dapsone and proguanil

dapsone has been researched along with proguanil in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (30.63)	18.7374
1990's	25 (22.52)	18.2507
2000's	39 (35.14)	29.6817
2010's	13 (11.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Black, RH; Ray, AP	1
Black, RH; Parkinson, AD; Ray, AP	1
Spicer, AJ	1
Edstein, MD; Shanks, GD; Yeo, AE	1
Edstein, MD; Shanks, GD; Suriyamongkol, V; Timsaad, S; Webster, HK	1
Karwacki, JJ; Shanks, GD; Suriyamongkol, V; Watanasook, C	1
González-Ruiz, A; Haworth, SJ; O'Neil, AB; Warhurst, DC	1
Edstein, MD; Rieckmann, KH; Veenendaal, JR	1
Brandling-Bennett, AD; Hoogstrate, M; Keuter, M; Ngwawe, WA; Raasveld, M; van de Ree, M; van Eijk, A; Watkins, WM; Were, JB	1
Bates, CJ; Bradley, AK; Fuller, NJ; Greenwood, AM; Greenwood, BM; Hayes, RJ; Tulloch, S	1
Berlin, OG; Bruckner, DA; Gonzalez, AH	1
Heap, BJ	1
Boriga, DA; Brandling-Bennett, AD; Carter, JY; Howells, RE; Koech, DK; Nevill, CG; Watkins, WM	1
Biddulph, J	1
Chiodini, PL	1
O'Sullivan, WJ; Rieckmann, KH; Scott, HV	1
Danis, M; Gentilini, M	1
Salako, LA	1
Black, RH	2
Wallace, DC	1
Botha, D	1
Laing, AB	2
Hunsicker, LG	1
Clyde, DF; DuPont, HL; McCarthy, VC; Miller, RM	1
Peters, W	3
Clyde, DF; McCarthy, VC; Miller, RM; Music, SI	1
Kreutzmann, DJ	1
Gregory, KG; Peters, W	1
Aubert, B; Jaatinen, M; Kihamia, CH; Kumano, M; Magnuson, LW; McLarty, DG; Murru, M; Webber, RH	1
Spracklen, FH	1
Rossan, RN; Schmidt, LH	1
Cynamon, MH; Majumder, SK; Meyer, SC	1
Bradley, DJ; Warhurst, DC	1
Comley, JC; Sterling, AM	1
Breckenridge, AM; Mberu, EK; Szwandt, IS; Watkins, WM; Winstanley, PA	1
Hughes, WT; Killmar, JT; Oz, HS	1
Edstein, MD; Rieckmann, KH; Shanks, GD; Teja-Isavadharm, P; Webster, HK	1
Brun-Pascaud, M; Chau, F; Derouin, F; Garry, L; Girard, PM; Jacobus, D	1
Chambo, O; Curtis, CF; Hills, E; Mbwana, H; Trigg, JK; Watkins, W	1
Yeo, AE	1
Edstein, MD; Rieckmann, KH; Shanks, GD; Yeo, AE	1
Rieckmann, KH; Yeo, AE	1
Edstein, MD; Rieckmann, KH; Yeo, AE	1
Amradee, S; Chinwongprom, K; Kyle, DE; Looareesuwan, S; Watkins, WM; White, NJ; Wilairatana, P	1
Amukoye, E; Hatcher, J; Lowe, B; Marsh, K; Minyiri, G; Mosobo, M; Ngumbao, E; Snow, RW; Ton, M; Watkins, WM; Winstanley, PA	1
Curtis, J; Duraisingh, MT; Warhurst, DC	1
Christopherson, RI; Seymour, KK; Yeo, AE	1
Blanco García, A; de Górgolas Hernández-Mora, M; Fernández Guerrero, ML; Martín Torres, MP	1
Griffin, JP	1
Curtis, J; Maxwell, CA; Ortelli, F; Watkins, WM	1
Hopkins Sibley, C; Mberu, EK; Monks, SA; Nduati, E; Nzila, AM; Watkins, WM; Winstanley, PA	1
Hills, E; Mberu, E; Mutabingwa, T; Nduati, E; Nzila, A; Watkins, W; Winstanley, P	1
Winstanley, P	1
Chimpeni, P; Cortese, JF; Dzinjalamala, FK; Kamwendo, DD; Kublin, JG; Lescano, AG; Malkin, EM; Martino, LM; Molyneux, ME; Mukadam, RA; Plowe, CV; Rogerson, SJ; Taylor, TE; Winstanley, PA	1
Chimpeni, P; Hatcher, J; Kublin, JG; Marsh, K; Molyneux, ME; Plowe, CV; Sulo, J; Taylor, TE; Watkins, WM; Winstanley, PA	1
Alloueche, A; Curtis, J; Maxwell, CA; Mkongewa, S; Msuya, FH; Warhurst, DC	1
Greenwood, B; Lang, T	1
Pincock, S	1
Schubert, C	1
BASU, PC; RAMAKRISHNAN, SP; SINGH, H; SINGH, N	1
OLSZEWSKI, B; THOMPSON, PE; WAITZ, JA	1
Carneiro, IA; Chambo, W; Curtis, CF; Magogo, F; Maxwell, CA; Mwaimu, M	1
Jomaa, H; Ortmann, R; Schlitzer, M; Wiesner, J	1
Zimmerman, PA	1
Imwong, M; Looareesuwan, S; Wilairatana, P	1
Alloueche, A; Bailey, W; Barton, S; Bwika, J; Chimpeni, P; Falade, CO; Fehintola, FA; Horton, J; Jaffar, S; Kanyok, T; Kremsner, PG; Kublin, JG; Lang, T; Missinou, MA; Mkandala, C; Oduola, AM; Premji, Z; Robertson, L; Sowunmi, A; Ward, SA; Winstanley, PA	1
Bukirwa, H; Critchley, J; Garner, P	1
Alloueche, A; Bates, SJ; Bwika, J; Happi, TC; Kremsner, PG; Kublin, JG; Premji, Z; Sibley, CH; Watkins, WM; Winstanley, PA	1
Imwong, M; Krudsood, S; Looareesuwan, S; Nonprasert, A; Pukrittayakamee, S; Snounou, G; White, NJ; Wilairatana, P	1
A Clode, S; Clark, RL; Gaunt, I; Ward, SA; White, TE; Winstanley, P	1
Peters, W; Robinson, BL; Stewart, LB	2
Hunt, S; Kamau, EM; Nduati, E; Nzila, A	1
Garner, P; Jones, K; Taylor-Robinson, D	1
Kamau, EM; Nduati, EW	1
Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P	1
Biagini, GA; Edwards, G	1
Hasan, MA; Klinkenberg, E; Leslie, T; Mayan, MI; Rowland, M; Safi, MH; Whitty, CJ	1
Nyunt, MM; Plowe, CV	1
Biagini, GA; Blencowe, H; Dube-Mbeye, Q; Dunyo, S; Duparc, S; Kanjala, MK; Kanyok, T; Kirby, PL; Molyneux, M; Neate, C; Nyirenda, M; Opara, H; Ward, S; Winstanley, PA; Woessner, M; Wootton, DG	1
Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C	1
Adjuik, M; Amenga-Etego, S; Asante, KP; Chandramohan, D; Dosoo, DK; Greenwood, B; Gyapong, J; Owusu, R; Owusu-Agyei, S	1
Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A	1
Dankyau, M; Madaki, AJ; Ogunfowokan, O; Thacher, TD	1
Briceño, M; Drakeley, C; Greenwood, BM; Mutabingwa, TK; Muze, K; Ord, R; Whitty, CJ	1
Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG	1
Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA	1
