dacarbazine has been researched along with lomeguatrib in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (61.90) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donnelly, DJ; Kelly, J; Margison, GP; McCormick, JE; McElhinney, RS; McMurry, TB; Middleton, MR; Thatcher, N | 1 |
| Donnelly, DJ; Margison, GP; McElhinney, RS; McMurry, TB; Middleton, MR; Thatcher, N | 1 |
| Barvaux, VA; Brown, R; Margison, GP; McElhinney, RS; McMurry, TB; Ranson, M | 1 |
| Fairbairn, LJ; Margison, GP; Milsom, MD; Southgate, TD; Woolford, LB | 1 |
| Clemons, M; Howell, A; Kelly, J; Margison, GP; McElhinney, RS; McMurry, TB; Watson, AJ | 1 |
| Amadori, S; Bonmassar, E; Bonmassar, L; Buccisano, F; Cantonetti, M; Caporaso, P; D'Atri, S; Turriziani, M; Venditti, A | 1 |
| Bridgewater, J; Dawson, M; Donnelly, D; Gumbrell, L; Halbert, G; Jowle, D; Lee, SM; Margison, GP; McElhinney, RS; McGrath, H; McMurry, TB; Middleton, MR; Ranson, M; Waller, S | 1 |
| Middleton, MR; Sabharwal, A | 1 |
| Alvino, E; Amadori, S; Bonmassar, E; Buccisano, F; Caporaso, P; D'Atri, S; Garbin, A; Marchesi, F; Tirindelli, MC; Toppo, L; Tortorelli, G; Turriziani, M; Venditti, A | 1 |
| Baka, S; Beith, J; Davis, ID; Harris, PA; Haydon, A; Hersey, P; Kefford, RF; Margison, GP; McArthur, GA; Middleton, MR; Mortimer, P; Ranson, M; Sabharwal, A; Seebaran, A; Thompson, D; Watson, AJ | 1 |
| Khan, OA; Levitt, NC; Margison, GP; Michael, M; Middleton, MR; Midgley, R; Mortimer, P; Olver, I; Ranson, M; Watson, AJ | 1 |
| Abdi, E; Beith, J; Corrie, PG; Kefford, RF; Kotasek, D; Margison, GP; Middleton, MR; Mortimer, P; Palmer, C; Ranson, M; Thomas, NP; Watson, AJ | 1 |
| Beith, J; Davis, ID; Haydon, A; Hayward, O; Hersey, P; Kefford, R; Lorigan, P; Margison, GP; McArthur, G; McGown, G; Middleton, MR; Mortimer, P; Ranson, M; Sabharwal, A; Thomson, D; Thorncroft, M; Watson, AJ | 1 |
| Kirkwood, JM; Moschos, S; Radkowski, R; Shipe-Spotloe, J; Sulecki, M; Tarhini, A; Tawbi, HA; Villaruz, L; Viverette, F | 1 |
| Gu, F; Li, WL; Sun, ZF | 1 |
| Canpinar, H; Castresana, JS; Ilgaz, S; Ozdemir, M; Ozkan, T; Oztuna, D; Rey, JA; Sunguroğlu, A; Taspinar, M; Ugur, HC | 1 |
| Kewitz, S; Kramm, CM; Staege, MS; Stiefel, M | 1 |
| Canpinar, H; Castresana, JS; Ilgaz, S; Rey, JA; Sert, F; Sunguroglu, A; Taspinar, M; Ugur, HC | 1 |
| Aquino, A; Bonmassar, E; Bonmassar, L; Caporali, S; Cioccoloni, G; D'Atri, S; Fuggetta, MP; Pagani, E | 1 |
| Cuperlovic-Culf, M; Morin, P; Poitras, JJ; St-Coeur, PD; Touaibia, M | 1 |
| Brambilla, D; Cavusoglu, M; Grandjean, J; Leroux, JC; Luciani, P; Martin, E; Papachristodoulou, A; Roth, P; Rudin, M; Signorell, RD; Silginer, M; Weller, M; Werner, B | 1 |
1 review(s) available for dacarbazine and lomeguatrib
| Article | Year |
|---|---|
Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Dacarbazine; DNA Adducts; DNA Methylation; DNA Topoisomerases, Type I; Drug Administration Schedule; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guanine; Humans; Irinotecan; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds; Prognosis; Promoter Regions, Genetic; Temozolomide; Topoisomerase I Inhibitors | 2006 |
6 trial(s) available for dacarbazine and lomeguatrib
| Article | Year |
|---|---|
Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanine; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Safety; Temozolomide | 2006 |
Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Disease Progression; Enzyme Inhibitors; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Purines; Skin Neoplasms; Temozolomide; Treatment Outcome | 2007 |
A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dacarbazine; Disease Progression; Female; Humans; Male; Middle Aged; Neoplasm Staging; Purines; Temozolomide; Treatment Failure | 2008 |
A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.
Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Agents; Child; Dacarbazine; Dose-Response Relationship, Drug; Female; Humans; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Neutropenia; Patient Selection; Purines; Skin Neoplasms; Temozolomide; Thrombocytopenia | 2009 |
O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.
Topics: Antineoplastic Agents; Biopsy; Dacarbazine; Disease Progression; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Humans; Kinetics; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Purines; Temozolomide | 2009 |
Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Administration Schedule; Female; Humans; Male; Melanoma; Middle Aged; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Purines | 2011 |
14 other study(ies) available for dacarbazine and lomeguatrib
| Article | Year |
|---|---|
O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Guanine; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Transplantation, Heterologous | 2000 |
Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model.
Topics: Adenosine Triphosphatases; Animals; Cell Division; Dacarbazine; Disease Models, Animal; Guanine; Humans; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Time Factors | 2002 |
Dual repair modulation reverses Temozolomide resistance in vitro.
Topics: Adaptor Proteins, Signal Transducing; Base Pair Mismatch; Carrier Proteins; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance; Guanine; Humans; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2004 |
The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Female; Genetic Therapy; Guanine; Humans; Male; Mice; Mice, Inbred C57BL; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Xenograft Model Antitumor Assays | 2006 |
O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.
Topics: Animals; Body Weight; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Male; Mice; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Xenograft Model Antitumor Assays | 2005 |
O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro.
Topics: Acute Disease; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Synergism; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Leukocytes, Mononuclear; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 2006 |
Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.
Topics: Animals; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Immunotherapy; Interleukin-2; Leukemia; Mice; O(6)-Methylguanine-DNA Methyltransferase; Pilot Projects; Purines; Temozolomide; Tumor Suppressor Proteins | 2007 |
[Analysis of the relevant factors of mechanism for telozolomide chemoresistance].
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzimidazoles; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Humans; Membrane Proteins; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Purines; Pyrimidines; Temozolomide; Tumor Suppressor Protein p53 | 2011 |
Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Proliferation; Comet Assay; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoenzyme Techniques; Male; Middle Aged; Polymerase Chain Reaction; Promoter Regions, Genetic; Purines; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2013 |
Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells.
Topics: Antineoplastic Agents, Alkylating; Azacitidine; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hodgkin Disease; Humans; Immunoblotting; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Purines; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Purines; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2014 |
Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro.
Topics: Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Enzyme Inhibitors; HCT116 Cells; HT29 Cells; Humans; In Vitro Techniques; Lactones; Leukocytes, Mononuclear; Neoplasms; Orlistat; Purines; Temozolomide; Tumor Suppressor Proteins | 2015 |
Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Glioblastoma; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Purines; Temozolomide; Tritium; Tumor Suppressor Proteins | 2015 |
Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Enzyme Inhibitors; Glioblastoma; Guanine; Liposomes; Magnetic Resonance Imaging; Mice; O(6)-Methylguanine-DNA Methyltransferase; Ultrasonic Waves | 2019 |