Compounds > darglitazone
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darglitazone and thiazoles

darglitazone has been researched along with thiazoles in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (38.46)18.2507
2000's8 (61.54)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berger, J; Diaz, E; Hayes, N; Smith, R; Szalkowski, D; Zhang, B1
Boden, G; Chaiken, RL; Eckert-Norton, M; Gelfand, RA; Lebovitz, HE; Pasmantier, R; Ryan, I1
Camirand, A; Rabelo, R; Silva, JE1
Camirand, A; Marie, V; Rabelo, R; Silva, JE1
Bondjers, G; Camejo, G; Olsson, U1
Aleo, MD; Avery, MJ; Beierschmitt, WP; Drupa, CA; Fortner, JH; Kaplan, AH; Navetta, KA; Shepard, RM; Walsh, CM1
Bakopanos, E; Silva, JE1
Jacinto, SM; Ljung, B; Oakes, ND; Thalén, PG1
Andresen, SM; Bamberg, K; Dalen, KT; Gustafsson, JA; Haugen, F; Hollung, K; Jacinto, S; Juvet, LK; Nebb, HI; Schuster, GU; Tobin, KA; Ulven, SM1
Camirand, A; López-Solache, I; Marie, V; Silva, JE; Vignault, E1
Camirand, A; López-Solache, I; Marie, V; Silva, JE1
Aleo, MD; Blackwell, DK; Coleman, GL; Kluwe, WM; Lundeen, GR; Smith, WM; Stadnicki, SW1
Cabré, A; Camejo, G; Hultén, LM; Norén, K; Pedreño, J; Svensson, L; Vallvé, JC; Wiklund, O1

Trials

1 trial(s) available for darglitazone and thiazoles

ArticleYear
Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects.
    Diabetologia, 1995, Volume: 38, Issue:11

    Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids, Nonesterified; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Obesity; Thiazoles; Thiazolidinediones

1995

Other Studies

12 other study(ies) available for darglitazone and thiazoles

ArticleYear
Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes.
    The Journal of biological chemistry, 1994, Oct-14, Volume: 269, Issue:41

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Muscles; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pioglitazone; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Signal Transduction; Thiazoles; Thiazolidinediones

1994
3',5'-cyclic adenosine monophosphate-response sequences of the uncoupling protein gene are sequentially recruited during darglitazone-induced brown adipocyte differentiation.
    Endocrinology, 1997, Volume: 138, Issue:12

    Topics: Adipocytes; Adipose Tissue, Brown; Animals; Base Sequence; Carrier Proteins; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Ion Channels; Membrane Proteins; Mice; Mitochondrial Proteins; Norepinephrine; Rats; Thiazoles; Thiazolidinediones; Tumor Cells, Cultured; Uncoupling Protein 1

1997
Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle.
    Endocrinology, 1998, Volume: 139, Issue:1

    Topics: Adipose Tissue; Animals; Cell Line; Chromans; Gene Expression Regulation; Hypoglycemic Agents; Insulin Resistance; Ion Channels; Membrane Transport Proteins; Mice; Mitochondrial Proteins; Muscle, Skeletal; Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Uncoupling Protein 2

1998
Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins.
    Diabetes, 1999, Volume: 48, Issue:3

    Topics: Aggrecans; Arteries; Cell Division; Cells, Cultured; Decorin; Extracellular Matrix Proteins; Fatty Acids, Nonesterified; Fibronectins; Gene Expression Regulation; Glycoproteins; Humans; Hypoglycemic Agents; Lectins, C-Type; Linoleic Acid; Lipoproteins, LDL; Membrane Glycoproteins; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Proteoglycans; RNA, Messenger; Syndecans; Thiazoles; Thiazolidinediones; Transcription, Genetic

1999
The use of explant lens culture to assess cataractogenic potential.
    Annals of the New York Academy of Sciences, 2000, Volume: 919

    Topics: Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Benzopyrans; Biotransformation; Cataract; Drug-Related Side Effects and Adverse Reactions; Glutathione; Lens, Crystalline; Lipoxygenase Inhibitors; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Toxicity Tests; Xenobiotics

2000
Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.
    Diabetes, 2000, Volume: 49, Issue:12

    Topics: 3T3 Cells; Adrenergic beta-Agonists; Animals; Carrier Proteins; Cell Line; Chromans; Dioxoles; Drug Combinations; Half-Life; Ion Channels; Membrane Proteins; Mice; Mitochondrial Proteins; Norepinephrine; Propranolol; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Uncoupling Protein 1

2000
Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability.
    Diabetes, 2001, Volume: 50, Issue:5

    Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Fasting; Fatty Acids, Nonesterified; Glucose Clamp Technique; Humans; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Kinetics; Lipid Mobilization; Lipoproteins, VLDL; Liver; Male; Metabolic Clearance Rate; Muscle, Skeletal; Obesity; Oxidation-Reduction; Polyethylene Glycols; Postprandial Period; Rats; Rats, Zucker; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides

2001
On the role of liver X receptors in lipid accumulation in adipocytes.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:2

    Topics: Adipocytes; Adipose Tissue; Animals; Anticholesteremic Agents; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Desmosterol; DNA-Binding Proteins; Fatty Acid Synthases; Female; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Lipid Metabolism; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Orphan Nuclear Receptors; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Sterol Regulatory Element Binding Protein 1; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Up-Regulation

2003
Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase.
    Endocrine, 2002, Volume: 19, Issue:2

    Topics: Animals; Cell Line; Chromans; Ion Channels; Membrane Transport Proteins; Mitochondrial Proteins; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Proteins; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Uncoupling Protein 2

2002
Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming ef
    Endocrine, 2002, Volume: 19, Issue:2

    Topics: Amanitins; Animals; Cell Line; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; Ion Channels; Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscle Fibers, Skeletal; Muscle, Skeletal; Nucleic Acid Synthesis Inhibitors; Osmolar Concentration; Protein Biosynthesis; Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Thyroid Hormone; RNA, Messenger; Stereoisomerism; Thiazoles; Thiazolidinediones; Thyroxine; Transcription Factors; Transcription, Genetic; Triiodothyronine; Uncoupling Protein 2

2002
Mechanism and implications of brown adipose tissue proliferation in rats and monkeys treated with the thiazolidinedione darglitazone, a potent peroxisome proliferator-activated receptor-gamma agonist.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3

    Topics: Adipose Tissue, Brown; Animals; Cell Division; Female; Glucocorticoids; Insulin; Macaca fascicularis; Male; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors

2003
Fatty acids modulate the effect of darglitazone on macrophage CD36 expression.
    European journal of clinical investigation, 2003, Volume: 33, Issue:6

    Topics: Arteriosclerosis; CD36 Antigens; Diabetes Mellitus, Type 2; Fatty Acids; Humans; Macrophages; Receptors, Immunologic; Receptors, Scavenger; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones

2003