dacarbazine has been researched along with guanine in 114 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (1.75) | 18.7374 |
1990's | 28 (24.56) | 18.2507 |
2000's | 55 (48.25) | 29.6817 |
2010's | 26 (22.81) | 24.3611 |
2020's | 3 (2.63) | 2.80 |
Authors | Studies |
---|---|
Bonfanti, M; Catapano, CV; Citti, L; D'Incalci, M; Taverna, P | 1 |
Baan, RA; Keizer, HJ; Ouwerkerk, J; van Delft, JH; van den Ende, AM | 1 |
Boussiotis, VA; Kyrtopoulos, SA; Pangalis, GA; Souliotis, VL | 1 |
Försti, A; Hemminki, K; Hietanen, P; Mustonen, R | 2 |
Janzer, RC; Kleihues, P; Kolar, GF; Meer, L | 1 |
Tisdale, MJ | 1 |
Bigner, DD; Catino, JJ; Dolan, ME; Friedman, HS; Keir, S; Marcelli, S; Pegg, AE; Schold, SC | 1 |
Elder, RH; Fairbairn, LJ; Margison, GP; Rafferty, JA; Watson, AJ | 1 |
Boussiotis, VA; Kyrtopoulos, SA; Pangalis, GA; Souliotis, VL; Valavanis, C | 2 |
Baer, JC; Freeman, AA; Margison, GP; Newlands, ES; Rafferty, JA; Watson, AJ | 1 |
May, BL; Newlands, ES; Porteus, JK; Wedge, SR | 1 |
Alas, LG; Belanich, M; Citron, ML; Dolan, ME; Gander, M; Kibitel, JT; Lejeune, FJ; Li, BF; Pastor, MA; Randall, T; Schold, SC; Wasserman, P; White, AB; Yarosh, DB | 1 |
Newlands, ES; Wedge, SR | 1 |
Newlands, ES; Porteous, JK; Wedge, SR | 2 |
Bonmassar, E; D'Atri, S; Graziani, G; Lacal, PM; Orlando, L | 1 |
Gerson, SL; Liu, L; Markowitz, S | 1 |
Ashby, J; Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Margison, GP; Rafferty, JA; Tinwell, H | 1 |
Benincasa, E; Bonmassar, E; Faraoni, I; Franco, D; Graziani, G; Lacal, PM; Tentori, L | 1 |
Bailey, JA; Cooper, DP; Deans, B; Elder, RH; Heeran, MC; Jansen, JG; Margison, GP; Mynett, KJ; Rafferty, JA; van Zeeland, AA; Watson, AJ; Weeks, RJ; Wijnhoven, SW; Willington, MA | 1 |
Chinnasamy, N; Dexter, TM; Fairbairn, LJ; Hickson, I; Lashford, LS; Margison, GP; Rafferty, JA; Thatcher, N | 1 |
Ganesan, TS; Harris, AL; Kyrtopoulos, SA; Mitchell, K; Philip, PA; Salisbury, A; Souliotis, VL; Tates, AD; van Delft, JH | 1 |
Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH | 1 |
Davis, BM; Gerson, SL; Liu, L; Reese, JS | 1 |
Chan, TH; Damian, Z; De Marte, J; Jean-Claude, BJ; Leyland-Jones, B; Mustafa, A; Vasilescu, DE; Yen, R | 1 |
Arends, MJ; Clarke, AR; Dekker, M; Howard, LA; Kelly, J; Margison, GP; te Riele, H; Toft, NJ; Winton, DJ; Wyllie, AH | 1 |
Bonmassar, E; Franco, D; Graziani, G; Levati, L; Roy, R; Serafino, A; Tentori, L; Turriziani, M | 1 |
Alvino, E; Bonmassar, E; D'Atri, S; Lacal, PM; Nunziata, C; Pagani, E; Pepponi, R | 1 |
Donnelly, DJ; Kelly, J; Margison, GP; McCormick, JE; McElhinney, RS; McMurry, TB; Middleton, MR; Thatcher, N | 1 |
Goodger, S; Kelly, J; Margison, GP; Middleton, MR; Thatcher, N | 1 |
Kyrtopoulos, SA; Psaroudi, MC | 1 |
Arends, MJ; Brookes, RA; Clarke, AR; Margison, GP; Sansom, OJ; Toft, NJ; Winton, DJ; Wood, M | 1 |
Cai, Y; Dolan, ME; Ludeman, SM; Pegg, AE; Wu, MH; Xu-Welliver, M | 1 |
Arance, A; Lee, SM; Margison, GP; Middleton, MR; Thatcher, N; Wood, M | 1 |
Arris, CE; Bleasdale, C; Boyle, FT; Calvert, AH; Curtin, NJ; Dalby, C; Golding, BT; Griffin, RJ; Kanugula, S; Lembicz, NK; Newell, DR; Pegg, AE | 1 |
Brent, TP; Houghton, P; Sawai, N; Sorrentino, BP; Vanin, EF; Zhou, S | 1 |
Bocangel, DB; Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC | 1 |
Dolan, ME; Long, L | 1 |
Berman, E; Gallo, JM; Ma, J; Murphy, M; O'Dwyer, PJ; Reed, K | 1 |
Donnelly, DJ; Margison, GP; McElhinney, RS; McMurry, TB; Middleton, MR; Thatcher, N | 1 |
Bigner, DD; Colvin, OM; Dolan, ME; Friedman, HS; Houghton, PJ; Keir, S; Moschel, RC; Pegg, AE | 1 |
Berger, MS; Erickson, LC; Hirose, Y; Kreklau, EL; Pieper, RO | 1 |
Allay, ER; Brent, TP; Hanawa, H; Hargrove, PW; Nienhuis, AW; Persons, DA; Sawai, N; Sorrentino, BP | 1 |
Germano, IM; Ito, H; Kanzawa, T; Kondo, S; Kondo, Y; Kyo, S | 1 |
