dabigatran has been researched along with cobicistat in 4 studies
| Studies (dabigatran) | Trials (dabigatran) | Recent Studies (post-2010) (dabigatran) | Studies (cobicistat) | Trials (cobicistat) | Recent Studies (post-2010) (cobicistat) |
|---|---|---|---|---|---|
| 3,887 | 261 | 3,490 | 300 | 75 | 282 |
| Protein | Taxonomy | dabigatran (IC50) | cobicistat (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.15 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 9.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alfaro, RM; Brooks, KM; George, JM; Gordon, LA; Hadigan, C; Kellogg, A; Kumar, P; Lozier, J; McManus, M; Nghiem, K; Penzak, SR | 2 |
| Fulco, PP; Higginson, RT; Kakadiya, PP | 1 |
| Brown, JD; Cristofoletti, R; Farhan, N; George, JM; Gordon, LA; Hadigan, C; Kim, S; Kumar, P; Lingineni, K; Penzak, S; Schmidt, S | 1 |
2 trial(s) available for dabigatran and cobicistat
| Article | Year |
|---|---|
Antiretroviral Boosting Agent Cobicistat Increases the Pharmacokinetic Exposure and Anticoagulant Effect of Dabigatran in HIV-Negative Healthy Volunteers.
Topics: Administration, Oral; Anti-HIV Agents; Antithrombins; Blood Coagulation; Cobicistat; Cytochrome P-450 CYP3A Inhibitors; Dabigatran; Drug Interactions; Healthy Volunteers; Humans; Thrombin Time | 2016 |
Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran.
Topics: Adult; Antithrombins; Antiviral Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cobicistat; Dabigatran; Drug Interactions; Female; Healthy Volunteers; Humans; Intestinal Mucosa; Intestines; Male; Middle Aged; Ritonavir; Thrombin Time | 2017 |
2 other study(ies) available for dabigatran and cobicistat
| Article | Year |
|---|---|
Ritonavir-Boosted Protease Inhibitors but Not Cobicistat Appear Safe in HIV-Positive Patients Ingesting Dabigatran.
Topics: Aged; Anti-HIV Agents; Cobicistat; Dabigatran; Darunavir; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Male; Ritonavir | 2018 |
Quantitative Benefit-Risk Assessment of P-gp-Mediated Drug-Drug Interactions of Dabigatran Coadministered With Pharmacokinetic Enhancers in Patients With Renal Impairment.
Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Cobicistat; Dabigatran; Drug Interactions; Hemorrhage; Humans; Kidney Diseases; Risk Assessment; Ritonavir | 2021 |