Page last updated: 2024-08-23

daunorubicin and daunorubicinol

daunorubicin has been researched along with daunorubicinol in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (31.43)	18.7374
1990's	17 (24.29)	18.2507
2000's	17 (24.29)	29.6817
2010's	11 (15.71)	24.3611
2020's	3 (4.29)	2.80

Authors

Authors	Studies
Eksborg, S	1
Andersson, B; Beran, M; Ehrsson, H; Eksborg, S	1
Desager, JP; Hulhoven, R	1
Batley, R; Cecalupo, AJ; Egorin, MJ; Lo, WD; Mortensen, ME	1
Baker, RM; Bartels, CJ; Beehler, BC; Gessner, T; Vaughan, LA	1
Robert, J; Schott, B	1
Gahrton, G; Liliemark, J; Paul, C; Peterson, C; Tidefelt, U	1
Liliemark, J; Paul, C; Peterson, C; Tidefelt, U	1
Anisova, LN; Bartoshevich, IuE; Krasil'nikova, OL; Romanova, NB	1
Hagenbeek, A; Kokenberg, E; Löwenberg, B; Sizoo, W; Sonneveld, P	1
Azarnia, N; Bolanowska, W; Gessner, T; Goldberg, J; Grunwald, H; Joyce, R; Preisler, HD; Vogler, WR	1
Deurloo, J; Nooter, K; Oostrum, R	1
Erb, N; Erttmann, R; Landbeck, G	1
Diquet, B; Nguyen-Huu, JJ; Turk, P	1
Hagenbeek, A; Martens, A; Nooter, K; Schultz, F; Sonneveld, P	1
Gewirtz, DA; Yanovich, S	1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y; Terasaki, T	1
DeGregorio, MW; Holleran, WM; Linker, CA; Macher, BA; Wilbur, JR	1
Foo, W; Goodman, A; Harvey, J; Rahman, A; Schein, PS; Smith, FP	1
Baurain, R; Hjelle, JT; Masquelier, M; Trouet, A	1
Deurloo, J; Hagenbeek, A; Martens, A; Nooter, K; Oostrum, R; Schultz, F; Sonneveld, P	1
Benjamin, RS	1
Crespi-Perellino, N; Grein, A; Merli, S; Minghetti, A; Spalla, C	1
Akpofure, C; Evans, WE; Riley, CA; Sinkule, JA	1
Cornblatt, B; Doyle, LA; Ross, DD; Tong, Y; Yang, W	1
Akman, S; Doroshow, J; Forrest, GL; Gonzalez, B; Kaplan, WD; Rivera, H	1
Cusack, BJ; Olson, RD; Young, SP	1
Boutagy, J; Galettis, P; Ma, DD	1
Paul, C; Sundman-Engberg, B; Tidefelt, U	1
Shi, Y; Wang, C; Zhao, H	1
Boucek, RJ; Cusack, BJ; Li, X; Mushlin, PS; Olson, RD; Voulelis, LD	1
Amitai, Y; Bhooma, T; Frischer, H	1
Berlion, M; Kernaleguen, D; Le Bot, MA; Riché, C; Simon, I	1
Paul, C; Prenkert, M; Tidefelt, U	1
Cusack, BJ; Johnson, CJ; Mushlin, PS; Olson, RD; Vestal, RE	1
Cusack, BJ; Olson, RD; Vestal, RE; Young, SP	1
Boven, E; Haisma, HJ; Houba, PH; Leenders, RG; Pinedo, HM; Scheeren, JW; van der Meulen-Muileman, IH	1
Boiardi, A; D'Incalci, M; Parisi, I; Piccolrovazzi, S; Silvani, A; Zucchetti, M	1
Fiallo, MM; Garnier-Suillerot, A; Kozlowski, H; Matzanke, B	1
Ax, W; Koch, L; Maser, E; Soldan, M	1
Kasimir-Bauer, S; Scheulen, ME; Schröder, JK; Seeber, S	1
Careddu, A; D'Incalci, M; Fumagalli, L; Lazzarin, A; Parisi, I; Viganò, MG; Zecca, B; Zucchetti, M	1
Boucek, RJ; Cusack, BJ; Fill, M; Gambliel, HA; Li, X; Mushlin, PS; Olson, RD; Palade, P; Shadle, SE	1
Auvrignon, A; Baruchel, A; Bellenger, P; Bellott, R; Bertrand, Y; Gandemer, V; Leblanc, T; Leverger, G; Méchinaud, F; Pérel, Y; Robert, J; Vernois, J	1
Bonoron-Adèle, S; Platel, D; Robert, J	1
Boos, J; Flege, S; Hempel, G; Schulze-Westhoff, P	1
Albrecht, KW; Bakker, PJ; Beijnen, JH; Bosch, AD; de Witt Hamer, PC; Kaaijk, P; Leenstra, S; Troost, D	1
Blom, HJ; Boers, GH; De Boo, TM; Haagsma, CJ; Laan, RF; Thomas, CM; van de Putte, LB; van Ede, AE	1
Blaschke, G; Boos, J; Griese, N; Hempel, G	1
Aarons, L; Burgess, M; Callies, S; de Alwis, DP; Mehta, A	1
Broyles, TS; Charlier, HA; Cusack, BJ; Larson, CL; Mercer, WK; Muhlestein, DJ; Olson, DR; Olson, RD; Shadle, SE; Thornock, CM	1
Bjorklund, C; Bruesch, AJ; Charlier, HA; Cusack, BJ; Gambliel, HA; Larson, C; Lee, LM; Olson, RD; Peloquin, J; Primbs, T; Shadle, SE; Slupe, A; Warner, DL; Williams, B	1
Deng, A; Liu, J; Lu, Y; Yang, X; Zhu, Z	1
Blanco, JG; Ghosh, D; Gonzalez-Covarrubias, V; Lakhman, SS; Pendyala, L	1
