d-alpha tocopherol has been researched along with paclitaxel in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.79) | 18.2507 |
| 2000's | 26 (20.47) | 29.6817 |
| 2010's | 84 (66.14) | 24.3611 |
| 2020's | 16 (12.60) | 2.80 |
| Authors | Studies |
|---|---|
| Gibbons, S; Kaatz, GW; Zloh, M | 1 |
| Bastow, KF; Chen, TH; Chiang, PC; Hung, MC; Lee, FC; Lee, FY; Lee, KH; Nakagawa-Goto, K; Nakamura, S; Spohn, B; Wang, SC; Yamada, K | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dintaman, JM; Silverman, JA | 1 |
| Constantinides, PP; Kessler, D; Lalji, S; Lambert, KJ; Ma, W; Quay, SC; Schneider, B; Tustian, AK; Wentzel, B; Worah, D | 1 |
| Feng, SS; Mu, L | 3 |
| Feng, SS; Huang, G; Mu, L; Win, KY | 1 |
| Cho, MC; Kim, DW; Kim, MS; Kim, YG; Kwon, JS; Lee, GS; Youn, TJ | 1 |
| Davis, SS; Han, J; Melia, CD; Papandreou, C; Washington, C | 1 |
| Argyriou, AA; Chroni, E; Ellul, J; Iconomou, G; Kalofonos, HP; Katsoulas, G; Koutras, A; Papapetropoulos, S | 1 |
| Ekonjo, GB; Gryboc, M; Janocha, A; Murawski, M; Saleh, Y; Siewinski, M; Symonowicz, K; Ziólkowski, P | 1 |
| Feng, SS; Zhang, Z | 2 |
| Bove, L; Jandolo, B; Pace, A | 1 |
| Feng, SS; Win, KY | 1 |
| Chodon, D; Padmavathi, R; Sakthisekaran, D; Senthilnathan, P | 1 |
| Mu, L; Seow, PH | 1 |
| Argyriou, AA; Chroni, E; Iconomou, G; Kalofonos, HP; Koutras, A; Papapetropoulos, S; Polychronopoulos, P | 1 |
| Perez, EA | 1 |
| Dong, Y; Feng, SS; Zhang, Z | 1 |
| Feng, SS; Pan, J | 1 |
| Chang, YW; Chao, YS; Chen, CT; Chiang, TH; Ho, PY; Lin, HL; Lo, YK; Wu, HY; Wu, SH; Yao, HT; Yeh, TK | 1 |
| Barton, D; Grothey, A; Kottschade, L; Loprinzi, C; Wolf, S | 1 |
| Sawant, RM; Sawant, RR; Torchilin, VP | 1 |
| Choi, MK; Kim, JK; Kim, MJ; Lim, SJ | 1 |
| Gilbert, BE; Kline, K; Latimer, P; Menchaca, M; Sanders, BG; Snyder, RM; Yu, W | 1 |
| Cui, F; Jiang, Y; Shi, K; Wang, Y; Zhang, M | 1 |
| Feng, SS; Zhao, L | 1 |
| Liu, W; Nie, N; Song, N; Tu, Q; Wang, J; Zhang, Y | 1 |
| Kumar, AP; Li, F; Loo, SY; Manu, KA; Rajendran, P; Sethi, G; Shanmugam, MK | 1 |
| Chandran, T; Katragadda, U; Rayaprolu, BM; Tan, C; Teng, Q | 1 |
| Ensign, L; Hanes, J; Lai, SK; Mert, O; Wang, YY; Wood, J; Yang, M | 1 |
| Jiang, X; Li, R; Li, X; Liu, B; Lu, X; Qian, X; Xu, H; Yin, H; Zhu, Z | 1 |
| Cao, W; He, ZG; Lian, H; Liu, YH; Sun, J; Sun, YH; Wang, SL; Wang, YJ; Yu, YP | 1 |
| Gill, KK; Kaddoumi, A; Nazzal, S | 1 |
| Chen, L; Li, Y; Shen, J; Yin, Q; Zhang, Z | 1 |
| Dou, H; Han, J; Tao, Y; Wang, X | 1 |
| Li, Y; Shen, J; Sun, H; Wang, S; Xu, P; Yin, Q; Yu, H; Zhang, Z | 1 |
| Huang, B; Liu, CS; Wang, G; Wu, Y; Yu, B; Yuan, Y | 1 |
| Fu, Q; Liu, F; Racette, K; Ramishetti, S; Tang, J; Wang, D; Wang, Y | 1 |
| Loganathan, R; Nesaretnam, K; Radhakrishnan, AK; Selvaduray, KR | 1 |
| Fu, Q; Liu, F; Racette, K; Tang, J; Wang, D; Wang, Y | 1 |
| Chen, H; Dong, Y; Huang, H; Zhang, J; Zhang, W; Zhao, T; Zhu, J | 1 |
| Chen, Y; Gao, X; Huang, Y; Li, J; Li, S; Lu, J; Venkataramanan, R; Zhao, W | 1 |
| Gao, L; Kang, J; Liu, G; Ma, J; Niu, M; Wang, H; Wang, X; Wang, Z | 1 |
| Ai, X; Ding, W; Han, X; He, Z; Kou, L; Li, L; Lian, H; Liu, X; Ren, G; Sun, J; Sun, Y; Wang, S; Wang, Y; Wu, C; Zhang, T; Zhang, Y | 1 |
| Bernabeu, E; Chiappetta, DA; Gonzalez, L; Helguera, G; Hocht, C; Legaspi, MJ; Taira, C | 1 |
| Li, Y; Meng, Q; Shen, J; Sui, H; Yin, Q; Yu, H; Zhang, Z | 1 |
| Abouzeid, AH; Patel, NR; Torchilin, VP | 1 |
| Guo, L; Sun, L; Wang, K; Xiong, W; Zheng, Y | 1 |
| Fallon, JK; Fu, Q; He, Z; Liu, D; Liu, F; Ma, Y; Wang, D; Wang, Y; Yang, X | 1 |
| Ju, RJ; Li, XT; Li, XY; Lou, JN; Lu, WL; Mu, LM; Shi, JF; Sun, MG; Zeng, F; Zhang, CX; Zhao, WY; Zhao, Y | 1 |
| Akgün-Dar, K; Arslan, M; Bilgiç, S; Çetin, B; Engin, KN; Erdem-Kuruca, S; Gürel, E; Karadenizli, S; Yemisci, B | 1 |
| Bu, H; He, X; Li, Y; Yin, Q; Yu, H; Zhang, Z | 1 |
| Fallon, JK; He, Z; Liu, D; Liu, F; Ma, Y; Wang, D; Wang, Y; Xu, XE; Yang, X; Zhao, Q | 1 |
| Emami, J; Hassanzadeh, F; Lavasanifar, A; Minaiyan, M; Mostafavi, A; Rezazadeh, M; Rostami, M; Sadeghi, H | 1 |
| Kulhari, H; Mukherjee, S; Pooja, D; Rachamalla, SS; Singh, MK; Sistla, R | 1 |
| Cui, Y; Li, L; Li, Y; Zhao, Y | 1 |
| Bao, Y; Cheng, B; Guo, Y; Li, D; Tan, S; Zhang, Z; Zhuang, X | 1 |
| Gao, X; Huang, Y; Li, J; Li, S; Lu, J; Venkataramanan, R; Zhang, P; Zhang, X; Zhang, Y; Zhao, W | 1 |
| Dai, X; Fan, W; Mckinley, D; Shi, L; Tan, C; Wang, Y | 1 |
| Feng, SS | 1 |
| Chen, Y; Lee, RJ; Sun, Y; Tang, S; Teng, L; Wang, G; Wu, Y; Xu, S; Yu, B; Yuan, Y; Zhang, X | 1 |
| Bora, HK; Chourasia, MK; Datta, D; Meher, JG; Panchal, SB; Pawar, VK; Sharma, K; Singh, A; Singh, P; Singh, Y | 1 |
