dapivirine has been researched along with rilpivirine in 11 studies
| Studies (dapivirine) | Trials (dapivirine) | Recent Studies (post-2010) (dapivirine) | Studies (rilpivirine) | Trials (rilpivirine) | Recent Studies (post-2010) (rilpivirine) |
|---|---|---|---|---|---|
| 196 | 64 | 160 | 580 | 93 | 513 |
| Protein | Taxonomy | dapivirine (IC50) | rilpivirine (IC50) |
|---|---|---|---|
| Gag-Pol polyprotein | HIV-1 M:B_HXB2R | 0.068 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 6.1612 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 1.7406 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 2.3635 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.2818 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.3363 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.5 | |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | 0.0759 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Andries, K; Arnold, E; Bohets, H; Clark, AD; Daeyaert, F; Das, K; de Béthune, MP; De Clerck, F; de Jonge, M; De Knaep, F; Frenkel, YV; Guillemont, J; Heeres, J; Hughes, SH; Janssen, PA; Koymans, L; Kukla, M; Lampo, A; Lewi, PJ; Ludovici, D; Medaer, B; Pasquier, E; Pauwels, R; Stoffels, P; Vinkers, M; Williams, P | 1 |
| Arnold, E; Clark, AD; Das, K; Frenkel, YV; Janssen, PA; Lewi, PJ; Wang, YH | 1 |
| Chen, CH; Jiang, S; Lai, W; Lee, KH; Lu, H; Qin, B; Tian, X; Xie, L | 1 |
| Anderson, KS; Arnold, E; Bauman, JD; Bollini, M; Cisneros, JA; Das, K; Frey, KM; Jorgensen, WL; Spasov, KA | 1 |
| Anderson, KS; Bollini, M; Cisneros, JA; Jorgensen, WL; Spasov, KA | 1 |
| Ariën, KK; De Winter, H; Franck, P; Heeres, J; Lewi, P; Maes, BU; Michiels, J; Sergeyev, S; Vande Velde, CM; Vanham, G; Yadav, AK | 1 |
| Jorgensen, WL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Colby-Germinario, SP; Han, Y; Huang, W; Oliveira, M; Petropoulos, CJ; Quan, Y; Wainberg, MA; Xu, HT | 1 |
| McGowan, I | 1 |
| Giacobbi, NS; Sluis-Cremer, N | 1 |
2 review(s) available for dapivirine and rilpivirine
| Article | Year |
|---|---|
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Topics: Administration, Oral; Anti-HIV Agents; Biological Availability; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Genome, Viral; HIV; HIV Infections; Humans; Interdisciplinary Communication; Models, Molecular; Molecular Structure; Mutation; Nitriles; Pyrimidines; Rilpivirine | 2005 |
An overview of antiretroviral pre-exposure prophylaxis of HIV infection.
Topics: Adenine; Anti-HIV Agents; Cyclohexanes; Drug Resistance, Viral; Female; HIV Infections; Humans; Male; Maraviroc; Medication Adherence; Nitriles; Organophosphonates; Pre-Exposure Prophylaxis; Pyridones; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Triazoles | 2014 |
9 other study(ies) available for dapivirine and rilpivirine
| Article | Year |
|---|---|
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
Topics: Absorption; Administration, Oral; Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Gastrointestinal Tract; Half-Life; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Light; Microscopy, Electron, Transmission; Models, Biological; Pyrimidines; Rats; Reverse Transcriptase Inhibitors; Scattering, Radiation; Solutions; Triazines | 2005 |
Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Pyridines; Structure-Activity Relationship | 2009 |
Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility.
Topics: Anti-HIV Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Molecular Structure; Pyrimidines; Solubility; Structure-Activity Relationship | 2013 |
Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.
Topics: Anti-HIV Agents; Cell Line, Transformed; Cell Proliferation; Dose-Response Relationship, Drug; HIV-1; Humans; Hydrazines; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Solubility; Structure-Activity Relationship | 2013 |
2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.
Topics: Aniline Compounds; Anti-HIV Agents; Cell Line; Dose-Response Relationship, Drug; Fluorobenzenes; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Pyridines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2016 |
Computer-aided discovery of anti-HIV agents.
Topics: Anti-HIV Agents; Computer-Aided Design; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; T-Lymphocytes | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors.
Topics: Alkynes; Amino Acid Substitution; Benzoxazines; Cyclopropanes; Delavirdine; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; HEK293 Cells; HIV Reverse Transcriptase; HIV-1; Humans; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Nevirapine; Nitriles; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Virus Replication | 2013 |
Topics: Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; Humans; Pyridines; Pyrimidines; Reproductive Tract Infections; Reverse Transcriptase Inhibitors; Rilpivirine; Urea | 2017 |