d-alpha tocopherol has been researched along with simvastatin in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (20.45) | 18.2507 |
| 2000's | 20 (45.45) | 29.6817 |
| 2010's | 13 (29.55) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bonal, J; Cantarell, C; Capdevila, L; Lauzurica, R; Pastor, C; Sierra, C | 1 |
| Brennan, GM; Bruce, I; Johnston, GD; McDowell, IF; McEneny, J; McVeigh, GE; Nicholls, DP; Trimble, ER; Young, IS | 1 |
| Delport, R; Human, JA; Jerling, JJ; Lagendijk, J; Potgieter, HC; Ubbink, JB; Vermaak, WJ; Vorster, HH | 1 |
| Katzenschlager, R; Kostner, K; Maurer, G; Neunteufl, T; Weidinger, F; Zehetgruber, M | 1 |
| Girona, J; La Ville, AE; Masana, L; Plana, N; Solà, R | 1 |
| Ferguson, JJ | 1 |
| Demacker, PN; Kleinveld, HA; Kroon, AA; Stalenhoef, AF | 1 |
| Joffe, BI; Kotze, MJ; Pilcher, GJ; Raal, FJ; Veller, MG | 1 |
| Kersting, F; Selenka, A; Walch, S | 1 |
| Albers, JJ; Brown, BG; Chait, A; Cheung, MC; Zhao, XQ | 1 |
| Iwasaki, K; Kuroda, N; Nakashima, A; Nakashima, K; Ohtawa, M; Wada, M | 1 |
| Alaupovic, P; Albers, JJ; Bolson, EL; Brown, BG; Chait, A; Cheung, MC; Dowdy, AA; Fisher, LD; Frohlich, J; Marino, EK; Morse, JS; Zhao, XQ | 1 |
| Aebischer, C; Elste, V; Raederstorff, D; Weber, P | 1 |
| Bernini, W; Bucciarelli, T; Ciabattoni, G; Cipollone, F; De Caterina, R; Falco, A; Filardo, FP; Lazzerini, G; Marchesani, P; Mezzetti, A; Muraro, R; Zimarino, M | 1 |
| Broccoletti, S; Croce, G; Desideri, G; Ferri, C; Passacquale, G; Santucci, A; Tucci, M; Valeri, L | 1 |
| Aleo, E; Dmitrieva, A; Littarru, GP; Passi, S; Stancato, A | 1 |
| el-Zorba, HY; Kamel, GM; Shalaby, MA | 1 |
| Ceska, R; Hilgertová, J; Kvasnicka, J; Skrha, J; Stulc, T; Weiserová, H | 1 |
| Amigues, L; Beraud, JJ; Canaud, B; Cristol, JP; Delbosc, S; Durant, R; Klouche, K; Morena, M | 1 |
| Abdalla, DS; Bertolami, MC; Faludi, AA; Pereira, EC; Sevanian, A | 1 |
| Lavoie, J; Nattel, S; Schram, G; Shiroshita-Takeshita, A | 1 |
| Eroğlu, S; Korkmaz, ME; Müderrisoğlu, H; Ozin, B; Pirat, B; Tayfun, E; Uluçam, M; Yildirir, A | 1 |
| Ahotupa, M; Gylling, H; Miettinen, T; Nuotio, I; Strandberg, T; Tikkanen, MJ; Vanhanen, H; Vasankari, T; Viikari, J | 1 |
| Colquhoun, DM; Goldsmith, J; Hicks, BJ; Jackson, R; Kostner, KM; Strakosch, C; Walters, M; Young, P | 1 |
| Cangemi, R; Carnevale, R; Loffredo, L; Pignatelli, P; Violi, F | 1 |
| Sylvester, PW; Wali, VB | 1 |
| Chumark, P; Khunawat, P; Morales, NP; Phivthong-Ngam, L; Phornchirasilp, S; Pongrapeeporn, KU; Ratanachamnong, P; Sanvarinda, Y; Srisawat, S | 1 |
| Andler, W; Haas, D; Hoffmann, GF; Menke, T; Niklowitz, P | 1 |
| Ahmad, B; Ahmad, M; Arshad, S; Khan, FZ; Syed, AA; Syed, NI | 1 |
| El-Azab, MF; Hazem, RM; Moustafa, YM | 1 |
| Baillie, RA; Fiehn, O; Kaddurah-Daouk, R; Karp, PD; Krauss, RM; Trupp, M; Wikoff, WR; Zeng, ZB; Zhu, H | 1 |
| Helmy, MM | 1 |
| Alexopoulos, E; Belechri, AM; Dogrammatzi, F; Efstratiadis, G; Kirmizis, D; Memmos, D; Papagianni, A | 1 |
| Gopalan, A; Kline, K; Sanders, BG; Yu, W | 1 |
| Abbas, AM; Sakr, HF | 1 |
| Ichinomiya, S; Iwata, H; Sato, H; Siddig, S; Suwa, E; Tuerdi, G; Ueno, K; Yano, T | 1 |
| Aisen, PS; Donohue, MC; Edland, SD; Galasko, D; Moghadam, SH; Petersen, RC; Rissman, RA; Roe, AD; Sano, M; Sun, CK; Thomas, RG | 1 |