| Chen, C; Chen, X; Fan, Z; Fang, X; Liang, H; Pang, X; Qi, Y; Sha, X; Yu, Z | 1 |
| Cui, F; Fang, L; Hong, J; Liang, N; Sun, S; Tian, J | 1 |
| Fallon, JK; Fu, Q; He, Z; Liu, D; Liu, F; Ma, Y; Wang, Y; Yang, X; Zhang, D | 1 |
| Bao, Y; Chu, Q; Tan, S; Wu, T; Wu, Y; Zhang, Z; Zhuang, X | 1 |
| Assanhou, AG; Kong, L; Li, W; Mo, R; Sun, H; Xue, L; Zhang, C; Zhang, L | 1 |
| Gao, Y; Ji, H; Liu, X; Qi, X; Tang, J; Wu, L; Zheng, N | 1 |
| Bernabeu, E; Cagel, M; Chiappetta, DA; Gergic, EP; Gonzalez, L; Moretton, MA | 1 |
| Bikiaris, DN; Filippousi, M; Leus, K; Nanaki, SG; Siafaka, PI; Tseligka, ED; Turner, S; Van Der Voort, P; Van Tendeloo, G; Vandichel, M; Vizirianakis, IS | 1 |
| Fallon, JK; Liu, D; Liu, F; Liu, H; Ma, Y | 1 |
| Deng, C; Meng, F; Wu, J; Zhang, J; Zhong, Z | 1 |
| Bernabeu, E; Chiappetta, DA; Gonzalez, L; Legaspi, MJ; Moretton, MA | 1 |
| He, W; Luan, Y; Yang, S; Zhang, H; Zhao, D | 1 |
| Kim, JE; Park, YJ | 1 |
| Jin, X; Li, M; Lv, H; Yin, L; Zhang, Z; Zhou, J | 1 |
| Jia, X; Song, J; Yan, H; Zhang, Z | 1 |
| Chen, Z; Han, L; Han, S; Jiang, L; Liu, B; Liu, J | 1 |
| Chen, Y; Feng, S; Gao, F; Liu, W; Yin, P; Yuan, Z | 1 |
| Cai, X; Xi, Y; Yang, X; Yu, A; Zhai, G | 1 |
| Dong, W; Han, X; Hao, H; Jin, Y; Liao, H; Liu, Y; Wang, B; Xia, X; Yang, Y; Ye, J | 1 |
| Fu, Y; Gong, T; Wang, Y; Zhang, ZR | 1 |
| Chen, F; Di, Y; Gai, X; Jia, L; Li, T; Liu, W; Pan, W; Wang, Y; Yang, X; Zhu, Z | 1 |
| Abu-Fayyad, A; Cardelli, J; Carroll, JL; Cody, R; Dragoi, AM; Kamal, MM; Nazzal, S | 1 |
| Deng, Y; He, C; Jin, Y; Li, X; Liu, Y; Qu, X; Wang, Z; Zhou, Y; Zou, Y | 1 |
| Chaurasiya, B; Du, Y; Huang, L; Sun, C; Tu, J; Webster, TJ; Xia, J | 1 |
| Gan, Z; He, F; Long, P; Su, H; Xiang, K; Xu, M; Yu, Q; Zhang, J; Zhang, X | 1 |
| Du, Y; Guo, X; Kong, F; Li, Q; Li, W; Luo, L; Wang, Z; Yang, J; You, J; Zhang, H; Zhu, C | 1 |
| Fu, S; Han, L; Lin, J; Liu, C; Lu, X; Yang, C; Zhao, C | 1 |
| Ji, J; Shi, X; Yang, X; Zhai, G | 1 |
| Baek, JS; Cho, CW; Han, SM; Hwang, SJ; Kim, MS | 1 |
| Cui, F; Gong, X; Li, Q; Liang, N; Sun, S; Yan, P | 1 |
| Choudhury, H; Gorain, B; Kesharwani, P; Pandey, M | 1 |
| Bhatta, RS; Chandasana, H; Chourasia, MK; Dixit, S; Kesharwani, P; Konwar, R; Meher, JG; Pathan, DK; Pawar, VK; Sharma, M; Singh, Y | 1 |
| Cheng, G; Fang, G; Gou, Y; Qian, Y; Tang, B | 1 |
| Ding, H; Ge, Y; Li, L; Yang, M; Zhu, Y | 1 |
| Chow, PK; Davoodi, P; Lei, C; Wang, CH; Zhan, W | 1 |
| Chen, Y; Chen, ZS; Gao, W; Jiang, Y; Lin, Z; Wang, B; Wu, S; Yang, X | 1 |
| Cui, F; Gong, X; Kawashima, Y; Liang, N; Sun, S; Zhang, X | 1 |
| Li, W; Xu, H; Xue, J | 1 |
| Bhatt, H; Biswas, S; Ghosh, B; Kiran Rompicharla, SV | 1 |
| Du, X; Feng, H; Lei, M; Ma, G; Sha, S; Wang, X; Zhu, Y | 1 |
| Lee, BJ; Ngo, HV; Tran, PHL; Tran, TTD | 1 |
| Flores-Villaseñor, SE; Franco, B; Meléndez-Ortiz, HI; Padilla-Vaca, F; Peralta-Rodríguez, RD; Ramirez-Contreras, JC | 1 |
| Chen, D; Hou, L; Huang, Q; Tian, C; Yan, Y; Yuan, Y; Zhang, H; Zhang, Z | 1 |
| Bhatt, H; Biswas, S; Ghosh, B; Kiran Rompicharla, SV; Torchilin, V | 1 |
| Du, Y; He, D; Shen, Y; Tu, J; Wang, S; Zhang, T | 1 |
| Ding, Y; Gao, M; Li, L; Ma, C; Ma, X; Wang, C; Wang, Y; Xu, Y | 1 |
| Chen, F; Chen, K; Li, Y; Pan, W; Qiao, S; Tan, G; Yang, Y; Zhang, L | 1 |
| Chourasia, MK; Dixit, S; Konwar, R; Meher, JG; Pawar, VK; Saklani, R; Singh, Y | 1 |
| Chen, R; Kuang, X; Tang, R; Wang, X; Wang, Z; Wu, S; Yan, G | 1 |
| Fang, K; Gao, X; Guo, D; Hu, S; Ji, C; Ji, H; Jiang, S; Li, G; Peng, L; Si, H; Song, X; Wang, J; Zhang, J; Zuo, R | 1 |
| Gong, Y; Li, Y; Li, Z; Wu, T; Xiong, X | 1 |
| Liu, S; Qian, J; Sun, J; Xiao, Y; Xie, Y; Yang, T; Zhang, Z; Zhao, J | 1 |
| Bi, D; Feng, L; Fu, J; Guo, Y; Han, J; Han, M; Wang, X; Zou, Y | 1 |
| Li, J; Luo, K; Wang, G; Xu, F; Yao, T; Yu, H; Zhu, J | 1 |
| Chen, J; Ding, W; Feng, J; Li, F; Li, Y; Liang, D; Tang, L; Xie, T; Yang, X; Zhang, Z; Zou, L | 1 |
| Dora, CP; Ghadi, R; Jain, S; Katiyar, SS; Kuche, K; Kushwah, V; Patil, R | 1 |
| Cheng, Y; Deng, X; Jia, L; Li, S; Lian, S; Lu, Y; Wang, J; Zhai, S | 1 |
| Banerjee, R; Jinka, S; Mondal, SK; Shankar, G; Srinivas, R | 1 |
| Chen, T; Chen, XJ; Liu, P; Liu, Q; Liu, W; Mo, Y; Wang, Q; Yuan, D; Yuan, Z | 1 |
| Chauhan, D; Chourasia, MK; Gayen, JR; Kalleti, N; Kedar, AS; Mishra, K; Mitra, K; Mugale, MN; Rana, R; Rath, SK; Saklani, R; Sharma, D; Tiwari, AK; Verma, S; Wahajuddin, M; Yadav, P; Yadav, PK | 1 |
4 review(s) available for d-alpha tocopherol and paclitaxel
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Novel enhanced delivery taxanes: an update.
