dacarbazine and decitabine

dacarbazine has been researched along with decitabine in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (23.08)29.6817
2010's10 (76.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brown, R; Kaye, SB; Plumb, JA; Sludden, J; Strathdee, G1
Gong, F; Ji, SP; Li, AM; Tai, JL; Zhang, YP; Zheng, CQ1
Geng, J; Luo, H; Pu, Y; Wu, X; Xu, W; Yang, Z; Zhou, Z1
Beumer, JH; Buch, SC; Christner, S; Egorin, MJ; Kirkwood, JM; Lin, Y; Moschos, S; Tarhini, AA; Tawbi, HA1
Jiang, Z; Kuo, PY; Leshchenko, VV; Parekh, S; Thirukonda, VK1
Dolan, ME; Godley, LA; Moen, EL; Stark, AL; Zhang, W1
Deutsch, J; Frees, M; Laux, D; Leon-Ferre, R; Milhem, M; Smith, BJ; Xia, C1
Cui, Y; Irudayaraj, J; Naz, A; Thompson, DH1
Berdasco, M; Caba, O; Cabeza, L; Gónzalez, B; Melguizo, C; Ortiz, R; Perazzoli, G; Prados, J1

Reviews

1 review(s) available for dacarbazine and decitabine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for dacarbazine and decitabine

ArticleYear
Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; Disease-Free Survival; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Skin Neoplasms; Temozolomide

2013
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).
    Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epigenomics; Eye Neoplasms; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Panobinostat; Skin Neoplasms; Temozolomide; Treatment Outcome

2014

Other Studies

10 other study(ies) available for dacarbazine and decitabine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.
    Cancer research, 2000, Nov-01, Volume: 60, Issue:21

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Base Pair Mismatch; Carboplatin; Carrier Proteins; Cisplatin; Colonic Neoplasms; Dacarbazine; Decitabine; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
[Detection of O6-methylguanine-DNA methyltransferase promoter methylation in chemotherapy for glioma].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:6

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Azacitidine; Brain Neoplasms; Cell Line, Tumor; CpG Islands; Dacarbazine; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Survival Rate; Temozolomide; Young Adult

2009
Methylation mediated silencing of miR-23b expression and its role in glioma stem cells.
    Neuroscience letters, 2012, Oct-24, Volume: 528, Issue:2

    Topics: Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Decitabine; Down-Regulation; Epigenesis, Genetic; Gene Silencing; Glioma; Humans; Methylation; MicroRNAs; Neoplastic Stem Cells; Promoter Regions, Genetic; Temozolomide

2012
Integrative genomic analysis of temozolomide resistance in diffuse large B-cell lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jan-15, Volume: 20, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Azacitidine; Cell Line, Tumor; Dacarbazine; Decitabine; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genomics; Humans; Lymphoma, Large B-Cell, Diffuse; Promoter Regions, Genetic; Temozolomide; Transcription Factors; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2014
The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Azacitidine; Cell Line, Tumor; CpG Islands; Cytosine; Dacarbazine; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Quantitative Trait Loci; Temozolomide; Tumor Suppressor Proteins

2014
Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide.
    Molecular pharmaceutics, 2015, Apr-06, Volume: 12, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Azacitidine; Biocompatible Materials; Boron Compounds; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Decitabine; DNA Methylation; Drug Delivery Systems; Drug Synergism; Glioblastoma; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Methacrylates; Methylmethacrylates; Micelles; Nanoconjugates; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Spectrometry, Fluorescence; Temozolomide

2015
Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents, Alkylating; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Cell Line, Tumor; Dacarbazine; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycoproteins; Guanine; Humans; Inhibitory Concentration 50; Peptides; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins

2015