Page last updated: 2024-09-05

dabigatran and irinotecan

dabigatran has been researched along with irinotecan in 4 studies

Compound Research Comparison

Studies (dabigatran)	Trials (dabigatran)	Recent Studies (post-2010) (dabigatran)	Studies (irinotecan)	Trials (irinotecan)	Recent Studies (post-2010) (irinotecan)
3,887	261	3,490	8,002	1,885	3,752

Protein Interaction Comparison

Protein	Taxonomy	irinotecan (IC50)
Solute carrier family 22 member 2	Homo sapiens (human)	2.7
Interstitial collagenase	Homo sapiens (human)	6.06
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	1.556
Alpha-2C adrenergic receptor	Homo sapiens (human)	3.171
Acetylcholinesterase	Homo sapiens (human)	1.827
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	7.9
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	4.7667

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Authors

Authors	Studies
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Merali, Z; Paré, G; Ross, S	1
Akiyoshi, T; Hattori, T; Imaoka, A; Ohtani, H	1
Ip, CM; Ji, X; Lai, YS; Ng, WL; Song, Q; Xiao, M; Zhang, J; Zhang, Y; Zuo, Z	1

Reviews

1 review(s) available for dabigatran and irinotecan

Article	Year
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect. Drug metabolism and drug interactions, 2014, Volume: 29, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Aspirin; Benzimidazoles; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Central Nervous System Stimulants; Clopidogrel; Dabigatran; Factor Xa Inhibitors; Genotype; Humans; Imidazolidines; Irinotecan; Isoenzymes; Methylphenidate; Oseltamivir; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Pyridines; Ticlopidine	2014

Article

Year

The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.

Drug metabolism and drug interactions, 2014, Volume: 29, Issue:3

Topics: Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Aspirin; Benzimidazoles; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Central Nervous System Stimulants; Clopidogrel; Dabigatran; Factor Xa Inhibitors; Genotype; Humans; Imidazolidines; Irinotecan; Isoenzymes; Methylphenidate; Oseltamivir; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Pyridines; Ticlopidine

2014

Other Studies

3 other study(ies) available for dabigatran and irinotecan

Article	Year
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate. Biopharmaceutics & drug disposition, 2019, Volume: 40, Issue:9 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Dabigatran; Gastrointestinal Diseases; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Male; Partial Thromboplastin Time; Rats	2019
Inhibition of Radix Scutellariae flavones on carboxylesterase mediated activations of prodrugs. Life sciences, 2022, Sep-15, Volume: 305 Topics: Animals; Carboxylesterase; Dabigatran; Flavones; Irinotecan; Molecular Docking Simulation; Prodrugs; Rats; Scutellaria; Scutellaria baicalensis	2022