Topics: Albumins; Animals; Antineoplastic Agents; Drug Carriers; Humans; Mice; Paclitaxel; Polyglutamic Acid; Vitamin E | 2007 |
Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies.
Topics: Acetylcarnitine; Acetylcysteine; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Baclofen; Calcium; Glutamine; Humans; Infusions, Intravenous; Ketamine; Magnesium; Naphthalenes; Nootropic Agents; Paclitaxel; Peripheral Nervous System Diseases; Pyridines; Randomized Controlled Trials as Topic; Vitamin E | 2008 |
Paclitaxel loaded vitamin E-TPGS nanoparticles for cancer therapy.
Topics: Animals; Drug Delivery Systems; Humans; Nanoparticles; Nanotechnology; Neoplasms; Paclitaxel; Vitamin E | 2018 |
2 trial(s) available for d-alpha tocopherol and paclitaxel
| Article | Year |
|---|---|
Vitamin E for prophylaxis against chemotherapy-induced neuropathy: a randomized controlled trial.
Topics: Administration, Oral; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Drug Administration Schedule; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Ovarian Neoplasms; Paclitaxel; Peripheral Nervous System Diseases; Pilot Projects; Testicular Neoplasms; Uterine Cervical Neoplasms; Vitamin E | 2005 |
Preventing paclitaxel-induced peripheral neuropathy: a phase II trial of vitamin E supplementation.
Topics: Administration, Oral; Antineoplastic Agents; Dietary Supplements; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel; Peripheral Nervous System Diseases; Treatment Outcome; Vitamin E | 2006 |
121 other study(ies) available for d-alpha tocopherol and paclitaxel
| Article | Year |
|---|---|
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular | 2004 |
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Humans; Taxoids | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Survival; Coloring Agents; Cyclosporine; Fluorouracil; Immunosuppressive Agents; Mice; Micelles; Paclitaxel; Polyethylene Glycols; Rhodamine 123; Vinblastine; Vitamin E | 1999 |
Formulation development and antitumor activity of a filter-sterilizable emulsion of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Emulsions; Female; Filtration; Humans; Melanoma; Mice; Mice, Inbred Strains; Paclitaxel; Particle Size; Serum Albumin; Skin Neoplasms; Solubility; Sterilization; Survival Analysis; Vitamin E | 2000 |
Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol).
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Delayed-Action Preparations; Excipients; Microspheres; Nanotechnology; Paclitaxel; Polyethylene Glycols; Polymers; Solvents; Vitamin E | 2002 |
A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.
Topics: Antineoplastic Agents, Phytogenic; Chemistry, Pharmaceutical; Delayed-Action Preparations; Lactic Acid; Nanotechnology; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Vitamin E | 2003 |
PLGA/TPGS nanoparticles for controlled release of paclitaxel: effects of the emulsifier and drug loading ratio.
Topics: Delayed-Action Preparations; Drug Compounding; Emulsifying Agents; Lactic Acid; Nanotechnology; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Vitamin E | 2003 |
Nanoparticles of biodegradable polymers for clinical administration of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Cell Division; Cell Survival; Drug Carriers; HT29 Cells; Humans; Kinetics; Nanotechnology; Paclitaxel; Particle Size; Polymers; Surface Properties; Vitamin E | 2004 |
Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model.
Topics: Administration, Oral; alpha-Tocopherol; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carotid Artery Injuries; Carotid Stenosis; Catheterization; Cell Division; Ethylene Glycols; Glycerol; Hyperplasia; Infusions, Parenteral; Intestines; Linoleic Acids; Male; Models, Animal; Myocytes, Smooth Muscle; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Radiography; Rats; Rats, Sprague-Dawley; Recurrence; Surface-Active Agents; Tocopherols; Tunica Intima; Verapamil | 2004 |
Design and evaluation of an emulsion vehicle for paclitaxel. I. Physicochemical properties and plasma stability.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bile Acids and Salts; Drug Stability; Emulsifying Agents; Emulsions; Microfluidics; Paclitaxel; Pharmaceutical Vehicles; Poloxamer; Polyethylene Glycols; Vitamin E | 2004 |
Determination of cysteine peptidases-like activity and their inhibitors in the serum of patients with ovarian cancer treated by conventional chemotherapy and vitamin E.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Cathepsin B; Cathepsin L; Cathepsins; Cell Transformation, Neoplastic; Cisplatin; Cysteine Endopeptidases; Drug Interactions; Enzyme Inhibitors; Female; Humans; Middle Aged; Ovarian Neoplasms; Paclitaxel; Vitamin E | 2004 |
Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release.
Topics: Antineoplastic Agents, Phytogenic; Drug Carriers; Drug Therapy; Humans; Lactic Acid; Molecular Structure; Molecular Weight; Nanostructures; Neoplasms; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Surface Properties; Vitamin E | 2006 |
Vitamin E for prophylaxis against chemotherapy-induced neuropathy: a randomized controlled trial.
Topics: Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Humans; Microtubules; Motor Neurons; Neurons, Afferent; Neuroprotective Agents; Paclitaxel; Peripheral Nerves; Peripheral Nervous System Diseases; Pilot Projects; Randomized Controlled Trials as Topic; Reproducibility of Results; Vitamin E | 2005 |
In vitro and in vivo studies on vitamin E TPGS-emulsified poly(D,L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation.