de Manzoni, G; Franceschi, L; Furlanut, M; Pasini, F; Poz, D; Tasselli, S; Tomezzoli, A	1
Bains, OS; Grigliatti, TA; Pfeifer, TA; Reid, RE; Riggs, KW; Takahashi, RH	1
Barisone, E; Boos, J; De Lorenzo, P; de Rossi, G; Hempel, G; Pieters, R; Relling, MV; Stary, J; Valsecchi, MG	1
Bogason, A; Gruber, A; Lafolie, P; Masquelier, M; Paul, C; Skogastierna, C; Vitols, S	1
Bennett, JM; Cripe, LD; Ketterling, RP; Lazarus, HM; Litzow, MR; Luger, S; Paietta, EM; Rowe, JM; Tallman, MS; Uno, H	1
Abraham, A; Ahmed, R; Balasubramanian, P; Chandy, M; George, B; Mathews, V; Shaji, RV; Srivastava, A; Varatharajan, S; Zhang, W	1
Bains, OS; Cragg, GE; Grigliatti, TA; Lubieniecka, JM; Reid, RE; Riggs, KW; Szeitz, A	1
Blanco, JG; Ferguson, D; Hageman Blair, R; Kalabus, JL; Quiñones-Lombraña, A; Redzematovic, A	1
Berg, SL; Broeckel, U; Delaney, SM; Devidas, M; Dolan, ME; Lorier, R; Reaman, GH; Scorsone, K; Sung, L; Thompson, P; Wheeler, HE	1
Ebert, B; Hintzpeter, J; Hornung, J; Martin, HJ; Maser, E	1
Abraham, A; Arthur, N; Balasubramanian, P; George, B; Karathedath, S; Lakshmi, KM; Mathews, V; Mohanan, E; Nemani, S; Panetta, JC; Srivastava, A; Srivastava, VM; Varatharajan, S	1
Cortez-Toledo, O; Dieli-Conwright, CM; Louie, SG; Mittelman, SD; Neely, M; Oberley, MJ; Orgel, E; Parmentier, JH; Pei, H; Sheng, X; Tucci, J	1
Ceckova, M; Hofman, J; Morell, A; Novotna, E; Sorf, A; Staud, F; Wsol, V	1
Lanchote, VL; Nardotto, GHB; Oliveira, ML; Pippa, LF; Rocha, A; Simões, BP	1
Rai, AK; Satija, NK	1
Bucki, A; Jamrozik, M; Koczurkiewicz-Adamczyk, P; Kołaczkowski, M; Pękala, E; Piska, K	1

Trials

9 trial(s) available for daunorubicin and daunorubicinol

Article	Year
Daunorubicin pharmacokinetics and the correlation with P-glycoprotein and response in patients with acute leukaemia. British journal of cancer, 1994, Volume: 70, Issue:2 Topics: Acute Disease; Adolescent; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Daunorubicin; Female; Humans; Leukemia, Myeloid; Male; Membrane Glycoproteins; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction	1994
The pharmacokinetics of liposomal encapsulated daunorubicin are not modified by HAART in patients with HIV-associated Kaposi's sarcoma. Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:6 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antibiotics, Antineoplastic; Daunorubicin; Drug Interactions; Drug Therapy, Combination; Female; HIV Protease Inhibitors; Humans; Indinavir; Liposomes; Male; Middle Aged; Ritonavir; Saquinavir; Sarcoma, Kaposi	2000
Pharmacokinetics of liposomal daunorubicin (DaunoXome) during a phase I-II study in children with relapsed acute lymphoblastic leukaemia. Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:1 Topics: Adolescent; Antibiotics, Antineoplastic; Child; Child, Preschool; Daunorubicin; Drug Carriers; Female; Half-Life; Humans; Liposomes; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Time Factors	2001
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis. Rheumatology (Oxford, England), 2002, Volume: 41, Issue:6 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Daunorubicin; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Linear Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation	2002
Population pharmacokinetic model for daunorubicin and daunorubicinol coadministered with zosuquidar.3HCl (LY335979). Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:1 Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Canaliculi; Daunorubicin; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Humans; Models, Theoretical; Quinolines	2004
Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation. Pharmacological research, 2007, Volume: 56, Issue:4 Topics: Adult; Aged; Antibiotics, Antineoplastic; Daunorubicin; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Gastroscopy; Humans; Injections; Injections, Intralesional; Liposomes; Lymph Nodes; Male; Middle Aged; Prospective Studies; Stomach Neoplasms; Tissue Distribution	2007
Pharmacokinetics of daunorubicin and daunorubicinol in infants with leukemia treated in the interfant 99 protocol. Pediatric blood & cancer, 2010, Volume: 54, Issue:3 Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Child; Child, Preschool; Daunorubicin; Female; Humans; Infant; Infant, Newborn; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2010
Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood, 2010, Nov-18, Volume: 116, Issue:20 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Dibenzocycloheptenes; Female; Humans; Leukemia, Myeloid, Acute; Male; Multivariate Analysis; Placebos; Prognosis; Quinolines; Remission Induction; Survival Analysis; Treatment Outcome	2010
Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia. European journal of clinical pharmacology, 2012, Volume: 68, Issue:12 Topics: Adolescent; Adult; Aged; Alcohol Oxidoreductases; Antibiotics, Antineoplastic; Cells, Cultured; Daunorubicin; Female; Humans; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Male; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Young Adult	2012

Other Studies

61 other study(ies) available for daunorubicin and daunorubicinol

Article	Year
Reversed-phase liquid chromatography of adriamycin and daunorubicin and their hydroxyl metabolites adriamycinol and daunorubicinol. Journal of chromatography, 1978, Feb-11, Volume: 149 Topics: Chromatography, Liquid; Daunorubicin; Doxorubicin	1978
Liquid chromatographic determination of daunorubicin and daunorubicinol in plasma from leukemic patients. Journal of chromatography, 1978, Jun-01, Volume: 153, Issue:1 Topics: Chromatography, Gas; Daunorubicin; Dose-Response Relationship, Drug; Leukemia; Solvents	1978
Quantitative determination of low levels of daunomycin and daunomycinol in plasma by high-performance liquid chromatography. Journal of chromatography, 1976, Sep-29, Volume: 125, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Daunorubicin; Doxorubicin; Methods; Microchemistry; Rabbits	1976
Inadvertent intrathecal injection of daunorubicin with fatal outcome. Medical and pediatric oncology, 1992, Volume: 20, Issue:3 Topics: Central Nervous System Diseases; Child, Preschool; Daunorubicin; Female; Humans; Injections, Spinal; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1992
Elevated pentose cycle and glucuronyltransferase in daunorubicin-resistant P388 cells. Cancer research, 1990, Jul-01, Volume: 50, Issue:13 Topics: Animals; Carbon Dioxide; Carmustine; Cell Survival; Daunorubicin; Doxorubicin; Drug Resistance; Glucose; Glucuronosyltransferase; Leukemia P388; Leukemia, Experimental; Pentose Phosphate Pathway	1990
Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22 Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Resistance; Epirubicin; Glioma; Rats; Tumor Cells, Cultured	1989
Pharmacokinetics of daunorubicin and doxorubicin in plasma and leukemic cells from patients with acute nonlymphoblastic leukemia. Therapeutic drug monitoring, 1989, Volume: 11, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; DNA; DNA Adducts; Doxorubicin; Humans; Leukemia, Myeloid, Acute; Metabolic Clearance Rate	1989
Increasing the accumulation of daunorubicin in human leukemic cells by prolonging the infusion time. Leukemia research, 1989, Volume: 13, Issue:2 Topics: Cell Transformation, Neoplastic; Daunorubicin; Humans; Infusions, Intravenous; Intracellular Fluid; Leukemia, Myeloid, Acute; Male; Middle Aged	1989
