dalteparin and ximelagatran

dalteparin has been researched along with ximelagatran in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's23 (88.46)29.6817
2010's3 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berkowitz, SD; Colwell, CW; Francis, CW; Ginsberg, JS; Heit, JA; Peters, G; Whipple, J1
Arfwidsson, AC; Bylock, A; Eriksson, BI; Eriksson, UG; Fager, G; Frison, L; Gustafsson, D; Kälebo, P1
Eriksson, UG; Fager, G; Frison, L; Gustafsson, D; Mattsson, C; Sarich, TC; Wolzt, M1
Andersson, C; Bylock, A; Eriksson, BI; Frison, L; Gustafsson, D; Larson, G; Lindahl, TL; Wåhlander, K1
Carlsson, S; Elg, M; Mattsson, C1
Bergqvist, D; Bylock, A; Dahl, OE; Eriksson, BI; Eriksson, UG; Frison, L; Gustafsson, D; Kälebo, P; Lindbratt, S; Welin, L1
Agnelli, G; Cohen, AT; Dahl, OE; Eriksson, BI; Eskilson, C; Frison, L; Mouret, P; Nylander, I; Ogren, M; Rosencher, N1
Andersson, M; Elg, S; Eriksson, UG; Fager, G; Gustafsson, D; Mattsson, C; Sarich, TC; Schmidt, A; Wollbratt, M; Wolzt, M1
Boström, SL; Hansson, GF; Kjaer, M; Sarich, TC1
Eriksson, H; Frison, L; Gustafsson, D; Schulman, S; Wåhlander, K; Welin, LT1
Berkowitz, SD; Colwell, CW; Davidson, BL; Francis, CW; Ginsberg, JS; Lieberman, JR; Lotke, PA; McElhattan, JL; Neubauer, J; Peters, GR1
Agnelli, G; Andersson, M; Cohen, AT; Dahl, OE; Eriksson, BI; Eskilson, C; Freij, A; Kälebo, P; Lassen, MR; Mouret, P; Panfilov, S; Rosencher, N1
Evans, HC; Faulds, D; Perry, CM1
Boström, SL; Hansson, GF; Sarich, TC; Wolzt, M1
Agnelli, G; Andersson, M; Cohen, A; Dahl, O; Eriksson, BI; Mouret, P; Panfilov, S; Rosencher, N1
Pokrovskaia, EV1
Cimminiello, C; Planès, A; Samama, MM1
Egorova, TD; Fedorova, AIu; Kolosova, KIu; Nesterova, SG; Ol'binskaia, LI1
Harenberg, J; Jörg, I; Weiss, C1
Ma, Q1
Agnelli, G; Andersson, M; Bylock, A; Cohen, AT; Dahl, OE; Eriksson, BI; Mouret, P; Ogren, M; Panfilov, S; Rosencher, N1
Agnelli, G; Andersson, M; Bergqvist, D; Boberg, B; Bylock, A; Cohen, AT; Dahl, OE; Eriksson, BI; Jensen, E; Lassen, MR; Mouret, P; Rosencher, N1
Depasse, F; Heptinstall, S; Kunitada, S; Oursin, A; Samama, MM1
Burghaus, R; Coboeken, K; Gaub, T; Kuepfer, L; Lippert, J; Mueck, W; Sensse, A; Siegmund, HU; Weiss, W1
Chu, XC; Gao, JH; Ning, B; Wang, LL; Zhao, CX1

Reviews

3 review(s) available for dalteparin and ximelagatran

ArticleYear
Ximelagatran/Melagatran: a review of its use in the prevention of venous thromboembolism in orthopaedic surgery.
    Drugs, 2004, Volume: 64, Issue:6

    Topics: Anticoagulants; Azetidines; Benzylamines; Drug Interactions; Drug Therapy, Combination; Enoxaparin; Glycine; Humans; Orthopedic Procedures; Randomized Controlled Trials as Topic; Thrombin; Thromboembolism; Venous Thrombosis; Warfarin

2004
[Novel possibilities of antithrombotic therapy in patients with chronic heart failure].
    Kardiologiia, 2005, Volume: 45, Issue:12

    Topics: Anticoagulants; Azetidines; Benzylamines; Dalteparin; Double-Blind Method; Enoxaparin; Fibrinolytic Agents; Fondaparinux; Heart Failure; Humans; Multicenter Studies as Topic; Oligosaccharides; Placebos; Polysaccharides; Randomized Controlled Trials as Topic; Risk Factors; Thromboembolism; Thrombomodulin; Thrombosis; Time Factors; Venous Thrombosis

2005
Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty: A network meta-analysis.
    Medicine, 2017, Volume: 96, Issue:40

    Topics: Anticoagulants; Arthroplasty; Azetidines; Benzylamines; Dabigatran; Enoxaparin; Heparin; Heparin, Low-Molecular-Weight; Humans; Network Meta-Analysis; Postoperative Complications; Pulmonary Embolism; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Treatment Outcome; Venous Thromboembolism; Warfarin

