dabigatran has been researched along with melagatran in 5 studies
| Studies (dabigatran) | Trials (dabigatran) | Recent Studies (post-2010) (dabigatran) | Studies (melagatran) | Trials (melagatran) | Recent Studies (post-2010) (melagatran) |
|---|---|---|---|---|---|
| 3,887 | 261 | 3,490 | 185 | 32 | 19 |
| Protein | Taxonomy | dabigatran (IC50) | melagatran (IC50) |
|---|---|---|---|
| Prothrombin | Homo sapiens (human) | 0.5239 | |
| Plasminogen | Homo sapiens (human) | 3.06 | |
| Cationic trypsin | Bos taurus (cattle) | 0.0112 | |
| Vitamin K-dependent protein C | Homo sapiens (human) | 1.3 | |
| Trypsin-1 | Homo sapiens (human) | 0.0119 | |
| Trypsin-2 | Homo sapiens (human) | 0.0119 | |
| Coagulation factor VII | Homo sapiens (human) | 3.3 | |
| Trypsin-3 | Homo sapiens (human) | 0.0119 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dreger, M; Fischer, JJ; Glinski, M; Graebner, OY; Koester, H; Kroll, F; Marais, A; Metternich, R; Michaelis, S; Schaudt, C; Schrey, AK; Sefkow, M | 1 |
| Fischer, PM | 1 |
| Gustafsson, D | 1 |
| Hauel, N; Priepke, H; Ries, UJ; Stassen, JM; Wienen, W | 1 |
| Christersson, C; Johnell, M; Siegbahn, A | 1 |
2 review(s) available for dabigatran and melagatran
| Article | Year |
|---|---|
Design of Small-Molecule Active-Site Inhibitors of the S1A Family Proteases as Procoagulant and Anticoagulant Drugs.
Topics: Amino Acid Sequence; Animals; Anticoagulants; Blood Coagulation; Catalytic Domain; Humans; Peptide Hydrolases; Protease Inhibitors; Small Molecule Libraries | 2018 |
Oral direct thrombin inhibitors in clinical development.
Topics: Anticoagulants; Azetidines; Benzimidazoles; Benzylamines; Dabigatran; Glycine; Hemostasis; Humans; Prodrugs; Pyridines; Stroke; Thrombin; Thrombosis; Venous Thrombosis; Vitamin K | 2003 |
3 other study(ies) available for dabigatran and melagatran
| Article | Year |
|---|---|
Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2).
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Enzyme Inhibitors; Hep G2 Cells; Humans; K562 Cells; Mass Spectrometry; Models, Chemical; Protein Binding; Proteomics; Pyridines; Quinone Reductases; Thrombin | 2012 |
Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis.
Topics: Administration, Oral; Animals; Anticoagulants; Azetidines; Benzimidazoles; Benzylamines; Dabigatran; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Heparin; Hirudin Therapy; Injections, Intravenous; Male; Partial Thromboplastin Time; Prodrugs; Pyridines; Rabbits; Venous Thrombosis | 2007 |
The influence of direct thrombin inhibitors on the formation of platelet-leukocyte aggregates and tissue factor expression.
Topics: Antithrombins; Azetidines; Benzimidazoles; Benzylamines; beta-Alanine; Blood Platelets; Cell-Derived Microparticles; Dabigatran; Gene Expression; Humans; Leukocytes; Myocardial Infarction; Platelet Activation; Platelet Aggregation; RNA, Messenger; Thromboplastin | 2010 |