[Use of a protoplasting method for altering the qualitative and quantitative composition of the anthracycline complex in Streptomyces peucetius var. caesius]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1988, Volume: 33, Issue:7 Topics: Antibiotics, Antineoplastic; Bacteriological Techniques; Daunorubicin; Doxorubicin; Mutation; Protoplasts; Selection, Genetic; Streptomyces	1988
Cellular pharmacokinetics of daunorubicin: relationships with the response to treatment in patients with acute myeloid leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:5 Topics: Adolescent; Adult; Aged; Bone Marrow; Daunorubicin; Female; Humans; Leukemia, Myeloid, Acute; Leukocytes; Male; Middle Aged	1988
Plasma levels of daunorubicin metabolites and the outcome of ANLL therapy. Medical oncology and tumor pharmacotherapy, 1987, Volume: 4, Issue:1 Topics: Acute Disease; Biotransformation; Daunorubicin; Humans; Injections, Intravenous; Kinetics; Leukemia; Naphthacenes	1987
Effects of verapamil on the pharmacokinetics of daunomycin in the rat. Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:2 Topics: Animals; Daunorubicin; Female; Half-Life; Rats; Tissue Distribution; Verapamil	1987
A rapid chromatographic procedure for the determination of adriamycin, daunomycin and their 13-OH metabolites adriamycinol and daunomycinol. Cancer chemotherapy and pharmacology, 1986, Volume: 17, Issue:1 Topics: Adult; Chromatography, Gel; Chromatography, High Pressure Liquid; Daunorubicin; Doxorubicin; Humans	1986
Determination of rubidazone and its metabolites in human plasma and urine by reversed-phase ion-pair high-performance liquid chromatography. Journal of chromatography, 1986, Aug-02, Volume: 380, Issue:2 Topics: Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Daunorubicin; Doxorubicin; Humans; Spectrometry, Fluorescence	1986
Tissue distribution and myelotoxicity of daunomycin in the rat: rapid bolus injection vs continuous infusion. European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:7 Topics: Animals; Bone Marrow; Cell Survival; Colony-Forming Units Assay; Daunorubicin; Female; Infusions, Intravenous; Injections, Intravenous; Rats; Time Factors; Tissue Distribution	1986
Metabolism of the anthracycline antibiotic daunorubicin to daunorubicinol and deoxydaunorubicinol aglycone in hepatocytes isolated from the rat and the rabbit. Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22 Topics: Animals; Bilirubin; Daunorubicin; In Vitro Techniques; Liver; Male; Naphthacenes; Rabbits; Rats; Rats, Inbred Strains	1986
Nuclear binding as a determinant of tissue distribution of adriamycin, daunomycin, adriamycinol, daunorubicinol and actinomycin D. Journal of pharmacobio-dynamics, 1984, Volume: 7, Issue:5 Topics: Animals; Cell Nucleus; Dactinomycin; Daunorubicin; DNA; Doxorubicin; In Vitro Techniques; Rabbits; Rats; Tissue Distribution	1984
Kinetics and sensitivity of daunorubicin in patients with acute leukemia. Cancer chemotherapy and pharmacology, 1984, Volume: 13, Issue:3 Topics: Adolescent; Adult; Aged; Biological Transport; Cells, Cultured; Daunorubicin; DNA Replication; DNA, Neoplasm; Female; Humans; Leukemia; Male; Middle Aged	1984
Clinical pharmacology of daunorubicin in phase I patients with solid tumors: development of an analytical methodology for daunorubicin and its metabolites. Seminars in oncology, 1984, Volume: 11, Issue:4 Suppl 3 Topics: Animals; Bile; Chromatography, High Pressure Liquid; Daunorubicin; Drug Evaluation; Humans; Kinetics; Neoplasms; Rats; Rats, Inbred Strains	1984