Topics: Antineoplastic Agents, Phytogenic; Area Under Curve; Drug Carriers; Drug Delivery Systems; Emulsifying Agents; Glycerol; Humans; Lactic Acid; Nanostructures; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Surface-Active Agents; Vitamin E | 2006 |
Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 dimethyl benz(a)anthracene-induced breast cancer in female Sprague Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Ascorbic Acid; Body Weight; Carcinogens; Catalase; Female; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Mammary Neoplasms, Experimental; Paclitaxel; Propolis; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vitamin E | 2006 |
Application of TPGS in polymeric nanoparticulate drug delivery system.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents, Phytogenic; Cell Membrane; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Kinetics; Nanotechnology; Paclitaxel; Polyethylene Glycols; Polymers; Surface Properties; Vitamin E | 2006 |
Self-assembled nanoparticles of poly(lactide)--Vitamin E TPGS copolymers for oral chemotherapy.
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Caco-2 Cells; Calorimetry, Differential Scanning; Cell Survival; Chemistry, Pharmaceutical; Humans; Hydrogen-Ion Concentration; Nanoparticles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Solubility; Vitamin E | 2006 |
d-alpha-Tocopheryl polyethylene glycol 1000 succinate (TPGS) modified poly(l-lactide) (PLLA) films for localized delivery of paclitaxel.
Topics: Calorimetry, Differential Scanning; Drug Delivery Systems; Paclitaxel; Polyesters; Polyethylene Glycols; Solubility; Tensile Strength; Vitamin E | 2008 |
Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticles.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Female; Folic Acid; Humans; Molecular Structure; Nanoparticles; Nanotechnology; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Spectrum Analysis; Vitamin E | 2008 |
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Caco-2 Cells; Ethanol; Glycerol; Humans; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Paclitaxel; Permeability; Polyethylene Glycols; Rhodamine 123; Solvents; Steroid Hydroxylases; Vitamin E | 2008 |
Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Carriers; Drug Stability; Hydrolysis; Mice; Micelles; Nucleosomes; Paclitaxel; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Solubility; Technology, Pharmaceutical; Time Factors; Vitamin E | 2008 |
Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
Topics: alpha-Tocopherol; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 8; Cell Growth Processes; Cell Line, Tumor; Drug Synergism; Drug Therapy, Combination; Humans; Neoplastic Stem Cells; Paclitaxel | 2009 |
Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases.
Topics: Administration, Inhalation; Aerosols; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Immunohistochemistry; Liposomes; Lymph Nodes; Lymphatic Metastasis; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neovascularization, Pathologic; Paclitaxel; Tumor Burden; Vitamin E | 2009 |
Tocopheryl succinate-based lipid nanospheres for paclitaxel delivery: preparation, characters, and in vitro release kinetics.
Topics: alpha-Tocopherol; Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Drug Carriers; Drug Compounding; Kinetics; Lipids; Microscopy, Electron, Transmission; Molecular Structure; Nanospheres; Paclitaxel; Particle Size; Solubility; Surface Properties; X-Ray Diffraction | 2010 |
Enhanced oral bioavailability of paclitaxel formulated in vitamin E-TPGS emulsified nanoparticles of biodegradable polymers: in vitro and in vivo studies.
Topics: Absorbable Implants; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Biological Availability; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Carriers; Electrochemistry; Excipients; Humans; Lactic Acid; Light; Microscopy, Electron, Scanning; Nanoparticles; Paclitaxel; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; Scattering, Radiation; Vitamin E | 2010 |
Folate-decorated hybrid polymeric nanoparticles for chemically and physically combined paclitaxel loading and targeted delivery.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Delivery Systems; Drug Screening Assays, Antitumor; Folic Acid; HeLa Cells; Humans; Mice; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanoparticles; NIH 3T3 Cells; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Vitamin E | 2011 |
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Chromans; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Induction; Genes, Reporter; Humans; Janus Kinases; Liver Neoplasms; NF-kappa B; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Vitamin E | 2011 |
Multi-drug delivery to tumor cells via micellar nanocarriers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Delayed-Action Preparations; Drug Carriers; Drug Combinations; Drug Delivery Systems; Female; Half-Life; Humans; Lactams, Macrocyclic; Micelles; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Phosphatidylethanolamines; Polyethylene Glycols; Vitamin E | 2011 |
A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles.
Topics: Antineoplastic Agents, Phytogenic; Cervix Mucus; Chemistry, Pharmaceutical; Drug Carriers; Humans; Lactic Acid; Nanoparticles; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface-Active Agents; Vitamin E | 2012 |
Paclitaxel/tetrandrine coloaded nanoparticles effectively promote the apoptosis of gastric cancer cells based on "oxidation therapy".
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Benzylisoquinolines; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Synergism; Genes, bcl-2; Humans; Nanoparticles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Stomach Neoplasms; Vitamin E | 2012 |
Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; Diffusion; Female; Humans; Micelles; Nanocapsules; Paclitaxel; Polyethylene Glycols; Vitamin E | 2011 |
Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Carriers; Humans; Inhibitory Concentration 50; Lung Neoplasms; Magnetic Resonance Spectroscopy; Micelles; Paclitaxel; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Sesquiterpenes; Vitamin E | 2012 |
Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Imines; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Male; Mice; Mice, Nude; Paclitaxel; Poloxalene; Polyethylene Glycols; Polyethylenes; RNA, Small Interfering; Survivin; Vitamin E | 2012 |
Nano-formulation of paclitaxel by vitamin E succinate functionalized pluronic micelles for enhanced encapsulation, stability and cytotoxicity.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Carriers; Drug Stability; Humans; Mice; Micelles; Paclitaxel; Succinic Acid; Vitamin E | 2013 |
Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma; Drug Combinations; Female; Genetic Therapy; Imines; Mice; Mice, Inbred BALB C; Mice, Nude; Nanocapsules; Paclitaxel; Poloxalene; Polyethylene Glycols; Polyethylenes; RNA, Small Interfering; Transfection; Treatment Outcome; Vitamin E | 2013 |
Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemical Precipitation; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Female; Humans; Lactic Acid; Lung Neoplasms; Mice; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Paclitaxel; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Treatment Outcome; Tumor Burden; Vitamin E; Xenograft Model Antitumor Assays | 2013 |
Multifunctional nanoparticles based on a single-molecule modification for the treatment of drug-resistant cancer.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorouracil; Humans; Hydrolysis; Models, Chemical; Nanoparticles; Neoplasms; Paclitaxel; Polyethylene Glycols; Rhodamine 123; Vitamin E | 2013 |
Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Count; Cell Proliferation; Chromans; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inhibitory Concentration 50; MCF-7 Cells; NF-kappa B p50 Subunit; Paclitaxel; Palm Oil; Plant Oils; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteolysis; Reagent Kits, Diagnostic; Signal Transduction; Tocotrienols; Vitamin E | 2013 |
Vitamin E reverses multidrug resistance in vitro and in vivo.