Ahmed, MM; Chendil, D; Kokkinakis, DM; Moschel, RC; Pegg, AE | 1 |
Bedwell, J; Germano, IM; Kanzawa, T; Kondo, S; Kondo, Y | 1 |
Baumgartner, M; Kaina, B; Roos, W | 1 |
Arris, CA; Calvert, HA; Canan-Koch, S; Curtin, NJ; Durkacz, BW; Hostomsky, Z; Kyle, S; Newell, DR; Wang, LZ; Webber, SE; Yiakouvaki, A | 1 |
Barvaux, VA; Brown, R; Margison, GP; McElhinney, RS; McMurry, TB; Ranson, M | 1 |
Koch, M; Koomen, GJ; Wanner, MJ | 1 |
Blank, A; Bobola, MS; Ellenbogen, RG; Geyer, JR; Goff, RD; Silber, JR | 1 |
Cai, S; Cooper, RJ; Ferkowicz, MJ; Hartwell, JR; Kelley, MR; Pollok, KE; Xu, Y | 1 |
Chiang, SY; Huang, TH; Lin, HY; Swenberg, JA; Uang, SN; Wei, YC; Wu, HD; Wu, KY | 1 |
Fairbairn, LJ; Margison, GP; Milsom, MD; Southgate, TD; Woolford, LB | 1 |
Bigner, DD; Birch, R; Brem, H; Dancey, JE; Delaney, SM; Desjardins, A; Dolan, ME; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Maxwell, J; McLendon, RE; Moschel, RC; Pegg, AE; Provenzale, JM; Quinn, JA; Reardon, DA; Rich, J; Sampson, JH; Tourt-Uhlig, S; Vredenburgh, J; Weingart, J | 1 |
Benimetskaya, L; Miller, P; Stein, CA | 1 |
Aikin, AA; Balis, FM; Fox, E; Libucha, M; Packer, RJ; Warren, KE; Widemann, BC | 1 |
Clemons, M; Howell, A; Kelly, J; Margison, GP; McElhinney, RS; McMurry, TB; Watson, AJ | 1 |
Aghi, M; Martuza, RL; Rabkin, S | 1 |
Amadori, S; Bonmassar, E; Bonmassar, L; Buccisano, F; Cantonetti, M; Caporaso, P; D'Atri, S; Turriziani, M; Venditti, A | 1 |
Covas, DT; Davis, BM; Encell, LP; Fontes, AM; Gerson, SL; Lingas, K; Loeb, LA; Pegg, AE; Zago, MA | 1 |
Bridgewater, J; Dawson, M; Donnelly, D; Gumbrell, L; Halbert, G; Jowle, D; Lee, SM; Margison, GP; McElhinney, RS; McGrath, H; McMurry, TB; Middleton, MR; Ranson, M; Waller, S | 1 |
Middleton, MR; Sabharwal, A | 1 |
Batista, LF; Kaina, B; Menck, CF; Naumann, SC; Roos, WP; Weller, M; Wick, W | 1 |
Baum, C; Fujita, J; Itoh, K; Itoh, Y; Masuda, T; Okanoue, T; Umemura, A; Yamaguchi, K | 1 |
Aldape, K; Black, PM; Chakravarti, A; Erkkinen, MG; Gilbert, MR; Loeffler, JS; Mehta, M; Nestler, U; Stupp, R | 1 |
Alvino, E; Bonmassar, E; Caporali, S; Caporaso, P; Castiglia, D; D'Atri, S; Fischer, F; Jiricny, J; Lacal, PM; Marra, G; Pepponi, R; Zambruno, G | 1 |
Boor, S; Hundsberger, T; Kaina, B; Koch, D | 1 |
Delaney, SM; Dolan, ME; Hansen, RJ; Nagasubramanian, R; Samson, LD | 1 |
Chen, CC; D'Andrea, A; Taniguchi, T | 1 |
Darga, TE; Dolan, ME; Kufe, DW; Weichselbaum, RR; Wu, MH; Yamini, B; Yu, X | 1 |
Billups, CA; Danks, MK; McLendon, RE; Wagner, LM; Weiss, BD; Yoon, KJ | 1 |
Adema, AD; Bhakat, KK; Boven, E; Fontijn, D; Peters, GJ; Pinedo, HM | 1 |
Boyett, JM; Broniscer, A; Danks, MK; Friedman, HS; Gajjar, A; Goldman, S; Gururangan, S; Kun, LE; MacDonald, TJ; Packer, RJ; Poussaint, TY; Stewart, CF; Wallace, D | 1 |
Ogawa, M; Ueda, T; Yamauchi, T | 1 |
Ancheta, K; Chtchetinin, J; Cloughesy, T; Lai, A; Nghiemphu, PL; Remington, M | 1 |
Kaina, B; Kiedron, O; Naumann, SC; Nikolova, T; Quiros, S; Roos, WP; Zdzienicka, MZ | 1 |
Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Rich, JN; Sampson, JH; Vredenburgh, JJ; Walker, A | 2 |
Desjardins, A; Friedman, HS; Gururangan, S; Herndon, JE; Jiang, SX; McLendon, RE; Quinn, JA; Reardon, DA; Sampson, JH; Vredenburgh, JJ | 1 |
Aikin, AA; Balis, FM; Cole, DE; Fox, E; Meany, HJ; Warren, KE | 1 |
Choi, U; Clevenger, JR; Donahue, RE; Dunbar, CE; Kang, E; Krouse, A; Larochelle, A; Loktionova, NA; Malech, HL; Metzger, M; Naumann, N; Persons, D; Shou, Y; Sorrentino, BP; Stewart, C | 1 |
Coffey, M; Hollywood, D; Lawler, M; Marignol, L; Marples, B; Martin, L | 1 |
Baumann, RP; Ishiguro, K; Penketh, PG; Sartorelli, AC; Shyam, K; Zhu, YL | 1 |
Dianov, GL; Digweed, M; Eich, M; Kaina, B; Roos, WP | 1 |
Jin, YH; Liu, HY; Shu, F; Wang, QJ; Wang, Z; Yang, Y; Zhang, WB | 1 |
Cai, W; Cui, W; Harutyunyan, N; Ji, L; Keshelava, N; Maldonado, NV; Reynolds, CP; Sposto, R | 1 |
