dapivirine has been researched along with darunavir in 5 studies
| Studies (dapivirine) | Trials (dapivirine) | Recent Studies (post-2010) (dapivirine) | Studies (darunavir) | Trials (darunavir) | Recent Studies (post-2010) (darunavir) |
|---|---|---|---|---|---|
| 196 | 64 | 160 | 1,148 | 224 | 780 |
| Protein | Taxonomy | dapivirine (IC50) | darunavir (IC50) |
|---|---|---|---|
| Chain A, HIV-1 protease | Human immunodeficiency virus 1 | 0.0028 | |
| Chain B, HIV-1 protease | Human immunodeficiency virus 1 | 0.0028 | |
| Chain A, HIV-1 protease | Human immunodeficiency virus 1 | 0.0028 | |
| Chain B, HIV-1 protease | Human immunodeficiency virus 1 | 0.0028 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 6.6 | |
| Protease | Human immunodeficiency virus 1 | 0.063 | |
| Protease | Human immunodeficiency virus 1 | 0.0014 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Brochard, P; Dereuddre-Bosquet, N; Desjardins, D; Feyaerts, M; Lagatie, O; Le Grand, R; Malcolm, RK; Murphy, DJ; Perrot, L; Pruvost, A; van Roey, J; Vanhooren, L | 1 |
| Cuppone, AM; De Falco, G; Ekeruche-Makinde, J; Hijazi, K; Hold, GL; Iannelli, F; Kelly, CG; Pozzi, G; Shattock, R; Smith, K; Stincarelli, MA | 1 |
| Berry, S; Ekeruche-Makinde, J; El-Omar, EM; Frank, B; Gwozdz, G; Hijazi, K; Hold, GL; Iannelli, F; Kelly, C; Mukhopadhya, I; Murray, GI; Pozzi, G; Shattock, R; Thomson, J | 1 |
| Boyd, P; Caldwell, A; Dereuddre-Bosquet, N; Desjardins, D; Kelly, C; Le Grand, R; Malcolm, RK; Murphy, DJ; Stimmer, L; van Roey, J | 1 |
5 other study(ies) available for dapivirine and darunavir
| Article | Year |
|---|---|
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.
Topics: Animals; Anti-HIV Agents; Body Fluids; Cervix Uteri; Contraceptive Devices, Female; Darunavir; Disease Models, Animal; Disease Transmission, Infectious; Drug Therapy, Combination; Female; HIV Infections; Humans; Inhibitory Concentration 50; Macaca; Pre-Exposure Prophylaxis; Pyrimidines; Rectum; Sulfonamides; Uterus; Vagina | 2014 |
Expression of Genes for Drug Transporters in the Human Female Genital Tract and Modulatory Effect of Antiretroviral Drugs.
Topics: Adult; Anti-HIV Agents; Biological Transport; Cell Line; Cell Line, Tumor; Cervix Uteri; Darunavir; Drug Resistance; Drug Synergism; Female; Gene Expression Regulation; Humans; Membrane Transport Proteins; Middle Aged; Organ Culture Techniques; Pyrimidines; Tenofovir; Vagina | 2015 |
Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.
Topics: Aged; Anti-Infective Agents; Caco-2 Cells; Darunavir; Epithelial Cells; Female; Gene Expression; Gene Expression Profiling; Humans; Intestinal Mucosa; Male; Membrane Transport Proteins; Middle Aged; Pyrimidines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tenofovir | 2016 |
Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques.
Topics: Animals; Anti-HIV Agents; Contraceptive Devices, Female; Darunavir; Drug Combinations; Drug Liberation; Female; Macaca fascicularis; Pyrimidines | 2018 |