Bell, DJ; Chimpeni, P; Hughes, DA; Kayange, N; Lalloo, DG; Molyneux, ME; Montgomery, J; Mukaka, M; Ward, SA; Winstanley, PA; Wootton, D	1
Kaye, DK; Mutyaba, TS; Ndeezi, G; Nshemerirwe, R	1
Carneiro, I; Chandramohan, D; Gesase, S; Gosling, RD; Greenwood, B; Hashim, R; Lemnge, M; Mosha, FW; Mosha, JF	1
Agbenyega, T; Awobusuyi, J; Carter, N; Dicko, A; Duparc, S; Goh, LE; Greenwood, B; Harrell, E; Ndububa, DA; Pamba, A; Pitmang, S; Tiono, AB; Ward, SA; Winstanley, PA	1
Cairns, M; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Greenwood, B; Hashim, R; Kaur, H; Lemnge, M; Mosha, FW; Mosha, JF	1
Hamel, MJ; Kariuki, S; Lindblade, K; Newman, RD; Odhiambo, FO; Otieno, P; Peterson, E; Slutsker, L; ter Kuile, FO; Vulule, J; Williamson, J	1
Luzzatto, L	1
Clark, RL; Gristwood, WE; Harrell, AW; Lewsley, R; Wilson, R	1
Bardsley, B; Barry, SJ; Drozdz, MA; Hancock, SA; Okafo, GN; Szafran, MM	1
Adiamoh, M; Bisseye, C; Cheung, YB; Conway, D; Diatta, M; Dunyo, S; Janha, R; Milligan, P; Njie, F; Nwakanma, D; Sesay, S; Sirugo, G; Sisay Joof, F; Snell, P; Temple, B; Walton, R	1
Carter, N; Duparc, S; Pamba, A; Waitumbi, JN	1
Bassat, Q; D' Alessandro, U; Daniel, A; Forret, P; González, R; Machevo, S; Nabasumba, C; Piola, P; Robert, A; Talisuna, A; Turyakira, E; Van Geertruyden, JP; van Loen, H; Van Malderen, C; Van Overmeir, C; Yeka, A	1
D'Alessandro, U; Donegan, S; Tudur Smith, C; Williamson, P	1
Carter, N; Duparc, S; Luzzatto, L; Pamba, A; Premji, Z; Richardson, ND; Tiono, AB	1
Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E	1

Reviews

12 review(s) available for dapsone and proguanil

Article	Year
Malaria chemoprophylaxis: an update. Papua and New Guinea medical journal, 1987, Volume: 30, Issue:1 Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Female; Humans; Malaria; Proguanil; Pyrimethamine; Sulfadoxine	1987
The chemoprophylaxis of malaria. The Journal of antimicrobial chemotherapy, 1987, Volume: 20, Issue:3 Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	1987
Pharmacokinetics of antimalarial drugs: their therapeutic and toxicological implications. Annali dell'Istituto superiore di sanita, 1985, Volume: 21, Issue:3 Topics: Adult; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Half-Life; Humans; Kinetics; Male; Mefloquine; Mice; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine; Sulfalene	1985
The pharmacology of the antimalarials. A rational approach to the therapy of resistant falciparum malaria. Archives of internal medicine, 1969, Volume: 123, Issue:6 Topics: Amodiaquine; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Sulfadimethoxine; Sulfisoxazole	1969
Malaria. Chemoprophylaxis and chemotherapy. British medical journal, 1971, Apr-10, Volume: 2, Issue:5753 Topics: Amodiaquine; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug Synergism; Humans; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Pyrimidines; Quinine; Sulfonamides; Triazines	1971
Malaria 1984. Part I. Malaria prophylaxis. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1984, Jun-30, Volume: 65, Issue:26 Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Malaria; Mosquito Control; Plasmodium falciparum; Plasmodium vivax; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; South Africa; Sulfadoxine	1984
Drug interactions with antimalarial agents. Adverse drug reactions and toxicological reviews, 1999, Volume: 18, Issue:1 Topics: Antimalarials; Dapsone; Drug Interactions; Humans; Malaria; Proguanil; Pyrimethamine; Quinolines; Sulfadoxine; Tetracycline	1999
Studies on anti-folate antimalarials in east Africa. Parassitologia, 1999, Volume: 41, Issue:1-3 Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	1999
New antimalarial drugs. Angewandte Chemie (International ed. in English), 2003, Nov-10, Volume: 42, Issue:43 Topics: Aminoquinolines; Animals; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Design; Drug Resistance; Ethanolamines; Flavonoids; Fluorenes; Fosfomycin; Global Health; Humans; Lumefantrine; Malaria; Naphthoquinones; Naphthyridines; Plasmodium falciparum; Proguanil; Sesquiterpenes	2003
Chlorproguanil-dapsone for treating uncomplicated malaria. The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4 Topics: Adult; Antimalarials; Child; Dapsone; Drug Combinations; Humans; Malaria; Proguanil; Randomized Controlled Trials as Topic	2004
Malaria: uncomplicated, caused by Plasmodium falciparum. Clinical evidence, 2005, Issue:13 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Proguanil; Pyrimethamine; Sesquiterpenes; Sulfadoxine	2005
Resisting resistance: dealing with the irrepressible problem of malaria. British journal of clinical pharmacology, 2006, Volume: 61, Issue:6 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria; Proguanil; Sesquiterpenes	2006

Trials

33 trial(s) available for dapsone and proguanil

Article	Year
Proguanil combined with dapsone chemoprophylaxis for malaria. The Medical journal of Australia, 1992, Jun-15, Volume: 156, Issue:12 Topics: Adult; Australia; Dapsone; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Military Personnel; Proguanil; Thailand	1992
Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border. The American journal of tropical medicine and hygiene, 1992, Volume: 46, Issue:6 Topics: Blood Cells; Cambodia; Dapsone; Doxycycline; Drug Therapy, Combination; Drug Tolerance; Glucosephosphate Dehydrogenase Deficiency; Humans; Leukocyte Count; Malaria, Falciparum; Malaria, Vivax; Male; Military Personnel; Patient Compliance; Proguanil; Pyrimethamine; Thailand	1992
Proguanil/sulfamethoxazole malaria chemoprophy-laxis on the Thai-Cambodian border. The Southeast Asian journal of tropical medicine and public health, 1991, Volume: 22, Issue:1 Topics: Adult; Animals; Cambodia; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Male; Military Personnel; Patient Compliance; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfamethoxazole; Thailand	1991
Comparison of chloroquine, pyrimethamine and sulfadoxine, and chlorproguanil and dapsone as treatment for falciparum malaria in pregnant and non-pregnant women, Kakamega District, Kenya. BMJ (Clinical research ed.), 1990, Sep-08, Volume: 301, Issue:6750 Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Dapsone; Drug Therapy, Combination; Female; Humans; Malaria; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Prospective Studies; Pyrimethamine; Sulfadoxine	1990
The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children. Annals of tropical paediatrics, 1988, Volume: 8, Issue:2 Topics: Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Erythrocyte Indices; Erythrocytes; Folic Acid; Gambia; Hematocrit; Humans; Infant; Leukocyte Count; Placebos; Proguanil; Pyrimethamine	1988
Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:3 Topics: Animals; Dapsone; Drug Therapy, Combination; Humans; Kenya; Malaria; Pilot Projects; Plasmodium falciparum; Proguanil	1988
Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970, Volume: 64, Issue:6 Topics: Adult; Amodiaquine; Anopheles; Antimalarials; Blood; Chloroquine; Clinical Trials as Topic; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Male; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine	1970
Prophylactic and sporontocidal treatment of chloroquine-resistant Plasmodium falciparum from Vietnam. The American journal of tropical medicine and hygiene, 1971, Volume: 20, Issue:1 Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Humans; Malaria; Male; Methemoglobin; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine; Sulfonamides; United States; Vietnam	1971
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10 Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine	1997
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. The Journal of infectious diseases, 1998, Volume: 177, Issue:5 Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Genes, Protozoan; Genetic Variation; Genotype; Humans; Isoleucine; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sulfadoxine	1998
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. The Journal of infectious diseases, 2002, Feb-01, Volume: 185, Issue:3 Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind Method; Drug Combinations; Drug Resistance, Bacterial; Humans; Infant; Malaria, Falciparum; Mutation; Proguanil; Prospective Studies; Pyrimethamine; Sensitivity and Specificity; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure	2002
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Lancet (London, England), 2002, Oct-12, Volume: 360, Issue:9340 Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; Drug Therapy, Combination; Female; Hemoglobinometry; Humans; Infant; Kenya; Malaria, Falciparum; Malawi; Male; Proguanil; Pyrimethamine; Recurrence; Retreatment; Sulfadoxine; Survival Rate	2002
Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment. The Journal of infectious diseases, 2002, Dec-15, Volume: 186, Issue:12 Topics: Animals; Antimalarials; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Follow-Up Studies; Genes, Protozoan; Humans; Infant; Malaria, Falciparum; Merozoite Surface Protein 1; Mutation; Parasitemia; Plasmodium falciparum; Proguanil; Tanzania; Tetrahydrofolate Dehydrogenase	2002
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Methemoglobin; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2004
Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial. JAMA, 2007, May-23, Volume: 297, Issue:20 Topics: Adolescent; Adult; Afghanistan; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Female; Folic Acid Antagonists; Humans; Malaria, Vivax; Male; Middle Aged; Pakistan; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2007
Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria. PloS one, 2008, Mar-05, Volume: 3, Issue:3 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisia; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Female; Gambia; Humans; Infant; Malaria, Falciparum; Malawi; Male; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Sample Size; Sesquiterpenes; Treatment Outcome	2008
