dactinomycin and losartan

dactinomycin has been researched along with losartan in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's2 (16.67)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
García-Sáinz, JA; González-Espinosa, C1
Alexander, RW; Clark, M; Griendling, KK; Lassègue, B; Murphy, TJ; Nickenig, G1
Chua, BH; Chua, CC; Hamdy, RC2
Carraro-Lacroix, LR; Girardi, AC; Malnic, G1
Anand-Srivastava, MB; Li, Y1

Reviews

1 review(s) available for dactinomycin and losartan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

11 other study(ies) available for dactinomycin and losartan

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Angiotensin II and active phorbol esters induce proto-oncogene expression in isolated rat hepatocytes.
    Biochimica et biophysica acta, 1992, Sep-09, Volume: 1136, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cycloheximide; Dactinomycin; Female; Gene Expression Regulation; Imidazoles; Liver; Losartan; Phorbol Esters; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetrazoles

1992
Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: evidence for homologous and heterologous regulation.
    Molecular pharmacology, 1995, Volume: 48, Issue:4

    Topics: Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Base Sequence; Biphenyl Compounds; Calcium; Cyclic AMP; Cytoplasm; Dactinomycin; Down-Regulation; Enzyme Activation; Imidazoles; Losartan; Molecular Sequence Data; Muscle Proteins; Muscle, Smooth, Vascular; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Purinergic P1; Receptors, Purinergic P2; RNA, Messenger; Signal Transduction; Tetrazoles; Transcription, Genetic

1995
Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells.
    Biochimica et biophysica acta, 1997, Jun-27, Volume: 1357, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Cell Line; Cycloheximide; Dactinomycin; Endothelium; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Losartan; Membrane Glycoproteins; Myocardium; Protein Kinase C; Pyridines; Rats; Tetrazoles; Thrombospondins

1997
Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells.
    Biochimica et biophysica acta, 1998, Feb-04, Volume: 1401, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Northern; Cattle; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Immunoblotting; Losartan; Lymphokines; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Rats; RNA, Messenger; Transcription Factors; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasoconstrictor Agents

1998
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.
    Pflugers Archiv : European journal of physiology, 2009, Volume: 458, Issue:5

    Topics: Ammonium Chloride; Androstadienes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Buffers; Cell Line, Transformed; Cell Membrane; Cycloheximide; Dactinomycin; Epithelial Cells; Gene Expression; Genistein; Hydrogen-Ion Concentration; Imidazoles; Kidney Tubules, Proximal; Losartan; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Protein-Tyrosine Kinases; Pyridines; Rats; Time Factors; Up-Regulation; Vacuolar Proton-Translocating ATPases; Wortmannin

2009
Implication of multiple signaling pathways in the regulation of angiotensin II induced enhanced expression of Giα proteins in vascular smooth muscle cells.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:8

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bucladesine; Calcium; Cell Line; Chelating Agents; Dactinomycin; Drug Interactions; Egtazic Acid; Estrenes; Gallic Acid; Gene Expression Regulation; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Losartan; Nucleic Acid Synthesis Inhibitors; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Rats; Signal Transduction; Type C Phospholipases

2012
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