Topics: Adenosine Triphosphate; Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Paclitaxel; Time Factors; Vitamin E; Xenograft Model Antitumor Assays | 2013 |
Paclitaxel-loaded poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 2000 succinate nanoparticles for lung cancer therapy.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Cell Survival; Coumarins; Drug Delivery Systems; Humans; Lung Neoplasms; Mice; Mice, Nude; Nanoparticles; Neoplasms, Experimental; Paclitaxel; Polyesters; Polyethylene Glycols; Thiazoles; Vitamin E; Xenograft Model Antitumor Assays | 2013 |
Design and characterization of PEG-derivatized vitamin E as a nanomicellar formulation for delivery of paclitaxel.
Topics: Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; Female; Humans; Mice; Mice, Inbred BALB C; Micelles; Nanotechnology; Paclitaxel; Polyethylene Glycols; Vitamin E | 2013 |
Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants: I. Acute toxicity and pharmacokinetics studies.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Coated Materials, Biocompatible; Mice; Nanoparticles; Paclitaxel; Particle Size; Polyethylene Glycols; Surface-Active Agents; Suspensions; Toxicity Tests, Acute; Vitamin E | 2013 |
Enhanced oral delivery of paclitaxel using acetylcysteine functionalized chitosan-vitamin E succinate nanomicelles based on a mucus bioadhesion and penetration mechanism.
Topics: Acetylcysteine; Animals; Chitosan; Drug Carriers; Micelles; Mucus; Paclitaxel; Rats; Rats, Sprague-Dawley; Spectrometry, X-Ray Emission; Thermogravimetry; Vitamin E | 2013 |
Paclitaxel-loaded PCL-TPGS nanoparticles: in vitro and in vivo performance compared with Abraxane®.
Topics: Albumin-Bound Paclitaxel; Albumins; Animals; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Proliferation; Humans; Male; Nanoparticles; Paclitaxel; Polyesters; Polyethylene Glycols; Polymers; Rats; Rats, Wistar; Vitamin E | 2014 |
iRGD conjugated TPGS mediates codelivery of paclitaxel and survivin shRNA for the reversal of lung cancer resistance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Inhibitor of Apoptosis Proteins; Integrin alphaVbeta3; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Nanotechnology; Oligopeptides; Paclitaxel; Permeability; Polyethylene Glycols; RNA Interference; RNA, Small Interfering; Survivin; Vitamin E | 2014 |
Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer.
Topics: Animals; Cell Line, Tumor; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Nude; Micelles; Ovarian Neoplasms; Paclitaxel; Phosphatidylethanolamines; Polyethylene Glycols; Vitamin E; Xenograft Model Antitumor Assays | 2014 |
Nanoparticles of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS for delivery of paclitaxel to prostate cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Male; Nanoparticles; Paclitaxel; Polyesters; Prostatic Neoplasms; Proton Magnetic Resonance Spectroscopy; Vitamin E | 2014 |
Combinational delivery of hydrophobic and hydrophilic anticancer drugs in single nanoemulsions to treat MDR in cancer.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Emulsions; Female; Fluorouracil; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Mice; Mice, Nude; Nanomedicine; Neoplasm Transplantation; Paclitaxel; Polyethylene Glycols; Skin Neoplasms; Vitamin E | 2014 |
Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Artemether; Artemisinins; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line, Tumor; Dequalinium; Drug Delivery Systems; Glioma; Liposomes; Male; Mannose; Mice; Mice, Inbred ICR; Paclitaxel; Phosphatidylethanolamines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Vitamin E | 2014 |
The evaluation of human tenon's fibroblasts and endothelial cell responses to antifibrotics alone and in combination with α-tocopherol.
Topics: Alkylating Agents; alpha-Tocopherol; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cells, Cultured; Cytochromes c; Drug Combinations; Fibroblasts; Flow Cytometry; Fluorouracil; Human Umbilical Vein Endothelial Cells; Humans; Mitomycin; Necrosis; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Tenon Capsule | 2015 |
A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Survival; Drug Carriers; Drug Resistance, Neoplasm; Emulsions; Humans; Inhibitory Concentration 50; Mammary Neoplasms, Experimental; MCF-7 Cells; Membrane Potential, Mitochondrial; Mice, Nude; Nanostructures; Paclitaxel; Vitamin E; Xenograft Model Antitumor Assays | 2014 |
Theranostic nanoemulsions: codelivery of hydrophobic drug and hydrophilic imaging probe for cancer therapy and imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Humans; Hydrophobic and Hydrophilic Interactions; Mice, Nude; Nanomedicine; Neoplasms; Paclitaxel; Rhodamines; Vitamin E | 2014 |
Co-delivery of paclitaxel and α-tocopherol succinate by novel chitosan-based polymeric micelles for improving micellar stability and efficacious combination therapy.
Topics: alpha-Tocopherol; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Stability; Female; Humans; Hydrophobic and Hydrophilic Interactions; Micelles; Oligosaccharides; Ovarian Neoplasms; Paclitaxel; Particle Size | 2015 |
Dendrimer-TPGS mixed micelles for enhanced solubility and cellular toxicity of taxanes.
Topics: Animals; Cell Death; Cell Line; Cell Survival; Dendrimers; Docetaxel; Hemolysis; Humans; Hydrogen-Ion Concentration; Micelles; Paclitaxel; Particle Size; Polyethylene Glycols; Rats; Solubility; Spectroscopy, Fourier Transform Infrared; Static Electricity; Taxoids; Vitamin E; X-Ray Diffraction | 2014 |
Stable phosphatidylcholine-bile salt mixed micelles enhance oral absorption of paclitaxel: preparation and mechanism in rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Cell Line, Tumor; Drug Carriers; Drug Stability; Glycine max; Humans; Intestinal Absorption; Male; Micelles; Paclitaxel; Permeability; Phosphatidylcholines; Poloxamer; Polyethylene Glycols; Polyethyleneimine; Rats; Rats, Wistar; Sodium Cholate; Vitamin E | 2014 |
D-α-tocopherol polyethylene glycol succinate-based redox-sensitive paclitaxel prodrug for overcoming multidrug resistance in cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Carriers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; G2 Phase Cell Cycle Checkpoints; Half-Life; Humans; Mice; Micelles; Ovarian Neoplasms; Oxidation-Reduction; Paclitaxel; Polyethylene Glycols; Prodrugs; Rats; Rats, Sprague-Dawley; Vitamin E | 2014 |
Fmoc-conjugated PEG-vitamin E2 micelles for tumor-targeted delivery of paclitaxel: enhanced drug-carrier interaction and loading capacity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Compounding; Drug Stability; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Micelles; Molecular Targeted Therapy; Neoplasm Transplantation; Paclitaxel; Particle Size; Polyethylene Glycols; Rats, Sprague-Dawley; Tissue Distribution; Vitamin E | 2014 |
Reduction-responsive crosslinked micellar nanoassemblies for tumor-targeted drug delivery.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cross-Linking Reagents; Drug Carriers; Drug Liberation; Drug Stability; Female; Humans; Mice, Nude; Micelles; Ovarian Neoplasms; Paclitaxel; Polyethylene Glycols; Surface Properties; Thioctic Acid; Tissue Distribution; Vitamin E; Xenograft Model Antitumor Assays | 2015 |
15. Vitamin E TPGS based nanoparticles of biodegradable polymers for controlled release of anticancer drugs: Original research article: a novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitami
Topics: alpha-Tocopherol; Antineoplastic Agents, Phytogenic; Delayed-Action Preparations; History, 21st Century; Lactic Acid; Nanoparticles; Paclitaxel; Polyesters; Polyethylene Glycols; Polymers; Succinates | 2014 |
Enhanced antitumor efficacy of vitamin E TPGS-emulsified PLGA nanoparticles for delivery of paclitaxel.
