darutigenol and darutoside

darutigenol has been researched along with darutoside* in 2 studies

Other Studies

2 other study(ies) available for darutigenol and darutoside

Article	Year
Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens. Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8 Five new diterpenoid glycosides, siegesides A-E (1-5), along with the known compound darutoside (6) were isolated and characterized from the ethanol extract of Siegesbeckia pubescens. The structural elucidation of the isolates was accomplished by extensive HRESIMS and NMR analysis. Compounds 1 and 2 are epimers of 6. All isolates were evaluated for their inhibition on the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, and compound 2 showed superior inhibitory activities in comparison with the positive control drug with IC Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Diterpenes; Female; Glycosides; Humans; Models, Molecular; Plant Extracts	2017
[Studies on antifertility constituents of Siegesbeckia glabrescens Mak]. Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:11 Three diterpenes including a new compound were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3 alpha, 15,16-trihydroxy pimarane 3,15-bis-(beta-glucopyranoside) based on the spectral evidence and chemical transformation. The other two were darutigenol and darutoside. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg. Topics: Abortifacient Agents, Nonsteroidal; Animals; Diterpenes; Drugs, Chinese Herbal; Female; Rats	1989

Article

Year

Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens.

Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8

Five new diterpenoid glycosides, siegesides A-E (1-5), along with the known compound darutoside (6) were isolated and characterized from the ethanol extract of Siegesbeckia pubescens. The structural elucidation of the isolates was accomplished by extensive HRESIMS and NMR analysis. Compounds 1 and 2 are epimers of 6. All isolates were evaluated for their inhibition on the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, and compound 2 showed superior inhibitory activities in comparison with the positive control drug with IC

Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Diterpenes; Female; Glycosides; Humans; Models, Molecular; Plant Extracts

2017

[Studies on antifertility constituents of Siegesbeckia glabrescens Mak].

Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:11

Three diterpenes including a new compound were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3 alpha, 15,16-trihydroxy pimarane 3,15-bis-(beta-glucopyranoside) based on the spectral evidence and chemical transformation. The other two were darutigenol and darutoside. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg.

Topics: Abortifacient Agents, Nonsteroidal; Animals; Diterpenes; Drugs, Chinese Herbal; Female; Rats

1989