Page last updated: 2024-08-21

d-alpha tocopherol and idebenone

d-alpha tocopherol has been researched along with idebenone in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.11)18.7374
1990's11 (40.74)18.2507
2000's7 (25.93)29.6817
2010's5 (18.52)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Amagata, A; Barnes, A; Hinman, A; Jankowski, O; Kheifets, V; Komatsuzaki, R; Lee, E; Miller, G; Mollard, P; Murase, K; Rioux, P; Shrader, WD; Wesson, K1
Coyle, JT; Murphy, TH; Schnaar, RL1
Coyle, JT; Miyamoto, M; Murphy, TH; Schnaar, RL1
Nagaoka, A; Suno, M2
Asai, K; Hayashi, T; Iguchi, A; Naito, M; Yamada, K; Yoshimine, N1
Oliveira, CR; Pereira, CM1
Oliveira, C; Pereira, C; Santos, MS2
Cardoso, SM; Oliveira, CR; Pereira, C1
Ishida, S; Lin, Y; Matsumoto, S; Mori, N; Ogata, T; Tsuchihashi, N; Yokoyama, H1
Fujino, H; Ikeda, K; Kubota, A; Nara, Y; Numano, F; Tagami, M; Yamagata, K; Yamori, Y1
Han, D; Kameyama, T; Nabeshima, T; Senzaki, K; Tanaka, T; Yamada, K1
Battaglia, A; Canonico, PL; Carfagna, N; Pamparana, F; Post, C; Sortino, MA1
Oliveira, CR; Rego, AC; Santos, MS1
Delanty, N; Praticò, D1
Jauslin, ML; Meier, T; Murphy, MP; Smith, RA1
Burch, JA; Lin, FH; Monteiro-Riviere, NA; Pinnell, SR; Selim, MA; Tournas, JA; Zielinski, JE1
Buzzoni, L; Ciliberti, N; Durini, E; Jauslin, ML; Manfredini, S; Meier, T; Palozza, P; Verdecchia, S; Vertuani, S1
Cooper, JM; Schapira, AH1
Ferraresi, A; Fetoni, AR; Greca, CL; Piacentini, R; Rizzo, D; Sergi, B; Tringali, G; Troiani, D1
Cordoba-Diaz, M; Hui, X; Maibach, HI; Wa, C; Zhai, H1
Firuzi, O; Miri, R; Saso, L; Tavakkoli, M1
Abdelazim, SA; Ali, SA; Darwish, HA; Kadry, MO; Rizk, MZ1
Brassington, R; Fahey, M; Kearney, M; Orrell, RW; Pandolfo, M1
GarcĂ­a Ron, A; Rodriguez Mesa, M1

Reviews

4 review(s) available for d-alpha tocopherol and idebenone

ArticleYear
Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease.
    The American journal of medicine, 2000, Volume: 109, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antioxidants; Ascorbic Acid; Benzoquinones; Central Nervous System; Central Nervous System Diseases; Clinical Trials as Topic; Drug Therapy, Combination; Free Radicals; Ginkgo biloba; Humans; Lipid Peroxidation; Neuroprotective Agents; Oxidation-Reduction; Phytotherapy; Plants, Medicinal; Selegiline; Ubiquinone; Vitamin E

2000
Friedreich's ataxia: coenzyme Q10 and vitamin E therapy.
    Mitochondrion, 2007, Volume: 7 Suppl

    Topics: Animals; Ataxia; Benzoquinones; Coenzymes; Disease Models, Animal; Friedreich Ataxia; Humans; Iron; Mutation; Neurodegenerative Diseases; Oxidative Stress; Oxygen; Quinones; Time Factors; Ubiquinone; Vitamin E

2007
Antioxidant therapy: current status and future prospects.
    Current medicinal chemistry, 2011, Volume: 18, Issue:25

    Topics: Acetylcysteine; Animals; Antioxidants; Antipyrine; Ascorbic Acid; Edaravone; Humans; Polyphenols; Thioctic Acid; Ubiquinone; Vitamin A; Vitamin E

2011
Pharmacological treatments for Friedreich ataxia.
    The Cochrane database of systematic reviews, 2016, Aug-30, Issue:8

    Topics: Antioxidants; Friedreich Ataxia; Heart; Humans; Hypertrophy, Left Ventricular; Randomized Controlled Trials as Topic; Rare Diseases; Ubiquinone; Ultrasonography; Vitamin E

2016

Other Studies

23 other study(ies) available for d-alpha tocopherol and idebenone

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Towards a modern definition of vitamin E-evidence for a quinone hypothesis.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: alpha-Tocopherol; Animals; CHO Cells; Cricetinae; Dogs; Dose-Response Relationship, Drug; Drug Design; Fibroblasts; Friedreich Ataxia; Humans; Hydrolases; Mice; Micronucleus Tests; Models, Chemical; NAD(P)H Dehydrogenase (Quinone); Nutritional Sciences; Oxidation-Reduction; Oxidative Stress; Quinones; Rats; Vitamin E

