dactinomycin and mitoxantrone

dactinomycin has been researched along with mitoxantrone in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199010 (32.26)18.7374
1990's5 (16.13)18.2507
2000's10 (32.26)29.6817
2010's5 (16.13)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Denny, WA; Feigon, J; Kearns, DR; Leupin, W1
Barrows, LR; Ireland, CM; Kokoshka, JM1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Akiyama, S; Baba, M; Furukawa, T; Nitanda, T; Okamoto, M; Sugimoto, Y; Wang, X1
Bu, X; Eleftheriou, A; Hayek, C; Parmar, A; Stewart, BW; Wakelin, LP1
Gibbons, S; Kaatz, GW; Zloh, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cold, S; Pfeiffer, P; Rose, C1
Ashley, SE; Hardy, JR; Jones, AL; Judson, IR; Powles, TJ1
Aloyo, MC; Morales, N; Sheardy, RD; Winkle, SA; Zambrano, TY1
Durr, FE; White, RJ1
Bartkowiak, J; Darzynkiewicz, Z; Kapuscinski, J; Melamed, MR1
Davies, SL; Davies, SM; Harris, AL; Hickson, ID1
Hamada, H; Ishida, Y; Minato, K; Ohtsu, T; Shimoyama, M; Sugimoto, Y; Tobinai, K; Tsuruo, T1
Ganapathi, R; Grabowski, D; Israel, M; Schmidt, H; Seshadri, R1
Baldi, A; Crespi, MD; Genovese, J; Ivanier, SE1
Bleumink, AR; Jensen, CG; Wilson, WR1
Himori, T; Ohnuma, T; Wakui, A1
Holland, JF; Richardson, CL; Roboz, J1
Behrens, CH; Behrens, DL; Chen, SF; Fredericks, JR; Kirshenbaum, MR; Papp, LM; Polkus, ST; Sipple, P; Stafford, MM; Sun, JH1
Cotter, TG; Knox, KA; McGahon, AJ; McKenna, SL; O'Gorman, DM1
Weiss, M1
Holguin, MH; Morgan, CD1
Peng, T; Wang, S; Yang, CF1
Abe, T; Goto, J; Hishinuma, T; Kobayashi, M; Mano, N; Okada, M; Takeuchi, T; Unno, M; Yamaguchi, H1
Pham, XH; Tran, NQ; Tuteja, N; Tuteja, R1
Berkowitz, RS; Elias, KM; Goldstein, DP; Horowitz, NS; Jareemit, N1

Reviews

3 review(s) available for dactinomycin and mitoxantrone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Cytotoxic treatment of metastatic breast cancer. Which drugs and drug combinations to use?
    Acta oncologica (Stockholm, Sweden), 1992, Volume: 31, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Epirubicin; Etoposide; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Mitomycin; Mitoxantrone; Neoplasm Metastasis; Vincristine

1992
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.
    Hematology/oncology clinics of North America, 2001, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Controlled Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Dactinomycin; Doxorubicin; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Randomized Controlled Trials as Topic; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine

2001

Trials

1 trial(s) available for dactinomycin and mitoxantrone

ArticleYear
A randomised trial comparing combination chemotherapy using mitomycin C, mitozantrone and methotrexate (3M) with vincristine, anthracycline and cyclophosphamide (VAC) in advanced breast cancer.
    British journal of cancer, 1991, Volume: 64, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dactinomycin; Female; Humans; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Mitoxantrone; Vincristine

1991

Other Studies

27 other study(ies) available for dactinomycin and mitoxantrone

ArticleYear
Interactions of antitumor drugs with natural DNA: 1H NMR study of binding mode and kinetics.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:4

    Topics: Antineoplastic Agents; Base Composition; Chemical Phenomena; Chemistry; DNA; Hydrogen Bonding; Intercalating Agents; Kinetics; Magnetic Resonance Spectroscopy; Structure-Activity Relationship

1984
Cell-based screen for identification of inhibitors of tubulin polymerization.
    Journal of natural products, 1996, Volume: 59, Issue:12

    Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured

1996
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.
    Molecular pharmacology, 2003, Volume: 63, Issue:1

    Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; CD4-Positive T-Lymphocytes; Cells, Cultured; Doxorubicin; Drug Resistance, Neoplasm; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Indoles; Lamivudine; Microbial Sensitivity Tests; Neoplasm Proteins; Reverse Transcriptase Inhibitors; Zidovudine

2003
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest.
    Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

    Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA, Superhelical; Electrophoresis, Agar Gel; Flow Cytometry; G2 Phase; Guanine; Humans; Hydrogen Bonding; Intercalating Agents; Kinetics; Mitosis; Structure-Activity Relationship

2003
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
    Bioorganic & medicinal chemistry letters, 2004, Feb-23, Volume: 14, Issue:4

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:11

    Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
Enhanced reactivity of a B-Z junction for cleavage by the restriction enzyme MboI.
    Biochemistry, 1991, Nov-05, Volume: 30, Issue:44

    Topics: Base Sequence; Binding Sites; Cobalt; Dactinomycin; Deoxyribonucleases, Type II Site-Specific; DNA; Ethidium; Kinetics; Macromolecular Substances; Mitoxantrone; Molecular Sequence Data; Nucleic Acid Conformation

1991
Development of mitoxantrone.
    Investigational new drugs, 1985, Volume: 3, Issue:2

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Cell Line; Chemistry, Pharmaceutical; Colonic Neoplasms; Cricetinae; Cricetulus; Dactinomycin; DNA; Doxorubicin; Drug Evaluation; Drug Synergism; Female; Heart; Humans; Intercalating Agents; Interphase; Leukemia L1210; Leukemia P388; Melanoma; Mice; Mitoxantrone; RNA; RNA, Double-Stranded; Structure-Activity Relationship

1985
Selective displacement of nuclear proteins by antitumor drugs having affinity for nucleic acids.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:13

    Topics: Animals; Antineoplastic Agents; Chromatin; Dactinomycin; Doxorubicin; Ethidium; Intercalating Agents; Kinetics; Ligands; Liver; Mitoxantrone; Nuclear Proteins; Plicamycin; Rats; Rats, Nude

1989
Isolation of two Chinese hamster ovary cell mutants hypersensitive to topoisomerase II inhibitors and cross-resistant to peroxides.
    Cancer research, 1989, Aug-15, Volume: 49, Issue:16

    Topics: Amsacrine; Animals; Cell Line; Cell Survival; Cricetinae; Dactinomycin; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Female; Mitoxantrone; Mutation; Ovary; Teniposide; Topoisomerase II Inhibitors

1989
Multidrug resistance in cultured human leukemia and lymphoma cell lines detected by a monoclonal antibody, MRK16.
    Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:10

    Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dactinomycin; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Gene Expression; Humans; Leukemia; Lymphoma; Membrane Glycoproteins; Mitoxantrone; RNA, Messenger; Tumor Cells, Cultured; Vinblastine; Vincristine; Vindesine

1989
Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells.
    Biochemical and biophysical research communications, 1985, Sep-16, Volume: 131, Issue:2

    Topics: Aminoacridines; Amsacrine; Animals; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line; Dactinomycin; Daunorubicin; DNA; Doxorubicin; Drug Interactions; Drug Resistance; Leukemia P388; Leukemia, Experimental; Menogaril; Mice; Mitoxantrone; Naphthacenes; Nogalamycin; Trifluoperazine

1985
Mitoxantrone affects topoisomerase activities in human breast cancer cells.
    Biochemical and biophysical research communications, 1986, Apr-29, Volume: 136, Issue:2

    Topics: Anthraquinones; Breast Neoplasms; Cell Line; Dactinomycin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Doxorubicin; Enzyme Induction; Humans; Kinetics; Mitoxantrone; Puromycin; Topoisomerase II Inhibitors

1986
Effects of amsacrine and other DNA-intercalating drugs on nuclear and nucleolar structure in cultured V79 Chinese hamster cells and PtK2 rat kangaroo cells.
    Cancer research, 1985, Volume: 45, Issue:2