Cellular pharmacology of amino acid derivatives of daunorubicin and doxorubicin in suspension of renal proximal tubules. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:2 Topics: Amino Acids; Animals; Antibiotics, Antineoplastic; Biotransformation; Daunorubicin; Doxorubicin; Hydrolysis; In Vitro Techniques; Kidney Tubules, Proximal; Naphthacenes; Rabbits	1984
Repeated daunomycin administration in rats. Pharmacokinetics and bone marrow toxicity. Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:3 Topics: Animals; Bone Marrow; Daunorubicin; Female; Kidney; Kinetics; Lung; Rats; Rats, Inbred BN; Tissue Distribution	1984
Clinical pharmacology of daunorubicin. Cancer treatment reports, 1981, Volume: 65 Suppl 4 Topics: Antibiotics, Antineoplastic; Daunorubicin; DNA; Humans; Kinetics; Leukemia; Naphthacenes; Oxidation-Reduction; Tissue Distribution	1981
Biosynthetic relationships among daunorubicin, doxorubicin and 13-dihydrodaunorubicin in Streptomyces peucetius. Experientia, 1982, Dec-15, Volume: 38, Issue:12 Topics: Carbon Radioisotopes; Daunorubicin; Doxorubicin; Streptomyces; Structure-Activity Relationship	1982
Quantitation of daunorubicin and its metabolites by high-performance liquid chromatography with electrochemical detection. Journal of chromatography, 1982, Nov-12, Volume: 232, Issue:2 Topics: Chromatography, High Pressure Liquid; Daunorubicin; Electrochemistry; Humans; Leukemia; Spectrometry, Fluorescence; Time Factors	1982
Susceptibility of idarubicin, daunorubicin, and their C-13 alcohol metabolites to transport-mediated multidrug resistance. Biochemical pharmacology, 1995, Nov-09, Volume: 50, Issue:10 Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Breast Neoplasms; Cell Survival; Culture Media; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Stability; HL-60 Cells; Humans; Idarubicin; Intracellular Fluid; Tumor Cells, Cultured	1995
Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells. Cancer research, 1995, Oct-15, Volume: 55, Issue:20 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Antibiotics, Antineoplastic; Base Sequence; Cells, Cultured; Cloning, Molecular; Daunorubicin; DNA Primers; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression; Humans; In Vitro Techniques; Leukemia, Erythroblastic, Acute; Mitomycin; Molecular Sequence Data; Oxidation-Reduction; Phenanthrenes; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Vitamin K	1995
Daunorubicin and daunorubicinol pharmacokinetics in plasma and tissues in the rat. Cancer chemotherapy and pharmacology, 1995, Volume: 35, Issue:3 Topics: Animals; Daunorubicin; Half-Life; Kidney; Liver; Lung; Muscle, Skeletal; Myocardium; Rats; Rats, Inbred F344; Tissue Distribution	1995
Comparison of the intracellular pharmacokinetics of daunorubicin and idarubicin in patients with acute leukemia. Leukemia research, 1994, Volume: 18, Issue:4 Topics: Acute Disease; Aged; Daunorubicin; Female; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged	1994
Relative binding free energy calculations of DNA to daunomycin and its 13-dihydro analogue. International journal of biological macromolecules, 1993, Volume: 15, Issue:4 Topics: Daunorubicin; DNA; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thermodynamics	1993
Daunorubicin-induced cardiac injury in the rabbit: a role for daunorubicinol? Toxicology and applied pharmacology, 1993, Volume: 118, Issue:2 Topics: Animals; Calcium; Daunorubicin; Dogs; Free Radicals; Glutathione; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Rabbits; Sarcoplasmic Reticulum	1993
Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes. The Journal of laboratory and clinical medicine, 1996, Volume: 127, Issue:6 Topics: Adult; Alcohol Oxidoreductases; Binding, Competitive; Biotransformation; Daunorubicin; Doxorubicin; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Humans; Primaquine	1996
