinghe, DS | 1 |
| Beck, WT; Bleeker, NP; Das, SG; Doshi, JM; Hermanson, DL; Srinivasan, B; Tang, R; Xing, C | 1 |
| Asensi, M; Brown, BD; Cerdá, M; Estrela, JM; Mena, S; Obrador, E; Ortega, A; Petschen, I; Priego, S; Rodriguez, ML | 1 |
| de Vere White, R; Gao, T; Lam, KS; Lara, PN; Li, Y; Lin, TY; Luo, J; Pan, CX; Zhang, H | 1 |
| Chae, SW; Kim, HJ; Kim, NH; Lee, HJ; Lee, K; Rhie, S; Xia, Y | 1 |
| Huang, W; Jiao, L; Li, Y; Liu, B; Qian, H; Qiu, Q; Zhao, T | 1 |
| Altmann, KH; Ambati, S; Calvo-Vidal, MN; Cerchietti, L; Díaz, JF; Fang, W; Jordi, M; Kahn, A; Moore, MAS; Pera, B | 1 |
| Hatem, E; He, T; Huang, ME; Lei, M; Vernis, L | 1 |
| Bosselaers, IE; Brand, W; De Jong, WH; Geertsma, RE; Giannakou, C; Kooi, MW; Noorlander, CW; Park, MV; Scholl, JH; Vandebriel, RJ | 1 |
| Chae, SW; Kwon, Y; Lee, HJ; Lee, J; Na, Y; Park, JH | 1 |
| Gennari, C; Halmos, G; Juhász, É; Mező, G; Neundorf, I; Schuster, S | 1 |
| Bonnabry, P; Fleury-Souverain, S; Guillarme, D; Maurin, J; Rudaz, S | 1 |
5 review(s) available for daunorubicin and paclitaxel
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Liposomal anthracyclines for breast cancer: overview.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Daunorubicin; Doxorubicin; Heart Failure; Humans; Liposomes; Neoplasm Metastasis; Paclitaxel | 2003 |
Liposomal anthracyclines in metastatic breast cancer: clinical update.
Topics: Anthracyclines; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Daunorubicin; Doxorubicin; Heart Diseases; Humans; Liposomes; Neoplasm Metastasis; Paclitaxel | 2003 |
Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Epirubicin; Female; Humans; Incidence; Leukemia, Myeloid; Leukemia, Myelomonocytic, Acute; Leukemia, Promyelocytic, Acute; Leukemia, Radiation-Induced; Lymphatic Metastasis; Melphalan; Middle Aged; Mitoxantrone; Neoplasms, Second Primary; Paclitaxel; Peripheral Blood Stem Cell Transplantation; Radiotherapy, Adjuvant; Thiotepa; Transplantation Conditioning; Transplantation, Autologous | 2003 |
Nanomedicinal products: a survey on specific toxicity and side effects.
Topics: Albumins; Amphotericin B; Daunorubicin; Doxorubicin; Drug Carriers; Humans; Liposomes; Nanomedicine; Nanoparticles; Nanostructures; Paclitaxel; Polyethylene Glycols; Surveys and Questionnaires | 2017 |
1 trial(s) available for daunorubicin and paclitaxel
| Article | Year |
|---|---|
Dose-finding and pharmacologic study of chronic oral idarubicin therapy in metastatic breast cancer patients.
Topics: Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Cyclophosphamide; Daunorubicin; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Epirubicin; Female; Fluorouracil; Humans; Idarubicin; Maximum Tolerated Dose; Methotrexate; Middle Aged; Neoplasm Metastasis; Paclitaxel; Taxoids; Time Factors | 2000 |
61 other study(ies) available for daunorubicin and paclitaxel
| Article | Year |
|---|---|
Cell-based screen for identification of inhibitors of tubulin polymerization.
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured | 1996 |
Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.
Topics: Adenosine Triphosphate; Anthracyclines; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport; Cell Membrane; Daunorubicin; Glutathione; Humans; Multidrug Resistance-Associated Proteins; Tumor Cells, Cultured | 1997 |
Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.
Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Humans; Karyotyping; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Sequence Homology, Amino Acid | 2000 |
Synthesis and evaluation of daunorubicin-paclitaxel dimers.
Topics: Antineoplastic Agents; Daunorubicin; Dimerization; Drug Screening Assays, Antitumor; Paclitaxel; Spectrometry, Fluorescence; Tumor Cells, Cultured | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Paclitaxel; Polyethylene Glycols; Structure-Activity Relationship; Vinblastine | 2006 |
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
Topics: Acetylene; Animals; Binding Sites; Binding, Competitive; Cattle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indazoles; Radioligand Assay; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2007 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Design; Drug Resistance, Neoplasm; Furans; Humans; Molecular Docking Simulation; Paclitaxel; Structure-Activity Relationship; Tetrahydroisoquinolines | 2021 |
Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.
Topics: Alkaloids; Animals; Antibodies, Monoclonal; Daunorubicin; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Immunotoxins; Leukocyte Count; Mice; Mice, Transgenic; Paclitaxel; Pseudomonas aeruginosa; Vinblastine; Vincristine | 1992 |
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Tolerance; Intestines; Leukocyte Count; Liver; Membrane Glycoproteins; Mice; Mice, Transgenic; Paclitaxel; Spleen; Verapamil; Vinblastine; Vincristine | 1991 |
New approaches to the chemotherapy of melanoma.
Topics: Alkaloids; Amifostine; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Carmustine; Cisplatin; Cyclophosphamide; Dacarbazine; Daunorubicin; Humans; Lomustine; Melanoma; Nitrosourea Compounds; Paclitaxel; Procarbazine; Tamoxifen; Taurine; Thiotepa; Vincristine; Vindesine | 1991 |
Cross-resistance of vinblastine- and taxol-resistant mutants of Chinese hamster ovary cells to other anticancer drugs.
Topics: Alkaloids; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cells, Cultured; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Hybrid Cells; Microtubules; Mutation; Paclitaxel; Tritium; Vinblastine | 1985 |
Use of slow Ca2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Nicotinic Acids; Nimodipine; Ovary; Paclitaxel; Pimozide; Verapamil | 1986 |
Cellular migration, proliferation, and contraction. An in vitro approach to a clinical problem--proliferative vitreoretinopathy.
Topics: Alkaloids; Animals; Cell Division; Cells, Cultured; Chemotaxis; Colchicine; Cytochalasin B; Daunorubicin; Fibroblasts; Paclitaxel; Rabbits; Retina; Retinal Diseases; Skin | 1986 |
Evaluation of new anticancer agents against human pancreatic carcinomas in nude mice.
Topics: Adult; Aged; Alkaloids; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Intraductal, Noninfiltrating; Daunorubicin; Doxorubicin; Drug Evaluation; Epirubicin; Female; Humans; Male; Menogaril; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Nogalamycin; Paclitaxel; Pancreatic Neoplasms; Random Allocation; Transplantation, Heterologous | 1987 |
Characterization of a human myeloid leukemia cell line highly resistant to taxol.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Daunorubicin; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Microtubules; Paclitaxel; Tumor Cells, Cultured; Verapamil | 1994 |
Fractionation of Cremophor EL delineates components responsible for plasma lipoprotein alterations and multidrug resistance reversal.
Topics: Animals; Antineoplastic Agents; Biological Transport; Chemical Fractionation; Chromatography, High Pressure Liquid; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Glycerol; Humans; Leukemia P388; Lipoproteins; Mice; Paclitaxel; Pharmaceutical Vehicles; Protein Binding | 1995 |
MDR1 substrates/modulators protect against beta-estradiol-17beta-D-glucuronide cholestasis in rat liver.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Carrier Proteins; Cholestasis; Chromatography, High Pressure Liquid; Cyclosporine; Daunorubicin; Estradiol; Male; Paclitaxel; Rats; Rats, Sprague-Dawley | 1996 |
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Line; Cell Survival; Daunorubicin; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin; Leukemia; Paclitaxel; Phenotype; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.