| He, J; Liu, J; Zhang, M; Zhang, W | 1 |
| Ghosh, SP; Hauer-Jensen, M; Kumar, VP; Pathak, R | 1 |
| Eswara, BRM; Manjappa, AS; Nagadeepthi, N; Sambamoorthy, U; Sanapala, AK | 1 |
| Attia, Y; El-Nabarawi, M; Mahmoud, K; Swidan, S; Teaima, M | 1 |
1 review(s) available for d-alpha tocopherol and simvastatin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
15 trial(s) available for d-alpha tocopherol and simvastatin
| Article | Year |
|---|---|
Vitamin E in kidney transplantation: effect of treatment with simvastatin in hypercholesterolemia.
Topics: Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Cyclosporine; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Male; Middle Aged; Simvastatin; Time Factors; Triglycerides; Vitamin E | 1995 |
The effect of probucol and vitamin E treatment on the oxidation of low-density lipoprotein and forearm vascular responses in humans.
Topics: Adult; Cholesterol, LDL; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Forearm; Humans; Hyperlipidemias; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Oxidation-Reduction; Probucol; Regional Blood Flow; Simvastatin; Vitamin E | 1994 |
MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience.
Topics: Adult; Aged; Antioxidants; Apolipoproteins; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Dietary Supplements; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Simvastatin; Treatment Outcome; Triglycerides; Vitamin E | 1999 |
The rebound of lipoproteins after LDL-apheresis. Effects on chemical composition and LDL-oxidizability.
Topics: Apolipoproteins B; Blood Component Removal; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Combined Modality Therapy; Fatty Acids; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Simvastatin; Vitamin E | 1999 |
Effects of cholestyramine on vitamin E levels in patients treated with statins.
Topics: Adult; Aged; Anticholesteremic Agents; Antioxidants; Cholesterol, LDL; Cholestyramine Resin; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Indoles; Lovastatin; Male; Middle Aged; Naphthalenes; Pravastatin; Simvastatin; Vitamin E | 2000 |
Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; beta Carotene; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Dietary Supplements; Drug Interactions; Female; Humans; Hypolipidemic Agents; Male; Middle Aged; Niacin; Particle Size; Selenium; Simvastatin; Vitamin E | 2001 |
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.
Topics: alpha-Tocopherol; Antioxidants; Apolipoproteins; Ascorbic Acid; beta Carotene; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Coronary Angiography; Coronary Disease; Coronary Stenosis; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lipids; Male; Middle Aged; Niacin; Selenium; Simvastatin; Vitamin E | 2001 |
Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E.
Topics: Antioxidants; Cholesterol; Cholesterol, LDL; Cross-Over Studies; Dinoprost; Drug Therapy, Combination; F2-Isoprostanes; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipid Peroxidation; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Patient Compliance; Simvastatin; Vitamin E | 2002 |
Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: evidence of different vascular protection by different lipid-lowering treatments.