A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008, Volume: 102, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Rural Health; Rwanda; Treatment Outcome	2008
An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria. PloS one, 2008, Jun-25, Volume: 3, Issue:6 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Infant; Lumefantrine; Malaria; Male; Polymerase Chain Reaction; Proguanil; Treatment Outcome	2008
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. PloS one, 2008, Volume: 3, Issue:12 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Oxidants; Polymorphism, Genetic; Proguanil; Pyrimethamine; Sulfadoxine	2008
Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria. The American journal of tropical medicine and hygiene, 2009, Volume: 80, Issue:2 Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Nigeria; Parasitemia; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2009
Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania. PloS one, 2009, Volume: 4, Issue:4 Topics: Adult; Amodiaquine; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Young Adult	2009
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. European journal of clinical pharmacology, 2009, Volume: 65, Issue:10 Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Gambia; Humans; Malaria, Falciparum; Malawi; Male; Middle Aged; Parasitic Sensitivity Tests; Proguanil; Time Factors	2009
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. PloS one, 2009, Aug-19, Volume: 4, Issue:8 Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Dapsone; Double-Blind Method; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Male; Patient Compliance; Proguanil; Treatment Outcome	2009
Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malaria journal, 2009, Aug-26, Volume: 8 Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Preschool; Dapsone; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Infant; Malaria; Malawi; Male; Medication Adherence; Plasma; Proguanil; Pyrimethamine; Sulfadoxine; Surveys and Questionnaires; Treatment Outcome; Young Adult	2009
A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda. Journal of infection in developing countries, 2008, Apr-01, Volume: 2, Issue:2 Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Dapsone; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Uganda; Young Adult	2008
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet (London, England), 2009, Oct-31, Volume: 374, Issue:9700 Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Resistance; Female; Follow-Up Studies; Half-Life; Humans; Immunization Schedule; Incidence; Infant; Infant Mortality; Logistic Models; Malaria, Falciparum; Male; Mefloquine; Multivariate Analysis; Proguanil; Pyrimethamine; Safety; Sulfadoxine; Tanzania; Treatment Outcome	2009
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria. The American journal of tropical medicine and hygiene, 2009, Volume: 81, Issue:6 Topics: Adolescent; Adult; Africa South of the Sahara; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Therapy, Combination; Female; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Proguanil; Time Factors	2009
Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants. PloS one, 2010, Mar-01, Volume: 5, Issue:3 Topics: Antimalarials; Dapsone; Drug Administration Schedule; Drug Combinations; Drug Resistance; Humans; Immunization Schedule; Infant; Infant, Newborn; Malaria; Mefloquine; Pediatrics; Placebos; Proguanil; Pyrimethamine; Research Design; Sulfadoxine; Tanzania; Time Factors; Treatment Outcome	2010
Intermittent preventive treatment in infants for the prevention of malaria in rural Western kenya: a randomized, double-blind placebo-controlled trial. PloS one, 2010, Apr-02, Volume: 5, Issue:4 Topics: Anemia; Antimalarials; Artemisinins; Artesunate; Dapsone; Double-Blind Method; Drug Combinations; Humans; Incidence; Infant; Kenya; Malaria; Premedication; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2010
Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. PloS one, 2011, Volume: 6, Issue:6 Topics: Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Aryl Hydrocarbon Hydroxylases; Case-Control Studies; Child; Cytochrome P-450 CYP2C19; Dapsone; Drug Combinations; Ethanolamines; Female; Fluorenes; Gambia; Genotype; Glucosephosphate Dehydrogenase; Hemoglobins; Humans; Incidence; Infant; Malaria; Male; Parasites; Patient Compliance; Proguanil; Treatment Failure; Treatment Outcome	2011
Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials. Malaria journal, 2011, Aug-17, Volume: 10 Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Female; Genotype; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Phenotype; Proguanil; Treatment Outcome	2011
Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria. Malaria journal, 2012, Jul-10, Volume: 11 Topics: Africa South of the Sahara; Anemia, Hemolytic; Antimalarials; Artemisinins; Artesunate; Case-Control Studies; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria; Male; Proguanil	2012
Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. PloS one, 2015, Volume: 10, Issue:11 Topics: Antimalarials; Cohort Studies; Dapsone; Double-Blind Method; Drug Combinations; Female; Genotype; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemolysis; Humans; Infant; Logistic Models; Malaria; Male; Mefloquine; Multivariate Analysis; Odds Ratio; Poisson Distribution; Polymorphism, Single Nucleotide; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	2015

Other Studies

66 other study(ies) available for dapsone and proguanil

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Experimental studies of the potentiation of proguanil and pyrimethamine by dapsone using Plasmodium berghei in white mice. Annals of tropical medicine and parasitology, 1977, Volume: 71, Issue:2 Topics: Animals; Chloroquine; Dapsone; Drug Synergism; Mice; Plasmodium berghei; Proguanil; Pyrimethamine	1977
Experimental studies on the effect of proguanil and dapsone against chloroquine-resistant Plasmodium berghei (ANKA) in white mice. Annals of tropical medicine and parasitology, 1979, Volume: 73, Issue:1 Topics: Animals; Chloroquine; Dapsone; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Female; Malaria; Male; Mice; Plasmodium berghei; Proguanil	1979
Treatment and chemoprophylaxis of malaria. The Practitioner, 1979, Volume: 223, Issue:1336 Topics: Aminoquinolines; Antimalarials; Biguanides; Chloroquine; Dapsone; Humans; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Quinine; Sulfonamides	1979
Dapsone in low doses prevents Pneumocystis carinii pneumonia in the rat model. The Journal of infection, 1991, Volume: 22, Issue:2 Topics: Administration, Oral; Animals; Dapsone; Diet; Disease Models, Animal; Immune Tolerance; Male; Pneumonia, Pneumocystis; Proguanil; Random Allocation; Rats; Rats, Inbred Strains; Triazines	1991
Multiple-dose kinetics in healthy volunteers and in vitro antimalarial activity of proguanil plus dapsone. Chemotherapy, 1990, Volume: 36, Issue:3 Topics: Adult; Animals; Anti-Infective Agents; Dapsone; Drug Administration Schedule; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Half-Life; Humans; Male; Plasmodium falciparum; Proguanil; Time Factors; Triazines	1990
In-vitro activity of dapsone and two potentiators against Mycobacterium avium complex. The Journal of antimicrobial chemotherapy, 1989, Volume: 24, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Synergism; Humans; Microbial Sensitivity Tests; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Proguanil; Sulfamethazine; Triazines	1989
Malaria chemoprophylaxis with a proguanil-chloroquine-maloprim combination in Papua New Guinea. Journal of the Royal Army Medical Corps, 1988, Volume: 134, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Military Personnel; Papua New Guinea; Plasmodium falciparum; Plasmodium vivax; Proguanil; Pyrimethamine	1988
Synergistic antimalarial activity of dapsone/dihydrofolate reductase inhibitors and the interaction of antifol, antipyrimidine and antipurine combinations against Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:5 Topics: Animals; Antimalarials; Antimetabolites; Dapsone; Drug Synergism; Plasmodium falciparum; Proguanil; Ribonucleosides; Triazines	1987
Malaria prophylaxis for Canadian travellers. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1985, Nov-15, Volume: 133, Issue:10 Topics: Amodiaquine; Canada; Chloroquine; Dapsone; Doxycycline; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Infant; Infant, Newborn; Malaria; Plasmodium; Plasmodium falciparum; Pregnancy; Premedication; Proguanil; Pyrimethamine; Quinine; Sulfadoxine; Travel	1985
[Malaria chemoprophylaxis. Resistance problems]. Archives francaises de pediatrie, 1985, Volume: 42 Suppl 2 Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Humans; Infant; Malaria; Mefloquine; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine	1985
Drug-resistant malaria. Lancet (London, England), 1969, Jun-21, Volume: 1, Issue:7608 Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine; Sulfonamides	1969
Malaria in the Australian army in South Vietnam: successful use of a proguanil-dapsone combination for chemoprophylaxis of chloroquine-resistant falciparum malaria. The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:26 Topics: Australia; Chloroquine; Dapsone; Disease Outbreaks; Drug Resistance, Microbial; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Proguanil; Seasons; Vietnam	1973
Letter: Malaria in the Australian army in South Vietnam. The Medical journal of Australia, 1973, Sep-15, Volume: 2, Issue:11 Topics: Australia; Dapsone; Humans; Malaria; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Proguanil; Vietnam	1973
Letter: Malaria in the Australian army in South Vietnam. The Medical journal of Australia, 1973, Sep-08, Volume: 2, Issue:10 Topics: Dapsone; Disease Outbreaks; Drug Resistance, Microbial; Humans; Malaria; Male; Military Medicine; Plasmodium falciparum; Plasmodium vivax; Proguanil	1973
