dactinomycin has been researched along with camptothecin in 99 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (36.36) | 18.7374 |
| 1990's | 29 (29.29) | 18.2507 |
| 2000's | 22 (22.22) | 29.6817 |
| 2010's | 11 (11.11) | 24.3611 |
| 2020's | 1 (1.01) | 2.80 |
| Authors | Studies |
|---|---|
| Bu, X; Eleftheriou, A; Hayek, C; Parmar, A; Stewart, BW; Wakelin, LP | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Dimmock, NJ; Minor, PD | 2 |
| Becker, Y | 1 |
| Kletzien, RF; Perdue, JF | 1 |
| Morais, R | 1 |
| Burstein, DE; Greene, LA | 1 |
| Oxford, JS; Schild, GC | 1 |
| Ben-Porath, E; Gibson, KD | 1 |
| Atherton, KT; Burke, DC | 1 |
| Kelly, DC; Lescott, T | 1 |
| Bernhard, W; Gajkowska, B; Puvion, E | 1 |
| Benecke, BJ; Penman, S; Zieve, G | 1 |
| Chan, H; Recher, L; Sykes, JA | 1 |
| Wilson, DL | 1 |
| Eliceiri, GL; Sayavedra, MS | 1 |
| Boyse, EA; Goldstein, G; Hammerling, U; Storrie, B | 1 |
| Cotter, TG | 1 |
| Chan, PK | 1 |
| Cotter, TG; Glynn, JM; Green, DR | 1 |
| Giorgi-Renault, S; Grondard, L; Helissey, P; Riou, JF | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Capranico, G; Jaxel, C; Kohn, KW; Markovits, J; Pommier, Y; Wassermann, K | 1 |
| Liu, J; Xu, B; Yang, SL | 1 |
| Desrosiers, R; Tanguay, RM | 1 |
| Bloom, SE; Muscarella, DE; Vogt, VM | 1 |
| Hamada, H; Naito, M; Tsuruo, T | 1 |
| Ling, YH; Shen, CY; Shi, QL; Xu, B | 1 |
| Kann, HE; Kohn, KW | 1 |
| Bergevin, PR; Blom, J; Tormey, DC | 1 |
| Hirsch, M; Penman, S | 1 |
| Becker, JE; Bushnell, DE; Potter, VR | 1 |
| Alberts, AW; Ferguson, K; Hennessy, S; Vagelos, PR | 1 |
| Bhuyan, BK; Fraser, TJ | 1 |
| McMahon, D; Miller, MJ | 1 |
| Delaunay, J; Schapira, G | 1 |
| Kumar, A; Wu, RS | 1 |
| Briggs, L; Chan, H; Parry, N; Recher, L | 1 |
| Chadwick, DE; Ignotz, GG; Ignotz, RA; Lieberman, I | 1 |
| Greene, LA; Liem, RK; Shelanski, ML | 1 |
| Adam, SA; Choi, YD; Dreyfuss, G | 1 |
| Bloom, SR; Lee, YC; Slayton, VW; Tischler, AS | 1 |
| Bhargava, G; Makman, MH | 1 |
| Greene, LA; Rukenstein, A | 1 |
| Caldwell, KA; Handel, MA; Wiltshire, T | 1 |
| Bicknell, GR; Cohen, GM; Snowden, RT | 1 |
| Janavs, JL; Pierce, ME; Takahashi, JS | 1 |
| Cotter, TG; Fernandes, RS | 1 |
| Burnham, P; Louis, JC; Magal, E; Varon, S | 1 |
| Aldea, M; Comella, JX; Esquerda, JE; Sanz-Rodriguez, C | 1 |
| Gorczyca, W; Melamed, MR; Pizzolo, JG; Qiao, L | 1 |
| Calderwood, SK; Coleman, CN; Price, BD; Tishler, RB | 1 |
| Kameoka, M; Kamiya, T; Kojima, K; Tanaka, Y; Tohno, Y; Yoshihara, K | 1 |
| Bertoglio, J; Bréard, J; Issaad, C; Léglise, MC; Pallardy, M; Roger, R; Turhan, AG | 1 |
| Kanematsu, T; Kawanami, K; Kohno, K; Kuwano, M; Taniguchi, K; Wada, M | 1 |
| Dalgleish, AG; Gibson, FM; Gordon-Smith, EC; Marsh, JC; Philpott, NJ; Scopes, J; Turner, AJ; Westby, M | 1 |
| Cotter, TG; Samali, A | 1 |
| Cortés, F; López Baena, M; Ortiz, T; Piñero, J | 1 |
| Kato, M; Suzuki, A | 1 |
| Piette, J; Piret, B | 1 |
| Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R | 1 |
| Bloom, SE; Muscarella, DE; Rachlinski, MK; Sotiriadis, J | 1 |
| Phan, TN; Tuteja, N | 1 |
| Carabillò, M; Giuliano, M; Lauricella, M; Tesoriere, G; Vassallo, E; Vento, R | 1 |
| Adami, GR; Buehler, PW; Negrusz, A; Robles, SJ | 1 |
| Cotter, TG; Creagh, EM | 1 |
| King, MA; Radicchi-Mastroianni, MA; Wells, JV | 1 |
| Ashcroft, M; Taya, Y; Vousden, KH | 1 |
| Cotter, TG; Knox, KA; McGahon, AJ; McKenna, SL; O'Gorman, DM | 1 |
| Suzuki, A; Tsutomi, Y | 1 |
| Fujikawa, K; Ito, M; Ito, T; Moriyama, M; Nakano, T; Shiraki, K; Sugimoto, K; Suzuki, A; Takase, K; Yamanaka, T | 1 |
| Bedner, E; Darzynkiewicz, Z; Halicka, HD | 1 |
| Kim, EJ; Park, TH; Rhee, WJ | 1 |
| Daza, P; García-Herdugo, G; Moreno, FJ; Torreblanca, J | 1 |
| Baran, V; Czikková, S; Fabian, D; Il'ková, G; Koppel, J; Rehák, P | 2 |
| Baran, V; Fabian, D; Koppel, J; Rehak, P | 1 |
| Barthelmes, HU; Boege, F; Christensen, MO; Hock, R; Krokowski, RM; Mielke, C | 1 |
| Daza, P; Moreno, FJ; Torreblanca, J | 1 |