Topics: Adenocarcinoma; Antineoplastic Agents; Binding, Competitive; Cell Nucleus; Cycloheximide; Dactinomycin; Daunorubicin; Dexamethasone; Doxorubicin; Enzyme Inhibitors; Humans; Kinetics; Lung Neoplasms; NF-kappa B; Oligodeoxyribonucleotides; Paclitaxel; Protein Kinase C; Transcription Factors; Tumor Cells, Cultured; Vincristine | 1997 |
Like p53, the proliferation-associated protein p120 accumulates in human cancer cells following exposure to anticancer drugs.
Topics: Antineoplastic Agents; Base Sequence; Cell Division; Dactinomycin; Daunorubicin; DNA Damage; DNA Primers; Doxorubicin; Humans; Microtubules; Mitomycin; Neoplasm Proteins; Nuclear Proteins; Paclitaxel; Polymerase Chain Reaction; Transcription, Genetic; tRNA Methyltransferases; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vincristine | 1998 |
Enhancement of cytotoxicity by electropermeabilization: an improved method for screening drugs.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carboplatin; Cell Line; Cell Survival; Cisplatin; Cricetinae; Cricetulus; Daunorubicin; Doxorubicin; Drug Screening Assays, Antitumor; Electroporation; Etoposide; Lung; Paclitaxel | 1998 |
Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells.
Topics: Anti-HIV Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cell Survival; Daunorubicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; HIV Protease Inhibitors; Humans; Indinavir; Leukemia, Erythroblastic, Acute; Nelfinavir; Paclitaxel; Ritonavir; Saquinavir; Sarcoma; Tumor Cells, Cultured; Uterine Neoplasms; Vinblastine | 1998 |
Role of intestinal P-glycoprotein in the plasma and fecal disposition of docetaxel in humans.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Daunorubicin; Docetaxel; Drug Resistance, Multiple; Feces; Half-Life; Humans; Intestinal Mucosa; Metabolic Clearance Rate; Mixed Function Oxygenases; Neoplasms; Paclitaxel; Quinolines; Taxoids; Tumor Cells, Cultured | 2000 |
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Cell Polarity; Cells, Cultured; Cyclosporine; Cyclosporins; Cytotoxins; Daunorubicin; Digoxin; Epithelial Cells; Humans; Ivermectin; Kidney; Paclitaxel; Pharmaceutical Preparations; Phosphatidylcholines; Recombinant Proteins; Spodoptera; Swine; Verapamil; Vinblastine | 2000 |
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Carcinoma, Squamous Cell; Colchicine; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Paclitaxel; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine | 2000 |
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carcinoma, Small Cell; Cell Cycle; Cell Survival; Chlorambucil; Cisplatin; Daunorubicin; Drug Resistance, Multiple; Epirubicin; Genistein; Humans; Lung Neoplasms; Paclitaxel; Tumor Cells, Cultured; Vinblastine; Vinorelbine | 2001 |
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Topics: Acridines; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Division; Cyclosporins; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Quinolines; Tetrahydroisoquinolines; Time Factors; Treatment Outcome; Tritium; Xenograft Model Antitumor Assays | 2001 |
[Efficient expression of multidrug resistance gene mdr1 in retroviral vector under control of an internal ribosome entry site].
Topics: Animals; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Encephalomyocarditis virus; Gene Expression Regulation, Neoplastic; Genes, MDR; Genetic Vectors; Glycoproteins; Humans; Mice; Paclitaxel; Retroviridae; Ribosomes; Transfection; Vincristine | 1998 |
Paclitaxel for treating KS.
Topics: AIDS-Related Opportunistic Infections; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Daunorubicin; Doxorubicin; Drug Carriers; Humans; Liposomes; Paclitaxel; Sarcoma, Kaposi | 1997 |
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.