Ahmed, MM; Gupta, S; Sathishkumar, S | 1 |
Banze, LA; Brown, AR; Goellner, EM; Hamilton, RL; Moore, B; Sobol, RW; Svilar, D; Tang, JB; Trivedi, RN; Wang, XH | 1 |
Bailey, B; Baluyut, AR; Cai, S; Chan, RJ; Ernstberger, A; Goebel, WS; Jones, DR; Juliar, BE; Mayo, LD; Pollok, KE; Sinn, AL; Wang, H | 1 |
Balis, FM; Berg, SL; Boyett, JM; Geyer, JR; Goldman, S; Gururangan, S; Kun, LE; McLendon, RE; Minturn, JE; Packer, RJ; Pollack, IF; Poussaint, TY; Wallace, D; Warren, KE | 1 |
Bradshaw, TD; Stevens, MF; Zhang, J | 1 |
Balabanov, S; Bokemeyer, C; Braig, M; Hagel, C; Hauber, J; Lamszus, K; Pällmann, N; Preukschas, M; Schulte, A; Sievert, H; Weber, K | 1 |
Christmann, M; Kaina, B; Knizhnik, AV; Nikolova, T; Quiros, S; Roos, WP; Tomaszowski, KH | 1 |
Bailey, BJ; Baluyut, AR; Cai, S; Cai, W; Crean, C; Czader, MB; Ernstberger, A; Goebel, WS; Mayo, LD; Pollok, KE; Shokolenkoc, I; Suvannasankha, A; Wang, H; Wang, MZ; Wilson, GL | 1 |
Hatzidaki, E; Papandreou, CN; Vlachostergios, PJ | 1 |
Eich, M; Kaina, B; Nikolova, T; Roos, WP | 1 |
Desai, A; Gerson, S | 1 |
Adair, JE; Baldock, AL; Beard, BC; Born, DE; Bridge, CA; Gonzalez-Cuyar, LF; Gori, JL; Guyman, LA; Hawkins-Daarud, A; Johnston, SK; Kiem, HP; Mrugala, MM; Rockhill, JK; Rockne, RC; Silbergeld, DL; Storer, BE; Swanson, KR | 1 |
Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N | 1 |
Boldorini, R; Buosi, R; Gaudino, E; Mancuso, G; Mercalli, F; Mezzapelle, R; Miglio, U; Paganotti, A; Rena, O; Veggiani, C | 1 |
Berdasco, M; Caba, O; Cabeza, L; Gónzalez, B; Melguizo, C; Ortiz, R; Perazzoli, G; Prados, J | 1 |
Bui, Y; Cloughesy, TF; Hong, I; Lai, A; Liau, LM; McBride, WH; Menjivar, JC; Nelson, SF; Stream, A; Tso, CL; Tso, JL; Yamada, K; Yang, S; Yong, WH; Zhang, Y | 1 |
Arita, H; Fukushima, S; Ichimura, K; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Shibui, S; Takami, H; Yonezawa, M; Yoshida, A | 1 |
Kasende, OE; Nziko, Vde P; Scheiner, S | 1 |
Luedtke, NW; Marsoner, T; Schmidt, OP; Triemer, T | 1 |
Goodfellow, E; Jean-Claude, B; Senhaji Mouhri, Z | 1 |
Chumakova, A; Lathia, JD | 1 |
Brambilla, D; Cavusoglu, M; Grandjean, J; Leroux, JC; Luciani, P; Martin, E; Papachristodoulou, A; Roth, P; Rudin, M; Signorell, RD; Silginer, M; Weller, M; Werner, B | 1 |
de Groot, JF; Gao, F; Koul, D; Li, X; Wu, S; Yung, WKA | 1 |
Bao, L; Kumar, A; Luo, W; Wang, C; Wang, Y; Xing, C; Yang, M; Zhou, M | 1 |
Gao, J; Kang, ZF; Mai, A; Ting, WJ; Tu, JY; Yao, QM; Ye, SW | 1 |
1 review(s) available for dacarbazine and guanine
Article | Year |
---|---|
Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Clinical Trials as Topic; Dacarbazine; DNA Adducts; DNA Methylation; DNA Topoisomerases, Type I; Drug Administration Schedule; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guanine; Humans; Irinotecan; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Organoplatinum Compounds; Prognosis; Promoter Regions, Genetic; Temozolomide; Topoisomerase I Inhibitors | 2006 |
12 trial(s) available for dacarbazine and guanine
Article | Year |
---|---|
O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Female; Guanine; Humans; Male; Melanoma; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease Progression; Female; Glioma; Guanine; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide | 2005 |
Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Guanine; Humans; Injections, Intravenous; Male; Maximum Tolerated Dose; Neoplasms; Prognosis; Temozolomide | 2005 |
Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanine; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Safety; Temozolomide | 2006 |
Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Dacarbazine; Enzyme Inhibitors; Female; Guanine; Humans; Infant; Male; Temozolomide; Treatment Outcome | 2007 |
Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2009 |
Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioma; Guanine; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome | 2009 |
Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Dacarbazine; Disease-Free Survival; Female; Glioma; Guanine; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Temozolomide | 2009 |
Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dacarbazine; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanine; Hematologic Diseases; Humans; Male; Neoplasms; Sex Factors; Tandem Mass Spectrometry; Temozolomide; Young Adult | 2009 |
A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study.
Topics: Adolescent; Antineoplastic Agents; Brain Stem Neoplasms; Child; Child, Preschool; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Therapy, Combination; Female; Glioma; Guanine; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Male; Proportional Hazards Models; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2012 |
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.
Topics: Adult; Bone Marrow; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Genetic Therapy; Glioblastoma; Guanine; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Models, Biological; Prospective Studies; Temozolomide; Tumor Suppressor Proteins | 2014 |
Frequency of O⁶-methylguanine-DNA methyltransferase promoter methylation in cytological samples from small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Dacarbazine; DNA Methylation; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Small Cell Lung Carcinoma; Temozolomide | 2015 |
101 other study(ies) available for dacarbazine and guanine
Article | Year |
---|---|
Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas.
Topics: Alkalies; Alkylation; Animals; Antineoplastic Agents; Cell Division; Dacarbazine; DNA Damage; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Guanine; Leukemia L1210; Methyltransferases; Mice; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1992 |
Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; DNA; Enzyme-Linked Immunosorbent Assay; Female; Guanine; Humans; Leukocytes; Male; Melanoma; Middle Aged; Sarcoma | 1992 |
In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; DNA; DNA Repair; Doxorubicin; Female; Guanine; Hodgkin Disease; Humans; Injections, Intravenous; Leukocytes; Lymphoma, Non-Hodgkin; Male; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Pilot Projects; Rats; Rats, Inbred Strains; Vinblastine; Vincristine | 1991 |
Measurement by 32P-postlabelling of 7-methylguanine levels in white blood cell DNA of healthy individuals and cancer patients treated with dacarbazine and procarbazine. Human data and method development for 7-alkylguanines.
Topics: Chromatography, Thin Layer; Dacarbazine; Deoxyguanine Nucleotides; DNA; DNA, Neoplasm; Guanine; Humans; Leukocytes; Neoplasms; Phosphorus Radioisotopes; Phosphorylation; Procarbazine | 1991 |
In vivo metabolism and reaction with DNA of the cytostatic agent, 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC).
Topics: Animals; Biotransformation; Carbon Dioxide; Carbon Radioisotopes; Dacarbazine; DNA; Female; Guanine; Methylation; Rats; Rats, Inbred F344 | 1986 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbazine; DNA Repair; Dose-Response Relationship, Drug; Guanine; Humans; Imidazoles; Kinetics; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Methyltransferases; Mice; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide | 1987 |
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
Topics: Animals; Carmustine; Central Nervous System Neoplasms; Dacarbazine; Female; Guanine; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Temozolomide; Transplantation, Heterologous | 1995 |
O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.