| Arts, J; Cik, M; Ercken, M; Grand-Perret, T; Janicot, M; Roevens, R; Valckx, A; Vander Borght, A; Vermeesen, A | 1 |
| Morikawa, Y | 1 |
| Kitabayashi, I; Okamoto, K; Taya, Y | 1 |
| Breitfeld, P; Crews, KR; Donaldson, SS; Houghton, P; Lyden, E; Meyer, WH; Pappo, AS; Parham, D; Wiener, E | 1 |
| Abe, T; Goto, J; Hishinuma, T; Kobayashi, M; Mano, N; Okada, M; Takeuchi, T; Unno, M; Yamaguchi, H | 1 |
| Nishida, T; Yamada, Y | 1 |
| Hayashi, Y; Hirato, J; Kuroiwa, M; Park, MJ; Sakamoto, J; Shimada, A; Sotomatsu, M; Suzuki, N | 1 |
| Pappo, A; Paulino, AC | 1 |
| Kumabe, T; Niizuma, H; Osawa, S; Saito, R; Sonoda, Y; Tominaga, T; Watanabe, M | 1 |
| Kopacek, J; Krizanova, O; Labudova, M; Lencesova, L; Ondrias, K; Pastorekova, S; Sirova, M | 1 |
| Pham, XH; Tran, NQ; Tuteja, N; Tuteja, R | 1 |
| Knox, AA; Turner, AJ; Watkins, NJ | 1 |
| Darwich, Z; Klymchenko, AS; Kucherak, OA; Mély, Y; Richert, L | 1 |
| Brenner, C; Caubere, C; Courilleau, D; Fischmeister, R; Gomez, AM; Liu, D; Mateo, P; Nicolas, V; Rouet, P; Vandecasteele, G; Varin, A; Wang, Z | 1 |
| Kamimura, S; Kinoshita, M; Miyachi, M; Moritake, H; Sawa, D; Yamada, A | 1 |
| Li, G; Tong, T; Xu, C; Yuan, F | 1 |
| Gdowicz-Kłosok, A; Krześniak, M; Rusin, M; Zajkowicz, A; Łasut, B | 1 |
| Ghaedi, K; Majd, A; Miralaei, N; Peymani, M; Safaei, M | 1 |
5 review(s) available for dactinomycin and camptothecin
| Article | Year |
|---|---|
Trends in research and development of antiviral substances.
Topics: Amanitins; Amantadine; Amino Acids; Antiviral Agents; Benzimidazoles; Camptothecin; Chemical Phenomena; Chemistry; Cystamine; Dactinomycin; Distamycins; DNA-Directed RNA Polymerases; Hydroxyurea; Interferon Inducers; Interferons; Methisazone; Nucleosides; Plicamycin; Polysaccharides; Research Design; Rhodanine; Rifamycins; Selenium; Silicon; Tungsten; Viruses; Zinc | 1975 |
Inhibitors of influenza virus replication.
Topics: Amanitins; Amantadine; Animals; Camptothecin; Dactinomycin; Drug Evaluation; Humans; Influenza A virus; Ribavirin; RNA, Viral; Virus Replication | 1979 |
Induction of apoptosis in cells of the immune system by cytotoxic stimuli.
Topics: Animals; Aphidicolin; Apoptosis; Camptothecin; Cell Cycle; Dactinomycin; Humans; Immune System; Necrosis | 1992 |
Guide to the use of cancer chemotherapeutic agents.
Topics: Alkylating Agents; Allopurinol; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Asparaginase; Azaserine; Azauridine; Bleomycin; Camptothecin; Carmustine; Cell Division; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Fluorouracil; Humans; Kinetics; Neoplasms; Nitrogen Mustard Compounds; Procarbazine; Triazines; Vincristine | 1972 |
[Childhood rhabdomyosarcoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Child; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Humans; Irinotecan; Radiotherapy Dosage; Rhabdomyosarcoma; Risk; Vincristine | 2005 |
1 trial(s) available for dactinomycin and camptothecin
| Article | Year |
|---|---|
Two consecutive phase II window trials of irinotecan alone or in combination with vincristine for the treatment of metastatic rhabdomyosarcoma: the Children's Oncology Group.
Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Drug Administration Schedule; Female; Humans; Infant; Irinotecan; Male; Neoplasm Metastasis; Rhabdomyosarcoma; Treatment Outcome; Vincristine | 2007 |
93 other study(ies) available for dactinomycin and camptothecin
| Article | Year |
|---|---|
Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest.
Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; DNA; DNA, Superhelical; Electrophoresis, Agar Gel; Flow Cytometry; G2 Phase; Guanine; Humans; Hydrogen Bonding; Intercalating Agents; Kinetics; Mitosis; Structure-Activity Relationship | 2003 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Inhibition of synthesis of influenza virus proteins: evidence of two host-cell-dependent events during multiplication.