[Effect of S9788, cyclosporin A and verapamil on intracellular accumulation of doxorubicin, daunorubicin and daunorubicinol in primary rat hepatocyte culture]. Annales de biologie clinique, 1996, Volume: 54, Issue:1 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Liver; Piperidines; Rats; Rats, Sprague-Dawley; Triazines; Verapamil	1996
Comparison of idarubicin and daunorubicin and their main metabolites regarding intracellular uptake and effect on sensitive and multidrug-resistant HL60 cells. Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:5 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Division; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin	1996
Aging increases the cardiotoxicity of daunorubicin and daunorubicinol in the rat. The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:5 Topics: Aging; Animals; Antibiotics, Antineoplastic; Daunorubicin; Heart; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Inbred F344	1996
Age-related pharmacokinetics of daunorubicin and daunorubicinol following intravenous bolus daunorubicin administration in the rat. Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:6 Topics: Aging; Animals; Antibiotics, Antineoplastic; Area Under Curve; Cardiomyopathies; Daunorubicin; Half-Life; Injections, Intravenous; Male; Rats; Rats, Inbred F344	1997
Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts. Biochemical pharmacology, 1999, Mar-15, Volume: 57, Issue:6 Topics: Animals; Area Under Curve; Daunorubicin; Female; Glucuronidase; Humans; Injections, Intravenous; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Prodrugs; Tissue Distribution; Transplantation, Heterologous	1999
Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin. Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:2 Topics: Adult; Antibiotics, Antineoplastic; Brain Neoplasms; Daunorubicin; Drug Carriers; Glioma; Humans; Liposomes; Middle Aged	1999
How Fe3+ binds anthracycline antitumour compounds. The myth and the reality of a chemical sphinx. Journal of inorganic biochemistry, 1999, Jun-15, Volume: 75, Issue:2 Topics: Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Circular Dichroism; Daunorubicin; Doxorubicin; Humans; Hydrogen-Ion Concentration; Idarubicin; Iron; Methanol; Spectrophotometry, Ultraviolet; Sulfonic Acids; Water	1999
Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction. Biochemical pharmacology, 2000, Feb-01, Volume: 59, Issue:3 Topics: Alcohol Oxidoreductases; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Daunorubicin; Drug Resistance, Neoplasm; Gene Expression; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oxidation-Reduction; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles	2000
In vitro effect of multidrug resistance modifiers on idarubicinol efflux in blasts of acute myeloid leukemia. Journal of cancer research and clinical oncology, 2000, Volume: 126, Issue:2 Topics: Antineoplastic Agents; Blast Crisis; Calcium Channel Blockers; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Idarubicin; Leukemia, Myeloid, Acute; Tumor Cells, Cultured; Verapamil	2000
Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol. Toxicology and applied pharmacology, 2000, Dec-01, Volume: 169, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Caffeine; Calcium; Daunorubicin; Dithiothreitol; Dogs; Female; In Vitro Techniques; Male; Microsomes; Sarcoplasmic Reticulum; Sulfhydryl Reagents	2000