Topics: Alkylating Agents; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Dacarbazine; Granulocytes; Guanine; Humans; Macrophages; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 1995 |
Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects.
Topics: Animals; Dacarbazine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Guanine; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Procarbazine; Rats; Species Specificity | 1993 |
Development of a 32P-postlabeling assay for 7-methylguanines in human DNA.
Topics: Adult; Aged; Chromatography, Ion Exchange; Dacarbazine; DNA; Dose-Response Relationship, Drug; Guanine; Humans; Leukocytes; Middle Aged; Neoplasms; Oligodeoxyribonucleotides; Phosphorus Radioisotopes; Procarbazine | 1993 |
Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.
Topics: Antineoplastic Agents; Dacarbazine; Drug Screening Assays, Antitumor; Drug Synergism; Guanine; Humans; Lomustine; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1993 |
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Cell Line; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1996 |
Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Cytoplasm; Dacarbazine; DNA Repair; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Guanine; Humans; Image Processing, Computer-Assisted; Lung Neoplasms; Melanoma; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous | 1996 |
O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Body Weight; Carmustine; Cell Division; Cell Line; Dacarbazine; Glioblastoma; Guanine; Humans; Kinetics; Methyltransferases; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1996 |
Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine.
Topics: Animals; Dacarbazine; DNA Damage; DNA Repair; Female; Guanine; Hodgkin Disease; Humans; Male; Methyltransferases; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity | 1996 |
3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.
Topics: Antineoplastic Agents, Alkylating; Benzamides; Carmustine; Dacarbazine; DNA Repair; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Guanine; Humans; Neoplasms; Temozolomide; Tumor Cells, Cultured | 1996 |
In vitro inactivation of human O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; DNA; Drug Resistance; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Spodoptera; Temozolomide; Triazenes; Tumor Cells, Cultured | 1996 |
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; DNA Adducts; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carmustine; Cell Division; Dacarbazine; Drug Synergism; Female; Guanine; Hematopoietic Stem Cells; Male; Mice; Temozolomide | 1997 |
Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Melanoma, Experimental; Methyltransferases; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 1997 |
Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-ribose) polymerase.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Dacarbazine; Enzyme Inhibitors; Guanine; HL-60 Cells; Humans; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Protein p53 | 1998 |
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Dacarbazine; DNA Glycosylases; Erythrocytes; Ethylnitrosourea; Female; Fibroblasts; Guanine; Hypoxanthine Phosphoribosyltransferase; Leukocyte Count; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutagens; Mutation; N-Glycosyl Hydrolases; Temozolomide | 1998 |
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Cell Line; Cell Survival; Dacarbazine; Gene Transfer Techniques; Genetic Vectors; Guanine; Hematopoietic Stem Cells; Humans; Nitrogen Mustard Compounds; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Retroviridae; Temozolomide | 1998 |
Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; DNA Adducts; DNA Repair; Female; Guanine; Humans; Hydroxyurea; Hypoxanthine Phosphoribosyltransferase; Leukocytes; Male; Melanoma; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1996 |
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured | 1996 |
Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carmustine; Colonic Neoplasms; Dacarbazine; Drug Combinations; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C3H; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
Cytokinetics of a novel 1,2,3-triazene-containing heterocycle, 8-nitro-3-methyl-benzo-1,2,3,5-tetrazepin-4(3H)-one (NIME), in the human epithelial ovarian cancer cell line OVCAR-3.
Topics: Alkylation; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Azepines; Base Sequence; Binding Sites; Cell Cycle; Cell Division; Cell Survival; Dacarbazine; DNA Damage; DNA, Neoplasm; Female; Guanine; Humans; Ovarian Neoplasms; Plasmids; RNA, Neoplasm; Structure-Activity Relationship; Temozolomide; Tumor Cells, Cultured | 1999 |
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.
Topics: Animals; Apoptosis; Cells, Cultured; Cisplatin; Dacarbazine; DNA Repair; DNA-Binding Proteins; Guanine; Intestinal Mucosa; Intestine, Small; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Mutagenesis; Mutagens; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Stem Cells; Temozolomide | 1999 |
Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Dacarbazine; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Jurkat Cells; Leukemia; N-Glycosyl Hydrolases; Poly(ADP-ribose) Polymerase Inhibitors; RNA, Messenger; Temozolomide; Transcription, Genetic; Triazenes | 1999 |
O(6)-benzylguanine enhances the in vitro immunotoxic activity of temozolomide on natural or antigen-dependent immunity.
