dacarbazine and isomethyleugenol

dacarbazine has been researched along with isomethyleugenol in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (22.92)	18.7374
1990's	3 (6.25)	18.2507
2000's	7 (14.58)	29.6817
2010's	25 (52.08)	24.3611
2020's	2 (4.17)	2.80

Authors

Authors	Studies
Borri-Voltattorni, C; Dominici, P; Fioretti, MC; Fuschiotti, P; Puccetti, P; Romani, L	1
Cerny, T; Margison, GP; Maynard, K; Parsons, PG	1
Catapano, CV; D'Incalci, M; Erba, E; Filippeschi, S; Zucchetti, M	1
Tisdale, MJ	2
Janzer, RC; Kleihues, P; Kolar, GF; Meer, L	1
Fioretti, MC; Puccetti, P; Romani, L	1
Dolzani, L; Monti-Bragadin, C; Sava, G; Tamaro, M	1
Gescher, A; Harland, S; Newell, D; Ross, D; Rutty, C	1
Broggini, M; Catapano, CV; Citti, L; D'Incalci, M; Erba, E; Mariani, L; Ponti, M	1
Bailey, E; Connors, TA; Farmer, PB; Gorf, SM; Rickard, J	1
Gurtoo, HL; Maccubbin, AE; Mudipalli, A; Nadadur, SS	1
Gerson, SL; Liu, L; Markowitz, S	1
Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH	1
Berger, MS; Hirose, Y; Katayama, M; Mirzoeva, OK; Pieper, RO	1
Altundag, K; Altundag, MB; Altundag, O; Boruban, C; Turen, S	1
Aldape, K; Black, PM; Chakravarti, A; Erkkinen, MG; Gilbert, MR; Loeffler, JS; Mehta, M; Nestler, U; Stupp, R	1
Del Maestro, R; Guiot, MC; Kavan, P; Lambert, C; Leblanc, R; Muanza, T; Panet-Raymond, V; Roberge, D; Shakibnia, L; Shenouda, G; Souhami, L	1
Boeckmann, L; Emmert, S; Gutzmer, R; Has, C; Kunz, M; Kuschal, C; Laspe, P; Struever, D; Thoms, KM	1
Ballman, KA; Carlson, BL; Decker, PA; Giannini, C; Grogan, PT; James, CD; Kitange, GJ; Mladek, AC; Sarkaria, JN; Schroeder, MA; Wu, W	1
Cheng, AL; Kuo, KT; Kuo, LT; Lee, WC; Lin, CH; Lin, YT; Lu, YS; Tasi, JC; Tseng, HM; Tseng, SH; Tu, YK; Wu, PF; Wu, RM; Yang, CH	1
Bilbao, JM; Del Maestro, RF; Fazl, M; Guiot, MC; Oh, J; Perry, JR; Tsao, MN	1
Agarwal, N; Ahluwalia, MS; Barnett, GH; Brewer, CJ; Elson, P; Peereboom, DM; Shepard, DR; Stevens, GH; Suh, JH; Toms, SA; Vogelbaum, MA; Weil, RJ	1
Blechschmidt, C; Czabanka, M; Koch, A; Misch, M; Plotkin, M; Stockhammer, F; Tuettenberg, J; Vajkoczy, P	1
Camaioni, E; Dantzer, F; Dorio, AS; Gold, B; Graziani, G; Leonetti, C; Muzi, A; Pellicciari, R; Scarsella, M; Shah, GM; Tentori, L; Xu, W; Zhang, J	1
Belinsky, SA; Bernauer, AM; Burki, EA; Costello, JF; Crowell, RE; Do, KC; Flores, KG; Gilliland, FD; Hong, C; Leng, S; Picchi, MA; Prados, MD; Stidley, CA; Tellez, CS; Tessema, M; Willink, RP; Yingling, CM	1
Hirose, Y; Kanai, R; Louis, DN; Martuza, RL; Rabkin, SD; Sgubin, D; Wakimoto, H; Yip, S; Zaupa, CM	1
Chatzisotiriou, A; Eleftheraki, AG; Fountzilas, G; Iliadis, G; Kotoula, V; Lambaki, S; Misailidou, D; Selviaridis, P; Televantou, D	1
Ewelt, C; Felsberg, J; Jakobs, O; Martus, P; Meinel, T; Reifenberger, G; Stummer, W	1
Carlson, BL; Cen, L; Decker, PA; Gupta, SK; Kitange, GJ; Lomberk, GA; Mladek, AC; Pokorny, JL; Sarkaria, JN; Schroeder, MA; Urrutia, RA; Wu, W	1
Geng, J; Luo, H; Pu, Y; Wu, X; Xu, W; Yang, Z; Zhou, Z	1
Lewis, BC; Miners, JO	1
Abrams, JS; Conley, BA; Freidlin, B; Korn, EL; McShane, LM; Polley, MY	1
Chamberlain, MC	1
Balañà, C; Capdevila, L; Carrato, C; Cros, S; Cuadra, JL; Etxaniz, O; Hostalot, C; Massuet, A; Ramirez, JL; Romeo, M; Sanz, C; Villà, S	1
Ohta, H; Sato, Y; Takeshima, H; Uehara, H; Yamasaki, K; Yamashita, S; Yokogami, K	1
Chapet, S; Lévy, S; Mazeron, JJ	1
He, W; Liu, R; Yang, SH; Yuan, F	1
Cai, Q; Chen, Q; Daofeng, T; Dong, H; Guo, Z; Ji, B; Liu, B; Liu, Y; Wang, J; Wang, L; Wu, L; Zhang, S; Zhu, X	1
Cloughesy, TF; Ha, W; Hitchins, MP; Lai, A; McDonald, KL; Nguyen, HN; Nowak, AK; Rapkins, RW; Wang, F	1
Benecke, R; Grossmann, A; Hildebrandt, G; Kirschstein, T; Piek, J; Rösche, J	1
Mohile, NA	1
Gallo, JM; Pickard, AJ; Wang, T	1
Choi, SH; Heo, DS; Jung, HW; Kim, DG; Kim, IH; Kim, SK; Kim, TM; Lee, SH; Lee, ST; Park, CK	1
Back, M; Brazier, D; Cook, R; Gzell, C; Harris, G; Jayamanne, D; Kastelan, M; Khasraw, M; Louw, S; Parkinson, J; Schembri, G; Wheeler, H	1
Bähr, O; Belka, C; Braun, C; Gerlach, R; Glas, M; Goldbrunner, R; Hänel, M; Hattingen, E; Hau, P; Herrlinger, U; Junold, N; Kebir, S; Kortmann, RD; Krex, D; Mack, F; Niessen, M; Proescholdt, M; Rohde, V; Sabel, M; Schäfer, N; Schaub, C; Schlegel, U; Schmidt-Graf, F; Steinbach, JP; Stuplich, M; Tzaridis, T; Vatter, H; Weyerbrock, A	1
Birkl-Toeglhofer, AM; Brawanski, KR; Freyschlag, CF; Haybaeck, J; Hoeftberger, R; Manzl, C; Sprung, S; Ströbel, T; Thomé, C	1
Harter, PN; Herms, J; Katzendobler, S; Niedermeyer, S; Niyazi, M; Stoecklein, VM; Thon, N; Tonn, JC; Trumm, C; Weller, J	1