Topics: Amanitins; Camptothecin; Cell Line; Cell Nucleus; Dactinomycin; Hemagglutinins, Viral; Influenza A virus; Neuraminidase; RNA, Viral; Viral Proteins; Virus Replication | 1975 |
Selective inhibition of influenza virus protein synthesis by inhibitors of DNA function.
Topics: 4-Nitroquinoline-1-oxide; Camptothecin; Cell Line; Dactinomycin; Daunorubicin; Echinomycin; Ethidium; Hemagglutinins, Viral; Influenza A virus; Neuraminidase; Newcastle disease virus; Nogalamycin; Plicamycin; Proflavine; Viral Proteins; Virus Replication | 1977 |
Regulation of sugar transport in chick embryo fibroblasts and in fibroblasts transformed by a temperature-sensitive mutant of the Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Biological Transport, Active; Blood; Camptothecin; Carbohydrate Metabolism; Cell Transformation, Neoplastic; Chick Embryo; Culture Media; Culture Techniques; Cycloheximide; Dactinomycin; Deoxyadenosines; Fibroblasts; Hexoses; Mutation; Temperature | 1976 |
Protein content and enzyme levels of cultured chick embryo cells treated with camptothecin and actinomycin D.
Topics: Animals; Camptothecin; Chick Embryo; Cytidine Triphosphate; Dactinomycin; Electron Transport Complex IV; Endonucleases; Fibroblasts; Leucine; Microsomes; Mitochondria; NADPH-Ferrihemoprotein Reductase; Phosphoric Monoester Hydrolases; Proteins; Succinate Dehydrogenase; Thymidine; Uridine | 1977 |
Evidence for RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factor.
Topics: Camptothecin; Cell Differentiation; Cell Line; Dactinomycin; Deoxyadenosines; Kinetics; Nerve Growth Factors; Nerve Regeneration; Neurons; Pheochromocytoma; RNA; RNA, Neoplasm | 1978 |
Effect of RNA synthesis inhibitors on stimulation of sulfation by L-3,5,3'-triiodothyronine.
Topics: Amanitins; Animals; Camptothecin; Cartilage; Chick Embryo; Chondroitin Sulfates; Dactinomycin; Kinetics; Poly A; Proteoglycans; Sulfates; Transcription, Genetic; Triiodothyronine | 1977 |
The effects of some different metabolic inhibitors on interferon superinduction.
Topics: Amanitins; Antimetabolites; Camptothecin; Cell Line; Cycloheximide; Dactinomycin; Humans; Interferons; Poly I-C; Protein Biosynthesis; RNA; RNA, Messenger | 1978 |
The effects of inhibitors of nucleic acid and protein synthesis on the replication of Spodoptera frugiperda nuclear polyhedrosis virus in cultured Spodoptera frugiperda cells.
Topics: Camptothecin; Cell Line; Cycloheximide; Cytarabine; Dactinomycin; Insect Viruses; Insecta; Puromycin; Rifampin; Virus Replication | 1976 |
Unusual perinucleolar accumulation of ribonucleoprotein granules induced by camptothecin in isolated liver cells.
Topics: Autoradiography; Camptothecin; Cell Nucleolus; Cells, Cultured; Dactinomycin; Liver; Nucleoproteins; Ribonucleoproteins; RNA, Ribosomal; Transcription, Genetic; Uridine | 1977 |
Synthesis of two classes of small RNA species in vivo and in vitro.
Topics: Amanitins; Camptothecin; Cell Nucleus; Cells, Cultured; Dactinomycin; Drosophila; HeLa Cells; Molecular Weight; Osmolar Concentration; RNA; RNA, Neoplasm; Toyocamycin; Transcription, Genetic | 1977 |
Further studies on the mammalian cell nucleolus.
Topics: Adenosine; Camptothecin; Cell Line; Cell Nucleolus; Chromatin; Dactinomycin; Hypertonic Solutions; Organoids; Proflavine | 1976 |
Alteration of protein metabolism in individual, identified neurons from Aplysia.
Topics: Acetates; Animals; Camptothecin; Chlorides; Dactinomycin; Ganglia; In Vitro Techniques; Mollusca; Nerve Tissue Proteins; Neurons; RNA, Messenger; Temperature | 1976 |
Small RNAs in the nucleus and cytoplasm of HeLa cells.
Topics: Camptothecin; Cell Nucleus; Cytoplasm; Dactinomycin; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Molecular Weight; RNA, Neoplasm; Transcription, Genetic; Uridine | 1976 |
Differentiation of thymocytes: evidence that induction of the surface phenotype requires transcription and translation.
Topics: Animals; Camptothecin; Cell Differentiation; Cycloheximide; Cytarabine; Dactinomycin; Deoxyadenosines; DNA; Hydroxyurea; In Vitro Techniques; Macromolecular Substances; Mice; Mice, Inbred Strains; Phenotype; Protein Biosynthesis; Protein Precursors; Puromycin; RNA; T-Lymphocytes; Thymus Extracts; Transcription, Genetic | 1976 |
Characterization and cellular localization of nucleophosmin/B23 in HeLa cells treated with selected cytotoxic agents (studies of B23-translocation mechanism).
Topics: Autoradiography; Camptothecin; Cell Nucleolus; Dactinomycin; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; HeLa Cells; Humans; Kinetics; Lysine; Methotrexate; Nuclear Proteins; Nucleophosmin; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Processing, Post-Translational; Tritium; Uridine | 1992 |
Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle.
