Page last updated: 2024-09-05

darunavir and aliskiren

darunavir has been researched along with aliskiren in 2 studies

Compound Research Comparison

Studies (darunavir)	Trials (darunavir)	Recent Studies (post-2010) (darunavir)	Studies (aliskiren)	Trials (aliskiren)	Recent Studies (post-2010) (aliskiren)
1,148	224	780	978	211	611

Protein Interaction Comparison

Protein	Taxonomy	aliskiren (IC50)
Renin	Homo sapiens (human)	0.001
Renin-1	Mus musculus (house mouse)	0.0045
Renin	Rattus norvegicus (Norway rat)	0.084
Cytochrome P450 3A4	Homo sapiens (human)	0.0004
Cytochrome P450 2C9	Homo sapiens (human)	0.0023
Renin	Macaca mulatta (Rhesus monkey)	0.0012
Renin	Oryctolagus cuniculus (rabbit)	0.011

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Leonis, G; Mavromoustakos, T; Megariotis, G; Papadopoulos, MG; Supuran, CT; Tzoupis, H	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1

Reviews

1 review(s) available for darunavir and aliskiren

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

1 other study(ies) available for darunavir and aliskiren

Article	Year
Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations. Journal of medicinal chemistry, 2012, Jun-28, Volume: 55, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Diabetes Mellitus; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Hydrogen Bonding; Hypertension; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Renin; Sodium-Glucose Transporter 2 Inhibitors; Thermodynamics	2012

Article

Year

Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations.

Journal of medicinal chemistry, 2012, Jun-28, Volume: 55, Issue:12

Topics: Acquired Immunodeficiency Syndrome; Diabetes Mellitus; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Hydrogen Bonding; Hypertension; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Renin; Sodium-Glucose Transporter 2 Inhibitors; Thermodynamics

2012