Topics: Animals; Cell Line, Tumor; Ethanol; Female; Humans; Lactic Acid; Mice; Mice, Nude; Nanoparticles; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Vitamin E; Water; Xenograft Model Antitumor Assays | 2014 |
Immunotherapeutic vitamin E nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Compounding; Emulsions; Female; Hemolysis; Humans; Macrophages; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Rats; Rats, Wistar; Th1 Cells; Th2 Cells; Vitamin E | 2014 |
Adding vitamin E-TPGS to the formulation of Genexol-PM: specially mixed micelles improve drug-loading ability and cytotoxicity against multidrug-resistant tumors significantly.
Topics: Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Chemistry, Pharmaceutical; Coumarins; Drug Carriers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Space; Lactic Acid; Micelles; Paclitaxel; Particle Size; Polyesters; Polyethylene Glycols; Polymers; Spheroids, Cellular; Thiazoles; Vitamin E | 2015 |
In vivo pharmacokinetics, biodistribution and antitumor effect of paclitaxel-loaded micelles based on α-tocopherol succinate-modified chitosan.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Delivery Systems; Female; Half-Life; Humans; MCF-7 Cells; Mice; Micelles; Paclitaxel; Rats; Rats, Wistar; Succinic Acid; Tissue Distribution | 2016 |
Programmed Hydrolysis in Designing Paclitaxel Prodrug for Nanocarrier Assembly.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Disulfides; Drug Carriers; Erythrocytes; Hemolysis; Humans; Hydrolysis; Mice; Mice, Inbred BALB C; Mice, Nude; Nanostructures; Neoplasms; Paclitaxel; Particle Size; Polyethylene Glycols; Prodrugs; Tissue Distribution; Vitamin E | 2015 |
D-α-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Lung Neoplasms; MCF-7 Cells; Mice; Micelles; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Particle Size; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Sarcoma; Succinates; Vitamin E | 2015 |
Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hyaluronic Acid; Indazoles; Lipids; Liposomes; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Paclitaxel; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Vitamin E | 2015 |
Vitamin E derivative-based multifunctional nanoemulsions for overcoming multidrug resistance in cancer.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Emulsions; Humans; Membrane Potential, Mitochondrial; Nanostructures; Paclitaxel; Particle Size; Surface Properties; Vitamin E | 2016 |
Novel Soluplus(®)-TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Compounding; Drug Liberation; Female; Humans; Immunoblotting; MCF-7 Cells; Micelles; Microscopy, Electron, Transmission; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Poly(ADP-ribose) Polymerases; Polyethylene Glycols; Polyvinyls; Solubility; Vitamin E | 2016 |
Biocompatible Zr-based nanoscale MOFs coated with modified poly(ε-caprolactone) as anticancer drug carriers.
Topics: Antineoplastic Agents; Caproates; Cell Line, Tumor; Cisplatin; Coated Materials, Biocompatible; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Humans; Hydrophobic and Hydrophilic Interactions; Lactones; Nanoparticles; Paclitaxel; Particle Size; Polyethylene Glycols; Polymers; Vitamin E; Zirconium | 2016 |
The Effect of Surfactant on Paclitaxel Nanocrystals: An In Vitro and In Vivo Study.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Size; Diffusion; Female; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Nanocapsules; Neoplasms, Experimental; Organ Specificity; Paclitaxel; Polyethylene Glycols; Surface-Active Agents; Tissue Distribution; Treatment Outcome; Vitamin E | 2016 |
Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Breast Neoplasms; Cell Survival; Drug Carriers; Drug Delivery Systems; Female; Glutamic Acid; Glycols; Humans; Lactic Acid; Mice; Nanoparticles; Paclitaxel; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Surface-Active Agents; Tumor Cells, Cultured; Vitamin E; Xenograft Model Antitumor Assays | 2016 |
Paclitaxel-Loaded TPGS-b-PCL Nanoparticles: In Vitro Cytotoxicity and Cellular Uptake in MCF-7 and MDA-MB-231 Cells versus mPEG-b-PCL Nanoparticles and Abraxane®.
Topics: Albumin-Bound Paclitaxel; Cytotoxins; Female; Humans; MCF-7 Cells; Nanoparticles; Neoplasms; Paclitaxel; Polyesters; Polyethylene Glycols; Vitamin E | 2016 |
Redox-sensitive mPEG-SS-PTX/TPGS mixed micelles: An efficient drug delivery system for overcoming multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ethylene Glycols; Humans; MCF-7 Cells; Micelles; Oxidation-Reduction; Paclitaxel; Vitamin E | 2016 |
High paclitaxel-loaded and tumor cell-targeting hyaluronan-coated nanoemulsions.
Topics: alpha-Tocopherol; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chlorides; Drug Carriers; Drug Delivery Systems; Emulsions; Female; Ferric Compounds; Humans; Hyaluronan Receptors; Hyaluronic Acid; Microscopy, Electron, Transmission; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Particle Size; Polysorbates; Solubility; Soybean Oil; Temperature | 2017 |
Tyroservatide-TPGS-paclitaxel liposomes: Tyroservatide as a targeting ligand for improving breast cancer treatment.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Cell Line, Tumor; Drug Combinations; Drug Delivery Systems; Female; Humans; Liposomes; Mice; Mice, Nude; Oligopeptides; Paclitaxel; Vitamin E | 2017 |
Hyaluronic acid-modified didecyldimethylammonium bromide/ d-a-tocopheryl polyethylene glycol succinate mixed micelles for delivery of baohuoside I against non-small cell lung cancer: in vitro and in vivo evaluation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Flavonoids; Humans; Hyaluronic Acid; Inhibitory Concentration 50; Injections, Intravenous; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Micelles; Paclitaxel; Quaternary Ammonium Compounds; Solubility; Surface Properties; Technology, Pharmaceutical; Time Factors; Vitamin E; Xenograft Model Antitumor Assays | 2017 |
Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer.
Topics: alpha-Tocopherol; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell-Penetrating Peptides; Cisplatin; Drug Carriers; Drug Delivery Systems; Female; Humans; Lipids; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Phosphatidylethanolamines; Polyethylene Glycols; Prodrugs; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Vitamin E Succinate-Grafted-Chitosan Oligosaccharide/RGD-Conjugated TPGS Mixed Micelles Loaded with Paclitaxel for U87MG Tumor Therapy.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Drug Carriers; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Oligopeptides; Oligosaccharides; Paclitaxel; Particle Size; Succinates; Vitamin E | 2017 |
Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel.