Reviews

5 review(s) available for dacarbazine and isomethyleugenol

Article	Year
Chemical xenogenization of experimental tumors. Cancer metastasis reviews, 1987, Volume: 6, Issue:2 Topics: Animals; Antigens, Neoplasm; Carmustine; Cell Line; Dacarbazine; DNA; Histocompatibility Antigens; Immunotherapy; Methylation; Methylnitronitrosoguanidine; Neoplasms, Experimental; T-Lymphocytes, Cytotoxic; Triazenes	1987
N-methyl antitumour agents. A distinct class of anticancer drugs? Cancer chemotherapy and pharmacology, 1987, Volume: 19, Issue:2 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Dacarbazine; Formamides; Humans; Methylation; Nitrosourea Compounds; Procarbazine; Structure-Activity Relationship	1987
Generation, validation, and application of a P450 homology model. Current topics in medicinal chemistry, 2013, Volume: 13, Issue:18 Topics: Antineoplastic Agents; Biocatalysis; Cytochrome P-450 CYP1A1; Dacarbazine; Humans; Kinetics; Melanoma; Methylation; Models, Molecular; Mutation; Prodrugs; Reproducibility of Results; Structure-Activity Relationship	2013
[Management of gliomas]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2014, Volume: 18, Issue:5-6 Topics: Age Factors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Drug Resistance, Neoplasm; Glioma; Humans; Lomustine; Methylation; Multicenter Studies as Topic; Neoplasm Proteins; Neurosurgical Procedures; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Outcome; Vincristine	2014
How I treat glioblastoma in older patients. Journal of geriatric oncology, 2016, Volume: 7, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Geriatric Assessment; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Quality of Life; Seizures; Standard of Care; Temozolomide; Tumor Suppressor Proteins	2016