Topics: 3T3 Cells; Adenosine Triphosphate; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Line; CHO Cells; Cricetinae; Daunorubicin; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Genes, MDR; Humans; Hydrolysis; Mice; Paclitaxel; Piperidines; Pyridines; Rhodamine 123; Tamoxifen; Vinblastine | 2001 |
Chemotherapy and pregnancy.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cytarabine; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Etoposide; Female; Fetus; Humans; Nucleic Acid Synthesis Inhibitors; Paclitaxel; Pregnancy; Pregnancy Complications, Neoplastic; Topotecan; Trastuzumab; Vinblastine; Vincristine | 2002 |
[Expression of Mdr1 gene in a murine bone marrow transplantation model].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow Cells; Bone Marrow Transplantation; Daunorubicin; Drug Resistance, Multiple; Gene Expression; Genetic Vectors; Hematopoietic Stem Cells; Leukocyte Count; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Models, Animal; Paclitaxel; Retroviridae; Transfection | 2002 |
High-dose consolidation chemotherapy with Idarubicin and alkylating agents following induction with gemcitabine-epirubicin-paclitaxel in metastatic breast cancer: a dose finding study.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Daunorubicin; Deoxycytidine; Disease Progression; Disease-Free Survival; Dose-Response Relationship, Drug; Epirubicin; Female; Humans; Idarubicin; Melphalan; Middle Aged; Neoplasm Metastasis; Paclitaxel; Remission Induction; Taxoids; Thiotepa; Time Factors; Transplantation Conditioning; Treatment Outcome | 2003 |
Effects of carvedilol on MDR1-mediated multidrug resistance: comparison with verapamil.
Topics: Adrenergic beta-Antagonists; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Carbazoles; Carvedilol; Cell Division; Cell Line; Daunorubicin; Digoxin; DNA, Complementary; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epithelial Cells; Fluorouracil; HeLa Cells; Humans; Inhibitory Concentration 50; Kidney; Paclitaxel; Propanolamines; Swine; Transfection; Verapamil; Vinblastine | 2003 |
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro.
Topics: Acids; Antineoplastic Agents; Cell Survival; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Humans; Paclitaxel; Tissue Distribution; Tumor Cells, Cultured | 2003 |
Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Daunorubicin; Dioxoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; Paclitaxel; Polycyclic Compounds; Prohibitins; Vincristine | 2006 |
Modification of multidrug resistance of tumor cells by ionizing radiation.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Count; Cell Line, Tumor; Combined Modality Therapy; Cyclosporine; Daunorubicin; Dose-Response Relationship, Radiation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Laryngeal Neoplasms; Paclitaxel; Radiation, Ionizing; Reactive Oxygen Species; Rhodamine 123; Time Factors; Vincristine | 2008 |
An integrative approach for the isolation, screening and analysis of antitumor agents by liquid chromatography combined with mass spectrometry.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colchicine; Daunorubicin; Ketoprofen; Mass Spectrometry; Paclitaxel; Swine; Tubulin | 2009 |
Simultaneous determination of anthracyclines and taxanes in human serum using online sample extraction coupled to high performance liquid chromatography with UV detection.
Topics: Anthracyclines; Antineoplastic Agents; Blood Proteins; Calibration; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Daunorubicin; Docetaxel; Doxorubicin; Epirubicin; Humans; Paclitaxel; Sensitivity and Specificity; Taxoids | 2010 |
MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Daunorubicin; DNA Primers; Drug Resistance, Neoplasm; Etoposide; Humans; Male; MicroRNAs; Paclitaxel; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sirtuin 1; Tumor Suppressor Protein p53 | 2010 |
Pgp inhibition by UIC2 antibody can be followed in vitro by using tumor-diagnostic radiotracers, 99mTc-MIBI and 18FDG.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Female; Fluorodeoxyglucose F18; Glucose; Humans; Ovarian Neoplasms; Paclitaxel; Protein Binding; Rhodamine 123; Technetium Tc 99m Sestamibi; Tumor Cells, Cultured | 2010 |
SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells.