2012
Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1990, Apr-01, Volume: 4, Issue:6

    Topics: Animals; Benzoquinones; Biological Transport; Carbachol; Cell Survival; Cells, Cultured; Cerebral Cortex; Cystine; Fetus; Glutamates; Homocysteine; In Vitro Techniques; Neurons; Oxadiazoles; Quinones; Quisqualic Acid; Rats; Ubiquinone; Vitamin E

1990
Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Animals; Antioxidants; Benzoquinones; Cell Survival; Cystine; Excitatory Amino Acid Antagonists; Glutamates; Glutathione; Mice; Peroxides; Quinones; Rats; Sulfhydryl Compounds; Time Factors; Tumor Cells, Cultured; Ubiquinone; Vitamin E

1989
Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition.
    Biochemical and biophysical research communications, 1984, Dec-28, Volume: 125, Issue:3

    Topics: Animals; Antimycin A; Benzoquinones; Brain; Coenzymes; gamma-Aminobutyric Acid; Lipid Peroxides; Male; Mitochondria; NAD; Oxygen Consumption; Pantothenic Acid; Quinones; Rats; Rats, Inbred Strains; Rotenone; Thenoyltrifluoroacetone; Ubiquinone; Vitamin E

1984
Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619).
    Japanese journal of pharmacology, 1984, Volume: 35, Issue:2

    Topics: Animals; Benzoquinones; Brain Chemistry; Lipid Peroxides; Male; Malondialdehyde; Oxidation-Reduction; Quinones; Rats; Rats, Inbred Strains; Ubiquinone; Vitamin E

1984
Protective effects of idebenone on vascular endothelial cells against toxicity induced by oxidatively modified low density lipoprotein.
    Artery, 1993, Volume: 20, Issue:6

    Topics: Animals; Aorta, Thoracic; Benzoquinones; Butylated Hydroxytoluene; Cattle; Cell Survival; Cells, Cultured; Copper; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Kinetics; L-Lactate Dehydrogenase; Lipid Peroxidation; Lipoproteins, LDL; Malondialdehyde; Thiobarbituric Acid Reactive Substances; Ubiquinone; Vitamin E

1993
Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress.
    Free radical biology & medicine, 1997, Volume: 23, Issue:4

    Topics: Animals; Antioxidants; Benzoquinones; Cell Death; Cystine; Dithiothreitol; Glutamic Acid; Glutathione; Glutathione Reductase; Kinetics; L-Lactate Dehydrogenase; Oxidative Stress; PC12 Cells; Rats; Selegiline; Ubiquinone; Vitamin E

1997
Metabolic inhibition increases glutamate susceptibility on a PC12 cell line.
    Journal of neuroscience research, 1998, Feb-01, Volume: 51, Issue:3

    Topics: Adenosine Triphosphate; Animals; Antioxidants; Benzoquinones; Cell Hypoxia; Disease Susceptibility; Energy Metabolism; Glutamic Acid; Hypoglycemia; Ischemia; Mitochondria; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Thiazoles; Ubiquinone; Vitamin E

1998
The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes.
    Biochemical and biophysical research communications, 1998, May-29, Volume: 246, Issue:3

    Topics: Adenine Nucleotides; Animals; Antioxidants; Ascorbic Acid; Benzoquinones; Brain; Free Radical Scavengers; Free Radicals; Glutathione; Iron; Lipid Peroxidation; Male; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfhydryl Compounds; Synaptosomes; Ubiquinone; Vitamin E

1998
Enhancement of nitroxide-reducing activity in rats after chronic administration of vitamin E, vitamin C, and idebenone examined by an in vivo electron spin resonance technique.
    Magnetic resonance in medicine, 1998, Volume: 40, Issue:2

    Topics: Animals; Antioxidants; Ascorbic Acid; Benzoquinones; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Male; Oxidation-Reduction; Rats; Rats, Wistar; Spin Labels; Ubiquinone; Vitamin E

1998
Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion.
    Laboratory investigation; a journal of technical methods and pathology, 1998, Volume: 78, Issue:11

    Topics: Animals; Antioxidants; Apoptosis; Benzoquinones; Cerebral Cortex; Cerebrovascular Disorders; Free Radical Scavengers; Genetic Predisposition to Disease; Hypoxia, Brain; Necrosis; Neurons; Nitric Oxide; Osmolar Concentration; Oxygen; Rats; Rats, Inbred SHR; Rats, Wistar; Reperfusion; Superoxide Dismutase; Ubiquinone; Vitamin E