Some pharmacological aspects of antimalarial drugs. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jun-15, Volume: 48, Issue:29 Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfonamides; Trimethoprim	1974
Antimalarial effects of sulphormethoxine, diaphenylsulphone and separate combinations of these with pyrimethamine: a review of preliminary investigations carried out in Tanzania. The Journal of tropical medicine and hygiene, 1968, Volume: 71, Issue:2 Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Dapsone; Drug Hypersensitivity; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Sulfonamides; Tanzania	1968
Studies on the chemotherapy of malaria. II. Pyrimethamine resistance in The Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970, Volume: 64, Issue:4 Topics: Carrier State; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Erythrocytes; Female; Gambia; Humans; Infant; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfonamides	1970
Simple qualitative test for the presence of both proguanil and dapsone in urine after oral ingestion. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1970, Volume: 64, Issue:1 Topics: Chromatography, Thin Layer; Dapsone; Fluorescence; Humans; Methods; Proguanil; Ultraviolet Rays	1970
The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages. Annals of tropical medicine and parasitology, 1970, Volume: 64, Issue:1 Topics: Animals; Antimalarials; Chloroquine; Dapsone; Malaria; Male; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfadiazine; Triazines	1970
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance. Experimental parasitology, 1965, Volume: 17, Issue:1 Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Sulfadiazine; Triazines	1965
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. II. Triazine resistance. Experimental parasitology, 1965, Volume: 17, Issue:1 Topics: Animals; Dapsone; In Vitro Techniques; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Sulfadiazine; Triazines	1965
Chemoprophylaxis of malaria in non-immune residents in Dar es Salaam, Tanzania. Lancet (London, England), 1984, Sep-22, Volume: 2, Issue:8404 Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Administration Schedule; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Infant; Malaria; Male; Middle Aged; Patient Compliance; Plasmodium falciparum; Proguanil; Pyrimethamine; Retrospective Studies; Sulfadoxine; Tanzania	1984
Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys. Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:5 Topics: Acedapsone; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance, Microbial; Macaca mulatta; Malaria; Particle Size; Plasmodium falciparum; Plasmodium vivax; Proguanil; Pyrimethamine; Time Factors; Triazines	1984
Malaria prophylaxis for long term visitors. British medical journal (Clinical research ed.), 1983, Nov-12, Volume: 287, Issue:6403 Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguanil; Pyrimethamine; Sulfonamides; Sulfones; Time Factors; Travel	1983
In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:8 Topics: Antimalarials; Cyclization; Dapsone; Folic Acid Antagonists; Humans; Microbial Sensitivity Tests; Mycobacterium avium Complex; Proguanil; Triazines	1995
Malaria prophylaxis: guidelines for travellers from Britain. Malaria Reference Laboratory of the Public Health Laboratory Service, London. BMJ (Clinical research ed.), 1995, Mar-18, Volume: 310, Issue:6981 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Culicidae; Dapsone; Doxycycline; Drug Administration Schedule; Drug Combinations; Humans; Infant; Infant, Newborn; Insect Bites and Stings; Malaria; Mefloquine; Proguanil; Pyrimethamine; Risk Factors; Travel	1995
Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:4 Topics: Animals; Antifungal Agents; Atovaquone; Dapsone; Drug Therapy, Combination; Mice; Mice, SCID; Naphthoquinones; Pneumonia, Pneumocystis; Proguanil; Rifabutin; Trimethoprim, Sulfamethoxazole Drug Combination	1995
In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:4 Topics: Animals; Dapsone; Dihydropteroate Synthase; Drug Combinations; Drug Synergism; Folic Acid Antagonists; Granulocytes; Hematopoietic Stem Cells; Humans; Plasmodium falciparum; Proguanil	1995
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model. The Journal of infectious diseases, 1994, Volume: 170, Issue:4 Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Trials as Topic; Dapsone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Naphthoquinones; Pentamidine; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1994
Oxidative activation of proguanil and dapsone acetylation in Thai soldiers. British journal of clinical pharmacology, 1994, Volume: 37, Issue:1 Topics: Acetylation; Biotransformation; Chromatography, High Pressure Liquid; Dapsone; Humans; Malaria; Military Personnel; Oxidation-Reduction; Polymorphism, Genetic; Proguanil; Thailand; Triazines	1994
Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:9 Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Immunosuppression Therapy; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim	1996
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone. Acta tropica, 1997, Volume: 63, Issue:2-3 Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Infant; Malaria, Falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	1997
Direct comparison of antimalarial activity among PS-15 combination therapies by bioassay of serum samples from treated Saimiri sciureus. The Journal of parasitology, 1997, Volume: 83, Issue:3 Topics: Animals; Antimalarials; Atovaquone; Biological Assay; Dapsone; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Malaria, Falciparum; Naphthoquinones; Proguanil; Regression Analysis; Saimiri; Sulfamethoxazole	1997
Ex vivo antimalarial activity of proguanil combined with dapsone against cycloguanil-resistant Plasmodium falciparum isolates. Acta tropica, 1997, Sep-10, Volume: 66, Issue:3 Topics: Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Triazines	1997
The activity of triple combinations of antifolate biguanides, with and without folinic acid, against plasmodium falciparum in vitro. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:3 Topics: Animals; Anti-Infective Agents; Antimalarials; Atovaquone; Dapsone; Drug Resistance, Multiple; Leucovorin; Naphthoquinones; Plasmodium falciparum; Proguanil; Saimiri	1997
Antimalaria activity of the triple combination of proguanil, atovaquone and dapsone. Acta tropica, 1997, Sep-30, Volume: 67, Issue:3 Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Resistance, Multiple; Drug Synergism; Drug Therapy, Combination; Humans; Malaria, Falciparum; Naphthoquinones; Plasmodium falciparum; Proguanil; Thailand	1997
Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Pilot Projects; Plasmodium falciparum; Proguanil; Thailand; Treatment Outcome	1997
Pyrimidine antagonists and antifolates as antimalarial drugs. Advances in experimental medicine and biology, 1998, Volume: 431 Topics: Animals; Antimalarials; Dapsone; Deoxyribonucleotides; Drug Resistance, Multiple; Enzyme Inhibitors; Folic Acid Antagonists; Orotic Acid; Plasmodium falciparum; Proguanil; Pyrimidines; Ribonucleotides	1998
[Chemoprophylaxis of malaria in travelers to endemic zones]. Revista clinica espanola, 1998, Volume: 198, Issue:6 Topics: Antimalarials; Chloroquine; Dapsone; Doxycycline; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Proguanil; Pyrimethamine; Travel	1998
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum. The Journal of infectious diseases, 2000, Volume: 181, Issue:6 Topics: Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Peptide Synthases; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2000
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet (London, England), 2001, Oct-13, Volume: 358, Issue:9289 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	2001
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Antimalarials; Artemisinins; Clinical Trials, Phase III as Topic; Dapsone; Drug Approval; Drug Combinations; Drug Therapy, Combination; Health Services Accessibility; Humans; Malaria, Falciparum; Proguanil; Sesquiterpenes	2001
The development of Lapdap, an affordable new treatment for malaria. The Lancet. Infectious diseases, 2003, Volume: 3, Issue:3 Topics: Animals; Antimalarials; Child; Clinical Trials as Topic; Dapsone; Drug Approval; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Proguanil; Time Factors; United Kingdom	2003
Drug company to offer new malaria drug cheaply in Africa. BMJ (Clinical research ed.), 2003, Aug-16, Volume: 327, Issue:7411 Topics: Africa; Antimalarials; Dapsone; Drug Combinations; Drug Costs; Drug Industry; Humans; International Cooperation; Malaria, Falciparum; Proguanil	2003
New malaria drug to be unveiled in Africa. Nature medicine, 2003, Volume: 9, Issue:9 Topics: Africa; Antimalarials; Dapsone; Drug Combinations; Drug Costs; Drug Industry; Drug Utilization; Humans; Proguanil; Pyrimethamine; Sulfadoxine	2003
Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria. Bulletin of the World Health Organization, 1962, Volume: 27 Topics: Animals; Antimalarials; Birds; Chloroquine; Dapsone; Malaria; Malaria, Avian; Proguanil; Pyrimethamine; Quinine	1962
LABORATORY STUDIES ON THE REPOSITORY ANTIMALARIAL ACTIVITY OF 4,4'-DIACETYLAMINODIPHENYLSULFONE, ALONE AND MIXED WITH CYCLOGUANIL PAMOATE (CI-501). The American journal of tropical medicine and hygiene, 1965, Volume: 14 Topics: Animals; Antimalarials; Dapsone; Haplorhini; Malaria; Mice; Pharmacology; Proguanil; Research; Triazines	1965
Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets. Malaria journal, 2003, Sep-10, Volume: 2 Topics: Altitude; Animals; Anopheles; Antigens, Protozoan; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Humans; Incidence; Infant; Insecticides; Malaria, Falciparum; Plasmodium falciparum; Prevalence; Proguanil; Protective Devices; Pyrethrins; Secondary Prevention; Tanzania	2003