Trials

3 trial(s) available for dacarbazine and isomethyleugenol

Article	Year
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme. Journal of neuro-oncology, 2010, Volume: 98, Issue:1 Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiotherapy; Temozolomide; Tumor Suppressor Proteins; Young Adult	2010
Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation. Journal of neuro-oncology, 2014, Volume: 117, Issue:1 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Neoadjuvant Therapy; Radiation-Sensitizing Agents; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult	2014
Tumor growth patterns of MGMT-non-methylated glioblastoma in the randomized GLARIUS trial. Journal of cancer research and clinical oncology, 2018, Volume: 144, Issue:8 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cell Growth Processes; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Irinotecan; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Radiotherapy; Temozolomide; Tumor Suppressor Proteins	2018

Other Studies

40 other study(ies) available for dacarbazine and isomethyleugenol

Article	Year
DNA methylating activity in murine lymphoma cells xenogenized by triazene derivatives. International journal of cancer, 1987, Jun-15, Volume: 39, Issue:6 Topics: Animals; Azacitidine; Carmustine; Cell Line; Cytarabine; Dacarbazine; DNA, Neoplasm; Lymphoma; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinacrine; Triazenes	1987
Relationships among cell survival, O6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines. Cancer research, 1989, Sep-01, Volume: 49, Issue:17 Topics: Adenoviruses, Human; Alkylating Agents; Cell Survival; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Melanoma; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Simplexvirus; Tumor Cells, Cultured	1989
Temozolomide induced differentiation of K562 leukemia cells is not mediated by gene hypomethylation. Biochemical pharmacology, 1989, Jul-01, Volume: 38, Issue:13 Topics: Blotting, Northern; Cell Cycle; Cell Differentiation; Dacarbazine; DNA Damage; DNA, Neoplasm; Flow Cytometry; Genes, ras; Humans; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methylation; Proto-Oncogenes; Temozolomide; Tumor Cells, Cultured	1989
Antitumour imidazotetrazines--XVIII. Modification of the level of 5-methylcytosine in DNA by 3-substituted imidazotetrazinones. Biochemical pharmacology, 1989, Apr-01, Volume: 38, Issue:7 Topics: 5-Methylcytosine; Antineoplastic Agents; Cell Division; Cell Line; Cytosine; Dacarbazine; DNA; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Humans; Imidazoles; Lymphocytes; Methylation; Temozolomide	1989
In vivo metabolism and reaction with DNA of the cytostatic agent, 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC). Biochemical pharmacology, 1986, Oct-01, Volume: 35, Issue:19 Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Radioisotopes; Dacarbazine; DNA; Female; Guanine; Methylation; Rats; Rats, Inbred F344	1986
Antitumour imidazotetrazines-X. Effect of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4-(3H)-one (CCRG 81045; M & B 39831; NSC 362856) on DNA methylation during induction of haemoglobin synthesis in human leukaemia cell line K562. Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2 Topics: 5-Methylcytosine; Antineoplastic Agents; Cell Differentiation; Cell Line; Cytosine; Dacarbazine; DNA Replication; DNA, Neoplasm; Gene Expression Regulation; Globins; Hemoglobins; Humans; Imidazoles; Leukemia, Erythroblastic, Acute; Methylation; Temozolomide; Templates, Genetic; Time Factors	1986
Mutagenic activity of the dacarbazine analog p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt in bacterial cells. Pharmacological research communications, 1986, Volume: 18, Issue:5 Topics: Animals; Antineoplastic Agents; Biotransformation; Dacarbazine; Escherichia coli; Methylation; Microsomes, Liver; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium; Structure-Activity Relationship; Triazenes	1986
In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas. Cancer research, 1987, Sep-15, Volume: 47, Issue:18 Topics: Animals; Antineoplastic Agents; Carmustine; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Flow Cytometry; Leukemia L1210; Methylation; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide	1987
Methylation of cysteine in hemoglobin following exposure to methylating agents. Cancer research, 1981, Volume: 41, Issue:6 Topics: Alkylating Agents; Animals; Chemical Phenomena; Chemistry; Cricetinae; Cysteine; Dacarbazine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Environmental Exposure; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Hemoglobins; Humans; Methyl Methanesulfonate; Methylation; Mice; Poultry; Rats; Species Specificity	1981
Mutations induced by dacarbazine activated with cytochrome P-450. Mutation research, 1995, Volume: 327, Issue:1-2 Topics: Biotransformation; Cell Line, Transformed; Cell-Free System; Cytochrome P-450 Enzyme System; Dacarbazine; Escherichia coli; Genes, Reporter; Genes, Suppressor; Genetic Vectors; Humans; Hydroxylation; Kidney; Methylation; Microsomes, Liver; Mutagenesis; Mutation; NADP; Point Mutation; Prodrugs; RNA, Bacterial; RNA, Transfer; Sequence Deletion	1995
