Compounds > darunavir
Page last updated: 2024-09-05

darunavir and itraconazole

darunavir has been researched along with itraconazole in 4 studies

Compound Research Comparison

Studies
(darunavir)		Trials
(darunavir)		Recent Studies (post-2010)
(darunavir)		Studies
(itraconazole)		Trials
(itraconazole)		Recent Studies (post-2010) (itraconazole)
1,1482247802494108
1,1482247806,4406532,357

Protein Interaction Comparison

ProteinTaxonomydarunavir (IC50)itraconazole (IC50)
Tyrosine-protein kinase FynHomo sapiens (human)3.89
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.666
Cytochrome P450 3A4Homo sapiens (human)0.4256
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.2
C-X-C chemokine receptor type 1Homo sapiens (human)2.5676
CruzipainTrypanosoma cruzi3
Vasopressin V2 receptorHomo sapiens (human)3.476
C-C chemokine receptor type 4Homo sapiens (human)3.2689
Lanosterol 14-alpha demethylaseHomo sapiens (human)3.6
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Bonnal, C; Descamps, D; Desselas, E; Giraud, J; Lariven, S; Le Meur, L; Lê, MP; Lillo-Le-Louet, A; Massias, L; Peytavin, G; Sonneville, R; Tantet, C; Yazdanpanah, Y1
Cai, JP; Chen, C; Gao, N; Hu, GX; Lin, Q; Xie, SL; Xu, RA; Yang, YJ; Zhu, X1

Reviews

1 review(s) available for darunavir and itraconazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

3 other study(ies) available for darunavir and itraconazole

ArticleYear
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Serious neuropsychiatric adverse effects related to interaction between itraconazole and darunavir/ritonavir in an HIV-infected patient with cerebral histoplasmosis.
    The Journal of antimicrobial chemotherapy, 2018, 04-01, Volume: 73, Issue:4

    Topics: Anti-HIV Agents; Antifungal Agents; Darunavir; Drug Interactions; Histoplasmosis; HIV Infections; Humans; Itraconazole; Male; Mental Disorders; Middle Aged; Plasma; Ritonavir

2018
Genetic variations of CYP3A4 on the metabolism of itraconazole in vitro.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 181

    Topics: Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Cytochrome P-450 CYP3A; Darunavir; Drug Interactions; Genetic Variation; Humans; Itraconazole; Lopinavir; Tandem Mass Spectrometry

2023