Topics: Animals; Aphidicolin; Camptothecin; Cell Cycle; Cell Death; Dactinomycin; Drug Resistance; Hybridomas; T-Lymphocytes | 1992 |
Inhibition of eukaryotic DNA topoisomerase I and II activities by indoloquinolinedione derivatives.
Topics: Camptothecin; Dactinomycin; DNA; DNA Damage; Humans; Quinones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Yeasts | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.
Topics: Animals; Antibiotics, Antineoplastic; Camptothecin; Dactinomycin; DNA; DNA Damage; Doxorubicin; Mice; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1990 |
Effects of lycobetaine on chromatin structure and activity of murine hepatoma cells.
Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatin; Dactinomycin; DNA Damage; DNA, Neoplasm; Harringtonines; Homoharringtonine; Indolizines; Liver Neoplasms, Experimental; Mice; Oncogenes; Time Factors; Tumor Cells, Cultured | 1990 |
Transcriptional inhibitors affecting topoisomerase II induce changes in histone methylation patterns similar to those induced by heat shock.
Topics: Animals; Camptothecin; Cells, Cultured; Dactinomycin; Drosophila melanogaster; Ethidium; Histones; Hot Temperature; In Vitro Techniques; Methylation; Novobiocin; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Uridine | 1989 |
Characterization of ribosomal RNA synthesis in a gene dosage mutant: the relationship of topoisomerase I and chromatin structure to transcriptional activity.
Topics: Aneuploidy; Animals; Camptothecin; Cell Nucleus; Chickens; Chromatin; Dactinomycin; Deoxyribonuclease I; DNA Topoisomerases, Type I; DNA, Ribosomal; Endonucleases; Gene Expression Regulation; Genes; Methylation; RNA Processing, Post-Transcriptional; RNA, Ribosomal; Single-Strand Specific DNA and RNA Endonucleases; Transcription, Genetic | 1987 |
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.
Topics: Adenosine Triphosphate; Binding Sites; Biological Transport; Camptothecin; Cell Membrane; Dactinomycin; Doxorubicin; Drug Resistance; Fluorouracil; Kinetics; Leukemia, Myeloid; Magnesium; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1988 |
[Effects of four antitumor agents on DNA circular dichroism].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cattle; Circular Dichroism; Dactinomycin; DNA; Harringtonines; Homoharringtonine; Nucleic Acid Conformation | 1987 |
Effects of deoxyribonucleic acid-reactive drugs on ribonucleic acid synthesis in leukemia L1210 cells.
Topics: Acridines; Acrylamides; Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzazepines; Camptothecin; Carbazoles; Carbon Isotopes; Cell Nucleolus; Cell Nucleus; Centrifugation, Density Gradient; Dactinomycin; Daunorubicin; Deoxyadenosines; DNA, Neoplasm; Ethidium; Leukemia L1210; Mechlorethamine; Methionine; Phenanthridines; Pyridines; Pyrroles; RNA, Neoplasm; Tritium; Uridine | 1972 |
The messenger-like properties of the poly(A)plus RNA in mammalian mitochondria.
Topics: Adenine Nucleotides; Base Sequence; Camptothecin; Cell Fractionation; Centrifugation, Density Gradient; Chloramphenicol; Dactinomycin; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Ethidium; Half-Life; HeLa Cells; Humans; Mitochondria; Neoplasm Proteins; Polynucleotides; Protein Biosynthesis; Puromycin; RNA, Messenger; RNA, Neoplasm; RNA, Ribosomal; Tritium; Uridine | 1974 |
The role of messenger RNA in tyrosine aminotransferase superinduction: effects of camptothecin on hepatoma cells in culture.
Topics: Animals; Camptothecin; Carcinoma, Hepatocellular; Cells, Cultured; Dactinomycin; Deoxyadenosines; Enzyme Induction; Hydrocortisone; Insulin; Liver; Liver Neoplasms; Neoplasms, Experimental; Protein Biosynthesis; Rats; RNA, Messenger; Time Factors; Tyrosine Transaminase | 1974 |
Regulation of lipid synthesis in cultured animal cells.
Topics: Acetates; Acetyl-CoA Carboxylase; Animals; Camptothecin; Carbon Radioisotopes; Cell Line; Culture Media; Cyclic AMP; Dactinomycin; Enzyme Induction; Epithelial Cells; Fatty Acid Synthases; Fatty Acids, Nonesterified; HeLa Cells; Humans; Insulin; L Cells; Liver; Mice; Mice, Inbred Strains; RNA; Sterols; Theophylline; Time Factors | 1974 |
Frozen DON cells as a source for a cell cycle assay of antitumor agents.
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Biological Assay; Camptothecin; Carbazoles; Cell Division; Cell Line; Cell Survival; Cricetinae; Cryoprotective Agents; Cytarabine; Cytological Techniques; Dactinomycin; Dimethyl Sulfoxide; Floxuridine; Formates; Freezing; Glycerol; Hydroxyurea; Lung; Mitosis; Proteins; Pyridines; Ribonucleosides; Thiosemicarbazones; Time Factors | 1974 |
Synthesis and maturation of chloroplast and cytoplasmic ribosomal RNA in Chlamydomonas reinhardi.
Topics: Adenine; Camptothecin; Chlamydomonas; Chloroplasts; Cytoplasm; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Genes; Isotope Labeling; Molecular Weight; Mutation; Phosphorus Radioisotopes; Rifamycins; RNA, Ribosomal; Species Specificity; Time Factors; Transcription, Genetic; Tritium | 1974 |
Ribosomes and cancer.
