Compounds > d-alpha tocopherol

Page last updated: 2024-08-21

d-alpha tocopherol and sirolimus

d-alpha tocopherol has been researched along with sirolimus in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (21.43)	29.6817
2010's	9 (64.29)	24.3611
2020's	2 (14.29)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chai, A; Chan, AO; O'Mahony, D; Ramtoola, Z; Silverman, JA; Tran-Tau, P; Wacher, VJ; Wong, S; Yu, XQ	1
Forrest, ML; Kwon, GS; Malick, AW; Won, CY	1
Davies, NM; Forrest, ML; Kwon, GS; Ohgami, Y; Yáñez, JA	1
Kline, K; Sanders, BG; Tiwary, R; Yu, W	1
Cho, WK; Hwang, SJ; Kim, JS; Kim, MS	1
Cha, KH; Cho, W; Hwang, SJ; Kim, JS; Kim, MS; Park, HJ; Park, J	1
Bae, YS; Kim, JJ; Park, JH	1
Cholkar, K; Earla, R; Gunda, S; Mitra, AK; Pal, D	1
Baek, IH; Cho, CW; Cho, Y; Ha, ES; Hwang, SJ; Kim, MS	1
Lv, H; Xie, Z; Zhang, Z	1
Chen, M; Han, Q; Wang, S; Wang, Y; Wei, Z; Xie, J	1
Banjare, N; Behera, C; Chashoo, G; Gupta, PN; Kour, J; Sawant, SD; Verma, PK	1

Reviews

1 review(s) available for d-alpha tocopherol and sirolimus

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

13 other study(ies) available for d-alpha tocopherol and sirolimus

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Humans; Intestinal Absorption; Ketoconazole; Kinetics; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Sirolimus; Tumor Cells, Cultured; Vitamin E	2002
In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles. Journal of controlled release : official journal of the Controlled Release Society, 2006, Jan-10, Volume: 110, Issue:2 Topics: Algorithms; alpha-Tocopherol; Anti-Bacterial Agents; Calorimetry, Differential Scanning; Ethylene Glycols; Excipients; Kinetics; Micelles; Particle Size; Polyesters; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases; Viscosity; X-Ray Diffraction	2006
Pharmacometrics and delivery of novel nanoformulated PEG-b-poly(epsilon-caprolactone) micelles of rapamycin. Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:1 Topics: Acetamides; alpha-Tocopherol; Animals; Anti-Bacterial Agents; Area Under Curve; Brain; Drug Carriers; Ethylene Glycols; Excipients; Half-Life; Injections, Intravenous; Male; Micelles; Neurotoxicity Syndromes; Polyesters; Polyethylene Glycols; Polysorbates; Rats; Rats, Sprague-Dawley; Sirolimus; Solubility; Tissue Distribution	2008
α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. British journal of cancer, 2011, Jan-04, Volume: 104, Issue:1 Topics: 1-Phosphatidylinositol 4-Kinase; alpha-Tocopherol; Androstadienes; Anthracenes; Antioxidants; Apoptosis; Blotting, Western; Breast Neoplasms; Butadienes; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Insulin Receptor Substrate Proteins; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phosphorylation; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Wortmannin	2011
Enhanced solubility and oral absorption of sirolimus using D-α-tocopheryl polyethylene glycol succinate micelles. Artificial cells, nanomedicine, and biotechnology, 2013, Volume: 41, Issue:2 Topics: Absorption; Animals; Antibiotics, Antineoplastic; Area Under Curve; Drug Carriers; Drug Stability; Lecithins; Male; Mice; Micelles; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Sirolimus; Solubility; Vitamin E; Water	2013
Supersaturatable formulations for the enhanced oral absorption of sirolimus. International journal of pharmaceutics, 2013, Mar-10, Volume: 445, Issue:1-2 Topics: Absorption; Administration, Oral; Animals; Biological Availability; Drug Compounding; Excipients; Hypromellose Derivatives; Immunosuppressive Agents; Male; Methylcellulose; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Sirolimus; Sucrose; Vitamin E	2013
Involvement of PI3K-AKT-mTOR pathway in protein kinase CKII inhibition-mediated senescence in human colon cancer cells. Biochemical and biophysical research communications, 2013, Apr-19, Volume: 433, Issue:4 Topics: Ascorbic Acid; Casein Kinase II; Cellular Senescence; Enzyme Activation; Enzyme Assays; Ethidium; Fluoresceins; Fluorescence; HCT116 Cells; Humans; Hydrogen Peroxide; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Vitamin E	2013
Nanomicellar Topical Aqueous Drop Formulation of Rapamycin for Back-of-the-Eye Delivery. AAPS PharmSciTech, 2015, Volume: 16, Issue:3 Topics: Administration, Ophthalmic; Administration, Topical; Animals; Aqueous Humor; Cells, Cultured; Chemistry, Pharmaceutical; Drug Delivery Systems; Epithelial Cells; Epithelium, Corneal; Humans; Male; Ophthalmic Solutions; Polyethylene Glycols; Rabbits; Retinal Pigment Epithelium; Sirolimus; Tissue Distribution; Vitamin E	2015
Enhanced supersaturation and oral absorption of sirolimus using an amorphous solid dispersion based on Eudragit® e. Molecules (Basel, Switzerland), 2015, May-25, Volume: 20, Issue:6 Topics: Animals; Biological Availability; Biomimetic Materials; Drug Carriers; Drug Stability; Excipients; Gastric Juice; Hydrogen-Ion Concentration; Hydrolysis; Hypromellose Derivatives; Male; Oral Mucosal Absorption; Polyethylene Glycols; Polymethacrylic Acids; Rats; Rats, Sprague-Dawley; Sirolimus; Solubility; Vitamin E	2015
Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration. International journal of pharmaceutics, 2019, Sep-10, Volume: 568 Topics: Administration, Oral; Animals; Caco-2 Cells; Cell Survival; Coumarins; Drug Carriers; Drug Liberation; Humans; Intestinal Absorption; Lecithins; Male; Nanoparticles; Rats, Sprague-Dawley; Sirolimus; Thiazoles; Vitamin E; Zein	2019
Phenanthrene induces autism-like behavior by promoting oxidative stress and mTOR pathway activation. Toxicology, 2021, Volume: 461 Topics: Animals; Animals, Outbred Strains; Autistic Disorder; Behavior, Animal; Dose-Response Relationship, Drug; Glutathione; Hippocampus; Male; Mice; Oxidative Stress; Phenanthrenes; Sirolimus; TOR Serine-Threonine Kinases; Vitamin E	2021
Mechanistic investigation of synergistic interaction of tocopherol succinate with a quinoline-based inhibitor of mammalian target of rapamycin. The Journal of pharmacy and pharmacology, 2022, Apr-20, Volume: 74, Issue:4 Topics: alpha-Tocopherol; Apoptosis; Autophagy; Cell Line, Tumor; Poly(ADP-ribose) Polymerases; Quinolines; Sirolimus; TOR Serine-Threonine Kinases	2022