Topics: Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents, Alkylating; Cell Line; Dacarbazine; Enzyme Inhibitors; Guanine; Humans; Immunity, Cellular; Immunity, Innate; Immunosuppressive Agents; Interleukin-2; Monocytes; T-Lymphocytes, Regulatory; Temozolomide; Tumor Cells, Cultured | 1999 |
O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Synergism; Enzyme Inhibitors; Guanine; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Transplantation, Heterologous | 2000 |
Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Guanine; Humans; Male; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous | 2000 |
Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.
Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Dacarbazine; DNA Methylation; DNA Mutational Analysis; Enzyme Induction; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Liver Extracts; Male; Methylnitrosourea; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Rats, Sprague-Dawley | 2000 |
In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biotransformation; Cisplatin; Cytochrome P-450 Enzyme System; Dacarbazine; DNA Damage; Enzyme Inhibitors; Guanine; Intestine, Small; Methylnitrosourea; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; CHO Cells; Cricetinae; Cyclophosphamide; Dacarbazine; Drug Interactions; Enzyme Inhibitors; Guanine; Mutagenicity Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
Topics: Antineoplastic Agents, Alkylating; Cell Extracts; Dacarbazine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Temozolomide; Tumor Cells, Cultured | 2000 |
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents, Alkylating; B-Lymphocytes; Blood Platelets; Blotting, Southern; Cell Culture Techniques; Dacarbazine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Female; Flow Cytometry; Genetic Vectors; Granulocytes; Green Fluorescent Proteins; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hemoglobins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Models, Genetic; Neutrophils; Plasmids; Retroviridae; T-Lymphocytes; Temozolomide; Time Factors | 2001 |
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carmustine; Dacarbazine; Deoxyguanosine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
Topics: Antineoplastic Agents; Biotransformation; Carmustine; Cytochrome P-450 Enzyme System; Cytosol; Dacarbazine; DNA Repair; Guanine; Humans; Isoenzymes; Kinetics; Liver; Microsomes, Liver; Temozolomide | 2001 |
Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Carrier Proteins; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dacarbazine; DNA Repair Enzymes; DNA-Binding Proteins; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Glioma; Guanine; Humans; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Paclitaxel; Phenotype; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model.
Topics: Adenosine Triphosphatases; Animals; Cell Division; Dacarbazine; Disease Models, Animal; Guanine; Humans; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Temozolomide; Time Factors | 2002 |
O6-benzylguanine-mediated enhancement of chemotherapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Camptothecin; Carmustine; Central Nervous System Neoplasms; Cyclophosphamide; Dacarbazine; DNA; Enzyme Inhibitors; Female; Guanine; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Protein Synthesis Inhibitors; Temozolomide | 2002 |
Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Cell Survival; Colony-Forming Units Assay; Dacarbazine; G2 Phase; Glioma; Guanine; Humans; Mitosis; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Tumor Cells, Cultured | 2003 |
Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.
Topics: Animals; beta-Thalassemia; Crosses, Genetic; Dacarbazine; Drug Resistance; Female; Genetic Vectors; Globins; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Fusion Proteins; Selection, Genetic; Temozolomide; Transplantation Chimera; Transplantation Conditioning | 2003 |
Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Cell Death; Cell Division; Dacarbazine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Glioma; Guanine; Humans; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomerase; Temozolomide; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Dacarbazine; Deoxyguanosine; DNA Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanine; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Time Factors | 2003 |
Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2003 |
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Division; Dacarbazine; DNA Damage; DNA Replication; fas Receptor; Gamma Rays; Gene Expression Regulation; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Temozolomide; Tumor Suppressor Protein p53 | 2004 |
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.
Topics: Adenine; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Azulenes; Base Pair Mismatch; Benzodiazepines; Cell Division; Cell Line, Tumor; Cisplatin; Dacarbazine; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Genotype; Guanine; Humans; Models, Chemical; NAD; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide | 2004 |
Dual repair modulation reverses Temozolomide resistance in vitro.
Topics: Adaptor Proteins, Signal Transducing; Base Pair Mismatch; Carrier Proteins; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance; Guanine; Humans; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2004 |
Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O(6)-benzylguanine.
Topics: Antineoplastic Agents; Cell Line, Tumor; Dacarbazine; Diazomethane; DNA Methylation; Drug Resistance, Neoplasm; Guanine; Humans; Hydrolysis; Prodrugs; Temozolomide; Triazenes | 2004 |
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Brain; Carmustine; Cell Survival; Child; Child, Preschool; Dacarbazine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Female; Guanine; Humans; Male; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Time Factors; Tumor Cells, Cultured | 2005 |
Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Carmustine; Cell Death; Cell Nucleus; Dacarbazine; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Methyl Methanesulfonate; Mitochondria; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection | 2005 |
Analysis of 7-methylguanine using isotope dilution and gas chromatography/electron-capture negative chemical ionization mass spectrometry.