2017

Trials

17 trial(s) available for dalteparin and ximelagatran

ArticleYear
Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study.
    Archives of internal medicine, 2001, Oct-08, Volume: 161, Issue:18

    Topics: Administration, Oral; Adult; Aged; Anticoagulants; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Dose-Response Relationship, Drug; Drug Administration Schedule; Enoxaparin; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Postoperative Complications; Prodrugs; Pulmonary Embolism; Thrombin; Treatment Outcome; Venous Thrombosis

2001
A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran, and its subcutaneous form, melagatran, compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I. MElagatran for THRombin inhibition in
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:2

    Topics: Administration, Oral; Adolescent; Aged; Aged, 80 and over; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Dalteparin; Female; Glycine; Humans; Incidence; Injections, Subcutaneous; Male; Middle Aged; Partial Thromboplastin Time; Postoperative Complications; Prodrugs; Safety; Sweden; Thrombin; Thromboembolism; Treatment Outcome; Venous Thrombosis

2002
Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects.
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:2

    Topics: Administration, Oral; Adult; Anticoagulants; Antithrombin III; Azetidines; Benzylamines; Dalteparin; Feedback; Humans; Male; Peptide Fragments; Peptide Hydrolases; Prothrombin; Thrombin

2002
Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery.
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:4

    Topics: Activated Protein C Resistance; Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Dalteparin; DNA Mutational Analysis; Double-Blind Method; Europe; Factor V; Female; Genetic Predisposition to Disease; Genotype; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Promoter Regions, Genetic; Prospective Studies; Prothrombin; Pulmonary Embolism; Risk Factors; Thrombophilia; Venous Thrombosis

2002
Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial.
    Lancet (London, England), 2002, Nov-09, Volume: 360, Issue:9344

    Topics: Adult; Aged; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Dalteparin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Prodrugs; Thromboembolism

2002
Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement.
    Thrombosis and haemostasis, 2003, Volume: 89, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Cause of Death; Double-Blind Method; Drug Administration Schedule; Enoxaparin; Female; Glycine; Hemorrhage; Humans; Injections, Subcutaneous; Male; Middle Aged; Postoperative Complications; Prodrugs; Prospective Studies; Pulmonary Embolism; Safety; Thrombin; Treatment Outcome; Venous Thrombosis

2003
Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects.
    Journal of the American College of Cardiology, 2003, Feb-19, Volume: 41, Issue:4

    Topics: Administration, Oral; Adult; Azetidines; Benzylamines; Dose-Response Relationship, Drug; Enoxaparin; Fibrinolytic Agents; Hirudins; Humans; Male; Platelet Activation; Recombinant Proteins; Reference Values; Thrombin

2003
Effects of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, and dalteparin on the endogenous thrombin potential in venous blood from healthy male subjects.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003, Volume: 14, Issue:5

    Topics: Administration, Oral; Adult; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Factor Xa Inhibitors; Glycine; Humans; Inhibitory Concentration 50; Injections, Subcutaneous; Male; Reference Values; Thrombin; Time Factors; Veins

2003
A randomized, controlled, dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute deep vein thrombosis: THRIVE I.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:1

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Leg; Male; Middle Aged; Phlebography; Prodrugs; Radionuclide Imaging; Treatment Outcome; Venous Thrombosis; Warfarin

2003
Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:10

    Topics: Administration, Oral; Aged; Anticoagulants; Arthroplasty, Replacement, Hip; Azetidines; Benzylamines; Double-Blind Method; Enoxaparin; Female; Hemorrhage; Hemostatics; Humans; Male; Middle Aged; Prodrugs; Random Allocation; Thrombin; Thromboembolism; Venous Thrombosis; Wound Healing

2003
The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: the EXPRESS study.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Double-Blind Method; Enoxaparin; Female; Glycine; Hemorrhage; Humans; Male; Middle Aged; Preoperative Care; Therapeutic Equivalency; Thrombin; Thromboembolism; Venous Thrombosis

2003
The inhibitory effect of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma.
    Thrombosis research, 2004, Volume: 113, Issue:1

    Topics: Administration, Oral; Adult; Anticoagulants; Area Under Curve; Azetidines; Benzylamines; Blood Coagulation Tests; Dose-Response Relationship, Drug; Enoxaparin; Hirudins; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Prodrugs; Safety; Thrombin; Time Factors

2004
Significantly lower need for blood transfusions associated with post-operatively initiated subcutaneous melagatran/oral ximelagatran compared with enoxaparin.
    Thrombosis and haemostasis, 2004, Volume: 92, Issue:2

    Topics: Administration, Oral; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Azetidines; Benzylamines; Blood Transfusion; Drug Therapy, Combination; Enoxaparin; Glycine; Humans; Logistic Models; Odds Ratio; Time Factors