    Topics: Aminacrine; Aminoacridines; Amsacrine; Animals; Anthraquinones; Cell Nucleolus; Cell Nucleus; Cell Survival; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Dactinomycin; Dipodomys; Doxorubicin; Fibroblasts; Intercalating Agents; Kidney; Microscopy, Electron; Mitoxantrone

1985
[Differential cell growth inhibition and terminal differentiation induction by chemotherapeutic agents of a human acute myelogenous leukemia cell line (HL-60) in vitro].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:8

    Topics: Anthraquinones; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Phagocytes; Thioguanine; Vincristine

1984
Competitive fluorescence polarization study of the binding of 1,4-dihydroxy-5,8-bis[(2-[(2-hydroxyethyl) amino] ethyl]amino] 9-10-anthracenedione to DNA.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 27, Issue:3

    Topics: Acridine Orange; Anthracenes; Antineoplastic Agents; Binding, Competitive; Chemical Phenomena; Chemistry; Dactinomycin; Daunorubicin; DNA; DNA, Bacterial; Doxorubicin; Fluorescence Polarization; Micrococcus; Mitoxantrone

1980
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
    Cancer research, 1994, Apr-15, Volume: 54, Issue:8

    Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Isoquinolines; KB Cells; Kinetics; Leucine; Leukemia L1210; Leukemia P388; Mammary Neoplasms, Experimental; Melanoma; Melanoma, Experimental; Mesylates; Mice; Mitoxantrone; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured; Uridine

1994
Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
    Leukemia, 2000, Volume: 14, Issue:4

    Topics: Androstadienes; Antineoplastic Agents; Apigenin; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Camptothecin; Carrier Proteins; Cell Survival; Chromones; Cycloheximide; Dactinomycin; Dimerization; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Flavonoids; Genes, bcl-2; HL-60 Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Wortmannin

2000
Chemotherapeutic stress mediated by certain antitumor antibiotics induces an atypical CD69+ surface phenotype in peripheral T-lymphocytes.
    International immunopharmacology, 2002, Volume: 2, Issue:2-3

    Topics: Antibiotics, Antineoplastic; Antibodies, Blocking; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bleomycin; Dactinomycin; Dose-Response Relationship, Drug; Humans; Immunophenotyping; Lectins, C-Type; Mannitol; Mitomycin; Mitoxantrone; Plicamycin; Spectrometry, Fluorescence; Stress, Physiological; T-Lymphocytes; Thymidine

2002
Investigation on the interaction of DNA and electroactive ligands using a rapid electrochemical method.
    Journal of biochemical and biophysical methods, 2003, Mar-28, Volume: 55, Issue:3

    Topics: Animals; Binding Sites; Cattle; Dactinomycin; DNA; Electrochemistry; Fishes; Intercalating Agents; Ligands; Macromolecular Substances; Male; Mitoxantrone; Models, Chemical; Protein Binding; Spermatozoa

2003
Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.
    Cancer letters, 2008, Feb-18, Volume: 260, Issue:1-2

    Topics: Antineoplastic Agents; Camptothecin; Chenodeoxycholic Acid; Dactinomycin; Docetaxel; Fluorescent Dyes; Humans; Irinotecan; Kinetics; Lysine; Mitoxantrone; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Signal Processing, Computer-Assisted; Solute Carrier Organic Anion Transporter Family Member 1B3; Spectrometry, Fluorescence; Taxoids; Transfection

2008
Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.
    Plant signaling & behavior, 2011, Volume: 6, Issue:3

    Topics: Adenosine Triphosphatases; Camptothecin; Cisplatin; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Enzyme Inhibitors; Etoposide; Intercalating Agents; Mitoxantrone; Nogalamycin; Novobiocin; Pisum sativum; Plant Proteins

2011
EMA vs EMACO in the treatment of gestational trophoblastic neoplasia.
    Gynecologic oncology, 2020, Volume: 158, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dactinomycin; Doxorubicin; Etoposide; Female; Gestational Trophoblastic Disease; Humans; Leucovorin; Methotrexate; Mitoxantrone; Multivariate Analysis; Neoplasm Staging; Pregnancy; Retrospective Studies; Vincristine

2020