Topics: Aflatoxins; Animals; Camptothecin; Cell Transformation, Neoplastic; Cells, Cultured; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Humans; Molecular Conformation; Neoplasms; Plant Proteins; Protein Biosynthesis; Proteins; Ribosomes; Ricin; RNA, Ribosomal; Transcription, Genetic; Vinca Alkaloids | 1974 |
Role of ribosomal RNA transcription in ribosome processing in HeLa cells.
Topics: Biological Transport; Camptothecin; Carbon Isotopes; Cell Fractionation; Cell Nucleolus; Centrifugation, Density Gradient; Chromomycins; Cytoplasm; Dactinomycin; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Methionine; Ribosomes; RNA, Ribosomal; Transcription, Genetic; Tritium; Uridine | 1973 |
Ultrastructural changes inducible with the plant alkaloid camptothecin.
Topics: Antineoplastic Agents; Autoradiography; Camptothecin; Cell Line; Cell Nucleolus; Chromatin; Dactinomycin; Drug Interactions; Humans; Microscopy, Electron; RNA; Time Factors; Tritium | 1972 |
Inhibitors of RNA synthesis and passage of chick embryo fibroblasts through the G1 period.
Topics: Animals; Benzimidazoles; Camptothecin; Cells, Cultured; Chick Embryo; Dactinomycin; Deoxyadenosines; DNA; Dose-Response Relationship, Drug; Interphase; Protein Biosynthesis; RNA | 1980 |
Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factor.
Topics: Animals; Axons; Camptothecin; Cell Line; Dactinomycin; Fluorescent Antibody Technique; Hot Temperature; Microtubule-Associated Proteins; Microtubules; Nerve Growth Factors; Nerve Tissue Proteins; Pheochromocytoma; Phosphoproteins; Protein Biosynthesis; Proteins; Rats; Staining and Labeling | 1983 |
Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription.
Topics: Camptothecin; Dactinomycin; Dichlororibofuranosylbenzimidazole; Emetine; HeLa Cells; Humans; Kinetics; Molecular Weight; Neoplasm Proteins; Protein Biosynthesis; Ribonucleoproteins; Ribonucleosides; RNA, Messenger; Transcription, Genetic; Ultraviolet Rays | 1984 |
Kinetics of regulation of neurotensin content in PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Camptothecin; Cell Line; Dactinomycin; Dexamethasone; Kinetics; Nerve Growth Factors; Neurotensin; Pheochromocytoma; Rats | 1983 |
Effect of tunicamycin on the turnover of epidermal growth factor receptors in cultured calf aorta smooth muscle cells. Comparison with IMR-90 human lung fibroblasts.
Topics: Animals; Aorta, Thoracic; Binding Sites; Camptothecin; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblasts; Glucosamine; Half-Life; Humans; Lung; Male; Mice; Muscle, Smooth, Vascular; Peptides; Tunicamycin | 1980 |
Regulation of acetylcholinesterase activity by nerve growth factor. Role of transcription and dissociation from effects on proliferation and neurite outgrowth.
Topics: Acetylcholinesterase; Adrenal Gland Neoplasms; Animals; Axons; Camptothecin; Cell Division; Clone Cells; Dactinomycin; Enzyme Activation; Nerve Growth Factors; Pheochromocytoma; Rats; Transcription, Genetic | 1981 |
Culture of pachytene spermatocytes for analysis of meiosis.
Topics: Animals; Camptothecin; Cells, Cultured; Chromatin; Chromosomes; Dactinomycin; Ethers, Cyclic; Male; Meiosis; Mice; Microscopy, Electron; Okadaic Acid; Prophase; Spermatocytes; Transcription, Genetic | 1995 |
Formation of high molecular mass DNA fragments is a marker of apoptosis in the human leukaemic cell line, U937.
Topics: Apoptosis; Biomarkers; Camptothecin; Cycloheximide; Dactinomycin; DNA Damage; DNA, Neoplasm; Emetine; Flow Cytometry; Humans; Leukemia, Promyelocytic, Acute; Molecular Weight; Neoplasm Proteins; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1994 |
RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells.
Topics: Amidohydrolases; Anisomycin; Arylamine N-Acetyltransferase; Calcium; Camptothecin; Colforsin; Cyclic AMP; Dactinomycin; Dopamine; Egtazic Acid; Eye Neoplasms; Humans; Melatonin; Nerve Tissue Proteins; Protein Synthesis Inhibitors; Retinoblastoma; Topoisomerase I Inhibitors; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death.
Topics: Alkylating Agents; Apoptosis; Camptothecin; Cell Death; Cell Line; Chlorambucil; Dactinomycin; DNA; Glutathione; Humans; Melphalan; Necrosis | 1994 |
Cooperative effects of ciliary neurotrophic factor and norepinephrine on tyrosine hydroxylase expression in cultured rat locus coeruleus neurons.
Topics: Adrenergic Fibers; Animals; Anisomycin; Camptothecin; Cell Differentiation; Cell Survival; Cells, Cultured; Ciliary Neurotrophic Factor; Cycloheximide; Dactinomycin; Drug Synergism; In Vitro Techniques; Locus Coeruleus; Nerve Tissue Proteins; Neurotransmitter Agents; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase | 1993 |
Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro.
Topics: Animals; Anisomycin; Apoptosis; Blotting, Southern; Camptothecin; Cell Communication; Cell Separation; Cell Survival; Centrifugation, Density Gradient; Chick Embryo; Chickens; Cycloheximide; Dactinomycin; Deoxyadenosines; DNA; Gene Expression; Immunohistochemistry; Metrizamide; Microscopy, Electron; Motor Neurons; Muscle Denervation; Muscles; Neurofilament Proteins; Puromycin; Spinal Cord | 1994 |
p145 expression during the cell cycle in HL-60 cell line and normal human lymphocytes: effects of camptothecin, vinblastine, cycloheximide, actinomycin D, retinoic acid and DMSO.