Topics: Adipates; alpha-Tocopherol; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Liberation; Heparin; Humans; Hydrophobic and Hydrophilic Interactions; Nanoparticles; Oxidation-Reduction; Paclitaxel; Particle Size; Polymers | 2017 |
Vitamin E-rich Nanoemulsion Enhances the Antitumor Efficacy of Low-Dose Paclitaxel by Driving Th1 Immune Response.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Cytokines; Drug Carriers; Drug Interactions; Emulsions; Female; Humans; Mice, Inbred C57BL; Nanoparticles; Paclitaxel; Signal Transduction; Vitamin E | 2017 |
Matrix Stiffness Differentially Regulates Cellular Uptake Behavior of Nanoparticles in Two Breast Cancer Cell Lines.
Topics: Breast Neoplasms; Humans; MCF-7 Cells; Nanoparticles; Paclitaxel; Poloxamer; Polyethylene Glycols; Vitamin E | 2017 |
pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Drug Carriers; Drug Liberation; Dynamic Light Scattering; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Mice; Micelles; Microscopy, Electron, Transmission; Neoplasms; Paclitaxel; Particle Size; Polyethylene Glycols; Xenograft Model Antitumor Assays | 2017 |
Development and in-vitro characterization of nanoemulsions loaded with paclitaxel/γ-tocotrienol lipid conjugates.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Emulsions; Humans; Lipids; Nanoparticles; Paclitaxel; Polyethylene Glycols; Tocotrienols; Vitamin E | 2018 |
Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Glycerophospholipids; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Micelles; Paclitaxel; Polyamines; Polymers; Rats; Rats, Sprague-Dawley; Transcytosis | 2018 |
Redox-responsive micelles from disulfide bond-bridged hyaluronic acid-tocopherol succinate for the treatment of melanoma.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Disulfides; Drug Delivery Systems; Female; Hyaluronic Acid; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Micelles; Nanoparticles; Oxidation-Reduction; Paclitaxel; Tumor Microenvironment | 2018 |
CD44-Targeted Facile Enzymatic Activatable Chitosan Nanoparticles for Efficient Antitumor Therapy and Reversal of Multidrug Resistance.
Topics: alpha-Tocopherol; Animals; Chitosan; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hyaluronan Receptors; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasm Proteins; Neoplasms; NIH 3T3 Cells; Paclitaxel; Xenograft Model Antitumor Assays | 2018 |
Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Drug Delivery Systems; Drug Liberation; HT29 Cells; Humans; Hyaluronic Acid; Male; Mice; Micelles; NIH 3T3 Cells; Paclitaxel | 2018 |
Redox-responsive F127-folate/F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate/P123 mixed micelles loaded with paclitaxel for the reversal of multidrug resistance in tumors.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Disulfides; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Folic Acid; Humans; Inhibitory Concentration 50; MCF-7 Cells; Micelles; Mitochondria; Neoplasms; Oxidation-Reduction; Paclitaxel; Poloxalene; Poloxamer; Reactive Oxygen Species; Vitamin E | 2018 |
Development of redox-responsive theranostic nanoparticles for near-infrared fluorescence imaging-guided photodynamic/chemotherapy of tumor.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorophyllides; Drug Compounding; Drug Delivery Systems; Female; Heparin, Low-Molecular-Weight; Humans; Infrared Rays; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Neoplasm Transplantation; Optical Imaging; Paclitaxel; Photochemotherapy; Porphyrins; Random Allocation; Reactive Oxygen Species; Theranostic Nanomedicine; Tumor Burden; Whole Body Imaging | 2018 |
Surface modification of paclitaxel-loaded liposomes using d-α-tocopheryl polyethylene glycol 1000 succinate: Enhanced cellular uptake and cytotoxicity in multidrug resistant breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Survival; Drug Liberation; Drug Resistance, Neoplasm; Female; Humans; Liposomes; MCF-7 Cells; Microscopy, Confocal; Paclitaxel; Particle Size; Polysorbates; Solubility; Vitamin E | 2018 |
Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Chitosan; Drug Delivery Systems; Female; Glycerol; Humans; Injections, Intravenous; Male; MCF-7 Cells; Mice; Micelles; Paclitaxel; Particle Size; Polymers; Proton Magnetic Resonance Spectroscopy; Rabbits; Spectroscopy, Fourier Transform Infrared; Static Electricity; X-Ray Diffraction | 2018 |
Paclitaxel-loaded TPGS enriched self-emulsifying carrier causes apoptosis by modulating survivin expression and inhibits tumour growth in syngeneic mammary tumours.
Topics: Animals; Apoptosis; Drug Delivery Systems; Emulsions; Female; Humans; Isografts; Mammary Neoplasms, Experimental; MCF-7 Cells; Micelles; Neoplasm Transplantation; Paclitaxel; Rats; Rats, Sprague-Dawley; Vitamin E | 2018 |
VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Female; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Nanoparticles; Paclitaxel; Protein Structure, Secondary; Rhodamines; Vitamin E; Xenograft Model Antitumor Assays | 2018 |
Co-delivery of paclitaxel and doxorubicin using mixed micelles based on the redox sensitive prodrugs.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disulfides; Doxorubicin; Drug Delivery Systems; Drug Liberation; Female; Melanoma, Experimental; Mice; Micelles; Oxidation-Reduction; Paclitaxel; Prodrugs; Propionates; Tumor Burden; Vitamin E | 2019 |
Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Glioma; Lactic Acid; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Polyethylene Glycols; Polyglycolic Acid; Rats; Tissue Distribution; Vitamin E | 2019 |
A personalized and long-acting local therapeutic platform combining photothermal therapy and chemotherapy for the treatment of multidrug-resistant colon tumor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Elastic Modulus; Gold; Humans; Hydrogels; Hyperthermia, Induced; Inhibitory Concentration 50; Male; Mice, Nude; Micelles; Nanoparticles; Nanotubes; Neoplasm Recurrence, Local; Paclitaxel; Phototherapy; Polyethylene Glycols; Temperature; Time Factors; Vitamin E | 2018 |
Tumor-targeting micelles based on folic acid and α-tocopherol succinate conjugated hyaluronic acid for paclitaxel delivery.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cell Survival; Drug Delivery Systems; Drug Screening Assays, Antitumor; Folic Acid; Humans; Hyaluronic Acid; Male; MCF-7 Cells; Mice; Mice, Inbred Strains; Micelles; Molecular Structure; Neoplasms, Experimental; Paclitaxel; Particle Size; Tumor Cells, Cultured | 2019 |
Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Movement; Drug Carriers; Female; Humans; Inhibitory Concentration 50; Male; Mice, Inbred BALB C; Mice, Nude; Micelles; Neoplasms; Paclitaxel; Polyethylene Glycols; Stearic Acids; Tissue Distribution; Tumor Burden; Vitamin E; Whole Body Imaging | 2019 |
α-Tocopherol Succinate-Anchored PEGylated Poly(amidoamine) Dendrimer for the Delivery of Paclitaxel: Assessment of in Vitro and in Vivo Therapeutic Efficacy.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Breast Neoplasms; Cell Proliferation; Dendrimers; Drug Carriers; Drug Delivery Systems; Female; Humans; In Vitro Techniques; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Nylons; Paclitaxel; Polyamines; Polyethylene Glycols; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Hyaluronic Acid; Liposomes; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Polyethylene Glycols; Polymers; Rats; Sorafenib; Vitamin E | 2019 |
The roles of a surfactant in zein-HPMC blend solid dispersions for improving drug delivery.