Topics: Adult; Anticholesteremic Agents; Antioxidants; Benzimidazoles; Dinoprost; E-Selectin; Endothelium, Vascular; F2-Isoprostanes; Female; Humans; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Middle Aged; Simvastatin; Solubility; Vascular Cell Adhesion Molecule-1; Vitamin E | 2003 |
Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.
Topics: Acetylglucosaminidase; Adult; Aged; alpha-Tocopherol; Ascorbic Acid; Cholesterol; Czech Republic; Diabetes Mellitus, Type 2; Drug Administration Schedule; E-Selectin; Endothelium; Female; Fenofibrate; Fibrinolysis; Glutathione; Humans; Hyperlipidemias; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Plasminogen Activator Inhibitor 1; Simvastatin; Superoxide Dismutase; Time Factors; Triglycerides; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2004 |
[The effects of simvastatin combined with different antioxidant vitamin regimens on serum lipid profile in patients with low HDL cholesterol levels].
Topics: Administration, Oral; Antioxidants; Ascorbic Acid; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Drug Administration Schedule; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipids; Male; Simvastatin; Treatment Outcome; Vitamin E | 2004 |
Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations.
Topics: alpha-Tocopherol; Atorvastatin; beta Carotene; Cholesterol, LDL; Chromatography, High Pressure Liquid; Female; gamma-Tocopherol; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles; Simvastatin | 2004 |
Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment.
Topics: Adult; alpha-Tocopherol; Amino Acids, Essential; Biomarkers, Pharmacological; Cholesterol, LDL; Citrulline; Cystine; Female; Fructose; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lauric Acids; Male; Metabolomics; Nitric Oxide Synthase; Ornithine; Simvastatin; Stearic Acids; Succinic Acid; Xanthine | 2012 |
The effects of vitamin E-coated membrane dialyzer compared to simvastatin in patients on chronic hemodialysis.
Topics: Acrylamides; Aged; Antioxidants; beta-Alanine; Biomarkers; C-Reactive Protein; Coated Materials, Biocompatible; Cross-Over Studies; Equipment Design; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-6; Kidney Failure, Chronic; Male; Membranes, Artificial; Middle Aged; Oxidative Stress; Renal Dialysis; Simvastatin; Treatment Outcome; Vitamin E | 2012 |
Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Biomarkers; Blood Chemical Analysis; Cognitive Dysfunction; Disease Progression; Donepezil; Female; Heterozygote; Humans; Indans; Longitudinal Studies; Male; Nootropic Agents; Peptide Fragments; Piperidines; Severity of Illness Index; Simvastatin; Vitamin E | 2015 |
28 other study(ies) available for d-alpha tocopherol and simvastatin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia.
Topics: Adult; Anticholesteremic Agents; Antioxidants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coenzymes; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipid Peroxidation; Lovastatin; Male; Middle Aged; Simvastatin; Ubiquinone; Vitamin E | 1997 |
Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men.
Topics: Adult; Anticholesteremic Agents; Brachial Artery; Coronary Circulation; Drug Therapy, Combination; Endothelium, Vascular; Humans; Hypercholesterolemia; Male; Middle Aged; Simvastatin; Treatment Outcome; Vascular Resistance; Vasodilation; Vitamin E | 1998 |
Simvastatin decreases aldehyde production derived from lipoprotein oxidation.
Topics: Aldehydes; Antioxidants; Humans; Hyperlipidemias; Hypolipidemic Agents; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, HDL; Lipoproteins, LDL; Simvastatin; Vitamin E | 1999 |
Meeting highlights. Highlights of the 48th scientific sessions of the American College of Cardiology.
Topics: Abciximab; Alanine; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Antibodies, Monoclonal; Aspirin; Benzamidines; Biphenyl Compounds; Cardiology; Cardiovascular Agents; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Coronary Disease; Dalteparin; Defibrillators, Implantable; Double-Blind Method; Enalapril; Endothelial Growth Factors; Fatty Acids, Omega-3; Guanidines; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin Fab Fragments; Laser Therapy; Lymphokines; Metoprolol; Multicenter Studies as Topic; Myocardial Revascularization; Platelet Aggregation Inhibitors; Pyrrolidines; Randomized Controlled Trials as Topic; Simvastatin; Sodium-Hydrogen Exchangers; Stents; Sulfones; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitamin E | 1999 |
Efficacy of vitamin E compared with either simvastatin or atorvastatin in preventing the progression of atherosclerosis in homozygous familial hypercholesterolemia.