Topics: Antigens, Nuclear; Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Differentiation; Cycloheximide; Dactinomycin; Dimethyl Sulfoxide; Flow Cytometry; Humans; Lymphocyte Activation; Lymphocytes; Nuclear Proteins; Tretinoin; Tumor Cells, Cultured; Vinblastine | 1993 |
Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.
Topics: 3T3 Cells; Animals; Antibodies; Antineoplastic Agents; Base Sequence; Camptothecin; Dactinomycin; DNA; DNA Damage; Electrophoresis; Gene Expression Regulation; Hydrogen Peroxide; Mice; Molecular Sequence Data; Oligonucleotides; Protein Binding; Time Factors; Tumor Suppressor Protein p53 | 1993 |
Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers.
Topics: Adenosine; Alkaloids; Apoptosis; Calcimycin; Camptothecin; Dactinomycin; DNA, Neoplasm; Drug Resistance, Neoplasm; Electrophoresis, Agar Gel; Enzyme Inhibitors; HL-60 Cells; Humans; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Staurosporine; Teniposide | 1995 |
BCR-ABL does not prevent apoptotic death induced by human natural killer or lymphokine-activated killer cells.
Topics: Apoptosis; Camptothecin; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; DNA Damage; DNA, Neoplasm; Etoposide; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Hydrogen Peroxide; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Leukemia, Megakaryoblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Puromycin; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins.
Topics: Antibiotics, Antineoplastic; Benz(a)Anthracenes; Camptothecin; Carcinoma, Squamous Cell; Dactinomycin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; KB Cells; Neoplasm Proteins; RNA, Messenger; RNA, Neoplasm; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1996 |
The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques.
Topics: Apoptosis; Camptothecin; Carcinoma; Cell Count; Cell Separation; Dactinomycin; DNA Damage; DNA, Neoplasm; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Erythroblastic, Acute; Pancreatic Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Tumor Cells, Cultured | 1996 |
Heat shock proteins increase resistance to apoptosis.
Topics: Animals; Apoptosis; Camptothecin; Cell Line; Cell Survival; Dactinomycin; DNA Damage; Etoposide; Fibrosarcoma; Heat-Shock Proteins; Heat-Shock Response; Humans; Mice; Monocytes; Tumor Cells, Cultured | 1996 |
Sister chromatid exchange induced by DNA topoisomerases poisons in late replicating heterochromatin: influence of inhibition of replication and transcription.
Topics: Amsacrine; Animals; Aphidicolin; Camptothecin; CHO Cells; Chromatin; Cricetinae; Dactinomycin; DNA Replication; Enzyme Inhibitors; Euchromatin; Heterochromatin; Isomerases; Sister Chromatid Exchange; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transcription, Genetic | 1996 |
Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm.
Topics: Amino Acid Sequence; Animals; Apoptosis; Camptothecin; Carcinoma, Hepatocellular; Caspase 1; Cell Extracts; Cell Nucleus; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Dactinomycin; DNA; Humans; Irinotecan; Liver; Liver Neoplasms; Male; Molecular Sequence Data; Oligopeptides; Protein Synthesis Inhibitors; Rats; Tumor Cells, Cultured | 1996 |
Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells.
Topics: Antioxidants; Camptothecin; Cell Line; Cycloheximide; Dactinomycin; Daunorubicin; DNA; DNA Damage; DNA Topoisomerases, Type I; Etoposide; HIV-1; NF-kappa B; Nucleic Acid Synthesis Inhibitors; Poly(ADP-ribose) Polymerase Inhibitors; Topoisomerase I Inhibitors; Transcriptional Activation; Virus Activation | 1996 |
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors | 1997 |
Contribution of gene-specific lesions, DNA-replication-associated damage, and subsequent transcriptional inhibition in topoisomerase inhibitor-mediated apoptosis in lymphoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Transformation, Viral; Chickens; Dactinomycin; DNA Damage; DNA Replication; DNA, Ribosomal; Etoposide; Genes, myc; Kinetics; Lymphoma, B-Cell; Lymphoma, T-Cell; Topoisomerase I Inhibitors; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Inhibition of pea chloroplast DNA helicase unwinding and ATPase activities by DNA-interacting ligands.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amsacrine; Camptothecin; Chloroplasts; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Ethidium; Etoposide; Genistein; Hydrolysis; Intercalating Agents; Ligands; Nogalamycin; Novobiocin; Pisum sativum | 1998 |
Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors.
Topics: Amsacrine; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Dactinomycin; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; Enzyme Inhibitors; Etoposide; Humans; Insulin-Like Growth Factor Binding Protein 3; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Retinal Neoplasms; Retinoblastoma; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Permanent cell cycle arrest in asynchronously proliferating normal human fibroblasts treated with doxorubicin or etoposide but not camptothecin.
Topics: Antineoplastic Agents; Camptothecin; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; DNA Damage; Doxorubicin; Etoposide; Fibroblasts; Humans; Tumor Suppressor Protein p53 | 1999 |
Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Blotting, Western; Camptothecin; Dactinomycin; fas Receptor; Heat-Shock Proteins; Heat-Shock Response; HSP27 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Jurkat Cells; Molecular Chaperones; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; T-Lymphocytes | 1999 |
There is substantial nuclear and cellular disintegration before detectable phosphatidylserine exposure during the camptothecin-induced apoptosis of HL-60 cells.