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer research, 1996, Dec-01, Volume: 56, Issue:23 Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay	1996
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:4 Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured	1996
Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer research, 2005, Jun-01, Volume: 65, Issue:11 Topics: Antineoplastic Agents, Alkylating; Astrocytes; Cell Line, Transformed; Cell Line, Tumor; Checkpoint Kinase 2; Dacarbazine; Enzyme Activation; G2 Phase; Glioblastoma; Humans; Methylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Temozolomide	2005
Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma. Medical hypotheses, 2005, Volume: 65, Issue:4 Topics: Dacarbazine; DNA Repair; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Phenytoin; Temozolomide	2005
Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-01, Volume: 12, Issue:15 Topics: Animals; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; DNA Damage; Glioblastoma; Guanine; Humans; Methylation; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous; Xenograft Model Antitumor Assays	2006
Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis. International journal of radiation oncology, biology, physics, 2009, Feb-01, Volume: 73, Issue:2 Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Radiotherapy, Intensity-Modulated; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Burden	2009
Modulation of the efficacy of temozolomide and dacarbazine melanoma treatment by DNA-repair factors in vivo and in vitro. International journal of clinical pharmacology and therapeutics, 2009, Volume: 47, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Clinical Trials as Topic; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes; Melanoma; Methylation; MutL Protein Homolog 1; MutS Homolog 2 Protein; Nuclear Proteins; Prodrugs; Promoter Regions, Genetic; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins	2009
Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts. International journal of radiation oncology, biology, physics, 2009, Sep-01, Volume: 75, Issue:1 Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Genes, erbB-1; Genes, p53; Glioblastoma; Humans; Methylation; Mice; O(6)-Methylguanine-DNA Methyltransferase; PTEN Phosphohydrolase; Radiation-Sensitizing Agents; Random Allocation; Survival Analysis; Temozolomide; Xenograft Model Antitumor Assays	2009
O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers. Lung cancer (Amsterdam, Netherlands), 2010, Volume: 68, Issue:3 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Temozolomide; Tumor Suppressor Proteins	2010
Recurrent PNET with MGMT methylation responds to temozolomide. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2009, Volume: 36, Issue:5 Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Methylation; Neuroectodermal Tumors, Primitive; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide	2009
Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma. Journal of neuro-oncology, 2010, Volume: 100, Issue:3 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorine Radioisotopes; Follow-Up Studies; Glioblastoma; Humans; Male; Methylation; Middle Aged; Positron-Emission Tomography; Pyrazoles; Retrospective Studies; Sulfonamides; Temozolomide; Tumor Suppressor Proteins; Tyrosine	2010
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. Current cancer drug targets, 2010, Volume: 10, Issue:4 Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Division; Cell Line, Tumor; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; G2 Phase; HeLa Cells; Humans; Melanoma, Experimental; Methylation; Mice; Netropsin; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide	2010
The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-01, Volume: 17, Issue:7 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Antineoplastic Agents, Alkylating; beta-Galactosidase; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genetic Association Studies; Haplotypes; Humans; Linkage Disequilibrium; Luciferases; Lung Neoplasms; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Precancerous Conditions; Promoter Regions, Genetic; Smoking; Sputum; Temozolomide; Transcription, Genetic; Tumor Suppressor Proteins	2011
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells. Journal of the National Cancer Institute, 2012, Jan-04, Volume: 104, Issue:1 Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Genetic Vectors; Glioblastoma; Humans; Immunoblotting; Immunohistochemistry; Methylation; Mice; Mice, Nude; Neoplastic Stem Cells; Oncolytic Virotherapy; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Simplexvirus; Temozolomide; Tumor Suppressor Proteins; Vero Cells; Virus Replication	2012
