Page last updated: 2024-08-21

d-alpha tocopherol and mevalonic acid

d-alpha tocopherol has been researched along with mevalonic acid in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's6 (25.00)18.2507
2000's2 (8.33)29.6817
2010's10 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakamura, H1
Cottalasso, D; Domenicotti, C; Marinari, UM; Nanni, G; Pronzato, MA; Tenca, C; Traverso, N1
Dada, OA; Threlfall, DR; Whistance, GR1
Goodwin, TW; Griffiths, WT; Threlfall, DR2
Morin, RJ; Srikantaiah, MV1
Hughes, PE; Tove, SB1
Charpentier, C; Finckh, B; Gibson, KM; Hoffmann, GF; Hübner, C; Kohlschütter, A; Lehr, HA; Puhl, H1
Clark, RW; Gordon, DA; Parker, RA; Pearce, BC; Wright, JJ1
Guyton, JR; Hughes, H; Karsan, D; Lenz, ML; Mathews, B; Selinger, E; Smith, CV1
Elson, CE; Hadisusilo, S; He, L; Mo, H; Qureshi, AA1
Fujinami, T; Hibino, T; Jinno, Y; Kunimatsu, M; Okada, M; Sakuma, N; Sasai, K; Tamai, N; Yoshimata, T; Yosikawa, M1
Chao, JT; Gapor, A; Theriault, A1
Jin, H; Koo, PT; Tsang, DJ; Xiao, H; Yang, CS; Yang, Z1
Bachawal, SV; Sylvester, PW; Wali, VB1
Freiser, H; Jiang, Q; Jiang, Z; Kim, CY; Li, G; Rao, X; Zhang, Q1
Dutta, D; Elfakhani, M; Fernandes, NV; Hynds, DL; Katuru, R; King, C; Mills, N; Mo, H1
Gopalan, A; Kline, K; Sanders, BG; Yu, W1
Ichinomiya, S; Iwata, H; Sato, H; Siddig, S; Suwa, E; Tuerdi, G; Ueno, K; Yano, T1
Deng, L; Ding, Y; Fan, J; Fu, Q; Li, W; Peng, Y; Wu, Y; Yang, M; Yang, R1
Chen, CC; Ho, CT; Huang, SP; Huang, TC; Liu, TY1
Deng, L; Ding, Y; Fan, J; Huang, B; Peng, Y1
Mo, H; Shen, CL; Torabi, S; Yeganehjoo, H1
Shah, AK; Yeganehjoo, H1

Other Studies

24 other study(ies) available for d-alpha tocopherol and mevalonic acid

ArticleYear
[Effect of vitamin E on the alteration of the cholesterol metabolism with the aging of mice (author's transl)].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1976, Volume: 51, Issue:4

    Topics: Acetates; Aging; Animals; Cholesterol; Fatty Acids; Feces; Kidney; Lipid Metabolism; Liver; Male; Mevalonic Acid; Mice; Proteins; Vitamin E

1976
Effects of CCl4 poisoning on metabolism of dolichol in rat liver microsomes and Golgi apparatus.
    Free radical research communications, 1990, Volume: 11, Issue:4-5

    Topics: Animals; Carbon Tetrachloride Poisoning; Dolichol Phosphates; Dolichols; Golgi Apparatus; Kinetics; Lipid Peroxidation; Liver; Male; Mevalonic Acid; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vitamin E

1990
Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots.
    European journal of biochemistry, 1968, Volume: 4, Issue:3

    Topics: Alkenes; Carbon Isotopes; Carotenoids; Chemical Phenomena; Chemistry, Physical; Mevalonic Acid; Plants; Quinones; Squalene; Sterols; Tritium; Ubiquinone; Vitamin E; Zea mays

1968
Observations on the nature and biosynthesis of terpenoid quinones and related compounds in tobacco shoots.
    European journal of biochemistry, 1968, Volume: 5, Issue:1

    Topics: Alkenes; Carbon Dioxide; Carbon Isotopes; Carotenoids; Chlorophyll; Chloroplasts; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mevalonic Acid; Nicotiana; Plants, Toxic; Quinones; Spectrophotometry; Spectrum Analysis; Sterols; Ubiquinone; Vitamin E

1968
Biosynthesis of the prenyl side chains of plastoquinone and related compounds in maize and barley shoots.
    The Biochemical journal, 1967, Volume: 103, Issue:3

    Topics: Carbon Dioxide; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Edible Grain; Light; Mevalonic Acid; Quinones; Radiation Effects; Terpenes; Ubiquinone; Vitamin E; Zea mays

1967
Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds.
    Pharmacological research communications, 1982, Volume: 14, Issue:10

    Topics: Acyclic Monoterpenes; Animals; Cytosol; Dolichols; In Vitro Techniques; Liver; Mevalonic Acid; Microsomes, Liver; Monoterpenes; Phytol; Rats; Squalene; Sterols; Terpenes; Ubiquinone; Vitamin E

1982
Synthesis of alpha-tocopherolquinone by the rat and its reduction by mitochondria.
    The Journal of biological chemistry, 1980, Aug-10, Volume: 255, Issue:15

    Topics: Adipose Tissue; Animals; Brain; Liver; Male; Mevalonic Acid; Mitochondria, Liver; Myocardium; Rats; Spleen; Tyrosine; Vitamin E

