dapivirine has been researched along with etravirine in 19 studies
| Studies (dapivirine) | Trials (dapivirine) | Recent Studies (post-2010) (dapivirine) | Studies (etravirine) | Trials (etravirine) | Recent Studies (post-2010) (etravirine) |
|---|---|---|---|---|---|
| 196 | 64 | 160 | 572 | 90 | 321 |
| Protein | Taxonomy | dapivirine (IC50) | etravirine (IC50) |
|---|---|---|---|
| Chain A, Reverse transcriptase/ribonuclease H | HIV-1 M:B_HXB2R | 0.0021 | |
| Chain B, p51 RT | HIV-1 M:B_HXB2R | 0.0021 | |
| Chain A, Reverse transcriptase/ribonuclease H | HIV-1 M:B_HXB2R | 0.0021 | |
| Chain B, p51 RT | HIV-1 M:B_HXB2R | 0.0021 | |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | 5.1 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.025 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 7.6 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.019 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.032 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.017 | |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | 0.37 | |
| Cruzipain | Trypanosoma cruzi | 4 | |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | 8.5 | |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 0.01 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.097 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.01 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.01 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.01 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.01 | |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | 0.2711 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.01 | |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | 7.8 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.01 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 6 | |
| Reverse transcriptase | Human immunodeficiency virus 1 | 0.0186 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Andries, K; Arnold, E; Azijn, H; Daeyaert, FF; Das, K; de Béthune, MP; De Corte, BL; de Jonge, MR; Heeres, J; Ho, CY; Janssen, PA; Kavash, RW; Koymans, LM; Kukla, MJ; Lewi, PJ; Lichtenstein, MA; Ludovici, DW; Pauwels, R; Van Aken, KJ; Ye, H | 1 |
| Andries, K; Arnold, E; Boyer, PL; Clark, AD; Clark, P; Daeyaert, F; Das, K; De Béthune, MP; De Corte, B; De Jonge, MR; Heeres, J; Ho, CY; Hughes, SH; Janssen, PA; Kavash, RW; Koymans, LM; Kukla, MJ; Lewi, PJ; Lichtenstein, MA; Ludovici, DW; Pauwels, R; Vinkers, HM; Ye, H | 1 |
| De Corte, BL | 1 |
| Arnold, E; Clark, AD; Das, K; Frenkel, YV; Janssen, PA; Lewi, PJ; Wang, YH | 1 |
| Bharadwaj, A; Thakur, A; Thakur, M; Thakur, S | 1 |
| Chen, FE; Liang, YH | 1 |
| Chen, CH; Jiang, S; Lai, W; Lee, KH; Lu, H; Qin, B; Tian, X; Xie, L | 1 |
| Bar-Magen, T; Brenner, BG; Oliveira, M; Quan, Y; Schader, SM; Wainberg, MA; Xu, H | 1 |
| Bar-Magen, T; Oliveira, M; Quan, Y; Schader, SM; Wainberg, MA; Xu, HT | 1 |
| Anderson, KS; Bollini, M; Cisneros, JA; Jorgensen, WL; Spasov, KA | 1 |
| Collu, G; Giliberti, G; La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB; Sanna, G | 1 |
| Ariën, KK; Augustyns, K; Cos, P; Dirié, B; Heeres, J; Joossens, J; Lewi, PJ; Lyssens, S; Maes, L; Michiels, J; Van der Veken, P; Vanham, G; Venkatraj, M | 1 |
| Jorgensen, WL | 1 |
| Gu, SX; Ju, XL; Liu, GY; Lu, HH; Zhu, YY | 1 |
| Armijos Rivera, JI; Badia, R; Cirilli, R; Crespan, E; Esté, JA; Forgione, M; Hailu, GS; Kirillov, IA; Lucidi, A; Maga, G; Mai, A; Nawrozkij, MB; Panella, C; Patsilinakos, A; Ragno, R; Riveira-Muñoz, E; Rotili, D; Tomaselli, D; Yablokov, AS | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Tarby, CM | 1 |
| Fransen, K; Garcia, S; Janssen, CG; Janssen, PA; Kestens, L; Lewi, PJ; Njai, HF; Vanham, G | 1 |
| Colby-Germinario, SP; Han, Y; Huang, W; Oliveira, M; Petropoulos, CJ; Quan, Y; Wainberg, MA; Xu, HT | 1 |
3 review(s) available for dapivirine and etravirine
| Article | Year |
|---|---|
From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Topics: Anti-HIV Agents; Benzodiazepines; Drug Design; Drug Resistance, Viral; HIV Reverse Transcriptase; Imidazoles; Nitriles; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors | 2005 |
Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2018 |
Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Clinical Trials as Topic; Coumarins; HIV Reverse Transcriptase; Humans; Imidazoles; Molecular Structure; Nitriles; Patents as Topic; Pyranocoumarins; Pyridazines; Pyrimidines; Quinazolines; Reverse Transcriptase Inhibitors; Sulfur Compounds | 2004 |
16 other study(ies) available for dapivirine and etravirine
| Article | Year |
|---|---|
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Topics: Anti-HIV Agents; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; HIV-1; Inhibitory Concentration 50; Mutation; Nitriles; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2001 |
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 varian
Topics: Anti-HIV Agents; Crystallography, X-Ray; Drug Resistance, Viral; HIV Reverse Transcriptase; Models, Molecular; Mutation; Nitriles; Protein Conformation; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors | 2004 |
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
Topics: Absorption; Administration, Oral; Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Gastrointestinal Tract; Half-Life; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Light; Microscopy, Electron, Transmission; Models, Biological; Pyrimidines; Rats; Reverse Transcriptase Inhibitors; Scattering, Radiation; Solutions; Triazines | 2005 |
SAR and QSAR studies: modelling of new DAPY derivatives.
Topics: Models, Molecular; Pyrimidines; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2008 |
QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains.
Topics: HIV-1; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Mutation, Missense; Pyrimidines; Quantitative Structure-Activity Relationship | 2009 |
Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Pyridines; Structure-Activity Relationship | 2009 |
Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine.
Topics: Anti-HIV Agents; Drug Resistance, Viral; HIV Reverse Transcriptase; Microbial Sensitivity Tests; Mutation; Nitriles; Pyridazines; Pyrimidines; Recombinant Proteins; Reverse Transcriptase Inhibitors | 2009 |
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.
Topics: Anti-HIV Agents; Base Sequence; Cell Line; DNA, Viral; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Recombinant Proteins; Reverse Transcriptase Inhibitors; Virus Replication | 2010 |
Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.
Topics: Anti-HIV Agents; Cell Line, Transformed; Cell Proliferation; Dose-Response Relationship, Drug; HIV-1; Humans; Hydrazines; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Solubility; Structure-Activity Relationship | 2013 |
Synthesis of novel fluoro analogues of MKC442 as microbicides.
Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil | 2014 |
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Parasitic Sensitivity Tests; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense | 2014 |
Computer-aided discovery of anti-HIV agents.
Topics: Anti-HIV Agents; Computer-Aided Design; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; T-Lymphocytes | 2016 |
Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones.
Topics: Anti-HIV Agents; Binding Sites; Cell Line; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Mutation; Protein Structure, Tertiary; Pyrimidinones; Stereoisomerism; Structure-Activity Relationship | 2019 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells.
Topics: CD4-Positive T-Lymphocytes; Coculture Techniques; Dendritic Cells; Dose-Response Relationship, Drug; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Leukocytes, Mononuclear; Nitriles; Pyridazines; Pyrimidines; Virus Replication | 2005 |
Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors.
Topics: Alkynes; Amino Acid Substitution; Benzoxazines; Cyclopropanes; Delavirdine; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; HEK293 Cells; HIV Reverse Transcriptase; HIV-1; Humans; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Nevirapine; Nitriles; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Virus Replication | 2013 |