Topics: Animals; Antineoplastic Agents, Alkylating; Carbon Isotopes; Dacarbazine; DNA Adducts; Gas Chromatography-Mass Spectrometry; Guanine; Liver; Male; Mice; Mice, Inbred C57BL; Reproducibility of Results; Sensitivity and Specificity | 2005 |
The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Female; Genetic Therapy; Guanine; Humans; Male; Mice; Mice, Inbred C57BL; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Xenograft Model Antitumor Assays | 2006 |
518A2 melanoma cells are protected by G3139 and other antineoplastic agents against the cytotoxic effects of DTIC.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cisplatin; Dacarbazine; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Guanine; Humans; Melanoma; Oligonucleotides, Antisense; Thionucleotides | 2005 |
O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.
Topics: Animals; Body Weight; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Male; Mice; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Xenograft Model Antitumor Assays | 2005 |
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
Topics: Animals; Antigens, Differentiation; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; Dacarbazine; DNA Damage; DNA Repair; Drug Synergism; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Oncolytic Viruses; Plasmids; Protein Phosphatase 1; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotide Reductases; RNA, Small Interfering; Simplexvirus; Temozolomide; Transcription, Genetic; Transfection; Transplantation, Heterologous | 2006 |
O6-(4-bromothenyl)guanine (PaTrin-2), a novel inhibitor of O6-alkylguanine DNA alkyl-transferase, increases the inhibitory activity of temozolomide against human acute leukaemia cells in vitro.
Topics: Acute Disease; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Synergism; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Leukocytes, Mononuclear; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Tumor Cells, Cultured | 2006 |
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
Topics: Alkylating Agents; Carmustine; Dacarbazine; Drug Resistance; Genetic Engineering; Guanine; Hematopoietic Stem Cells; Humans; K562 Cells; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic | 2006 |
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Damage; Fas Ligand Protein; Fas-Associated Death Domain Protein; Flow Cytometry; Glioma; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2007 |
In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Differentiation; Cell Line; Dacarbazine; Drug Resistance; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hepatocytes; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transduction, Genetic; Transplantation, Heterologous | 2006 |
Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms.
Topics: Animals; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; DNA Damage; Glioblastoma; Guanine; Humans; Methylation; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2006 |
A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system.
Topics: Antineoplastic Agents; Base Pair Mismatch; Dacarbazine; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Temozolomide; Tumor Cells, Cultured; Up-Regulation | 2006 |
Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance; Enzyme Inhibitors; Glioblastoma; Guanine; Humans; Infusions, Intralesional; Male; Neoplasm Recurrence, Local; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2007 |
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
Topics: Alkylating Agents; Animals; Carmustine; Cell Line, Tumor; Cyclophosphamide; Dacarbazine; Guanine; Male; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Transfection | 2007 |
The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fanconi Anemia Complementation Group D2 Protein; Fanconi Anemia Complementation Group F Protein; Fanconi Anemia Complementation Group Proteins; Glioma; Guanine; Humans; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Temozolomide; Time Factors; Transfection; Tumor Suppressor Proteins; Ubiquitins | 2007 |
Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; Guanine; Humans; Luciferases; Microscopy, Fluorescence; NF-kappa B; Protein Binding; Subcellular Fractions; Temozolomide; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor RelA | 2007 |
Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Guanine; Humans; Irinotecan; Mice; Mice, SCID; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neuroblastoma; Nuclear Proteins; Temozolomide; Tumor Suppressor Proteins | 2007 |
O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Blotting, Western; Dacarbazine; DNA Methylation; DNA Mismatch Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fibroblast Growth Factor 2; Guanine; Humans; Luciferases; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Skin Neoplasms; Temozolomide; Tumor Cells, Cultured | 2007 |
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cadmium Chloride; Carmustine; Cell Line, Tumor; Cell Proliferation; Comet Assay; Dacarbazine; DNA Mismatch Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Guanine; Humans; Hydroxylamines; Nimustine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temozolomide | 2008 |
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Cell Nucleus; Cell Proliferation; Cell Survival; Cycloheximide; Dacarbazine; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression Regulation, Neoplastic; Glioma; Green Fluorescent Proteins; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2009 |
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.
Topics: Animals; Apoptosis; BRCA2 Protein; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Dacarbazine; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Down-Regulation; Fluorescent Antibody Technique; Guanine; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange; Temozolomide; Transfection | 2009 |
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Dacarbazine; Genetic Therapy; Genetic Vectors; Guanine; Hematopoietic Stem Cell Transplantation; Homeodomain Proteins; Lentivirus; Macaca mulatta; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.
