darunavir has been researched along with grl 02031 in 3 studies
| Studies (darunavir) | Trials (darunavir) | Recent Studies (post-2010) (darunavir) | Studies (grl 02031) | Trials (grl 02031) | Recent Studies (post-2010) (grl 02031) |
|---|---|---|---|---|---|
| 1,148 | 224 | 780 | 6 | 0 | 4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, DD; Baldridge, A; Ghosh, AK; Koh, Y; Leshchenko-Yashchuk, S; Miller, HB; Mitsuya, H; Noetzel, M; Tie, Y; Wang, YF; Weber, IT | 1 |
| Chang, YC; Ghosh, AK; Harrison, RW; Tie, Y; Wang, YF; Weber, IT; Yashchuk, S; Yu, X; Zhang, Y | 1 |
| Agniswamy, J; Ghosh, AK; Louis, JM; Rao, KV; Sayer, JM; Shen, CH; Wang, YF; Weber, IT; Xu, CX | 1 |
3 other study(ies) available for darunavir and grl 02031
| Article | Year |
|---|---|
Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.
Topics: Binding Sites; Crystallography, X-Ray; Drug Design; HIV Protease Inhibitors; Ligands; Oxazolidinones; Protein Binding; Pyrrolidinones; Structure-Activity Relationship | 2009 |
Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.
Topics: Carbamates; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Viral; HIV Protease; HIV Protease Inhibitors; HIV-1; Kinetics; Models, Molecular; Molecular Conformation; Mutation; Pyrrolidinones; Sulfonamides | 2012 |
Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran.
Topics: Binding Sites; Calorimetry, Differential Scanning; Carbamates; Crystallization; Darunavir; Drug Resistance, Multiple; Drug Resistance, Viral; Escherichia coli; Furans; Genes, Synthetic; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Models, Molecular; Mutation; Pyrrolidinones; Structure-Activity Relationship; Sulfonamides | 2013 |