2004
Incidence of recurrent venous thromboembolism of patients after termination of treatment with ximelagatran.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:3

    Topics: Administration, Oral; Anticoagulants; Arteries; Azetidines; Benzylamines; Drug Therapy, Combination; Enoxaparin; Follow-Up Studies; Germany; Hemorrhage; Humans; Incidence; International Normalized Ratio; Muscle, Skeletal; Prospective Studies; Recurrence; Retinal Vein Occlusion; Time Factors; Venous Thrombosis; Warfarin

2006
Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty.
    Pathophysiology of haemostasis and thrombosis, 2006, Volume: 35, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthroplasty; Aspirin; Azetidines; Benzylamines; Bleeding Time; Blood Loss, Surgical; Blood Transfusion; Double-Blind Method; Enoxaparin; Europe; Female; Humans; Lower Extremity; Male; Middle Aged; Platelet Aggregation Inhibitors; South Africa; Thrombosis

2006
Safety assessment of new antithrombotic agents: lessons from the EXTEND study on ximelagatran.
    Thrombosis research, 2009, Volume: 123, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Anticoagulants; Arthroplasty, Replacement, Hip; Azetidines; Benzylamines; Double-Blind Method; Enoxaparin; Female; Hip Fractures; Humans; Liver; Male; Middle Aged; Postoperative Complications; Time Factors; Venous Thromboembolism

2009
Comparison of a direct Factor Xa inhibitor, edoxaban, with dalteparin and ximelagatran: a randomised controlled trial in healthy elderly adults.
    Thrombosis research, 2010, Volume: 126, Issue:4

    Topics: Administration, Cutaneous; Administration, Oral; Aged; Anticoagulants; Antithrombins; Azetidines; Benzylamines; Blood Coagulation; Dalteparin; Factor Xa Inhibitors; Female; Humans; Male; Pyridines; Thiazoles; Thrombosis

2010

Other Studies

6 other study(ies) available for dalteparin and ximelagatran

ArticleYear
Effects of ximelagatran, the oral form of melagatran, in the treatment of caval vein thrombosis in conscious rats.
    Thrombosis research, 2002, Aug-15, Volume: 107, Issue:3-4

    Topics: Administration, Oral; Animals; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glycine; Hirudins; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Thrombosis; Venae Cavae

2002
[The first oral thrombin inhibitor. Competition to heparins and marcumar?].
    MMW Fortschritte der Medizin, 2003, Mar-06, Volume: 145, Issue:10

    Topics: Administration, Oral; Anticoagulants; Azetidines; Benzylamines; Clinical Trials as Topic; Enoxaparin; Fibrinolytic Agents; Glycine; Humans; Phenprocoumon; Placebos; Prodrugs; Thrombin; Thromboembolism; Thrombosis; Time Factors

2003
[Novel antithrombotic drugs. From the 19th Congress of the International Society on Thrombosis and Haemostasis].
    Kardiologiia, 2004, Volume: 44, Issue:3

    Topics: Adult; Age Factors; Aged; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Female; Fibrinolytic Agents; Fondaparinux; Humans; Male; Middle Aged; Multicenter Studies as Topic; Oligosaccharides; Placebos; Polysaccharides; Prodrugs; Pulmonary Embolism; Randomized Controlled Trials as Topic; Thromboembolism; Thrombomodulin; Time Factors; Warfarin

2004
Prevention of venous thromboembolism after orthopedic surgery: the EXPRESS study.
    Journal of thrombosis and haemostasis : JTH, 2004, Volume: 2, Issue:11

    Topics: Anticoagulants; Azetidines; Benzylamines; Clinical Trials as Topic; Dissent and Disputes; Enoxaparin; Glycine; Humans; Orthopedic Procedures; Therapeutic Equivalency; Thromboembolism; Treatment Outcome; Venous Thrombosis

2004
Development of oral anticoagulants.
    British journal of clinical pharmacology, 2007, Volume: 64, Issue:3

    Topics: Administration, Oral; Anticoagulants; Azetidines; Benzimidazoles; Benzylamines; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dabigatran; Drug Delivery Systems; Drug Design; Enoxaparin; Factor Xa Inhibitors; Humans; Morpholines; Postoperative Hemorrhage; Pyridines; Rivaroxaban; Thiophenes; Venous Thromboembolism; Venous Thrombosis; Warfarin

2007
Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.
    PloS one, 2011, Apr-22, Volume: 6, Issue:4

    Topics: Anticoagulants; Azetidines; Benzylamines; Blood Circulation; Blood Coagulation; Computer Simulation; Enoxaparin; Humans; Models, Biological; Morpholines; Naphthalenes; Partial Thromboplastin Time; Propionates; Rivaroxaban; Thiophenes; Translational Research, Biomedical; Treatment Outcome; Warfarin

2011