Topics: Cell Division; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Mismatch Repair; Drug Resistance, Neoplasm; Enzyme Activation; G2 Phase; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Radiation Dosage; Radiation Tolerance; Temozolomide | 2009 |
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Guanine; Humans; Hydrazines; Mice; O(6)-Methylguanine-DNA Methyltransferase; Sulfonamides; Temozolomide | 2010 |
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Caspase 7; Cell Cycle Proteins; Cell Line, Transformed; Cell Line, Tumor; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Fibroblasts; Guanine; Homozygote; Humans; Melanoma; Methylnitronitrosoguanidine; Mutagens; Mutation; Necrosis; Nijmegen Breakage Syndrome; Nuclear Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Temozolomide; Uveal Neoplasms | 2010 |
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Guanine; Humans; Mechanistic Target of Rapamycin Complex 1; Methylnitronitrosoguanidine; Multiprotein Complexes; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2010 |
Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Dacarbazine; Female; Guanine; Humans; Irinotecan; Mice; Mice, Nude; Neuroblastoma; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide; Xenograft Model Antitumor Assays | 2010 |
Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Mismatch Repair; Fibroblasts; Guanine; Humans; In Situ Nick-End Labeling; Mice; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Temozolomide; Tumor Suppressor Protein p53 | 2010 |
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Polymerase beta; DNA Repair; DNA Repair Enzymes; Drug Synergism; Glioma; Guanine; Humans; Hydroxylamines; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins | 2011 |
Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Cell Line, Tumor; Cord Blood Stem Cell Transplantation; Dacarbazine; Dose-Response Relationship, Drug; Female; Glioblastoma; Guanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Survival Analysis; Temozolomide; Transplantation Chimera; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Temozolomide: mechanisms of action, repair and resistance.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Central Nervous System Neoplasms; Dacarbazine; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide; Tumor Suppressor Proteins | 2012 |
Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Carmustine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Dacarbazine; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Lysine; Male; Mixed Function Oxygenases; Molecular Targeted Therapy; Neoplasm Grading; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Temozolomide | 2012 |
Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dacarbazine; DNA Damage; DNA Mismatch Repair; DNA Modification Methylases; DNA-Binding Proteins; Glioma; Guanine; Homologous Recombination; Humans; Protein Serine-Threonine Kinases; Temozolomide; Tumor Suppressor Proteins | 2013 |
Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Dacarbazine; DNA Damage; DNA Methylation; DNA, Mitochondrial; fas Receptor; Gene Expression Profiling; Guanine; Histones; Humans; Membrane Potential, Mitochondrial; Myeloid Progenitor Cells; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotide Array Sequence Analysis; Signal Transduction; Temozolomide; Tumor Suppressor Protein p53 | 2013 |
MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NFκB and mutant p53.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guanine; Humans; Mutation; NF-kappa B; Temozolomide; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2013 |
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
Topics: Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Melanoma; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinases; Signal Transduction; Temozolomide; Tumor Suppressor Proteins | 2013 |
Exo1 independent DNA mismatch repair involves multiple compensatory nucleases.
Topics: Animals; Cell Line; Dacarbazine; DNA Mismatch Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Endonucleases; Exodeoxyribonucleases; Fibroblasts; Guanine; Mice; Mice, Inbred C57BL; MRE11 Homologue Protein; Multifunctional Enzymes; Nuclear Proteins; Temozolomide; Up-Regulation | 2014 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glutathione; Guanine; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Molecular Targeted Therapy; Temozolomide; Thioctic Acid; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Cell Line, Tumor; Dacarbazine; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycoproteins; Guanine; Humans; Inhibitory Concentration 50; Peptides; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2015 |
Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide.
Topics: Antineoplastic Agents, Alkylating; Bone Morphogenetic Protein 7; Cell Proliferation; Cell Survival; Dacarbazine; DNA Modification Methylases; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Neoplastic Stem Cells; Temozolomide; Tumor Cells, Cultured | 2015 |
Glioblastomas with IDH1/2 mutations have a short clinical history and have a favorable clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Dacarbazine; DNA Methylation; Female; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Japan; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Mutation; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Temozolomide | 2016 |
Interactions of Nucleic Acid Bases with Temozolomide. Stacked, Perpendicular, and Coplanar Heterodimers.
Topics: Adenine; Cytosine; Dacarbazine; Dimerization; Guanine; Quantum Theory; Temozolomide; Thymine; Uracil | 2016 |
DNA-Targeted Inhibition of MGMT.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; DNA; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Guanine; Humans; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2017 |
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cricetulus; Dacarbazine; DNA Repair; DNA, Neoplasm; Guanine; Humans; Mutation; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide | 2017 |
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O
Topics: Antineoplastic Agents, Alkylating; Dacarbazine; DNA; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Humans; Temozolomide | 2018 |
Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Delivery Systems; Enzyme Inhibitors; Glioblastoma; Guanine; Liposomes; Magnetic Resonance Imaging; Mice; O(6)-Methylguanine-DNA Methyltransferase; Ultrasonic Waves | 2019 |
PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Guanine; Humans; Mice; Poly ADP Ribosylation; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide; Tumor Suppressor Proteins | 2021 |
KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.
Topics: Alkylating Agents; Dacarbazine; DNA; DNA Repair; Epigenesis, Genetic; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Parthanatos; Poly(ADP-ribose) Polymerase Inhibitors; Temozolomide | 2022 |
Thymoquinone induces apoptosis in temozolomide-resistant glioblastoma cells via the p38 mitogen-activated protein kinase signaling pathway.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioblastoma; Guanine; Mice; Mice, Nude; p38 Mitogen-Activated Protein Kinases; Purines; Signal Transduction; Temozolomide | 2023 |