darunavir has been researched along with grl 98065 in 7 studies
| Studies (darunavir) | Trials (darunavir) | Recent Studies (post-2010) (darunavir) | Studies (grl 98065) | Trials (grl 98065) | Recent Studies (post-2010) (grl 98065) |
|---|---|---|---|---|---|
| 1,148 | 224 | 780 | 5 | 0 | 0 |
| 1,148 | 224 | 780 | 5 | 0 | 1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Azijn, H; de Bethune, MP; de Kock, HA; De Meyer, S; Jonckers, TH; King, NM; Pauwels, R; Peeters, A; Pille, GM; Prabu-Jeyabalan, M; Schiffer, CA; Surleraux, DL; Tahri, A; Verschueren, WG; Wigerinck, PB | 1 |
| Amano, M; Boross, PI; Das, D; Ghosh, AK; Koh, Y; Leschenko, S; Li, J; Mitsuya, H; Wang, YF; Weber, IT | 1 |
| Amano, M; Baldridge, A; Das, D; Davis, DA; Ghosh, AK; Koh, Y; Leschenko, S; Li, J; Matsumi, S; Mitsuya, H; Shioda, T; Yarchoan, R | 1 |
| Boross, PI; Ghosh, AK; Harrison, RW; Tie, Y; Tozser, J; Wang, YF; Weber, IT | 1 |
| Ghosh, AK | 1 |
| Aniana, A; Ghosh, AK; Kovalevsky, AY; Louis, JM; Weber, IT | 1 |
| Kar, P; Knecht, V | 1 |
1 review(s) available for darunavir and grl 98065
| Article | Year |
|---|---|
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Antiviral Agents; Aspartic Acid Endopeptidases; Biological Products; Darunavir; Drug Design; Drug Discovery; Drug Resistance, Viral; Enzyme Inhibitors; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Molecular Mimicry; Molecular Structure; Peptides; Structure-Activity Relationship; Sulfonamides | 2009 |
6 other study(ies) available for darunavir and grl 98065
| Article | Year |
|---|---|
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; Cell Line; Crystallography, X-Ray; Darunavir; Dogs; Drug Resistance, Multiple, Viral; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; In Vitro Techniques; Microsomes, Liver; Models, Molecular; Molecular Conformation; Mutation; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thermodynamics | 2005 |
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
Topics: Amino Acid Sequence; Drug Design; Drug Resistance, Multiple, Viral; Furans; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Sulfonamides; Urethane; Virus Replication | 2007 |
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.
Topics: Animals; CCR5 Receptor Antagonists; CD4 Antigens; Chlorocebus aethiops; COS Cells; Darunavir; Dimerization; Dose-Response Relationship, Drug; Enzyme Activation; Fluorescence Resonance Energy Transfer; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Protein Processing, Post-Translational; Pyridines; Pyrones; Receptors, CCR5; Sulfonamides; Virus Replication | 2007 |
Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
Topics: Crystallography, X-Ray; Darunavir; Drug Resistance, Viral; HIV Protease; HIV Protease Inhibitors; Models, Molecular; Molecular Structure; Mutation; Sulfonamides | 2007 |
Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease.
Topics: Antiviral Agents; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Darunavir; Dimerization; HIV Protease; HIV Protease Inhibitors; HIV-2; Hydrogen Bonding; Solvents; Static Electricity; Sulfonamides; Zinc | 2008 |
Origin of decrease in potency of darunavir and two related antiviral inhibitors against HIV-2 compared to HIV-1 protease.
Topics: Antiviral Agents; Bridged Bicyclo Compounds, Heterocyclic; Darunavir; HIV Protease; HIV Protease Inhibitors; HIV-2; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Structure-Activity Relationship; Sulfonamides | 2012 |