Topics: Alternative Splicing; Carcinoma, Non-Small-Cell Lung; Caspase 9; Cell Line, Tumor; Cisplatin; Daunorubicin; Drug Resistance, Neoplasm; Drug Synergism; Enhancer Elements, Genetic; Erlotinib Hydrochloride; HeLa Cells; Humans; Introns; Lung Diseases; Nuclear Proteins; Paclitaxel; Quinazolines; RNA Precursors; RNA Splice Sites; RNA-Binding Proteins; RNA, Antisense; RNA, Small Interfering; Serine-Arginine Splicing Factors | 2011 |
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues.
Topics: Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Cell Survival; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; HCT116 Cells; HL-60 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; K562 Cells; Mitoxantrone; Molecular Structure; Neoplasms; Paclitaxel; Stereoisomerism; Structure-Activity Relationship; Vincristine | 2011 |
Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.
Topics: Albumin-Bound Paclitaxel; Albumins; Animals; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Cytokines; Daunorubicin; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione; Humans; Isoxazoles; Melanoma; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Remission Induction; Survival Analysis; Xenograft Model Antitumor Assays | 2012 |
Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Daunorubicin; Dogs; Drug Carriers; Drug Delivery Systems; Fluorescent Dyes; Male; Mice; Mice, SCID; Micelles; Nanoparticles; Paclitaxel; Peptides, Cyclic; Tissue Distribution; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2012 |
Effect of coumarin derivative-mediated inhibition of P-glycoprotein on oral bioavailability and therapeutic efficacy of paclitaxel.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cell Line, Tumor; Cell Survival; Coumarins; Daunorubicin; Humans; Male; Mice; Mice, Nude; Neoplasms; Paclitaxel; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
6,7-Dimethoxy-2-{2-[4-(1H-1,2,3-triazol-1-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolines as superior reversal agents for P-glycoprotein-mediated multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Benzamides; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Daunorubicin; Drug Resistance, Neoplasm; Humans; K562 Cells; Paclitaxel; Protein Binding; Rhodamine 123; Structure-Activity Relationship; Tetrahydroisoquinolines; Triazoles; Vincristine | 2015 |
High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Hematopoietic Stem Cells; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Macrolides; Mice; Microtubules; Neoplastic Stem Cells; Paclitaxel; Time Factors; Tubulin Modulators | 2015 |
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug.
Topics: Antineoplastic Agents; Dactinomycin; Daunorubicin; Doxorubicin; Fluorouracil; Gene Knockdown Techniques; HeLa Cells; Homeodomain Proteins; Humans; Neoplasms; Paclitaxel; Reactive Oxygen Species; Vinblastine; Vitamin K 3 | 2015 |
Intestinal P-glycoprotein inhibitors, benzoxanthone analogues.
Topics: Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Daunorubicin; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; MCF-7 Cells; Molecular Structure; Paclitaxel; Rats, Sprague-Dawley; Structure-Activity Relationship; Xanthones | 2018 |
Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cathepsin B; Cell Line, Tumor; Daunorubicin; Female; Gonadotropin-Releasing Hormone; Humans; Molecular Targeted Therapy; Ovarian Neoplasms; Paclitaxel; Petromyzon; Pyrrolidonecarboxylic Acid; Receptors, LHRH | 2022 |
Development and application of a liquid chromatography coupled to mass spectrometry method for the simultaneous determination of 23 antineoplastic drugs at trace levels.
Topics: Antineoplastic Agents; Busulfan; Carboplatin; Chromatography, Liquid; Cyclophosphamide; Cytarabine; Dacarbazine; Daunorubicin; Docetaxel; Doxorubicin; Epirubicin; Etoposide; Fluorouracil; Ganciclovir; Humans; Idarubicin; Ifosfamide; Irinotecan; Methanol; Methotrexate; Oxaliplatin; Paclitaxel; Pemetrexed; Tandem Mass Spectrometry; Topotecan; Vinblastine; Vincristine; Water | 2022 |