Volumetric and MGMT parameters in glioblastoma patients: survival analysis. BMC cancer, 2012, Jan-03, Volume: 12 Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Profiling; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Analysis; Temozolomide; Tumor Burden; Tumor Suppressor Proteins	2012
Prospective cohort study of radiotherapy with concomitant and adjuvant temozolomide chemotherapy for glioblastoma patients with no or minimal residual enhancing tumor load after surgery. Journal of neuro-oncology, 2012, Volume: 108, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Postoperative Complications; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult	2012
Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Aug-01, Volume: 18, Issue:15 Topics: Acetylation; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Methylation; Mice; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Tumor Suppressor Proteins; Up-Regulation; Vorinostat; Xenograft Model Antitumor Assays	2012
Methylation mediated silencing of miR-23b expression and its role in glioma stem cells. Neuroscience letters, 2012, Oct-24, Volume: 528, Issue:2 Topics: Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Decitabine; Down-Regulation; Epigenesis, Genetic; Gene Silencing; Glioma; Humans; Methylation; MicroRNAs; Neoplastic Stem Cells; Promoter Regions, Genetic; Temozolomide	2012
Statistical and practical considerations for clinical evaluation of predictive biomarkers. Journal of the National Cancer Institute, 2013, Nov-20, Volume: 105, Issue:22 Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins	2013
Treatment of newly diagnosed malignant glioma in the elderly people: new trials that impact therapy. International journal of clinical practice, 2013, Volume: 67, Issue:12 Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemoradiotherapy; Dacarbazine; Glioblastoma; Guanosine; Humans; Methylation; Middle Aged; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide	2013
Case of primary diffuse leptomeningeal gliomatosis. Brain tumor pathology, 2014, Volume: 31, Issue:3 Topics: Antineoplastic Agents, Alkylating; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Fatal Outcome; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Methylation; Middle Aged; Neoplasms, Neuroepithelial; Promoter Regions, Genetic; Radiotherapy; Temozolomide; Tumor Suppressor Proteins	2014
Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas. Anti-cancer drugs, 2015, Volume: 26, Issue:3 Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electron Transport Complex I; Glioma; Humans; Male; Methylation; Mitochondria; Promoter Regions, Genetic; Rats, Sprague-Dawley; Tamoxifen; Temozolomide; Tumor Suppressor Proteins	2015
LRIG1, human EGFR inhibitor, reverses multidrug resistance through modulation of ABCB1 and ABCG2. Brain research, 2015, Jun-22, Volume: 1611 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Membrane Glycoproteins; Methylation; Neoplasm Proteins; Promoter Regions, Genetic; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins; Up-Regulation	2015
The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide. Neuro-oncology, 2015, Volume: 17, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Alleles; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins	2015
[Perampanel in the treatment of a patient with glioblastoma multiforme without IDH1 mutation and without MGMT promotor methylation]. Fortschritte der Neurologie-Psychiatrie, 2015, Volume: 83, Issue:5 Topics: Alkylating Agents; Brain Neoplasms; Dacarbazine; Epilepsies, Partial; Excitatory Amino Acid Antagonists; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Mutation; Nitriles; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Pyridones; Survival Analysis; Temozolomide	2015
Histone Methylation by Temozolomide; A Classic DNA Methylating Anticancer Drug. Anticancer research, 2016, Volume: 36, Issue:7 Topics: Animals; Antineoplastic Agents, Alkylating; Arginine; Dacarbazine; DNA Methylation; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Temozolomide; Xenopus	2016
The survival significance of a measurable enhancing lesion after completing standard treatment for newly diagnosed glioblastoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 34 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult	2016
Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy. International journal of radiation oncology, biology, physics, 2017, 07-15, Volume: 98, Issue:4 Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Kaplan-Meier Estimate; Methylation; Multivariate Analysis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Regression Analysis; Retrospective Studies; Temozolomide; Time Factors; Tumor Suppressor Proteins	2017
Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide. International journal of molecular sciences, 2023, Mar-24, Volume: 24, Issue:7 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Progression-Free Survival; Temozolomide; Tumor Suppressor Proteins	2023
Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status. Journal of neuro-oncology, 2023, Volume: 163, Issue:2 Topics: Aged; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Prognosis; Tumor Suppressor Proteins	2023