Topics: Annexin A5; Apoptosis; Camptothecin; Cell Nucleus; Dactinomycin; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; HL-60 Cells; Humans; Phosphatidylserines | 2000 |
Stress signals utilize multiple pathways to stabilize p53.
Topics: Blotting, Northern; Camptothecin; Cells, Cultured; Chelating Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; Deferoxamine; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Humans; Immunoblotting; Microscopy, Fluorescence; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Stress, Physiological; Time Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
Topics: Androstadienes; Antineoplastic Agents; Apigenin; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Camptothecin; Carrier Proteins; Cell Survival; Chromones; Cycloheximide; Dactinomycin; Dimerization; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Flavonoids; Genes, bcl-2; HL-60 Cells; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitoxantrone; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sirolimus; Wortmannin | 2000 |
Inductions of fibroblast-like morphology and high growth activity by low-dose CPT-11 in PC12 cells: role of tenascin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carboxylic Acids; Caspase Inhibitors; Caspases; Cell Division; Cell Nucleus; Cell Survival; Cell Transformation, Neoplastic; Culture Media, Conditioned; Dactinomycin; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fumonisins; Irinotecan; Oligopeptides; PC12 Cells; Rats; Tenascin; Tumor Necrosis Factor-alpha | 2000 |
Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Camptothecin; Carcinoma, Hepatocellular; Dactinomycin; Doxorubicin; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; Receptors, Tumor Necrosis Factor; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis.
Topics: Apoptosis; Benzimidazoles; Bromouracil; Camptothecin; Coloring Agents; Cycloheximide; Dactinomycin; DNA; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; HL-60 Cells; Humans; Pyronine; RNA; Topoisomerase I Inhibitors; Tumor Necrosis Factor-alpha; Uridine | 2000 |
Silkworm hemolymph as a potent inhibitor of apoptosis in Sf9 cells.
Topics: Animals; Apoptosis; Bombyx; Camptothecin; Caspase 1; Caspases; Cell Line; Dactinomycin; Electrophoresis, Agar Gel; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Hemolymph; Insecta; Mass Spectrometry; Protein Synthesis Inhibitors; Staurosporine; Time Factors | 2002 |
DNA strand-breaks induced by the topoisomerase I inhibitor camptothecin in unstimulated human white blood cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Nucleus; Comet Assay; Dactinomycin; Deoxyadenosines; DNA; DNA Damage; DNA Repair; DNA Topoisomerases, Type I; Humans; Interphase; Leukocytes; Male; Nucleic Acid Synthesis Inhibitors; RNA; Topoisomerase I Inhibitors | 2002 |
Induced cell death of preimplantation mouse embryos cultured in vitro evaluated by comet assay.
Topics: Animals; Apoptosis; Benzimidazoles; Blastocyst; Camptothecin; Comet Assay; Culture Techniques; Dactinomycin; DNA; Embryo, Mammalian; Embryonic Development; Female; Fluorescent Dyes; Mice; Mice, Inbred ICR; Pregnancy; Propidium | 2003 |
Nucleolus in apoptosis-induced mouse preimplantation embryos.
Topics: Animals; Apoptosis; Biomarkers; Blastocyst; Blastomeres; Camptothecin; Cell Nucleolus; Cell Survival; Chromosomal Proteins, Non-Histone; Dactinomycin; Female; Fluorescent Antibody Technique, Indirect; Mice; Mice, Inbred ICR; Nuclear Proteins; Nucleophosmin; Phosphoproteins; Pregnancy; Staurosporine | 2003 |
Inhibitory effect of IGF-I on induced apoptosis in mouse preimplantation embryos cultured in vitro.
Topics: Animals; Apoptosis; Benzimidazoles; Blastocyst; Camptothecin; Cell Nucleus; Comet Assay; Culture Techniques; Dactinomycin; DNA Damage; Embryonic Development; Female; Fluorescent Dyes; Humans; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred ICR; Pregnancy; Recombinant Proteins | 2004 |
Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.
Topics: Binding Sites; Camptothecin; Catalysis; Cell Line; Cell Nucleolus; Cell Nucleus; Dactinomycin; DNA; DNA-Directed RNA Polymerases; DNA, Ribosomal; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Luminescent Proteins; Microscopy, Confocal; Mutation; Protein Structure, Tertiary; RNA Polymerase I; RNA, Ribosomal; Time Factors; Topoisomerase I Inhibitors; Transcription, Genetic | 2004 |
The comet assay differentiates efficiently and rapidly between genotoxins and cytotoxins in quiescent cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Comet Assay; Dactinomycin; Deoxyadenosines; DNA; Enzyme Inhibitors; Floxuridine; Humans; Leukocytes; Male; Mutagens; Puromycin | 2004 |
Assay development for high throughput screening of p21(Waf1/Cip1) protein expression in intact cells using fluorometric microvolume assay technology.
Topics: Belgium; Camptothecin; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Dactinomycin; Fluorometry; Gene Expression; Humans; Microchemistry; Reproducibility of Results; Technology, Pharmaceutical; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2004 |
KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dactinomycin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Combinations; Gamma Rays; Humans; Neoplasms; Proto-Oncogene Proteins c-mdm2; Repressor Proteins; Signal Transduction; Tripartite Motif-Containing Protein 28; Tumor Suppressor Protein p53 | 2006 |
Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.
Topics: Antineoplastic Agents; Camptothecin; Chenodeoxycholic Acid; Dactinomycin; Docetaxel; Fluorescent Dyes; Humans; Irinotecan; Kinetics; Lysine; Mitoxantrone; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Signal Processing, Computer-Assisted; Solute Carrier Organic Anion Transporter Family Member 1B3; Spectrometry, Fluorescence; Taxoids; Transfection | 2008 |
SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin.