1980
Decreased plasma ubiquinone-10 concentration in patients with mevalonate kinase deficiency.
    Pediatric research, 1993, Volume: 34, Issue:2

    Topics: Cells, Cultured; Child; Child, Preschool; Creatine Kinase; Dolichols; Female; Fibroblasts; Humans; Infant; Lipoproteins, LDL; Male; Metabolism, Inborn Errors; Mevalonic Acid; Oxidation-Reduction; Phosphotransferases (Alcohol Group Acceptor); Ubiquinone; Vitamin E

1993
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    The Journal of biological chemistry, 1993, May-25, Volume: 268, Issue:15

    Topics: Acetates; Acetic Acid; Androstenes; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Chickens; CHO Cells; Cholesterol; Chromans; Cricetinae; Gene Expression Regulation, Enzymologic; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ketoconazole; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Suppression, Genetic; Tritium; Tumor Cells, Cultured; Vitamin E

1993
Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants.
    Atherosclerosis, 1995, Volume: 118, Issue:2

    Topics: Animals; Antioxidants; Aorta; Butylated Hydroxytoluene; Cell Death; Cells, Cultured; Copper; Culture Media; Deferoxamine; Enzyme Inhibitors; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketocholesterols; Lipid Peroxidation; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Oxidation-Reduction; Probucol; Swine; Thiobarbituric Acid Reactive Substances; Vitamin E

1995
Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo.
    The Journal of nutrition, 1997, Volume: 127, Issue:5

    Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Chromans; Dose-Response Relationship, Drug; Edible Grain; Female; Fruit; Melanoma, Experimental; Mevalonic Acid; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Norisoprenoids; Terpenes; Time Factors; Tumor Cells, Cultured; Vegetables; Vitamin E

1997
alpha-tocopherol protects the peroxidative modification of LDL to be recognized by LDL receptors.
    Journal of nutritional science and vitaminology, 1998, Volume: 44, Issue:5

    Topics: Adult; Cholesterol, LDL; Copper; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Lymphocytes; Mevalonic Acid; Pravastatin; Receptors, LDL; Vitamin E

1998
Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion.
    Journal of nutritional science and vitaminology, 2002, Volume: 48, Issue:5

    Topics: Arteriosclerosis; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Models, Biological; Monocytes; Tocotrienols; Umbilical Veins; Vitamin E

2002
Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells.
    International journal of cancer, 2010, Feb-15, Volume: 126, Issue:4

    Topics: Atorvastatin; Celecoxib; Cell Cycle; Cell Division; Cell Line, Tumor; Chromans; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Drug Synergism; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Polyisoprenyl Phosphates; Pyrazoles; Pyrroles; Sulfonamides; Vitamin E

2010
Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment.
    Lipids, 2009, Volume: 44, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chromans; Drug Synergism; Female; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Mice, Inbred BALB C; Vitamin E

2009
Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.
    International journal of cancer, 2012, Feb-01, Volume: 130, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Ceramides; Chromans; Humans; Intracellular Space; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Sphingosine; Tumor Burden; Vitamin E

2012
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
    Experimental biology and medicine (Maywood, N.J.), 2011, May-01, Volume: 236, Issue:5

    Topics: 3T3-L1 Cells; Alkaline Phosphatase; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Diterpenes; Humans; Lovastatin; Melanoma, Experimental; Mevalonic Acid; Mice; Vitamin E

2011
Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol.
    Cancer letters, 2013, Jan-28, Volume: 328, Issue:2

    Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Ceramides; Chromans; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mevalonic Acid; Neoplastic Stem Cells; Retinal Dehydrogenase; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Vitamin E

2013
Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells.
    Cancer letters, 2013, Oct-01, Volume: 339, Issue:1

    Topics: Apoptosis; Atorvastatin; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chromans; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mesothelioma; Metabolic Networks and Pathways; Mevalonic Acid; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Simvastatin; Vitamin E

2013
γ-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor.
    Bone, 2014, Volume: 67

    Topics: Animals; Bone Resorption; Chromans; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Mice, Inbred C57BL; Ovariectomy; Vitamin E

2014
Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase.
    Cellular signalling, 2015, Volume: 27, Issue:11

    Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cholesterol; Chromans; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; HL-60 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactoylglutathione Lyase; Lovastatin; Mevalonic Acid; NF-kappa B; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyruvaldehyde; raf Kinases; Signal Transduction; Vitamin E

2015
Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 167

    Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Chromans; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hydroxymethylglutaryl CoA Reductases; MCF-7 Cells; Membrane Potential, Mitochondrial; Mevalonic Acid; Reactive Oxygen Species; Vitamin E

2017
Peroxisome proliferator-activated receptor γ down-regulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes.
    Nutrition research (New York, N.Y.), 2016, Volume: 36, Issue:12

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Differentiation; Down-Regulation; Glucose; Glucose Transporter Type 4; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Lovastatin; Mevalonic Acid; Mice; PPAR gamma; Protein Serine-Threonine Kinases; Rosiglitazone; Thiazolidinediones; Triglycerides; Vitamin E

2016
The stimulatory impact of d-δ-Tocotrienol on the differentiation of murine MC3T3-E1 preosteoblasts.
    Molecular and cellular biochemistry, 2019, Volume: 462, Issue:1-2

    Topics: Alkaline Phosphatase; Animals; Cell Differentiation; Cell Line; Down-Regulation; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Mice; Osteoblasts; Osteogenesis; ras Proteins; Vitamin E

2019