dactinomycin has been researched along with lovastatin in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bansal, N; Houle, A; Melnykovych, G | 1 |
| Barbu, V; Dautry, F | 1 |
| Bankhurst, AD; Cutts, JL; Scallen, TJ; Watson, J | 1 |
| Choi, JW; Lundquist, EN; Peffley, DM | 1 |
| Addeo, R; Altucci, L; Beato, M; Bresciani, F; Cicatiello, L; Dauvois, S; Parker, MG; Sica, V; Truss, M; Weisz, A | 1 |
| Duan, H; Lange, Y; Mazzone, T | 1 |
| Kanayama, Y; Negoro, N; Okamura, M; Takeda, T; Umetani, N | 1 |
| Guo, YS; Houston, CW; Jin, GF; Thompson, JC; Townsend, CM | 1 |
| Choi, JW; Jung, SE | 1 |
| Bertoglio, J; Blaie, S; Bolla, M; Boquet, P; Créminon, C; Degraeve, F; Habib, A; Lévy-Toledano, S; Quéré, I | 1 |
| Hohl, RJ; Holstein, SA; Wohlford-Lenane, CL | 1 |
| Dimitroulakos, J; Goss, G; Lorimer, IA; Mantha, AJ; McFee, KE; Niknejad, N | 1 |
| Berge, KE; Cameron, J; Kulseth, MA; Leren, TP; Ranheim, T | 1 |
| Bu, P; Perlman, JI; Richards, MP; Stubbs, EB; Von Zee, CL | 1 |
| Austin, CP; Hirota, K; Huang, R; Kono, K; Sakamuru, S; Takeda, S; Tice, RR; Witt, KL; Xia, M; Yamamoto, KN | 1 |
| Trenin, AS | 1 |
1 review(s) available for dactinomycin and lovastatin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
20 other study(ies) available for dactinomycin and lovastatin
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.
Topics: Cell Division; Cell Survival; Cycloheximide; Dactinomycin; Deoxyribonucleases; Dexamethasone; DNA Damage; Humans; Hydroxycholesterols; In Vitro Techniques; Leukemia, T-Cell; Lovastatin; Mevalonic Acid; Mifepristone; Nuclear Proteins; Tumor Cells, Cultured | 1991 |
Mevalonate deprivation alters the induction of fos and myc by growth factors.
Topics: Blotting, Northern; Cells, Cultured; Dactinomycin; Epidermal Growth Factor; Gene Expression; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
Role of mevalonic acid in the regulation of natural killer cell cytotoxicity.
Topics: Cell Line; Cell Survival; Cells, Cultured; Cholesterol; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Dolichols; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Killer Cells, Natural; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lovastatin; Mevalonic Acid; Sterols | 1989 |
Inhibition of protein synthesis in baby-hamster kidney cells blocks oxysterol-mediated suppression of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA at a post-transcriptional level.
Topics: Animals; Cells, Cultured; Cricetinae; Cycloheximide; Dactinomycin; Gene Expression Regulation, Enzymologic; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Kidney; Lovastatin; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic | 1993 |
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.
Topics: Breast Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; Dactinomycin; DNA; Estradiol; Female; G1 Phase; Gene Expression; Genes, Reporter; Humans; Lovastatin; Luciferases; Oncogene Proteins; Phosphorylation; Proto-Oncogene Proteins; Retinoblastoma Protein; RNA, Messenger; Simvastatin; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Cholesterol homeostasis is modulated by amphiphiles at transcriptional and post-transcriptional loci.
Topics: 3T3 Cells; Animals; Anticholesteremic Agents; Chloramphenicol O-Acetyltransferase; Chloroquine; Cholesterol; Dactinomycin; Estradiol; Gene Expression Regulation; Homeostasis; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mice; Monensin; Protein Processing, Post-Translational; Receptors, LDL; RNA, Messenger; Surface-Active Agents; Transcription, Genetic | 1996 |
Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages.
Topics: Cell Line; Dactinomycin; Enzyme Inhibitors; Farnesol; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Macrophages; Membrane Proteins; Mevalonic Acid; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B; Tetradecanoylphorbol Acetate | 1996 |
Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Dactinomycin; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation; Genes, MDR; Genes, ras; Insulin-Like Growth Factor I; Lovastatin; Mice; Mitochondria; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1998 |
Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells.
Topics: Anticholesteremic Agents; Apoptosis; Cell Division; Cell Line; Chromatin; Cycloheximide; Dactinomycin; DNA Fragmentation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Microscopy, Electron; Microscopy, Fluorescence; Neuroglia; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins.
Topics: Amides; Aorta; Apoptosis; Bacterial Proteins; Bacterial Toxins; Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dactinomycin; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inhibitory Concentration 50; Interleukin-1; Isoenzymes; Leucine; Lovastatin; Membrane Proteins; Mevalonic Acid; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein Prenylation; Pyridines; rho GTP-Binding Proteins; Time Factors | 2001 |
Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line; Cycloheximide; Dactinomycin; Humans; K562 Cells; Lovastatin; Mevalonic Acid; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA; Time Factors; Transcription, Genetic; Up-Regulation | 2002 |
Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cycloheximide; Dactinomycin; Drug Delivery Systems; ErbB Receptors; Head and Neck Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Protein-Tyrosine Kinases | 2003 |
Berberine decreases PCSK9 expression in HepG2 cells.
Topics: Anticholesteremic Agents; Berberine; Cell Line; Dactinomycin; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Lovastatin; Plant Extracts; Proprotein Convertase 9; Proprotein Convertases; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Time Factors; Transcription, Genetic | 2008 |
Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin.
Topics: Actins; Cell Line, Transformed; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Lovastatin; Polyisoprenyl Phosphates; Prenylation; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Subcellular Fractions; Trabecular Meshwork | 2009 |
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.
Topics: Acetamides; Animals; Cell Line; Chickens; Chromosome Aberrations; Dactinomycin; DNA Damage; DNA Repair-Deficiency Disorders; Doxorubicin; Lovastatin; Melphalan; Mutagenicity Tests; Mutagens; Resorcinols; Toluene | 2011 |
[Microbial model of Halobacterium salinarum for screening inhibitors of sterol biosynthesis].
Topics: Antibiotics, Antineoplastic; Automation, Laboratory; Bacterial Proteins; Dactinomycin; Drug Discovery; Halobacterium salinarum; High-Throughput Screening Assays; Humans; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Mevalonic Acid; Microbial Viability; Mitomycin; Sterols; Streptonigrin | 2013 |