1998
Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.
    The European journal of neuroscience, 1999, Volume: 11, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Avoidance Learning; Benzoquinones; Brain Chemistry; Drug Interactions; Injections, Intraventricular; Lipid Peroxidation; Locomotion; Male; Maze Learning; Memory; Nerve Degeneration; Neurotoxins; Oxidative Stress; Peptide Fragments; Rats; Rats, Wistar; Ubiquinone; Vitamin E

1999
Neuroprotective effects of nicergoline in immortalized neurons.
    European journal of pharmacology, 1999, Mar-05, Volume: 368, Issue:2-3

    Topics: Animals; Antioxidants; Benzoquinones; Buthionine Sulfoximine; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Maleates; Neurons; Neuroprotective Agents; Nicergoline; Staurosporine; Tetrazolium Salts; Thiazoles; Ubiquinone; Vitamin E

1999
Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress.
    Free radical biology & medicine, 1999, Volume: 26, Issue:11-12

    Topics: Animals; Antioxidants; Benzoquinones; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radicals; Hypoglycemia; Ischemia; Neurons; Oxidative Stress; Reactive Oxygen Species; Retina; Ubiquinone; Vitamin E

1999
Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: protection by antioxidants.
    Neurobiology of disease, 1999, Volume: 6, Issue:3

    Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Antioxidants; Benzoquinones; Deoxyglucose; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Glutathione; Glycolysis; Mitochondria; Multienzyme Complexes; NAD(P)H Dehydrogenase (Quinone); Neurons; Neuroprotective Agents; Oxidative Stress; Oxidoreductases; PC12 Cells; Peptide Fragments; Pyruvic Acid; Rats; Succinate Dehydrogenase; Tritium; Ubiquinone; Vitamin E

1999
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:13

    Topics: Antioxidants; Benzoquinones; Cell Death; Drug Delivery Systems; Fibroblasts; Friedreich Ataxia; Humans; Mitochondria; Models, Biological; Organophosphorus Compounds; Oxidative Stress; Ubiquinone; Vitamin E

2003
Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid.
    The Journal of investigative dermatology, 2006, Volume: 126, Issue:5

    Topics: Antioxidants; Ascorbic Acid; Benzoquinones; Coumaric Acids; Humans; Kinetin; Radiation-Protective Agents; Skin; Ubiquinone; Ultraviolet Rays; Vitamin E

2006
Protective effects of Fe-Aox29, a novel antioxidant derived from a molecular combination of Idebenone and vitamin E, in immortalized fibroblasts and fibroblasts from patients with Friedreich Ataxia.
    Molecular and cellular biochemistry, 2007, Volume: 302, Issue:1-2

    Topics: Animals; Antioxidants; Benzoquinones; Cell Line, Transformed; Cell Survival; Chromans; Fibroblasts; Friedreich Ataxia; Humans; Hydrogen Peroxide; Protective Agents; Rats; Reactive Oxygen Species; Ubiquinone; Vitamin E

2007
Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E.
    Neuroreport, 2008, Feb-12, Volume: 19, Issue:3

    Topics: Animals; Antioxidants; Benzoquinones; Drug Synergism; Electrophysiology; Guinea Pigs; Hearing; Hearing Loss, Noise-Induced; In Situ Nick-End Labeling; Microscopy, Electron, Scanning; Noise; Organ of Corti; Ubiquinone; Vitamin E

2008
Determination of the antioxidative capacity of an antioxidant complex and idebenone: an in vitro rapid and sensitive method.
    Journal of cosmetic dermatology, 2008, Volume: 7, Issue:2

    Topics: Antioxidants; Caffeic Acids; Coumaric Acids; Flavonoids; Luminescence; Luminescent Measurements; Phenols; Plant Extracts; Polyphenols; Solubility; Superoxides; Ubiquinone; Ultraviolet Rays; Vitamin E

2008
Potential antifibrotic and angiostatic impact of idebenone, carnosine and vitamin E in nano-sized titanium dioxide-induced liver injury.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:6

    Topics: Alanine Transaminase; Angiogenesis Inhibitors; Animals; Antioxidants; Aspartate Aminotransferases; Carnosine; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Glutathione Transferase; Hep G2 Cells; Humans; Liver Cirrhosis; Male; Mice; Nitrates; Nitrites; Smad2 Protein; Titanium; Transforming Growth Factor beta; Ubiquinone; Vascular Endothelial Growth Factor A; Vitamin E

2015
Compassionate use of human recombinant insulin-like growth factor-1 therapy in Friedreich's ataxia.
    Neurologia, 2020, Volume: 35, Issue:2

    Topics: Adolescent; Compassionate Use Trials; Female; Friedreich Ataxia; Humans; Insulin-Like Growth Factor I; Ubiquinone; Vitamin E

2020