Topics: Adolescent; Adult; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Carotid Arteries; Child; Child, Preschool; Cholesterol, HDL; Cholesterol, LDL; Disease Progression; DNA; Female; Heptanoic Acids; Homozygote; Humans; Hyperlipoproteinemia Type II; Male; Mutation; Pyrroles; Receptors, LDL; Simvastatin; Treatment Outcome; Triglycerides; Tunica Intima; Vitamin E | 1999 |
Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.
Topics: Animals; Antioxidants; Fatty Acids, Monounsaturated; Fluvastatin; Free Radical Scavengers; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Microsomes, Liver; Oxygen; Pravastatin; Probucol; Rats; Reactive Oxygen Species; Simvastatin; Singlet Oxygen; Vitamin E | 2001 |
Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Antioxidants; Cholesterol; Chromans; Cricetinae; Lipids; Lipoproteins, LDL; Male; Mesocricetus; Random Allocation; Simvastatin; Tocotrienols; Vitamin E | 2002 |
Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA.
Topics: Antioxidants; Atorvastatin; Catalase; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coenzymes; Erythrocytes; Fatty Acids, Unsaturated; Glutathione; Glutathione Peroxidase; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lymphocytes; Male; Middle Aged; Pravastatin; Pyrroles; Simvastatin; Superoxide Dismutase; Ubiquinone; Vitamin E | 2003 |
Effect of alpha-tocopherol and simvastatin on male fertility in hypercholesterolemic rats.
Topics: Administration, Oral; alpha-Tocopherol; Animals; Capsules; Cholesterol, Dietary; Diet; Drug Administration Schedule; Drug Therapy, Combination; Female; Gelatin; Hypercholesterolemia; Infertility, Male; Male; Organ Size; Prostate; Rats; Reproduction; Semen; Seminiferous Tubules; Simvastatin; Sperm Count; Sperm Motility; Spermatozoa; Testis; Testosterone; Time Factors | 2004 |
Superoxide anion overproduction in sepsis: effects of vitamin e and simvastatin.
Topics: APACHE; C-Reactive Protein; Cell Line; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocyte Count; Male; Middle Aged; Models, Biological; Oxidative Stress; Reference Values; Sepsis; Simvastatin; Superoxides; Tetradecanoylphorbol Acetate; Triglycerides; Vitamin E | 2004 |
Antioxidant effect of simvastatin is not enhanced by its association with alpha-tocopherol in hypercholesterolemic patients.
Topics: alpha-Tocopherol; Anticholesteremic Agents; Antioxidants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Lipids; Male; Middle Aged; Simvastatin; Sulfhydryl Compounds; Triglycerides | 2004 |
Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs.
Topics: Animals; Antioxidants; Ascorbic Acid; Atrial Fibrillation; Calcium Channels, L-Type; Cardiac Pacing, Artificial; Dogs; Drug Evaluation, Preclinical; Drug Therapy, Combination; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Oxidative Stress; Refractory Period, Electrophysiological; Simvastatin; Vitamin E | 2004 |
Effects of simvastatin on blood lipids, vitamin E, coenzyme Q10 levels and left ventricular function in humans.
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Antioxidants; Apolipoproteins; Cholesterol, LDL; Coenzymes; Echocardiography; Female; Humans; Hypercholesterolemia; Lipids; Male; Middle Aged; Simvastatin; Ubiquinone; Ventricular Function, Left; Vitamin E | 2005 |
Statins enhance circulating vitamin E.
Topics: Atorvastatin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Syndrome; Middle Aged; Oxidative Stress; Pyrroles; Retrospective Studies; Simvastatin; Vitamin E | 2008 |
Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mammary Neoplasms, Animal; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Proto-Oncogene Proteins c-akt; Simvastatin; Vitamin E | 2007 |
The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves.