Role of daunorubicinol in daunorubicin-induced cardiotoxicity as evaluated with the model of isolated perfused rat heart. Pharmacology & toxicology, 2001, Volume: 88, Issue:5 Topics: Animals; Antibiotics, Antineoplastic; Blood Pressure; Body Weight; Daunorubicin; Diastole; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Injections, Intraperitoneal; Male; Models, Cardiovascular; Myocardial Contraction; Perfusion; Rats; Rats, Sprague-Dawley; Ventricular Function, Left; Ventricular Pressure	2001
Quantification of daunorubicin and daunorubicinol in plasma by capillary electrophoresis. Journal of chromatography. B, Biomedical sciences and applications, 2001, Jul-15, Volume: 758, Issue:2 Topics: Antibiotics, Antineoplastic; Daunorubicin; Electrophoresis, Capillary; Humans; Reproducibility of Results	2001
High concentration of Daunorubicin and Daunorubicinol in human malignant astrocytomas after systemic administration of liposomal Daunorubicin. Journal of neuro-oncology, 2001, Volume: 53, Issue:3 Topics: Adult; Aged; Antibiotics, Antineoplastic; Astrocytoma; Daunorubicin; Female; Humans; Injections, Intravenous; Liposomes; Male; Middle Aged; Osmolar Concentration; Time Factors	2001
Determination of free and liposome-associated daunorubicin and daunorubicinol in plasma by capillary electrophoresis. Journal of chromatography. A, 2002, Dec-06, Volume: 979, Issue:1-2 Topics: Antibiotics, Antineoplastic; Daunorubicin; Electrophoresis, Capillary; Humans; Liposomes; Reference Standards; Reproducibility of Results	2002
Investigations of calsequestrin as a target for anthracyclines: comparison of functional effects of daunorubicin, daunorubicinol, and trifluoperazine. Molecular pharmacology, 2005, Volume: 67, Issue:5 Topics: Animals; Anthracyclines; Calsequestrin; Daunorubicin; Dogs; Dose-Response Relationship, Drug; Drug Delivery Systems; Myocardial Contraction; Rabbits; Trifluoperazine	2005
Reduction of 13-deoxydoxorubicin and daunorubicinol anthraquinones by human carbonyl reductase. Cardiovascular toxicology, 2005,Fall, Volume: 5, Issue:4 Topics: Alcohol Oxidoreductases; Animals; Anthraquinones; Daunorubicin; Doxorubicin; Humans; Models, Molecular; Oxidation-Reduction; Protein Structure, Tertiary; Recombinant Proteins	2005
A potential pathological role of angiopoietins expression in glomeruli during progressive glomerulisclerosis related to podocyte injury. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2006, Volume: 26, Issue:3 Topics: Angiopoietin-1; Angiopoietin-2; Animals; Daunorubicin; Disease Progression; Glomerulosclerosis, Focal Segmental; Immunohistochemistry; In Situ Hybridization; Kidney Glomerulus; Microscopy, Electron, Transmission; Nephrectomy; Podocytes; Random Allocation; Rats; Rats, Wistar; RNA, Messenger	2006
A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:6 Topics: Alcohol Oxidoreductases; Catalysis; Cloning, Molecular; Daunorubicin; DNA, Complementary; Genotype; Humans; Kinetics; Models, Molecular; NADP; Polymorphism, Single Nucleotide; Rutin; Sequence Analysis, DNA	2007
Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:6 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Daunorubicin; Doxorubicin; Fluorescence; Humans; Hydroxysteroid Dehydrogenases; Recombinant Proteins	2008
Daunorubicin metabolism in leukemic cells isolated from patients with acute myeloid leukemia. Drug metabolism letters, 2010, Volume: 4, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Alcohol Oxidoreductases; Antibiotics, Antineoplastic; Biotransformation; Blotting, Western; Chromatography, High Pressure Liquid; Daunorubicin; Enzyme Inhibitors; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Polymerase Chain Reaction; RNA, Messenger	2010