Topics: Amino Acid Sequence; Animals; Camptothecin; Cell Line; Cell Nucleolus; Cytoplasm; Dactinomycin; DNA Damage; Endopeptidases; Humans; Male; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins; Nucleophosmin; Small Ubiquitin-Related Modifier Proteins | 2008 |
Manifestation of alveolar rhabdomyosarcoma as primary cutaneous lesions in a neonate with Beckwith-Wiedemann syndrome.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Beckwith-Wiedemann Syndrome; Bone Marrow Transplantation; Camptothecin; Cyclophosphamide; Dactinomycin; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Infant, Newborn; Irinotecan; Potassium Channels, Voltage-Gated; Rhabdomyosarcoma, Alveolar; Skin Neoplasms; Transcription, Genetic; Vincristine | 2009 |
Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk?
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Camptothecin; Child; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Dactinomycin; Etoposide; Fatal Outcome; Female; Foot; Groin; Humans; Ifosfamide; Irinotecan; Lymph Node Excision; Lymphatic Metastasis; Lymphatic System; Male; Niacinamide; Phenylurea Compounds; Pyridines; Radiotherapy, Adjuvant; Radiotherapy, High-Energy; Rhabdomyosarcoma, Alveolar; Salvage Therapy; Soft Tissue Neoplasms; Sorafenib; Temozolomide; Thigh; Vincristine | 2009 |
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Carboplatin; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dactinomycin; Doxorubicin; Etoposide; Humans; Ifosfamide; Infant; Infratentorial Neoplasms; Irinotecan; Melphalan; Neoplasm Metastasis; Neuroblastoma; Rhabdomyosarcoma; Thiotepa; Topotecan; Vincristine | 2011 |
Apoptosis induced clustering of IP(3)R1 in nuclei of non-differentiated PC12 cells.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; bcl-2-Associated X Protein; Boron Compounds; Calcium; Camptothecin; Caspase 3; Cell Differentiation; Cell Nucleus; Cycloheximide; Dactinomycin; Dexamethasone; Etoposide; Inositol 1,4,5-Trisphosphate Receptors; PC12 Cells; Permeability; Rats; RNA, Messenger; Time Factors; Up-Regulation | 2011 |
Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.
Topics: Adenosine Triphosphatases; Camptothecin; Cisplatin; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Enzyme Inhibitors; Etoposide; Intercalating Agents; Mitoxantrone; Nogalamycin; Novobiocin; Pisum sativum; Plant Proteins | 2011 |
Nucleolar disruption leads to the spatial separation of key 18S rRNA processing factors.
Topics: Camptothecin; Cell Nucleolus; Dactinomycin; Dichlororibofuranosylbenzimidazole; HeLa Cells; Humans; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Protein Binding; Protein Synthesis Inhibitors; Protein Transport; Ribonucleoproteins, Small Nucleolar; RNA Polymerase I; RNA, Ribosomal, 18S; Topoisomerase I Inhibitors; Transcription, Genetic | 2012 |
Detection of apoptosis through the lipid order of the outer plasma membrane leaflet.
Topics: Apoptosis; Camptothecin; Cell Line, Tumor; Cell Membrane; Cholesterol; Dactinomycin; Fluorescent Dyes; HeLa Cells; Humans; Lipid Bilayers; Lipids; Microscopy, Fluorescence; Oxazines; Spectrometry, Fluorescence; Sphingomyelins; Staurosporine | 2012 |
A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death.
Topics: Adenylyl Cyclases; Animals; Apoptosis; Bicarbonates; Calcium; Camptothecin; Cells, Cultured; Cyclic AMP; Dactinomycin; Guanine Nucleotide Exchange Factors; Heart Ventricles; Hydrogen Peroxide; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Permeability; Rats; Rats, Wistar; Signal Transduction; Troponin I | 2016 |
Successful treatment of metastatic alveolar rhabdomyosarcoma with MGMT gene promoter methylation by temozolomide-based combination chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoradiotherapy; Child, Preschool; Cyclophosphamide; Dacarbazine; Dactinomycin; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Humans; Irinotecan; Male; MicroRNAs; Neoplasm Metastasis; Promoter Regions, Genetic; Rhabdomyosarcoma, Alveolar; RNA, Neoplasm; Temozolomide; Tumor Suppressor Proteins; Vincristine | 2018 |
Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis.
Topics: Amino Acid Sequence; Antineoplastic Agents; Camptothecin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Dactinomycin; Etoposide; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Humans; Nuclear Proteins; Phosphoproteins; Protein Binding; Protein Transport; Ribosomes; RNA, Ribosomal; RNA, Small Interfering; Signal Transduction; Telomeric Repeat Binding Protein 2 | 2018 |
PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
Topics: Amino Acid Sequence; Apoptosis; bcl-Associated Death Protein; Camptothecin; Cell Line, Tumor; Dactinomycin; Drug Synergism; Gene Knockdown Techniques; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Long Noncoding; RNA, Messenger; Serine; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53; Up-Regulation | 2018 |
Integrated pan-cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aurora Kinase A; Azepines; Benzodioxoles; Biomarkers, Tumor; Camptothecin; Cell Line, Tumor; Chromones; Dactinomycin; Datasets as Topic; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Irinotecan; Kaplan-Meier Estimate; Male; Middle Aged; Morpholines; Neoplasms; Prognosis; Pyridines; Triazoles | 2021 |