Topics: Crystallization; Drug Liberation; Hydrophobic and Hydrophilic Interactions; Hypromellose Derivatives; Paclitaxel; Surface-Active Agents; Vitamin E; Wettability; Zein | 2019 |
Preparation of Peppermint Oil-Based Nanodevices Loaded with Paclitaxel: Cytotoxic and Apoptosis Studies in HeLa Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Cytotoxins; Dose-Response Relationship, Drug; Drug Liberation; HeLa Cells; Humans; Mentha piperita; Nanospheres; Paclitaxel; Plant Oils; Polyethylene Glycols; Surface-Active Agents; Vitamin E | 2019 |
Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Cell Survival; Cytosol; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hyaluronan Receptors; Hyaluronic Acid; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Micelles; Molecular Targeted Therapy; Paclitaxel; Polymers | 2019 |
Transferrin/α-tocopherol modified poly(amidoamine) dendrimers for improved tumor targeting and anticancer activity of paclitaxel.
Topics: alpha-Tocopherol; Antineoplastic Agents; Cell Survival; Dendrimers; Drug Delivery Systems; Flow Cytometry; HeLa Cells; Humans; Microscopy, Confocal; Nanoparticles; Paclitaxel; Polyamines; Polyethylene Glycols; Spheroids, Cellular; Transferrin | 2019 |
Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms.
Topics: alpha-Tocopherol; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Humans; Hyaluronan Receptors; Hyaluronic Acid; Micelles; Nanoparticles; Oxidation-Reduction; Oxyphil Cells; Paclitaxel; Particle Size | 2020 |
Mixed micelles of TPGS and Soluplus
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Female; Fenretinide; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Paclitaxel; Polyethylene Glycols; Polyvinyls; Rats; Rats, Wistar; Tumor Burden; Vitamin E; Xenograft Model Antitumor Assays | 2020 |
Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Drug Delivery Systems; Drug Liberation; Endocytosis; Female; Folic Acid; Glutathione; Hemolysis; Humans; Hyaluronic Acid; MCF-7 Cells; Mice; Micelles; Molecular Targeted Therapy; NIH 3T3 Cells; Oxidation-Reduction; Paclitaxel; Polymers; Rabbits; Xenograft Model Antitumor Assays | 2020 |
Paclitaxel-Loaded Colloidal Silica and TPGS-Based Solid Self-Emulsifying System Interferes Akt/mTOR Pathway in MDA-MB-231 and Demonstrates Anti-tumor Effect in Syngeneic Mammary Tumors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Availability; Cell Line, Tumor; Colloids; Drug Delivery Systems; Emulsions; Humans; Mammary Neoplasms, Animal; Paclitaxel; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Research Design; Silicon Dioxide; TOR Serine-Threonine Kinases; Vitamin E | 2020 |
Chemosensitizing micelles self-assembled from amphiphilic TPGS-indomethacin twin drug for significantly synergetic multidrug resistance reversal.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Indomethacin; MCF-7 Cells; Micelles; Mitochondria; Paclitaxel; Reactive Oxygen Species; Vitamin E | 2021 |
Encapsulating Halofuginone Hydrobromide in TPGS Polymeric Micelles Enhances Efficacy Against Triple-Negative Breast Cancer Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Compounding; Female; Humans; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Mice, Nude; Micelles; Paclitaxel; Piperidines; Polymers; Quinazolinones; Reactive Oxygen Species; Treatment Outcome; Triple Negative Breast Neoplasms; Vitamin E | 2021 |
Preparation and In Vitro/Vivo Evaluation of Folate-conjugated Pluronic F87-PLGA/TPGS Mixed Nanoparticles for Targeted Drug Delivery.
Topics: Apoptosis; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Female; Folic Acid; Humans; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Poloxamer; Polyethylene Glycols; Vitamin E | 2021 |
Polyethyleneimine- -Tocopherol Hydrogen Succinate/Hyaluronic Acid-Quercetin (PEI-TOS/HA-QU) Core-Shell Micelles Delivering Paclitaxel for Combinatorial Treatment of MDR Breast Cancer.
Topics: alpha-Tocopherol; Animals; Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Humans; Hyaluronic Acid; Hydrogen; Mice; Micelles; Paclitaxel; Polyethyleneimine; Quercetin; Succinates | 2021 |
Pterostilbene nanoparticles with small particle size show excellent anti-breast cancer activity
Topics: Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Drug Compounding; Female; HeLa Cells; Humans; Lecithins; MCF-7 Cells; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Particle Size; Solubility; Stilbenes; Treatment Outcome; Tumor Burden; Vitamin E; Xenograft Model Antitumor Assays | 2021 |
TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of chemotherapeutic agent against multidrug-resistant cancer.
Topics: Albumins; Animals; Breast Neoplasms; Cell Proliferation; Cell Survival; Chondroitin Sulfates; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hyaluronan Receptors; Lipids; MCF-7 Cells; Mice; Nanoparticles; Paclitaxel; Vitamin E; Xenograft Model Antitumor Assays | 2021 |
Paclitaxel-Loaded TPGS
Topics: Biological Availability; Cell Line, Tumor; Cyclodextrins; Gelatin; HeLa Cells; Humans; Hyaluronic Acid; Nanoparticles; Paclitaxel; Vitamin E | 2022 |
Lipid- and TPGS-Based Core-Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential.
Topics: alpha-Tocopherol; Cell Line, Tumor; Humans; Lipids; Nanocapsules; Paclitaxel; Polyethylene Glycols; Vitamin E | 2022 |
Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy.
Topics: alpha-Tocopherol; Animals; Antioxidants; Apoptosis; beta Carotene; Cell Line, Tumor; Cell Proliferation; Lysine; Mice; Neoplasms; Paclitaxel; Quality of Life; Succinates | 2022 |
Modification of α-Tocopherol Succinate with a Tumor-targeting Peptide Conjugate Enhances the Antitumor Efficacy of a Paclitaxel-loaded Lipid Aggregate.
Topics: alpha-Tocopherol; Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Neoplasm; Lipids; Melanoma; Mice; Paclitaxel; Peptides | 2023 |
Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Neoplasm; Mice; Mice, Nude; Micelles; Neoplasms; Oligopeptides; Paclitaxel; Polyethylene Glycols; Vitamin E; Zebrafish | 2022 |
Enhanced apoptosis and mitochondrial cell death by paclitaxel-loaded TPP-TPGS
Topics: Animals; Apoptosis; Cell Line, Tumor; Mice; Paclitaxel; Polyethylene Glycols; Tissue Distribution; Vitamin E | 2023 |