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets. The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:3 Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Insecticides; Malaria, Falciparum; Mosquito Control; Mutation; Plants; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2003
Chlorproguanil-dapsone for malaria in Africa. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2004
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites. The Journal of infectious diseases, 2004, Nov-15, Volume: 190, Issue:10 Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Protozoan; Humans; Kenya; Malaria, Falciparum; Malawi; Molecular Epidemiology; Mutation, Missense; Nigeria; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Tetrahydrofolate Dehydrogenase	2004
Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005, Volume: 99, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Female; Genotype; Humans; Malaria, Falciparum; Male; Middle Aged; Mutation; Plasmodium falciparum; Proguanil; Prospective Studies; Recurrence; Sesquiterpenes; Tetrahydrofolate Dehydrogenase; Treatment Outcome	2005
Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit. Birth defects research. Part B, Developmental and reproductive toxicology, 2004, Volume: 71, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Embryonic Development; Female; Fetal Development; Pregnancy; Proguanil; Rabbits; Rats; Rats, Sprague-Dawley; Sesquiterpenes	2004
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate. Annals of tropical medicine and parasitology, 2004, Volume: 98, Issue:8 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combination; Folic Acid Antagonists; Malaria, Falciparum; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Sesquiterpenes; Triazines	2004
The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate. Annals of tropical medicine and parasitology, 2005, Volume: 99, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Rodent Diseases; Sesquiterpenes	2005
2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:9 Topics: Animals; Antimalarials; Dapsone; Dihydropteroate Synthase; Drug Combinations; Drug Synergism; Folic Acid Antagonists; Plasmodium; Proguanil; Pteridines; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase; Triazines	2005
Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy. Acta tropica, 2006, Volume: 97, Issue:3 Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Naphthoquinones; Plasmodium falciparum; Proguanil; Triazines	2006
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. British journal of clinical pharmacology, 2006, Volume: 61, Issue:3 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Proguanil; Prospective Studies; Triazines	2006
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance. Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Global Health; Half-Life; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine	2007
The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics. Lancet (London, England), 2010, Aug-28, Volume: 376, Issue:9742 Topics: Anemia, Hemolytic; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Glucosephosphate Dehydrogenase Deficiency; Humans; Malaria, Falciparum; Pharmacogenetics; Proguanil	2010
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity. Birth defects research. Part B, Developmental and reproductive toxicology, 2010, Volume: 89, Issue:5 Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Artesunate; Autoradiography; Dapsone; Female; Fetus; Male; Pregnancy; Proguanil; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Distribution	2010
Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets. Journal of pharmaceutical and biomedical analysis, 2011, Feb-20, Volume: 54, Issue:3 Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dapsone; Drug Combinations; Drug Stability; Drug Therapy, Combination; Hot Temperature; Humans; Humidity; Magnetic Resonance Spectroscopy; Malaria, Falciparum; Mass Spectrometry; Proguanil; Tablets	2011
Assessing the consistency assumption by exploring treatment by covariate interactions in mixed treatment comparison meta-analysis: individual patient-level covariates versus aggregate trial-level covariates. Statistics in medicine, 2012, Dec-20, Volume: 31, Issue:29 Topics: Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Dapsone; Drug Combinations; Ethanolamines; Fluorenes; Humans; Malaria; Meta-Analysis as Topic; Models, Statistical; Outcome Assessment, Health Care; Proguanil; Quinolines; Regression Analysis	2012
Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. Blood, 2012, Nov-15, Volume: 120, Issue:20 Topics: Acute Disease; Adolescent; Africa; Anemia, Hemolytic; Antimalarials; Blood Transfusion; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Dapsone; Drug Combinations; Female; Genotype; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Multicenter Studies as Topic; Oxidation-Reduction; Proguanil; Randomized Controlled Trials as Topic; Risk; Single-Blind Method	2012