Topics: Animals; Antioxidants; Atherosclerosis; Biphenyl Compounds; Body Weight; Cholesterol; Cholesterol, Dietary; Humans; Hypolipidemic Agents; Lipids; Lipoproteins, LDL; Male; Moringa oleifera; Picrates; Plant Extracts; Plant Leaves; Rabbits; Simvastatin; Thiobarbituric Acid Reactive Substances; Vitamin E; Water | 2008 |
Plasma and thrombocyte levels of coenzyme Q10 in children with Smith-Lemli-Opitz syndrome (SLOS) and the influence of HMG-CoA reductase inhibitors.
Topics: Blood Platelets; Child; Child, Preschool; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant; Simvastatin; Smith-Lemli-Opitz Syndrome; Ubiquinone; Vitamin E | 2008 |
A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits.
Topics: Animals; Antioxidants; Ascorbic Acid; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Hypercholesterolemia; Male; Rabbits; Simvastatin; Triglycerides; Vitamin A; Vitamin E; Vitamins | 2011 |
Role of simvastatin and/or antioxidant vitamins in therapeutic angiogenesis in experimental diabetic hindlimb ischemia: effects on capillary density, angiogenesis markers, and oxidative stress.
Topics: Angiogenesis Inducing Agents; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Capillaries; Diabetes Complications; Disease Models, Animal; Heme Oxygenase-1; Hindlimb; Ischemia; Male; Neovascularization, Physiologic; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Simvastatin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vitamin E; Vitamins | 2012 |
Potential hepato-protective effect of α-tocopherol or simvastatin in aged rats.
Topics: Age Factors; Aging; alpha-Tocopherol; Animals; Antioxidants; Catalase; Lipids; Liver; Liver Diseases; Male; Nitrates; Nitrites; Rats; Rats, Wistar; Simvastatin; Thiobarbituric Acid Reactive Substances | 2012 |
Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Ceramides; Chromans; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mevalonic Acid; Neoplastic Stem Cells; Retinal Dehydrogenase; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Vitamin E | 2013 |
Simvastatin and vitamin E effects on cardiac and hepatic oxidative stress in rats fed on high fat diet.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Diet, High-Fat; Dietary Fats; Drug Synergism; Glutathione Peroxidase; Glutathione Transferase; Hypercholesterolemia; Hypolipidemic Agents; Liver; Male; Obesity; Oxidative Stress; Rats; Rats, Sprague-Dawley; Simvastatin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E | 2013 |
Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells.
Topics: Apoptosis; Atorvastatin; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chromans; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mesothelioma; Metabolic Networks and Pathways; Mevalonic Acid; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Simvastatin; Vitamin E | 2013 |
Fabrication of TPGS-Stabilized Liposome-PLGA Hybrid Nanoparticle Via a New Modified Nanoprecipitation Approach: In Vitro and In Vivo Evaluation.
Topics: Animals; Atherosclerosis; Drug Carriers; Drug Liberation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liposomes; Mice; Nanoparticles; Oxidative Stress; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Rabbits; RAW 264.7 Cells; Simvastatin; Surface Properties; Vitamin E | 2018 |
Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin.
Topics: Animals; Chromans; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Occupational Exposure; Radiation, Ionizing; Simvastatin; Survival Analysis; Vitamin E | 2019 |
Vitamin E Oil Incorporated Liposomal Melphalan and Simvastatin: Approach to Obtain Improved Physicochemical Characteristics of Hydrolysable Melphalan and Anticancer Activity in Combination with Simvastatin Against Multiple Myeloma.
Topics: Animals; Liposomes; Melphalan; Mice; Multiple Myeloma; Particle Size; Polyethylene Glycols; Simvastatin; Vitamin E | 2021 |
Size-optimized simvastatin-loaded TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal transition in hepatocellular carcinoma: Role of PTEN/AKT signaling.
Topics: alpha-Tocopherol; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lipids; Liver Neoplasms; Nanocapsules; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Simvastatin; Tissue Distribution | 2023 |