dapsone has been researched along with chlorproguanil in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.00) | 18.7374 |
| 1990's | 7 (17.50) | 18.2507 |
| 2000's | 27 (67.50) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Cheong, SL; Ng, CH; Tibon, NS | 1 |
| González-Ruiz, A; Haworth, SJ; O'Neil, AB; Warhurst, DC | 1 |
| Bates, CJ; Bradley, AK; Fuller, NJ; Greenwood, AM; Greenwood, BM; Hayes, RJ; Tulloch, S | 1 |
| Boriga, DA; Brandling-Bennett, AD; Carter, JY; Howells, RE; Koech, DK; Nevill, CG; Watkins, WM | 1 |
| Breckenridge, AM; Mberu, EK; Szwandt, IS; Watkins, WM; Winstanley, PA | 1 |
| Chambo, O; Curtis, CF; Hills, E; Mbwana, H; Trigg, JK; Watkins, W | 1 |
| Amradee, S; Chinwongprom, K; Kyle, DE; Looareesuwan, S; Watkins, WM; White, NJ; Wilairatana, P | 1 |
| Amukoye, E; Hatcher, J; Lowe, B; Marsh, K; Minyiri, G; Mosobo, M; Ngumbao, E; Snow, RW; Ton, M; Watkins, WM; Winstanley, PA | 1 |
| Curtis, J; Duraisingh, MT; Warhurst, DC | 1 |
| Curtis, J; Maxwell, CA; Ortelli, F; Watkins, WM | 1 |
| Hopkins Sibley, C; Mberu, EK; Monks, SA; Nduati, E; Nzila, AM; Watkins, WM; Winstanley, PA | 1 |
| Hills, E; Mberu, E; Mutabingwa, T; Nduati, E; Nzila, A; Watkins, W; Winstanley, P | 1 |
| Winstanley, P | 1 |
| Chimpeni, P; Cortese, JF; Dzinjalamala, FK; Kamwendo, DD; Kublin, JG; Lescano, AG; Malkin, EM; Martino, LM; Molyneux, ME; Mukadam, RA; Plowe, CV; Rogerson, SJ; Taylor, TE; Winstanley, PA | 1 |
| Chimpeni, P; Hatcher, J; Kublin, JG; Marsh, K; Molyneux, ME; Plowe, CV; Sulo, J; Taylor, TE; Watkins, WM; Winstanley, PA | 1 |
| Greenwood, B; Lang, T | 1 |
| Carneiro, IA; Chambo, W; Curtis, CF; Magogo, F; Maxwell, CA; Mwaimu, M | 1 |
| Zimmerman, PA | 1 |
| Imwong, M; Looareesuwan, S; Wilairatana, P | 1 |
| Alloueche, A; Bailey, W; Barton, S; Bwika, J; Chimpeni, P; Falade, CO; Fehintola, FA; Horton, J; Jaffar, S; Kanyok, T; Kremsner, PG; Kublin, JG; Lang, T; Missinou, MA; Mkandala, C; Oduola, AM; Premji, Z; Robertson, L; Sowunmi, A; Ward, SA; Winstanley, PA | 1 |
| Bukirwa, H; Critchley, J; Garner, P | 1 |
| Alloueche, A; Bates, SJ; Bwika, J; Happi, TC; Kremsner, PG; Kublin, JG; Premji, Z; Sibley, CH; Watkins, WM; Winstanley, PA | 1 |
| A Clode, S; Clark, RL; Gaunt, I; Ward, SA; White, TE; Winstanley, P | 1 |
| Peters, W; Robinson, BL; Stewart, LB | 2 |
| Garner, P; Jones, K; Taylor-Robinson, D | 1 |
| Kamau, EM; Nduati, EW | 1 |
| Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P | 1 |
| Biagini, GA; Edwards, G | 1 |
| Hasan, MA; Klinkenberg, E; Leslie, T; Mayan, MI; Rowland, M; Safi, MH; Whitty, CJ | 1 |
| Nyunt, MM; Plowe, CV | 1 |
| Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C | 1 |
| Adjuik, M; Amenga-Etego, S; Asante, KP; Chandramohan, D; Dosoo, DK; Greenwood, B; Gyapong, J; Owusu, R; Owusu-Agyei, S | 1 |
| Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A | 1 |
| Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG | 1 |
| Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA | 1 |
| Agbenyega, T; Awobusuyi, J; Carter, N; Dicko, A; Duparc, S; Goh, LE; Greenwood, B; Harrell, E; Ndububa, DA; Pamba, A; Pitmang, S; Tiono, AB; Ward, SA; Winstanley, PA | 1 |
| Clark, RL; Gristwood, WE; Harrell, AW; Lewsley, R; Wilson, R | 1 |
| Bardsley, B; Barry, SJ; Drozdz, MA; Hancock, SA; Okafo, GN; Szafran, MM | 1 |
5 review(s) available for dapsone and chlorproguanil
| Article | Year |
|---|---|
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines | 2020 |
Studies on anti-folate antimalarials in east Africa.
Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 1999 |
Chlorproguanil-dapsone for treating uncomplicated malaria.
Topics: Adult; Antimalarials; Child; Dapsone; Drug Combinations; Humans; Malaria; Proguanil; Randomized Controlled Trials as Topic | 2004 |
Malaria: uncomplicated, caused by Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Proguanil; Pyrimethamine; Sesquiterpenes; Sulfadoxine | 2005 |
Resisting resistance: dealing with the irrepressible problem of malaria.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria; Proguanil; Sesquiterpenes | 2006 |
14 trial(s) available for dapsone and chlorproguanil
| Article | Year |
|---|---|
The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children.
