daidzein and dieckol

daidzein has been researched along with dieckol* in 1 studies

Other Studies

1 other study(ies) available for daidzein and dieckol

Article	Year
Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava. Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13 SARS-CoV 3CL(pro) plays an important role in viral replication. In this study, we performed a biological evaluation on nine phlorotannins isolated from the edible brown algae Ecklonia cava. The nine isolated phlorotannins (1-9), except phloroglucinol (1), possessed SARS-CoV 3CL(pro) inhibitory activities in a dose-dependently and competitive manner. Of these phlorotannins (1-9), two eckol groups with a diphenyl ether linked dieckol (8) showed the most potent SARS-CoV 3CL(pro) trans/cis-cleavage inhibitory effects (IC(50)s = 2.7 and 68.1 μM, respectively). This is the first report of a (8) phlorotannin chemotype significantly blocking the cleavage of SARS-CoV 3CL(pro) in a cell-based assay with no toxicity. Furthermore, dieckol (8) exhibited a high association rate in the SPR sensorgram and formed extremely strong hydrogen bonds to the catalytic dyad (Cys145 and His41) of the SARS-CoV 3CL(pro). Topics: Antiviral Agents; Benzofurans; Cysteine Proteases; Cysteine Proteinase Inhibitors; Humans; Molecular Docking Simulation; Phaeophyceae; Quantitative Structure-Activity Relationship; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus	2013

Article

Year

Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.

Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13

SARS-CoV 3CL(pro) plays an important role in viral replication. In this study, we performed a biological evaluation on nine phlorotannins isolated from the edible brown algae Ecklonia cava. The nine isolated phlorotannins (1-9), except phloroglucinol (1), possessed SARS-CoV 3CL(pro) inhibitory activities in a dose-dependently and competitive manner. Of these phlorotannins (1-9), two eckol groups with a diphenyl ether linked dieckol (8) showed the most potent SARS-CoV 3CL(pro) trans/cis-cleavage inhibitory effects (IC(50)s = 2.7 and 68.1 μM, respectively). This is the first report of a (8) phlorotannin chemotype significantly blocking the cleavage of SARS-CoV 3CL(pro) in a cell-based assay with no toxicity. Furthermore, dieckol (8) exhibited a high association rate in the SPR sensorgram and formed extremely strong hydrogen bonds to the catalytic dyad (Cys145 and His41) of the SARS-CoV 3CL(pro).

Topics: Antiviral Agents; Benzofurans; Cysteine Proteases; Cysteine Proteinase Inhibitors; Humans; Molecular Docking Simulation; Phaeophyceae; Quantitative Structure-Activity Relationship; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus

2013