A correlation between cytotoxicity and reductase-mediated metabolism in cell lines treated with doxorubicin and daunorubicin. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 347, Issue:2 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Antibiotics, Antineoplastic; Cell Culture Techniques; Cell Line; Cell Survival; Daunorubicin; Doxorubicin; Humans; Lethal Dose 50; Organ Specificity; Rats; Species Specificity	2013
Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome. Pharmaceutical research, 2014, Volume: 31, Issue:7 Topics: 3-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member C3; Anthracyclines; Cardiotoxins; Daunorubicin; Down Syndrome; Female; Gene Expression; Genotype; Heart; Humans; Hydroxyprostaglandin Dehydrogenases; Male; Myocardium; Neoplasms; RNA, Messenger	2014
Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group. Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:4 Topics: Absorptiometry, Photon; Antibiotics, Antineoplastic; Body Composition; Body Mass Index; Child; Daunorubicin; Drug Screening Assays, Antitumor; Female; Genome-Wide Association Study; Glutathione S-Transferase pi; Haplotypes; Humans; Male; Metabolic Clearance Rate; Models, Statistical; Neoplasms; Obesity; Oxygenases; Pharmacogenetics; Polymorphism, Genetic	2014
Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1. Chemico-biological interactions, 2015, Jun-05, Volume: 234 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Curcumin; Daunorubicin; Humans; NADP; Neoplasms	2015
Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia. Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:5 Topics: Adolescent; Adult; Alcohol Oxidoreductases; Antibiotics, Antineoplastic; Biotransformation; Daunorubicin; Drug Interactions; Female; Genetic Variation; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Prospective Studies; Treatment Outcome; Young Adult	2016
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Molecular cancer research : MCR, 2017, Volume: 15, Issue:12 Topics: 20-Hydroxysteroid Dehydrogenases; Adipocytes; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member C3; Cell Line, Tumor; Daunorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Humans; Hydroxysteroid Dehydrogenases; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Microenvironment	2017
Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters. Biochemical pharmacology, 2019, Volume: 163 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cloning, Molecular; Daunorubicin; Dogs; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Heart Diseases; Humans; Imidazoles; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Protein Binding; Pyrimidines	2019
Analysis of daunorubicin and its metabolite daunorubicinol in plasma and urine with application in the evaluation of total, renal and metabolic formation clearances in patients with acute myeloid leukemia. Journal of pharmaceutical and biomedical analysis, 2020, Nov-30, Volume: 191 Topics: Body Fluids; Daunorubicin; Humans; Kidney; Leukemia, Myeloid, Acute	2020
A comparative analysis of daunorubicin and its metabolite daunorubicinol interaction with apoptotic and drug resistance proteins using Journal of biomolecular structure & dynamics, 2023, Volume: 41, Issue:20 Topics: bcl-2-Associated X Protein; Daunorubicin; Drug Resistance, Multiple; Molecular Docking Simulation; Myeloid Cell Leukemia Sequence 1 Protein	2023
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance. Xenobiotica; the fate of foreign compounds in biological systems, 2023, Volume: 53, Issue:6-7 Topics: Adenosine Triphosphatases; Anthracyclines; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Daunorubicin; Doxorubicin; Humans; Neoplasms	2023