darifenacin has been researched along with indacaterol* in 1 studies
1 other study(ies) available for darifenacin and indacaterol
| Article | Year |
|---|---|
An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.
The synthesis of a series of indacaterol analogues in which each of the three structural regions of indacaterol are modified in a systematic manner is described. Evaluation of the affinity of these analogues for the β(2)-adrenoceptor identified the 3,4-dihydroquinolinone and 5-n-butylindanyl analogues to demonstrate the most similar profiles to indacaterol. An α-methyl aminoindane analogue was discovered to be 25-fold more potent than indacaterol, and functional studies revealed an atypical β(2)-adrenoceptor activation profile for this compound consistent with that of a slowly dissociating 'super agonist'. Topics: Adrenergic beta-2 Receptor Agonists; Dose-Response Relationship, Drug; Humans; Indans; Molecular Structure; Quinolones; Receptors, Adrenergic, beta-2; Structure-Activity Relationship | 2012 |