Topics: Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Erythrocyte Indices; Erythrocytes; Folic Acid; Gambia; Hematocrit; Humans; Infant; Leukocyte Count; Placebos; Proguanil; Pyrimethamine | 1988 |
Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study.
Topics: Animals; Dapsone; Drug Therapy, Combination; Humans; Kenya; Malaria; Pilot Projects; Plasmodium falciparum; Proguanil | 1988 |
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria.
Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine | 1997 |
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.
Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Genes, Protozoan; Genetic Variation; Genotype; Humans; Isoleucine; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sulfadoxine | 1998 |
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind Method; Drug Combinations; Drug Resistance, Bacterial; Humans; Infant; Malaria, Falciparum; Mutation; Proguanil; Prospective Studies; Pyrimethamine; Sensitivity and Specificity; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure | 2002 |
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.
Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; Drug Therapy, Combination; Female; Hemoglobinometry; Humans; Infant; Kenya; Malaria, Falciparum; Malawi; Male; Proguanil; Pyrimethamine; Recurrence; Retreatment; Sulfadoxine; Survival Rate | 2002 |
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.
Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Methemoglobin; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2004 |
Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial.
Topics: Adolescent; Adult; Afghanistan; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Female; Folic Acid Antagonists; Humans; Malaria, Vivax; Male; Middle Aged; Pakistan; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2007 |
A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Rural Health; Rwanda; Treatment Outcome | 2008 |
An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Infant; Lumefantrine; Malaria; Male; Polymerase Chain Reaction; Proguanil; Treatment Outcome | 2008 |
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Oxidants; Polymorphism, Genetic; Proguanil; Pyrimethamine; Sulfadoxine | 2008 |
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Gambia; Humans; Malaria, Falciparum; Malawi; Male; Middle Aged; Parasitic Sensitivity Tests; Proguanil; Time Factors | 2009 |
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Dapsone; Double-Blind Method; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Male; Patient Compliance; Proguanil; Treatment Outcome | 2009 |
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Africa South of the Sahara; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Therapy, Combination; Female; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Proguanil; Time Factors | 2009 |
21 other study(ies) available for dapsone and chlorproguanil
| Article | Year |
|---|---|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Dapsone in low doses prevents Pneumocystis carinii pneumonia in the rat model.
Topics: Administration, Oral; Animals; Dapsone; Diet; Disease Models, Animal; Immune Tolerance; Male; Pneumonia, Pneumocystis; Proguanil; Random Allocation; Rats; Rats, Inbred Strains; Triazines | 1991 |
In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs.
Topics: Animals; Dapsone; Dihydropteroate Synthase; Drug Combinations; Drug Synergism; Folic Acid Antagonists; Granulocytes; Hematopoietic Stem Cells; Humans; Plasmodium falciparum; Proguanil | 1995 |
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone.
Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Infant; Malaria, Falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania | 1997 |
Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand.
Topics: Adolescent; Adult; Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Pilot Projects; Plasmodium falciparum; Proguanil; Thailand; Treatment Outcome | 1997 |
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.
Topics: Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Peptide Synthases; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 2000 |
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania | 2001 |
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria.
Topics: Antimalarials; Artemisinins; Clinical Trials, Phase III as Topic; Dapsone; Drug Approval; Drug Combinations; Drug Therapy, Combination; Health Services Accessibility; Humans; Malaria, Falciparum; Proguanil; Sesquiterpenes | 2001 |
The development of Lapdap, an affordable new treatment for malaria.
Topics: Animals; Antimalarials; Child; Clinical Trials as Topic; Dapsone; Drug Approval; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Proguanil; Time Factors; United Kingdom | 2003 |
Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets.
Topics: Altitude; Animals; Anopheles; Antigens, Protozoan; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Humans; Incidence; Infant; Insecticides; Malaria, Falciparum; Plasmodium falciparum; Prevalence; Proguanil; Protective Devices; Pyrethrins; Secondary Prevention; Tanzania | 2003 |
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets.
Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Insecticides; Malaria, Falciparum; Mosquito Control; Mutation; Plants; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 2003 |
Chlorproguanil-dapsone for malaria in Africa.
Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 2004 |
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.
Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Protozoan; Humans; Kenya; Malaria, Falciparum; Malawi; Molecular Epidemiology; Mutation, Missense; Nigeria; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Tetrahydrofolate Dehydrogenase | 2004 |
Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Embryonic Development; Female; Fetal Development; Pregnancy; Proguanil; Rabbits; Rats; Rats, Sprague-Dawley; Sesquiterpenes | 2004 |
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combination; Folic Acid Antagonists; Malaria, Falciparum; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Sesquiterpenes; Triazines | 2004 |
The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Rodent Diseases; Sesquiterpenes | 2005 |
Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.
Topics: Animals; Antimalarials; Atovaquone; Dapsone; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Naphthoquinones; Plasmodium falciparum; Proguanil; Triazines | 2006 |
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Proguanil; Prospective Studies; Triazines | 2006 |
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Global Health; Half-Life; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine | 2007 |
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.
Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Artesunate; Autoradiography; Dapsone; Female; Fetus; Male; Pregnancy; Proguanil; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2010 |
Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets.
Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dapsone; Drug Combinations; Drug Stability; Drug Therapy, Combination; Hot Temperature; Humans; Humidity; Magnetic Resonance Spectroscopy; Malaria, Falciparum; Mass Spectrometry; Proguanil; Tablets | 2011 |